EKS-CAF-00170
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00170
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb445.76.0E-134410670261
StatusUnreviewed
Ensembl ProteinENSCAFP00000025865
UniProt AccessionF1PMJ3;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000017543ENSCAFP00000025865ENSCAFT00000027815
OrganismCanis familiaris
Functional Description
Protein Length782
Protein Sequence
(FASTA)
MCSLSLGYLS HHSWRREANL TGHAEKVGIE NFELLKVLGT GAYGKVFLVR KISGHDAGKL 60
YAMKVLKKAT IVQKAKTTEH TRTERQVLEH IRQSPFLVTL HYAFQTETKL HLILDYINGG 120
ELFTHLSQRE RFTEHEVRIY VGEIVLALEH LHKLGIIYRD IKLENILLDS NGHVVLTDFG 180
LSKEFVAEEA ERAYSFCGTI EYMAPDIVRG GDSGHDKAVD WWSLGVLMYE LLTGASPFTV 240
DGEKNSQAEI SRRILKSEPP YPQEMSALAK DLIQHLLMKD PKKRLGCGPR DADEIKEHLF 300
FQKINWDDLA AKKVPAPFKP VIRDELDVSN FAEEFTEMDP TYSPAALPQS SERLFQGYSF 360
VAPSILFKRN AAVIDPLQFH TGVDRPGVTN VARSAMMKDS PFYQHYDLDL KDKPLGEGSF 420
SICRKCIHKK SNQAFAVKII SKRMEANTQK EITALKLCEG HPNIVKLHEV FHDQLHTFLV 480
MELLNGGELF ERIKKKKHFS ETEASYIMRK LVSAVSHMHD VGVVHRDLKP ENLLFTDEND 540
NLEIKVIDFG FARLKPPDNQ PLKTPCFTLH YAAPELLNHN GYDESCDLWS LGVILYTMLS 600
GQVPFQSHDK SLTCTSAVEI MKKIKKGDFS FEGEAWKNVS QEAKDLIQGL LTVDPNKRLK 660
MSGLRYNEWL QDGSQLSSNP LMTPDILGSS GAAVQTCVKA TFHAFNKYKR EGFCLQNVDK 720
APLAKRRKMK KTSTSTETRS SSSESSHSSS SHSHGKTTPT KTLQPSHPAD ASTPDALFQF 780
SD 782
Nucleotide Sequence
(FASTA)
ATGTGCAGCC TTTCCCTAGG TTACCTGTCT CATCACAGTT GGAGGCGTGA AGCTAATTTA 60
ACAGGACATG CAGAGAAGGT GGGGATTGAA AATTTTGAGC TCCTGAAGGT TCTAGGAACT 120
GGAGCTTATG GGAAGGTCTT TCTAGTTCGT AAAATCAGCG GTCACGATGC TGGAAAGCTG 180
TATGCCATGA AAGTCTTAAA AAAGGCCACA ATCGTGCAAA AGGCCAAAAC CACAGAGCAC 240
ACGAGGACCG AGCGGCAAGT CCTGGAGCAC ATCAGGCAGT CGCCATTTTT AGTGACCTTG 300
CACTACGCTT TCCAGACAGA AACCAAACTT CATCTCATTT TAGATTATAT AAATGGTGGA 360
GAACTTTTTA CTCATCTTTC TCAAAGAGAG CGTTTCACAG AGCACGAGGT GCGGATCTAT 420
GTTGGAGAGA TCGTGCTTGC CCTCGAACAT CTCCACAAGT TGGGAATTAT ATACCGTGAC 480
ATTAAGCTTG AGAACATTCT CCTTGATTCT AATGGCCACG TGGTGCTGAC AGATTTTGGT 540
CTGAGTAAGG AGTTTGTGGC TGAAGAAGCT GAAAGAGCAT ATTCCTTTTG TGGGACTATT 600
GAATACATGG CACCGGATAT TGTCAGAGGG GGAGATTCAG GACATGACAA GGCAGTTGAC 660
TGGTGGAGTT TAGGTGTTCT AATGTATGAG TTACTAACTG GAGCATCTCC TTTCACTGTC 720
GATGGCGAGA AAAATTCCCA AGCTGAGATA TCTAGGAGAA TATTAAAAAG TGAGCCTCCA 780
TATCCTCAAG AAATGAGTGC TTTAGCTAAA GACCTAATTC AGCATCTTTT GATGAAAGAT 840
CCCAAAAAAA GATTGGGATG TGGTCCACGT GATGCGGATG AAATCAAAGA ACATCTCTTT 900
TTTCAGAAAA TAAATTGGGA TGATTTAGCC GCCAAAAAAG TGCCCGCGCC ATTTAAGCCA 960
GTCATCCGAG ATGAATTAGA TGTGAGTAAC TTTGCAGAAG AGTTCACAGA GATGGATCCC 1020
ACCTACTCCC CAGCAGCACT GCCCCAGAGC TCCGAGAGGC TGTTTCAGGG CTATTCCTTT 1080
GTTGCTCCTT CCATTCTGTT CAAGCGTAAT GCTGCTGTCA TAGATCCTCT TCAGTTTCAC 1140
ACGGGAGTTG ACCGTCCTGG AGTGACAAAT GTTGCCAGGA GCGCGATGAT GAAGGACTCC 1200
CCCTTCTATC AGCACTATGA CCTGGATCTG AAGGACAAGC CACTGGGAGA GGGAAGTTTT 1260
TCAATTTGTC GGAAGTGCAT ACACAAAAAA AGTAACCAAG CATTCGCAGT CAAAATAATC 1320
AGCAAAAGGA TGGAAGCCAA TACTCAGAAA GAAATAACAG CTCTGAAGCT CTGTGAAGGA 1380
CACCCCAATA TTGTGAAGCT GCATGAAGTT TTTCATGATC AGCTTCACAC ATTTCTGGTG 1440
ATGGAACTTC TGAACGGGGG AGAGCTGTTT GAGCGCATTA AGAAGAAGAA ACACTTCAGT 1500
GAGACGGAAG CCAGCTACAT CATGCGGAAG CTCGTTTCGG CTGTCAGCCA CATGCATGAC 1560
GTCGGCGTGG TGCACAGAGA CTTGAAGCCC GAGAATTTAT TGTTCACTGA TGAAAATGAC 1620
AATTTGGAAA TTAAAGTCAT CGATTTTGGG TTTGCACGCT TAAAGCCACC AGATAACCAG 1680
CCTCTCAAGA CGCCTTGCTT CACCCTGCAC TATGCGGCCC CAGAGCTCTT GAATCATAAT 1740
GGCTATGACG AGTCTTGTGA CCTCTGGAGC CTGGGCGTCA TCCTGTACAC GATGTTGTCA 1800
GGGCAAGTTC CCTTCCAGTC TCACGACAAA AGTCTGACGT GTACCAGTGC AGTGGAAATC 1860
ATGAAGAAAA TTAAAAAGGG AGATTTCTCC TTTGAAGGAG AAGCCTGGAA GAATGTATCC 1920
CAAGAAGCTA AAGATTTGAT CCAAGGACTT CTCACAGTTG ATCCAAATAA AAGGCTTAAA 1980
ATGTCAGGCT TGAGATACAA CGAATGGCTT CAAGATGGCA GCCAGCTGTC CTCAAATCCT 2040
CTTATGACTC CAGACATTCT AGGATCTTCA GGAGCTGCTG TGCAAACCTG TGTGAAAGCA 2100
ACTTTCCACG CCTTTAACAA ATACAAGAGA GAGGGCTTTT GCCTTCAAAA CGTCGATAAG 2160
GCCCCTCTGG CAAAGAGGAG GAAGATGAAG AAGACCAGCA CCAGCACGGA GACACGCAGC 2220
AGCTCCAGCG AGAGCTCTCA CTCATCCTCG TCCCACTCCC ACGGCAAGAC CACGCCCACC 2280
AAGACCCTGC AGCCCAGCCA CCCCGCAGAC GCCAGCACCC CTGACGCACT CTTCCAGTTC 2340
TCAGACTGA 2349
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c+hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 410   LKDKPLGEGSFSICRKCIHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  469
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 470   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  529
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 530   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  588
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 589   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  648
         *****************98888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 649   GLLTVDPNKRLKMSGLRYNEWL  670
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCIHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013