EKS-CAF-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.7	2.7E-111	727	1020	294

Status

Unreviewed

Ensembl Protein

ENSCAFP00000041504

UniProt Accession

E2R9H9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000016411	ENSCAFP00000041504	ENSCAFT00000045123
ENSCAFG00000016411	ENSCAFP00000024160	ENSCAFT00000026022

Organism

Canis familiaris

Functional Description

Protein Length

1391

Protein Sequence
(FASTA)

MPNPERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60

APLGTIIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GTDRSDRLHK HRHHQHRRSR 120

DLLKTKQTEK EKNQEVSSKS GSMKDRISGS SKRSNEENED YGKAQISKSS SNKESRSSKL 180

HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SPKQDDSPSG 240

ASYGQDYDLS PPRSHTSSNY DSYKKSPGST SRRQSISPPY KEPSAYQSST RSPSPYSRRQ 300

RSVSPYSRRR SSSYERSGSY SGRSPSPYGR RRSSSPFMSK RSLSRSPLPR KSMKSRSRSP 360

AYSRHSSSHS KKKRSGSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 420

KGSPIFLPRK ENSLVEAKDS GLESKKLTRG VKLEKSAPDT ELVNVPHLNT EVKNSLDTGK 480

VKLDENSEKH PIKDLKAQGS RDSKPIVLKE EIVTPKETET SEKETPPPVP TVTSPAPPLP 540

TTTPPPQTPP LPPLPPLPAI PQQPPLPPPQ PAFSQVLTSS TSTLPPSTHP RTSTLSSQAN 600

SQPLAQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ 660

RPRHLLTDLP LPPELPGGDP SPPDSPEPKA VTPPQQPYKK RPKICCPRYG ERRQTESDWG 720

KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ 780

LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM 840

KQLMEGLDYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW 900

YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW 960

PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL 1020

KDVELSKMDP PDLPHWQDCH ELWSKKRRRQ RQSGVVIEEP PPSKSSRKET TSGTSVEPVK 1080

NSSPAPPQPA PVKAEPGTGD AIGLGDITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI 1140

HSNPEMQQQL EALNQSISAL TEATSQQQDS EPMAPEESLK EAPPALVVQP SAEQTTSEAS 1200

STPADMQNML AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAEKRPPEP 1260

PGPPPPPPPP PLVEGDLSSA PQELNPAVTA ALLQLLSQPE AEPPGHLPHE HQALRPMEYS 1320

TRPHPNRTYG NTDGPETGFS ATDTDERNSG PALTESLTQT LVKNRTFSGS VSHLGESSSY 1380

QGTGWQQQKK G 1391

Nucleotide Sequence
(FASTA)

ATGCCCAATC CAGAGAGACA TGGGGGCAAG AAGGACGGGA GTGGAGGAGC TTCTGGAACT 60

TTGCAGCCGT CATCGGGAGG TGGCAGCTCC AACAGCAGAG AGCGTCACCG CTTGGTGTCG 120

AAGCACAAGC GGCATAAATC CAAGCACTCC AAAGACATGG GGTTGGTGAC CCCCGAAGCA 180

GCACCTTTGG GTACAATTAT CAAACCTCTG GTGGAGTATG ATGACATCAG CTCTGATTCA 240

GATACCTTCT CTGACGACAT GGCCTTCAAA CTAGACAGGA GGGAGAATGA TGAACGTCGT 300

GGGACTGATC GGAGTGACCG TCTGCACAAA CATCGTCACC ACCAGCACAG ACGTTCCCGG 360

GACTTACTAA AAACTAAACA AACAGAAAAA GAGAAAAACC AGGAAGTCTC CAGCAAATCG 420

GGATCGATGA AGGACCGGAT ATCAGGAAGT TCAAAGCGTT CAAATGAGGA GAATGAGGAC 480

TATGGGAAGG CACAGATATC CAAAAGCAGC AGCAACAAGG AATCCAGGTC ATCCAAACTT 540

CATAAGGAGA AGACACGGAA AGAACGTGAG TTGAAGTCTG GGCACAAAGA CCGGAGTAAA 600

AGTCATCGGA AGAGGGAAAC ACCCAAAAGC TACAAAACCG TAGACAGCCC CAAACGGAGA 660

TCCAGGAGTC CCCATAGAAA ATGGTCTGAC AGCCCCAAGC AAGATGATAG CCCCTCGGGA 720

GCTTCCTATG GCCAAGATTA TGACCTTAGT CCCCCAAGAT CTCACACCTC TAGCAATTAT 780

GACTCCTACA AGAAGAGTCC TGGAAGTACC TCAAGAAGAC AGTCAATTAG CCCTCCTTAC 840

AAGGAGCCTT CCGCCTACCA GTCAAGCACC CGGTCACCCA GTCCCTACAG TAGACGACAA 900

AGGTCTGTGA GTCCCTATAG TCGGAGACGT TCTTCCAGCT ATGAAAGGAG TGGCTCTTAC 960

AGTGGGAGAT CGCCTAGTCC CTATGGTCGA AGACGGTCTA GCAGCCCTTT CATGAGCAAA 1020

CGATCTCTGA GTCGGAGTCC ACTCCCCAGG AAATCCATGA AGTCTAGAAG TAGAAGTCCC 1080

GCATATTCAA GACACTCATC TTCTCATAGT AAAAAGAAGA GATCCGGGTC ACGCAGTCGA 1140

CATTCCAGCA TCTCACCTGT CAGGCTTCCA TTGAACTCCA GCTTGGGAGC TGAACTCAGT 1200

AGGAAAAAGA AGGAAAGAGC AGCTGCTGCT GCAGCAGCAA AAATGGATGG AAAGGAATCC 1260

AAGGGTTCAC CTATATTTTT GCCTAGAAAA GAGAACAGTT TAGTAGAGGC TAAAGATTCA 1320

GGCTTGGAGT CTAAAAAGTT AACCAGAGGT GTAAAATTGG AAAAATCTGC CCCAGATACT 1380

GAACTGGTGA ATGTACCACA TCTAAATACA GAAGTCAAAA ATTCTTTAGA TACAGGGAAA 1440

GTAAAGTTGG ATGAGAACTC TGAGAAGCAT CCTATTAAAG ATTTGAAAGC ACAGGGATCA 1500

AGAGACTCTA AACCCATAGT ATTGAAAGAG GAGATTGTTA CTCCAAAAGA GACAGAGACA 1560

TCAGAAAAGG AGACCCCTCC ACCTGTCCCC ACAGTTACTT CTCCTGCACC TCCTTTACCA 1620

ACAACTACCC CTCCACCTCA GACACCCCCT TTGCCACCTT TGCCTCCACT ACCAGCTATT 1680

CCACAGCAAC CACCTCTGCC TCCTCCCCAA CCAGCATTTA GTCAGGTTCT TACTTCTAGT 1740

ACTTCAACTT TGCCCCCTTC TACTCACCCA AGGACATCTA CTTTGTCCTC TCAGGCAAAT 1800

TCTCAGCCCC TTGCACAGGT TTCTGTGAAG ACTCAAGTAT CTGTAACAGC TGCTATTCCA 1860

CACCTAAAAA CTTCAACGTT GCCTCCTCTG CCCCTCCCAC CCTTATTACC AGGAGATGAT 1920

GACATGGATA GTCCAAAAGA AACTCTACCT TCAAAACCTG TAAAGAAAGA GAAGGAACAA 1980

AGGCCACGTC ACTTACTCAC AGACCTCCCC CTCCCTCCAG AACTTCCTGG TGGGGATCCA 2040

TCTCCTCCAG ACTCTCCAGA ACCAAAGGCA GTTACACCAC CTCAGCAACC ATATAAAAAG 2100

AGACCAAAAA TTTGTTGTCC TCGTTATGGA GAAAGAAGAC AAACAGAAAG TGACTGGGGG 2160

AAACGCTGTG TAGACAAGTT TGACATTATC GGGATTATTG GAGAGGGAAC CTATGGCCAA 2220

GTATATAAAG CCAAGGACAA AGACACAGGA GAGCTAGTGG CTCTGAAGAA GGTGAGACTG 2280

GACAATGAGA AGGAGGGCTT TCCAATCACA GCCATTCGTG AGATCAAAAT CCTTCGTCAG 2340

CTAATCCACC GAAGTGTTGT TAACATGAAG GAAATTGTTA CAGATAAACA AGATGCACTG 2400

GATTTCAAGA AGGACAAAGG TGCCTTTTAC CTTGTATTTG AATATATGGA CCATGACTTA 2460

ATGGGACTGC TAGAATCTGG TTTGGTGCAC TTTTCTGAGG ACCATATCAA GTCGTTCATG 2520

AAACAGCTAA TGGAAGGATT GGATTACTGT CACAAAAAGA ATTTCCTGCA TCGGGATATT 2580

AAGTGTTCTA ACATTTTGCT GAACAACAGT GGGCAAATCA AACTAGCAGA TTTTGGACTT 2640

GCTCGGCTCT ATAACTCTGA AGAGAGTCGC CCTTACACAA ACAAAGTCAT CACTCTGTGG 2700

TACCGACCTC CAGAACTTCT GCTTGGAGAG GAGCGTTACA CACCAGCCAT TGACGTTTGG 2760

AGCTGTGGAT GCATCCTCGG GGAACTGTTC ACAAAGAAGC CTATATTCCA AGCCAATCTG 2820

GAACTAGCTC AACTAGAACT GATCAGTCGA CTCTGTGGTA GCCCTTGTCC AGCTGTGTGG 2880

CCTGATGTTA TCAAGCTGCC CTACTTCAAT ACCATGAAAC CGAAGAAGCA ATATAGAAGG 2940

CGTCTACGAG AAGAATTCTC TTTCATTCCC TCAGCAGCAC TTGATTTACT GGACCACATG 3000

CTGACACTAG ATCCTAGCAA ACGTTGCACA GCTGAACAGA CTTTACAGAG TGACTTCCTT 3060

AAAGATGTTG AGCTCAGCAA AATGGATCCT CCAGACCTCC CCCACTGGCA GGATTGCCAT 3120

GAATTATGGA GTAAGAAACG GCGACGACAG CGACAGAGTG GTGTTGTGAT AGAAGAGCCA 3180

CCTCCATCCA AATCCTCTCG GAAAGAAACT ACCTCAGGGA CAAGTGTTGA GCCTGTGAAG 3240

AACAGCAGCC CAGCACCACC TCAGCCTGCT CCTGTCAAGG CGGAGCCTGG GACTGGGGAT 3300

GCAATAGGCC TCGGTGACAT CACACAGCAG TTGAATCAAA GTGAATTGGC AGTGTTACTG 3360

AATCTGCTGC AGAGCCAGAC CGACCTGAGC ATCCCTCAAA TGGCACAGCT GCTTAACATC 3420

CACTCCAACC CAGAGATGCA GCAGCAGCTG GAGGCCCTGA ACCAGTCCAT CAGTGCCCTA 3480

ACTGAAGCCA CTTCCCAGCA GCAGGACTCA GAGCCCATGG CCCCAGAGGA GTCTTTGAAG 3540

GAGGCACCTC CTGCCCTAGT GGTCCAGCCT TCAGCAGAAC AGACAACCTC TGAAGCTTCA 3600

AGCACACCAG CTGACATGCA GAATATGCTG GCAGTTCTTT TGAGTCAGCT GATGAAAACC 3660

CAGGAGCCAG CAGGCAGCCT GGAGGAAAAC AACAGTGACA AGAACAGTGG GCCACAGGGG 3720

CCCCGAAGAA CTCCCACAAT GCCACAGGAG GAGGCAGCAG AGAAGAGGCC CCCTGAGCCC 3780

CCCGGACCTC CACCGCCGCC ACCTCCACCC CCTCTGGTTG AAGGCGATCT TTCCAGCGCC 3840

CCCCAGGAGT TGAACCCAGC CGTGACAGCC GCCTTGCTGC AACTTTTATC CCAGCCTGAA 3900

GCAGAGCCTC CTGGCCACCT GCCACATGAG CACCAGGCCT TGAGACCAAT GGAATACTCC 3960

ACCCGACCCC ATCCCAACAG GACTTACGGA AACACTGATG GGCCTGAAAC AGGGTTCAGT 4020

GCCACTGACA CTGATGAACG CAACTCTGGT CCAGCTTTGA CAGAATCCTT GACCCAGACC 4080

CTGGTGAAGA ACAGGACCTT CTCAGGCTCT GTGAGCCACC TTGGGGAGTC CAGCAGTTAC 4140

CAGGGCACAG GGTGGCAGCA GCAGAAGAAA GGATAG 4176

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 727   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  786

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 787   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  845

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 846   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  905

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 906   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  965

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 966   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1020

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777	; P:protein autophosphorylation
GO:0043405	; P:regulation of MAP kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013