EKS-CAF-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	444.2	3.9E-133	2154	2478	325

Status

Unreviewed

Ensembl Protein

ENSCAFP00000024527

UniProt Accession

E2R2L2;

Protein Name

Protein Synonyms/Alias

Gene Name

MTOR

Gene Synonyms/Alias

MTOR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000016648	ENSCAFP00000024527	ENSCAFT00000026412

Organism

Canis familiaris

Functional Description

Protein Length

2550

Protein Sequence
(FASTA)

MLGTGPAAAT AATTTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 60

TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP 120

VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAVSVP 180

TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 240

AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 300

KDLMGFGTKP RHITPFTSFQ AVQPPQSNAL VGLLGYSSHQ GLMGFGASPS PAKSTLVESR 360

CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 420

LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA 480

TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 540

KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TALPEASDVG SITLALRTLG SFEFEGHSLT 600

QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSVHLISGH AHVVSQTAVQ VVADVLSKLL 660

VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 720

MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 780

LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA 840

LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 900

VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 960

DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 1020

SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 1080

VFMHDNSPGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEVPLP SRKAALETVD 1140

RLTESLDFTD YASRIIHPIV RTLDQSPELR PTAMDTLSSL VFQLGKKYQI FIPMVNKVLV 1200

RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV 1260

STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 1320

AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 1380

VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF 1440

GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK 1500

WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 1560

QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW 1620

ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD 1680

PSRQLDHPLP TVHPQVTYAY MKNMWKSTRK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK 1740

QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA 1800

VLHYKHQNQA RDEKKKLRHA SGANITSTTT AATTAATATA TATSTEGSNS ESEAESTENS 1860

PTPSPLQKKV TEDLSKTLLM YTVPAVQGFF RSISLSRGNN LQDTLRVLTL WFDYGHWPDV 1920

NEALVEGVKA IQIDTWLQVI PQLIARIDTP RPLVGRLIHQ LLTDIGRYHP QALIYPLTVA 1980

SKSTTTARHN AANKILKNMC EHSNTLVQQA MMVSEELIRV AILWHEMWHE GLEEASRLYF 2040

GERNVKGMFE VLEPLHAMME RGPQTLKETS FNQAYGRDLM EAQEWCRKYM KSGNVKDLTQ 2100

AWDLYYHVFR RISKQLPQLT SLELQYVSPK LLMCRDLELA VPGTYDPNQP IIRIQSIAPS 2160

LQVITSKQRP RKLTLMGSNG HEFVFLLKGH EDLRQDERVM QLFGLVNTLL ANDPTSLRKN 2220

LSIQRYAVIP LSTNSGLIGW VPHCDTLHAL IRDYREKKKI LLNIEHRIML RMAPDYDHLT 2280

LMQKVEVFEH AVNNTAGDDL AKLLWLKSPS SEVWFDRRTN YTRSLAVMSM VGYILGLGDR 2340

HPSNLMLDRL SGKILHIDFG DCFEVAMTRE KFPEKIPFRL TRMLTNAMEV TGLDGNYRIT 2400

CHTVMEVLRE HKDSVMAVLE AFVYDPLLNW RLMDTNTKGN KRSRTRTDSY SAGQSVEILD 2460

GVELGEPAHK KTGTTVPESI HSFIGDGLVK PEALNKKAIQ IINRVRDKLT GRDFSHDETL 2520

DVPTQVELLI KQATSHENLC QCYIGWCPFW 2550

Nucleotide Sequence
(FASTA)

ATGCTTGGAA CCGGACCTGC TGCCGCCACC GCAGCCACCA CCACGTCGAG TAACGTGAGC 60

GTCCTACAGC AGTTCGCCAG CGGCCTGAAG AGCCGGAATG AGGAGACCAG GGCCAAGGCT 120

GCCAAGGAGC TCCAACACTA TGTCACCATG GAGCTCCGAG AGATGAGTCA AGAGGAGTCT 180

ACTCGCTTCT ATGACCAGCT GAACCATCAC ATTTTTGAAC TGGTTTCCAG CTCAGATGCC 240

AATGAAAGGA AAGGTGGCAT CTTGGCCATA GCCAGCCTCA TAGGAGTGGA AGGTGGGAAT 300

GCCACTCGGA TTGGCAGATT CGCTAACTAT CTTCGGAACC TCCTCCCCTC TAATGACCCA 360

GTTGTAATGG AGATGGCATC CAAGGCCATT GGCCGCCTTG CCATGGCAGG GGACACTTTT 420

ACGGCTGAGT ATGTGGAGTT TGAGGTGAAG CGAGCCTTGG AGTGGCTGGG CGCCGACCGC 480

AACGAGGGCC GGAGACACGC AGCTGTTCTA GTTCTCCGTG AGCTGGCTGT CAGCGTCCCC 540

ACCTTCTTCT TCCAGCAAGT GCAACCCTTC TTTGACAACA TTTTTGTGGC TGTATGGGAC 600

CCCAAACAGG CCATCCGTGA GGGAGCTGTG GCTGCCCTTC GTGCCTGTTT GATCCTCACC 660

ACCCAGCGTG AGCCGAAGGA GATGCAGAAG CCTCAGTGGT ATCGGCACAC GTTTGAAGAA 720

GCAGAGAAAG GGTTTGATGA GACATTGGCC AAGGAGAAGG GCATGAATCG GGATGATCGC 780

ATCCATGGAG CCTTGCTGAT CCTCAACGAG TTGGTCCGAA TCAGCAGCAT GGAGGGAGAG 840

CGCCTGAGAG AAGAAATGGA GGAGATCACG CAGCAGCAGC TGGTGCACGA CAAGTACTGC 900

AAGGACCTCA TGGGCTTCGG GACGAAACCT CGCCACATCA CGCCCTTCAC CAGTTTCCAG 960

GCTGTCCAGC CCCCGCAGTC CAACGCCTTG GTGGGACTGC TGGGGTACAG CTCTCACCAA 1020

GGCCTCATGG GGTTCGGGGC TTCCCCCAGC CCAGCCAAGT CCACCCTGGT GGAGAGTCGG 1080

TGTTGCCGAG ACCTGATGGA GGAGAAGTTC GATCAGGTGT GCCAGTGGGT GCTGAAGTGC 1140

AGGAACAGCA AGAACTCGCT GATCCAAATG ACAATCCTTA ATTTGTTGCC CCGCCTGGCC 1200

GCGTTCCGAC CTTCTGCCTT CACAGATACC CAGTACCTCC AAGATACCAT GAACCATGTG 1260

TTAAGCTGCG TCAAGAAGGA GAAGGAACGT ACAGCAGCCT TCCAAGCCCT GGGGCTGCTT 1320

TCCGTGGCTG TGAGATCTGA GTTTAAGGTC TATTTACCTC GTGTGCTGGA CATCATCCGT 1380

GCAGCCCTAC CCCCTAAGGA CTTTGCCCAT AAGAGACAGA AGGCCATGCA GGTGGATGCC 1440

ACAGTGTTCA CCTGCATCAG CATGCTGGCC CGGGCAATGG GGCCGGGCAT CCAACAAGAT 1500

ATCAAGGAGC TGCTGGAGCC CATGCTGGCA GTGGGACTGA GCCCTGCCCT CACTGCTGTG 1560

CTCTACGACC TGAGCCGTCA GATTCCGCAG CTGAAGAAGG ACATCCAGGA TGGGCTCCTG 1620

AAGATGCTGT CCCTGGTCCT GATGCACAAA CCCCTCCGGC ACCCGGGCAT GCCCAAGGGC 1680

CTGGCCCACC AGCTAGCTTC CCCCGGCCTC ACAGCCCTCC CCGAGGCCAG CGATGTGGGC 1740

AGCATTACTC TTGCCCTGCG AACTCTTGGC AGCTTTGAGT TTGAAGGCCA CTCTCTGACC 1800

CAGTTTGTCC GCCACTGTGC GGATCATTTC CTAAACAGCG AGCACAAGGA GATCCGCATG 1860

GAAGCTGCCC GCACCTGCTC CCGCCTGCTC ACGCCCTCCG TCCACCTCAT CAGTGGCCAC 1920

GCTCATGTGG TCAGCCAGAC TGCAGTGCAA GTGGTGGCAG ACGTGCTCAG CAAACTGCTT 1980

GTGGTTGGGA TAACAGATCC TGACCCTGAC ATCCGCTACT GTGTCTTGGC GTCCCTGGAT 2040

GAGCGCTTTG ATGCACACCT GGCCCAGGCA GAGAATTTGC AGGCCCTGTT TGTGGCCCTG 2100

AACGACCAGG TGTTTGAGAT CCGGGAGCTG GCCATCTGCA CCGTGGGCCG GCTCAGTAGC 2160

ATGAACCCGG CCTTCGTCAT GCCTTTCCTG CGCAAGATGC TCATCCAGAT TCTGACAGAG 2220

CTGGAGCACA GCGGTATTGG AAGAATCAAA GAGCAGAGTG CCCGCATGCT GGGGCACCTG 2280

GTCTCCAATG CCCCCCGGCT CATCCGCCCC TACATGGAGC CCATCCTGAA GGCTTTAATT 2340

TTGAAACTGA AAGATCCAGA CCCTGATCCA AACCCAGGTG TGATCAACAA TGTCTTGGCT 2400

ACAATTGGAG AATTGGCTCA GGTTAGTGGC CTAGAGATGA GGAAGTGGGT GGATGAACTC 2460

TTTATTATCA TCATGGACAT GCTCCAGGAC TCCTCTCTGT TGGCCAAAAG GCAGGTGGCT 2520

CTGTGGACCC TGGGACAGTT GGTGGCCAGC ACTGGCTACG TGGTGGAGCC CTACCGGAAG 2580

TACCCCACTT TGCTTGAGGT CCTGCTGAAT TTTCTGAAGA CTGAGCAGAA CCAGGGTACA 2640

CGGAGAGAGG CTATCCGTGT GTTAGGGCTT TTGGGGGCCC TGGATCCCTA CAAGCACAAA 2700

GTGAACATCG GCATGATTGA CCAGTCCCGC GACGCTTCTG CTGTCAGCCT GTCTGAATCC 2760

AAGTCAAGTC AGGATTCCTC CGACTACAGC ACCAGTGAGA TGCTGGTCAA CATGGGCAAC 2820

CTGCCCCTGG ACGAGTTCTA CCCCGCCGTG TCCATGGTGG CGCTGATGCG GATCTTCCGA 2880

GACCAGTCCC TCTCGCACCA TCACACCATG GTTGTCCAGG CCATCACCTT CATCTTCAAG 2940

TCCCTGGGCC TCAAGTGTGT GCAGTTTCTG CCGCAGGTCA TGCCCACATT CCTCAATGTC 3000

ATTCGGGTCT GCGATGGGGC CATCCGGGAA TTCCTGTTCC AGCAGCTGGG AATGTTGGTG 3060

TCCTTTGTGA AGAGCCACAT CAGACCTTAC ATGGATGAAA TAGTCACCCT CATGAGAGAA 3120

TTCTGGGTCA TGAACACCTC GATCCAGAGC ACAATCATTC TTCTCATTGA GCAAATTGTG 3180

GTAGCTCTTG GGGGTGAATT TAAGCTCTAC CTGCCCCAGC TGATCCCACA CATGCTCCGC 3240

GTCTTCATGC ATGATAACAG CCCAGGCCGC ATCGTCTCCA TCAAGCTGTT GGCTGCCATC 3300

CAGCTGTTTG GTGCCAACCT GGATGACTAT CTGCATTTGT TGTTGCCTCC TATCGTGAAG 3360

CTGTTTGACG CCCCGGAAGT TCCCCTGCCG TCTCGGAAGG CAGCGCTAGA GACCGTAGAC 3420

CGCCTGACAG AGTCCCTGGA CTTCACTGAC TATGCCTCCC GTATCATTCA TCCGATTGTT 3480

CGGACGCTAG ACCAGAGCCC GGAGCTGCGT CCCACAGCCA TGGACACATT GTCTTCACTG 3540

GTCTTCCAAC TGGGGAAGAA GTACCAAATT TTCATTCCAA TGGTGAATAA AGTCCTGGTG 3600

CGACACCGAA TCAACCATCA GCGCTACGAC GTCCTCATCT GCAGAATCGT CAAGGGATAC 3660

ACCCTTGCTG ACGAGGAAGA GGACCCTTTG ATTTATCAGC ATCGAATGCT GAGGAGCGGC 3720

CAAGGGGATG CGTTGGCTAG TGGGCCAGTA GAAACGGGAC CCATGAAGAA ACTGCACGTC 3780

AGCACCATCA ACCTCCAAAA GGCCTGGGGA GCTGCCAGAA GGGTCTCCAA AGACGACTGG 3840

CTGGAATGGC TGAGGCGGCT GAGTCTGGAG CTCCTGAAGG ACTCCTCGTC GCCTTCCCTG 3900

CGCTCGTGCT GGGCCCTGGC TCAGGCCTAC AACCCGATGG CCAGGGATCT CTTTAATGCT 3960

GCATTTGTGT CCTGCTGGTC TGAACTGAAT GAAGACCAGC AGGATGAACT CATCAGAAGC 4020

ATCGAGTTGG CCCTCACCTC ACAGGACATT GCCGAAGTCA CGCAGACCCT CTTAAACTTG 4080

GCTGAATTCA TGGAACACAG TGACAAGGGC CCCCTGCCAT TGAGAGACGA CAATGGCATT 4140

GTCCTGCTGG GTGAGAGGGC AGCCAAGTGC CGAGCATATG CCAAAGCGCT GCACTACAAA 4200

GAACTGGAGT TCCAGAAAGG TCCCACCCCC GCCATCCTAG AGTCTCTCAT CAGCATTAAT 4260

AATAAGCTAC AGCAGCCAGA GGCAGCGGCC GGGGTGTTGG AATATGCCAT GAAACACTTC 4320

GGAGAGCTGG AGATCCAGGC TACCTGGTAC GAGAAACTGC ATGAGTGGGA GGATGCGCTG 4380

GTGGCCTATG ATAAGAAGAT GGACACGAAC AAGGATGACC CCGAGCTGAT GCTGGGCCGC 4440

ATGCGCTGCC TCGAGGCCTT GGGGGAATGG GGGCAGCTCC ACCAGCAGTG CTGTGAAAAG 4500

TGGACCCTGG TTAATGACGA GACCCAAGCC AAGATGGCCC GCATGGCTGC TGCAGCTGCG 4560

TGGGGCTTAG GCCAGTGGGA CAGCATGGAG GAGTACACCT GTATGATCCC TCGGGACACC 4620

CACGATGGGG CATTTTATAG AGCCGTGCTG GCGCTGCATC AGGACCTCTT CTCCTTGGCT 4680

CAACAGTGCA TCGACAAAGC CAGAGACCTG CTGGATGCGG AGTTAACTGC TATGGCAGGA 4740

GAGAGCTACA GTCGGGCATA TGGGGCCATG GTTTCTTGCC ACATGCTGTC CGAGCTGGAG 4800

GAGGTTATCC AGTACAAACT TGTCCCCGAG CGACGGGAGA TCATCCGCCA GATCTGGTGG 4860

GAGAGACTGC AGGGCTGCCA GCGCATCGTG GAAGACTGGC AGAAAATCCT CATGGTGCGG 4920

TCGCTGGTGG TCAGCCCTCA CGAGGACATG AGGACCTGGC TCAAGTATGC CAGCCTGTGT 4980

GGGAAGAGCG GTAGGCTGGC CCTTGCTCAT AAAACCTTAG TGTTGCTCCT GGGAGTCGAC 5040

CCATCTCGGC AGCTTGACCA TCCTCTGCCA ACAGTGCACC CTCAGGTGAC CTACGCCTAC 5100

ATGAAAAACA TGTGGAAGAG CACTCGCAAG ATCGATGCCT TCCAGCACAT GCAGCACTTC 5160

GTGCAGACCA TGCAGCAGCA AGCGCAGCAT GCCATCGCGA CCGAGGACCA GCAGCACAAG 5220

CAAGAGCTGC ACAAACTCAT GGCCCGGTGT TTCCTGAAAC TCGGGGAGTG GCAGCTGAAC 5280

CTTCAGGGCA TCAACGAGAG CACAATCCCC AAGGTGCTGC AGTACTACAG CGCTGCCACG 5340

GAGCATGACC GCAGCTGGTA CAAGGCCTGG CATGCGTGGG CGGTGATGAA CTTTGAAGCT 5400

GTGCTGCACT ACAAACACCA GAACCAAGCC CGGGACGAGA AGAAGAAGCT GCGTCACGCC 5460

AGCGGGGCCA ACATCACCAG CACGACCACC GCCGCCACCA CAGCAGCCAC GGCCACGGCC 5520

ACGGCCACCA GCACCGAGGG CAGCAACAGC GAGAGTGAGG CCGAGAGCAC CGAGAACAGC 5580

CCCACCCCGT CTCCTCTGCA GAAGAAGGTC ACTGAGGATT TGTCCAAGAC CCTCTTGATG 5640

TACACGGTCC CCGCCGTCCA GGGCTTCTTC CGTTCCATCT CCTTGTCACG AGGCAACAAC 5700

CTCCAGGACA CACTGAGAGT CCTCACCTTA TGGTTTGACT ATGGTCACTG GCCGGATGTA 5760

AACGAAGCCT TGGTGGAGGG GGTGAAAGCG ATCCAGATCG ACACCTGGTT ACAGGTTATA 5820

CCTCAGCTCA TTGCGAGAAT CGATACGCCT CGGCCCTTGG TGGGCCGCCT CATTCACCAG 5880

CTTCTCACAG ACATTGGCCG GTACCACCCC CAGGCCCTCA TCTACCCCCT GACCGTGGCC 5940

TCTAAATCCA CCACGACGGC CCGCCACAAC GCAGCCAACA AGATTCTGAA GAACATGTGC 6000

GAGCACAGCA ACACCCTGGT CCAGCAGGCC ATGATGGTGA GTGAGGAGCT CATCCGCGTG 6060

GCCATCCTCT GGCACGAGAT GTGGCACGAA GGCCTGGAAG AAGCGTCACG TTTGTACTTT 6120

GGGGAGAGGA ACGTGAAAGG CATGTTTGAG GTGCTGGAGC CCCTGCATGC TATGATGGAA 6180

CGGGGCCCCC AGACTCTGAA GGAAACATCT TTTAATCAGG CATATGGTCG AGACTTAATG 6240

GAGGCCCAGG AGTGGTGCAG GAAGTACATG AAATCCGGGA ACGTCAAGGA CCTCACCCAG 6300

GCCTGGGACC TCTATTACCA CGTGTTCAGA CGGATCTCCA AGCAGCTGCC TCAGCTCACC 6360

TCCCTGGAAC TGCAGTATGT TTCCCCCAAA CTTCTGATGT GCCGGGACCT TGAGTTGGCC 6420

GTGCCGGGAA CGTACGACCC CAACCAGCCC ATCATTCGCA TTCAGTCCAT AGCACCGTCC 6480

CTGCAGGTCA TCACCTCCAA GCAGAGGCCC CGGAAGCTGA CGCTCATGGG CAGCAACGGG 6540

CATGAGTTTG TTTTCCTCCT GAAGGGCCAC GAAGACCTGC GGCAGGATGA GCGGGTGATG 6600

CAGCTCTTCG GCCTGGTGAA CACCCTTCTG GCCAATGACC CAACGTCTCT TCGCAAGAAC 6660

CTCAGCATCC AGAGGTACGC TGTCATCCCC TTATCAACCA ACTCGGGCCT CATTGGCTGG 6720

GTCCCCCACT GCGACACGCT GCACGCCCTC ATCCGGGACT ACAGAGAGAA AAAGAAGATC 6780

CTTCTCAACA TCGAGCATCG CATCATGTTG CGGATGGCTC CAGACTACGA TCACCTGACG 6840

CTGATGCAGA AGGTGGAGGT GTTTGAGCAC GCCGTCAACA ACACAGCCGG GGACGACCTG 6900

GCCAAGCTGC TGTGGCTGAA AAGCCCTAGC TCCGAGGTAT GGTTTGACCG AAGAACCAAC 6960

TACACCCGCT CTTTAGCGGT CATGTCCATG GTTGGGTATA TTTTGGGCCT GGGAGATAGA 7020

CACCCATCCA ATCTGATGCT TGACCGGCTG AGTGGGAAGA TCCTGCACAT CGACTTTGGG 7080

GACTGCTTTG AGGTTGCTAT GACCAGAGAG AAATTCCCAG AGAAGATTCC ATTTAGACTA 7140

ACGAGAATGC TGACCAATGC TATGGAGGTT ACGGGTCTGG ACGGCAACTA CAGAATCACG 7200

TGCCACACGG TGATGGAGGT GCTTCGGGAA CACAAGGACA GCGTCATGGC CGTGCTGGAA 7260

GCCTTTGTCT ACGACCCCTT GCTGAACTGG AGGCTGATGG ACACAAATAC CAAAGGCAAC 7320

AAGCGGTCCC GAACAAGGAC AGATTCCTAC TCTGCTGGCC AGTCAGTAGA AATTTTGGAT 7380

GGTGTGGAAC TTGGGGAACC CGCCCACAAG AAAACAGGGA CCACAGTGCC GGAATCTATC 7440

CATTCTTTCA TTGGAGACGG TTTGGTGAAG CCAGAGGCCC TAAATAAGAA AGCTATCCAG 7500

ATAATTAACA GGGTTCGAGA TAAGCTCACT GGGCGGGACT TTTCTCACGA TGAAACCCTG 7560

GATGTCCCGA CACAAGTCGA GCTGCTCATC AAACAGGCCA CATCCCACGA GAACCTGTGT 7620

CAGTGCTACA TCGGCTGGTG TCCTTTCTGG TAA 7653

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i+++++++++++skq+p+kl+l+Gs+g+e+++L+kg+eDlrqderv+qlf+lvNtlLa+d

Q: 2154  IQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLAND  2213

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++ r++L+i++y+V+plst+sgli+wv+++++L++l+++++ekk++ll+        ++

Q: 2214  PTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN-------IEH  2266

         *************************************************9.......9**

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +++ +++p+++hl+l+  +evf+++++n ++ d l+kll+ k+ps+e+wf++r++ytrsl

Q: 2267  RIMLRMAPDYDHLTLMqkVEVFEHAVNN-TAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL  2325

         ****************************.999****************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         Av+s+vgyiLgLgdrh++nl++d+ +g+++hidfg +fe a+t++k+pek+PFRLTr+++

Q: 2326  AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT  2385

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeela  298

         na++vtg++G++r++c++v++vlre+k++++++Le+f+ydpl++w+ +++++k+++++++

Q: 2386  NAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRT  2445

         ************************************************************

S: 299   ekakaealkikkllskvekaenavatrdlllle  331

         ++++++a +++++l++ve +e+a+++++++++e

Q: 2446  RTDSYSAGQSVEILDGVELGEPAHKKTGTTVPE  2478

         ****************************99987

Domain Sequence
(FASTA)

IQSIAPSLQV ITSKQRPRKL TLMGSNGHEF VFLLKGHEDL RQDERVMQLF GLVNTLLAND 60

PTSLRKNLSI QRYAVIPLST NSGLIGWVPH CDTLHALIRD YREKKKILLN IEHRIMLRMA 120

PDYDHLTLMQ KVEVFEHAVN NTAGDDLAKL LWLKSPSSEV WFDRRTNYTR SLAVMSMVGY 180

ILGLGDRHPS NLMLDRLSGK ILHIDFGDCF EVAMTREKFP EKIPFRLTRM LTNAMEVTGL 240

DGNYRITCHT VMEVLREHKD SVMAVLEAFV YDPLLNWRLM DTNTKGNKRS RTRTDSYSAG 300

QSVEILDGVE LGEPAHKKTG TTVPE 325

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0012505	; C:endomembrane system
GO:0005764	; C:lysosome
GO:0016020	; C:membrane
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043022	; F:ribosome binding
GO:0001030	; F:RNA polymerase III type 1 promoter DNA binding
GO:0001031	; F:RNA polymerase III type 2 promoter DNA binding
GO:0001032	; F:RNA polymerase III type 3 promoter DNA binding
GO:0071456	; P:cellular response to hypoxia
GO:0031669	; P:cellular response to nutrient levels
GO:0007281	; P:germ cell development
GO:0045792	; P:negative regulation of cell size
GO:0016242	; P:negative regulation of macroautophagy
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0010592	; P:positive regulation of lamellipodium assembly
GO:0046889	; P:positive regulation of lipid biosynthetic process
GO:0050731	; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly
GO:0045945	; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045859	; P:regulation of protein kinase activity
GO:0032314	; P:regulation of Rac GTPase activity
GO:0043200	; P:response to amino acid stimulus
GO:0032868	; P:response to insulin stimulus
GO:0031529	; P:ruffle organization
GO:0031929	; P:TOR signaling cascade

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013