EKS-CAF-00157
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00157
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.91.1E-158416692277
StatusUnreviewed
Ensembl ProteinENSCAFP00000036774
UniProt AccessionE2QYW5;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000016518ENSCAFP00000036774ENSCAFT00000043646
ENSCAFG00000016518ENSCAFP00000024307ENSCAFT00000026179
OrganismCanis familiaris
Functional Description
Protein Length750
Protein Sequence
(FASTA)
MWLLLALLGV LVEVPGAPAL SLEASEEIEL EPCLAPSPEQ QEQELTVALG QAVRLCCGRA 60
ERGGHWYKEG SRLPPAGRVR GWRGRLEIAS FLPEDAGCYL CLARGSMLVL HNVTLVVDDS 120
LTSSNGNEDP KAHRVSRNGH IYSQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPMP 180
TIRWLKDGQD FHGEHRIGGI RAGLPANTTA VAGSDVELLC KVYSDAQPHI QWLKHIVING 240
SSFGADGFPY VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL 300
PEEDLTWTAA ASEARYTDII LYVSGSLALV VLLLLAGLYR GQVLISRQPR QPATVQKLSR 360
FPLARQFSLE SGSSAKSSSS LVRGVRLSSS GPPLLSGLVS LDLPLDPLWE FPRDRLVLGK 420
PLGEGCFGQV VRAEAFGMDP TQPDQASTVA VKMLKDNASD KDLADLVSEM EVMKLIGRHK 480
NIINLLGVCT QEGPLYVIVE CAAKGNLREF LRARRPPGPD LSPDGLRSSE GPLSFPALVS 540
CAYQVARGMQ YLESRKCIHR DLAARNVLVT EDNVMKIADF GLARGVHHID YYKKTSNGRL 600
PVKWMAPEAL FDRVYTHQSD VWSFGILLWE IFTLGGSPYP GIPVEELFSL LREGHRMDRP 660
PNCPPELYGL MRECWHAAPS QRPTFKQLVE ALDKVLLAVS EEYLDLRLTF GPYSSAGGDA 720
SSTCSSNDSV FCHDLLPLGP SSFSFPGAQT 750
Nucleotide Sequence
(FASTA)
ATGTGGCTGC TGTTGGCCCT GTTGGGGGTC CTGGTGGAGG TGCCTGGGGC TCCAGCTTTG 60
TCCCTTGAAG CCTCTGAGGA AATAGAACTA GAGCCCTGCC TGGCCCCCAG CCCAGAGCAG 120
CAAGAACAGG AGCTGACCGT GGCCCTTGGG CAGGCTGTGC GGCTATGCTG TGGGCGAGCT 180
GAACGTGGTG GCCACTGGTA CAAGGAAGGC AGTCGCCTAC CACCTGCTGG CCGGGTACGA 240
GGCTGGAGGG GCCGCTTGGA GATCGCCAGC TTCCTACCGG AGGATGCTGG CTGCTACCTC 300
TGCCTGGCAC GAGGCTCCAT GCTTGTCCTG CACAATGTTA CCTTGGTTGT GGATGACTCC 360
TTGACCTCTA GCAATGGCAA CGAGGACCCT AAGGCCCACA GGGTCTCCAG GAATGGGCAC 420
ATTTACTCCC AGCAAGCACC CTACTGGACA CACCCTCAGC GCATGGAGAA GAAACTTCAT 480
GCAGTGCCTG CCGGGAACAC TGTCAAGTTC CGCTGTCCAG CTGCAGGCAA CCCCATGCCC 540
ACCATCCGCT GGCTGAAGGA TGGACAGGAC TTCCATGGGG AGCATCGCAT TGGAGGCATT 600
CGGGCGGGGC TCCCGGCCAA CACCACAGCC GTGGCGGGCA GCGATGTAGA GCTGCTGTGC 660
AAGGTGTACA GCGACGCCCA GCCCCACATC CAGTGGCTGA AGCACATCGT CATCAATGGT 720
AGCAGTTTTG GCGCCGACGG CTTCCCCTAC GTGCAAGTCC TCAAGACAGC AGACATCAAT 780
AGCTCAGAGG TGGAGGTCCT ATACCTTCGG AACGTGTCAG CTGAGGATGC AGGCGAATAC 840
ACCTGCCTGG CAGGCAACTC CATTGGCCTC TCCTACCAGT CAGCCTGGCT CACAGTGCTG 900
CCAGAGGAGG ACCTCACATG GACAGCAGCA GCATCAGAGG CCAGGTATAC GGACATCATT 960
CTGTACGTGT CAGGCTCTCT GGCTTTGGTT GTCCTCCTGC TACTAGCTGG GTTGTATCGA 1020
GGGCAGGTAC TCATCAGCCG GCAGCCCAGG CAGCCCGCCA CCGTGCAGAA GTTGTCCCGC 1080
TTCCCTCTGG CCCGACAGTT CTCCCTGGAA TCGGGTTCTT CAGCCAAATC GAGCTCATCC 1140
TTGGTGCGGG GTGTCCGTCT CTCCTCCAGT GGCCCTCCCT TGCTCTCTGG CCTTGTGAGT 1200
CTAGACCTAC CTCTCGACCC ACTGTGGGAG TTCCCCCGGG ACAGGCTGGT GCTCGGAAAG 1260
CCACTGGGGG AGGGCTGCTT TGGGCAGGTA GTACGTGCAG AGGCCTTTGG CATGGACCCC 1320
ACCCAGCCTG ACCAAGCCAG CACTGTGGCT GTCAAGATGC TCAAGGACAA TGCCTCCGAC 1380
AAGGACCTGG CAGACCTGGT CTCTGAGATG GAGGTGATGA AGCTGATCGG CCGACATAAG 1440
AACATTATCA ATCTGCTGGG TGTCTGTACT CAGGAAGGAC CCCTGTATGT GATTGTGGAG 1500
TGTGCCGCCA AGGGAAACCT TCGGGAGTTC CTGCGGGCCC GGCGTCCCCC TGGCCCCGAC 1560
CTCAGCCCTG ATGGGCTGAG GAGCAGTGAG GGGCCCCTCT CCTTCCCCGC CCTGGTTTCC 1620
TGTGCCTACC AGGTGGCCCG AGGCATGCAG TATCTGGAGT CGAGGAAGTG CATCCACCGG 1680
GACCTGGCTG CCCGGAACGT ACTGGTGACA GAGGACAATG TGATGAAGAT TGCTGACTTT 1740
GGGCTGGCCC GTGGCGTCCA CCACATTGAC TACTACAAGA AAACCAGCAA TGGCCGCCTG 1800
CCTGTCAAGT GGATGGCACC CGAGGCCTTA TTTGACCGAG TCTACACACA CCAGAGTGAC 1860
GTGTGGTCGT TTGGGATCTT GCTGTGGGAG ATCTTCACCC TCGGGGGCTC CCCGTACCCT 1920
GGCATCCCTG TGGAGGAGCT GTTCTCACTG CTGCGGGAGG GGCATCGGAT GGACCGGCCC 1980
CCCAACTGCC CCCCAGAGCT GTATGGGCTA ATGCGGGAGT GCTGGCATGC AGCACCCTCT 2040
CAGAGGCCAA CTTTCAAGCA GCTGGTAGAG GCACTGGACA AGGTCCTGCT GGCCGTCTCC 2100
GAGGAGTACC TAGACCTCCG CCTGACCTTC GGACCCTACT CTTCGGCCGG TGGGGATGCC 2160
AGCAGCACCT GCTCCTCCAA CGACTCTGTC TTCTGCCATG ACCTCCTGCC ACTGGGGCCC 2220
AGCTCCTTCT CCTTCCCTGG GGCGCAGACA TGA 2253
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 416   LVLGKPLGEGCFGQVVRAEAFGMDPTQPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  475
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d  ++se  l++
Q: 476   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGLRSSEGPLSF  535
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 536   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  595
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 596   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  655
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 656   RMDRPPNCPPELYGLMRECWHAAPSQRPTFKQLVEAL  692
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPTQPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG LRSSEGPLSF 120
PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPNCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00141
EKS-BOT-00149
EKS-CAP-00150
EKS-EQC-00148
EKS-FEC-00139
EKS-ICT-00143
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORC-00140
EKS-PAT-00140
EKS-PTV-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013