EKS-CAF-00122

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00122

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	357.5	5.4E-107	41	313	273

Status

Unreviewed

Ensembl Protein

ENSCAFP00000024634

UniProt Accession

F1PGG9;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000016743	ENSCAFP00000024634	ENSCAFT00000026527

Organism

Canis familiaris

Functional Description

Protein Length

1304

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDL 60

ASGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCKGQL VDFLKKIESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IVDLYSNFPI 240

GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKFSIPP NDTRYSVFHD LIRATLKVNP 300

EERLSITELV NQLQEIAAAR NVNPKSPITE LLEQNGGYGN AVPSRGPPPP GGSSSGYSGG 360

LALAEYDQPY GGLLDILRGG TERLFTNLKD TSSKVIQSVA NYAKGDLDIS YITSRIAVMS 420

FPAEGVESAI KNNIEDVRLF LDSKHPGHYA VYNLSPRTYR PSKFHNRVSE CGWAARRAPN 480

LRSLYSVCRN MHSWLRQDHK NVCVVHCMDG RAASAVAVCS FLCFCRLFST AEAAVYMFSM 540

KRCPPGIWPS HKRYIEYMCD MVAEEPITPH SKPILVKAVV MTPVPLFSKQ RNGCRPFCEV 600

YVGDERVTTT SQEYDKMRDF RIEDGKAVIP LGITVQGDVL IVIYHARSTL GGRLQAKVAS 660

MKMFQVQFHT GFVPRNATTV KFAKYDLDAC DIQEKYPDLF QVNVEVEVEP RDRPSREAPP 720

WESTSMRGLN PKILFSSREE QQDILSKFGK PELPRQPGST AQYDAEAGSL DAEPTESDSP 780

QSSGTDTSHF LHTLDWHEEK DTETSPESHF AKENLSTLAE DAGGSEPSDE EAATPSTESR 840

DAADEDTPGP AARLPERDLI FDGATPATPQ EPTRQEDSVD LLGLHAEAGL APPVQASGAA 900

PSTADLLSRL LGGPDAAPEV PPGDLLGGEA PLLFASPAPS SSAQSPPREG PAADPFDPLL 960

LPSGPNTQPC SQPDLFGEFL HSESPAAVPA SFPSTHSAPP PACSTDFLHL GDLPAEPGKM 1020

TASTSHPDLL GGWEAWAEAP APAAAAEGPF FSAGGQPAAP SAPGSWTKSQ SLDPFADLGD 1080

LSSGLQGSPA GFAPGAFGAK TAPPPTGGSS WQQTGRPPAQ GTPWPPQAKP PPKACPQPRP 1140

NYAANVSVIG GREERGVRAP SFGQKPRVSE SDFEDLLSHQ GFSSKADRKG PRTMAEMRRQ 1200

EQARDADPLK LKLLEWTEGK ERNIRALLST LHTVLWDGES RWAPVGMADL VTPGQVKKQY 1260

RRAVLVVHPD KAAGQPYEQY AKMIFMELND AWAEFESQGS RPLF 1304

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCTGC GCTGGACTTC CTGGCGGGCC CGGGCTCCCT GGGCGGCGCC 60

GCCGGCCGCG ACCAGAGCGA CTTCGTGGGG CAGACGGTGG AGCTGGGCGA GCTGCGGCTG 120

CGGGTGCGGC GGGTCCTGGC GGAGGGAGGG TTTGCATTTG TGTATGAAGC TCAAGATCTG 180

GCAAGTGGCA GAGAATATGC CTTAAAGAGA TTATTGTCTA ACGAAGAGGA AAAGAACAGA 240

GCCATCATTC AGGAAGTTTG TTTCATGAAA AAACTTTCTG GCCACCCCAA TATTGTCCAG 300

TTTTGTTCTG CAGCGTCCAT AGGGAAAGAG GAGTCGGACA CTGGGCAGGC TGAGTTCCTG 360

CTGCTCACCG AGCTCTGCAA AGGGCAGCTG GTGGACTTTT TAAAGAAAAT TGAATCTAGA 420

GGTCCGCTCT CGTGCGATAC TGTTCTGAAG ATTTTCTATC AGACGTGCAG AGCGGTGCAG 480

CACATGCACA GACAAAAGCC GCCCATCATC CATAGAGACC TCAAGGTGGA AAACTTATTG 540

CTCAGTAACC AAGGGACCAT CAAGCTGTGT GACTTTGGCA GTGCCACGAC CATATCACAT 600

TACCCCGACT ACAGCTGGAG CGCCCAGAGG CGGGCCCTGG TGGAGGAAGA GATCACCAGG 660

AACACCACAC CCATGTACAG GACACCGGAA ATCGTGGACT TGTACTCCAA CTTCCCCATC 720

GGCGAGAAGC AGGACATCTG GGCGCTGGGC TGCATCTTGT ATCTGCTGTG CTTCCGGCAG 780

CATCCTTTTG AAGACGGAGC AAAGCTTCGG ATAGTCAACG GGAAGTTCTC GATCCCCCCC 840

AATGACACCC GGTACTCTGT GTTCCACGAC CTCATCCGCG CCACGCTGAA GGTCAACCCC 900

GAGGAGCGGC TGTCCATCAC AGAACTGGTG AACCAGCTCC AGGAGATCGC GGCCGCCAGG 960

AACGTGAACC CCAAGTCTCC CATCACTGAG CTCCTAGAGC AGAACGGAGG CTATGGGAAC 1020

GCTGTCCCTT CCCGAGGGCC ACCCCCTCCT GGGGGCTCCA GCAGCGGCTA CAGCGGAGGC 1080

CTGGCGCTGG CCGAGTACGA CCAGCCCTAC GGCGGGCTCC TGGACATCCT GCGGGGGGGC 1140

ACGGAGCGCC TCTTCACAAA CCTCAAGGAC ACCTCCTCCA AGGTCATCCA GTCTGTTGCC 1200

AATTACGCAA AAGGAGATTT GGACATCTCT TACATCACAT CTAGAATTGC TGTGATGTCG 1260

TTCCCAGCAG AAGGCGTGGA GTCGGCCATC AAGAACAACA TCGAAGACGT GCGGTTGTTT 1320

CTGGACTCCA AGCACCCGGG ACATTACGCC GTCTACAACC TGTCCCCAAG AACATACCGG 1380

CCCTCCAAAT TTCACAACCG GGTCTCCGAG TGTGGCTGGG CGGCCAGACG GGCCCCGAAC 1440

CTTCGCAGCC TGTACAGTGT GTGTCGGAAC ATGCACTCGT GGCTCCGGCA GGACCACAAG 1500

AACGTCTGTG TCGTGCACTG CATGGACGGG AGAGCTGCGT CTGCGGTGGC CGTGTGCTCC 1560

TTCCTGTGCT TCTGCCGCCT GTTCAGCACC GCGGAGGCTG CCGTGTACAT GTTCAGCATG 1620

AAGCGCTGCC CGCCAGGCAT TTGGCCATCC CACAAGAGGT ACATCGAGTA CATGTGTGAC 1680

ATGGTGGCCG AGGAGCCCAT CACACCCCAT AGCAAGCCCA TCCTGGTGAA AGCCGTGGTC 1740

ATGACACCCG TGCCCCTGTT CAGCAAGCAG AGAAACGGCT GCAGGCCCTT CTGCGAGGTC 1800

TACGTGGGGG ATGAGCGCGT GACTACCACG TCTCAGGAGT ACGACAAGAT GAGGGATTTC 1860

AGAATCGAGG ATGGCAAAGC AGTCATTCCC CTGGGCATAA CAGTGCAAGG GGACGTGCTC 1920

ATTGTCATCT ACCACGCCAG GTCCACCCTG GGAGGAAGAC TGCAGGCCAA GGTGGCATCC 1980

ATGAAGATGT TCCAGGTCCA GTTCCACACG GGGTTTGTGC CTCGGAATGC GACTACTGTG 2040

AAGTTTGCAA AGTATGACCT TGATGCGTGT GACATTCAGG AGAAATACCC AGATTTATTC 2100

CAAGTGAACG TGGAGGTGGA GGTGGAGCCC AGAGACAGGC CCAGCCGGGA GGCCCCACCC 2160

TGGGAGAGCA CCAGCATGAG GGGGCTCAAC CCCAAAATCC TGTTTTCCAG CCGAGAGGAG 2220

CAGCAAGACA TTCTGTCTAA ATTTGGGAAG CCGGAGCTCC CCAGGCAGCC CGGCTCCACC 2280

GCTCAGTACG ACGCCGAGGC AGGGTCCCTG GACGCAGAGC CCACAGAGTC TGATTCACCA 2340

CAGAGCAGCG GCACTGACAC CAGCCACTTC CTCCACACGC TGGATTGGCA CGAGGAGAAA 2400

GATACAGAGA CGAGTCCAGA AAGTCACTTT GCCAAGGAGA ACCTATCAAC CCTGGCCGAG 2460

GATGCAGGTG GGAGTGAGCC TTCGGACGAG GAAGCAGCCA CACCATCCAC CGAGAGCAGG 2520

GATGCTGCGG ATGAGGACAC ACCAGGGCCA GCGGCGAGGC TGCCAGAGCG AGATTTGATT 2580

TTTGATGGGG CCACGCCGGC CACACCGCAG GAGCCCACAC GGCAGGAGGA CAGTGTCGAC 2640

CTCCTAGGGC TGCATGCCGA GGCTGGGCTG GCCCCCCCTG TGCAGGCCAG TGGGGCAGCC 2700

CCCAGCACCG CCGACCTGCT CAGCCGCCTC CTGGGGGGCC CTGACGCTGC TCCGGAGGTG 2760

CCCCCGGGTG ACCTGCTGGG TGGAGAGGCT CCCCTCCTCT TCGCAAGCCC AGCCCCCTCC 2820

TCGAGCGCAC AGAGCCCGCC CCGTGAGGGG CCAGCTGCCG ACCCCTTTGA CCCTCTCCTG 2880

CTGCCATCTG GGCCCAACAC CCAGCCGTGC TCCCAGCCTG ACCTGTTCGG TGAATTTCTT 2940

CATTCGGAAT CTCCTGCCGC CGTGCCTGCG TCCTTCCCGT CCACCCACAG CGCCCCACCG 3000

CCCGCCTGCA GCACCGACTT CCTGCACCTG GGAGATCTAC CAGCAGAGCC TGGCAAGATG 3060

ACGGCCTCCA CCAGCCACCC GGATCTGCTG GGGGGGTGGG AGGCCTGGGC CGAGGCGCCG 3120

GCCCCCGCAG CTGCTGCAGA AGGTCCCTTC TTCTCTGCAG GAGGCCAGCC TGCCGCCCCC 3180

AGTGCCCCCG GGAGCTGGAC CAAGTCTCAG AGCCTGGACC CGTTTGCTGA CCTCGGTGAC 3240

CTCAGTTCTG GCCTCCAAGG CTCACCGGCT GGATTTGCTC CAGGGGCTTT TGGCGCCAAG 3300

ACGGCCCCCC CTCCCACGGG CGGCAGCTCC TGGCAGCAGA CGGGTCGGCC CCCGGCCCAG 3360

GGCACCCCGT GGCCCCCCCA GGCCAAGCCG CCCCCCAAGG CCTGTCCGCA GCCAAGGCCT 3420

AACTATGCTG CCAACGTGAG CGTGATTGGC GGCCGAGAGG AGAGAGGGGT CCGGGCCCCC 3480

AGCTTCGGCC AGAAGCCGAG AGTGTCCGAG AGCGACTTTG AGGACCTGCT GTCCCACCAG 3540

GGCTTCTCGT CCAAGGCTGA CCGGAAGGGG CCAAGGACCA TGGCTGAGAT GCGGCGGCAG 3600

GAGCAGGCGA GGGACGCAGA CCCGCTGAAG CTGAAGCTCC TGGAGTGGAC AGAGGGCAAG 3660

GAGAGGAACA TCCGCGCGCT GCTGTCGACC CTGCACACCG TGCTGTGGGA CGGCGAGAGC 3720

CGCTGGGCCC CCGTGGGCAT GGCCGACCTG GTGACCCCCG GGCAGGTGAA GAAGCAGTAC 3780

CGCCGCGCCG TGCTGGTGGT GCACCCGGAC AAGGCCGCAG GGCAGCCCTA CGAGCAGTAT 3840

GCCAAGATGA TCTTCATGGA GCTGAACGAC GCGTGGGCCG AGTTTGAGAG CCAGGGCTCC 3900

CGGCCGCTCT TCTGA 3915

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+++g++yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDLASGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+ck g+lvd+l+k +++g ls++++lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCK-GQLVDFLKKIESRGPLSCDTVLKIFYQTCRAV  159

         **877888999****************.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q+++ ++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQRRALVEEEIT  219

         *******************************************999999***********

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE++dlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngk+siP

Q: 220   RNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKFSIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +n++ ++ +++li++ l+v+peeR++i++++++l

Q: 280   PNDTRYSVFHDLIRATLKVNPEERLSITELVNQL  313

         ******************************9986

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDL ASGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCKGQL VDFLKKIESR GPLSCDTVLK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR 180

NTTPMYRTPE IVDLYSNFPI GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKFSIPP 240

NDTRYSVFHD LIRATLKVNP EERLSITELV NQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013