EKS-CAF-00112

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00112

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	472.2	4.0E-142	363	613	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000025891

UniProt Accession

E2RP25;

Protein Name

Protein Synonyms/Alias

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017565	ENSCAFP00000025891	ENSCAFT00000027842

Organism

Canis familiaris

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FENRHGKKRT LKGSIELSRI 60

KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET KNNNSLVPMY 120

HPNFWMDGRW RCCAQMEKLA VGCAQYDPTK NASKKPLPPT PEDNRRSLRE PEETIVIALY 180

DYQTNDPQEL MLQRNEEYYL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNSLETYEWY 240

NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIVSENNPCI KHYHIKETND 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGAGL VTRLRHPVCS WRQKAPVTAG LRYGKWVIDP 360

TELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LYGVCLEQAP ICLVFEFMEH GCLSDYLRNQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540

VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ITTGFRLYKP RLASSNIYQI MNHCWKEKPE 600

DRPPFCRLLS QLAEIAESGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TTATCCTCCT GGAAGAACAA CTCATCAAGA AATCACAACA AAAGAGAAGA 60

ACTTCTCCCT CAAACTTTAA AGTCCGTTTC TTTGTTTTAA CCAAAACCAG CCTGGCATAC 120

TTTGAGAATC GTCACGGGAA AAAGCGCACA TTGAAGGGCT CCATTGAACT CTCCCGAATC 180

AAATGTGTCG AGATTGTGAA AAGTGACATT AGCATCCCAT GCCACTATAA ATATCCATTT 240

CAGGTTGTGC ATGACAACTA CCTCCTCTAT GTGTTTGCTC CAGACCGTGA GAGCCGGCAG 300

CGCTGGGTTC TGGCCCTTAA AGAAGAAACA AAGAATAACA ACAGTTTGGT GCCCATGTAC 360

CATCCTAATT TCTGGATGGA TGGGAGGTGG AGGTGCTGTG CTCAGATGGA GAAGCTTGCA 420

GTGGGCTGTG CTCAGTACGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAAGACA ACAGGCGATC ACTTCGGGAA CCCGAAGAAA CCATTGTCAT TGCCTTGTAT 540

GACTACCAAA CAAATGACCC ACAGGAACTC ATGCTACAAC GCAATGAGGA GTACTACCTG 600

CTGGACAGTT CCGAGATTCA CTGGTGGAGG GTACAGGACA GGAATGGGCA TGAAGGATAT 660

GTACCAAGCA GTTATCTGGT GGAAAAGTCT CCAAATAGCC TGGAAACCTA TGAGTGGTAC 720

AATAAGAGTA TCAGTCGAGA CAAAGCTGAA AAACTTCTTT TAGACACAGG CAAAGAAGGA 780

GCCTTCATGG TACGAGATTC CAGAACTCCA GGAACATATA CTGTATCTGT TTTCACCAAA 840

GCCATTGTAA GTGAGAACAA CCCCTGTATC AAGCACTATC ACATTAAAGA AACAAATGAC 900

AACCCCAAGC GATATTATGT GGCTGAGAAG TACGTGTTTG ACTCCATTCC TCTCCTCATC 960

AATTATCACC AACACAATGG AGCAGGTCTG GTCACTAGAC TCCGGCACCC AGTTTGTTCT 1020

TGGAGGCAGA AAGCACCAGT CACTGCGGGA CTGAGATACG GGAAATGGGT GATTGATCCC 1080

ACTGAGCTCA CTTTTGTGCA GGAGATTGGC AGTGGACAGT TTGGGCTGGT GCATCTTGGC 1140

TACTGGCTTA ACAAGGACAA GGTGGCCATC AAAACCATTC AAGAAGGGGC TATGTCAGAA 1200

GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCACCCCAA ACTGGTCCAG 1260

CTGTATGGGG TATGCCTAGA GCAAGCTCCC ATCTGCCTGG TGTTTGAGTT CATGGAACAC 1320

GGCTGCCTGT CAGATTATCT TCGCAACCAG CGGGGACTCT TTGCTGCAGA AACCCTACTG 1380

GGCATGTGCC TGGATGTGTG TGAAGGCATG GCCTACTTGG AGGAGGCATG TGTCATCCAC 1440

AGAGACCTGG CTGCCAGAAA TTGTTTAGTG GGAGAAAACC AAGTCATCAA GGTGTCCGAC 1500

TTTGGGATGA CAAGGTTTGT CCTTGATGAT CAATACACCA GTTCCACAGG CACCAAGTTC 1560

CCGGTGAAGT GGGCATCCCC AGAAGTCTTC TCCTTCAGTC GCTATAGCAG CAAGTCAGAT 1620

GTGTGGTCAT TTGGTGTGCT AATGTGGGAA GTCTTCAGTG AAGGCAAAAT CCCGTATGAA 1680

AATAGAAGCA ACTCAGAAGT GGTGGAAGAC ATCACTACTG GATTTCGCTT ATACAAGCCC 1740

CGGCTGGCCT CCTCGAATAT CTACCAGATA ATGAATCATT GCTGGAAAGA GAAACCAGAG 1800

GACCGGCCAC CTTTCTGCAG ACTCTTGAGT CAACTGGCTG AAATTGCAGA ATCGGGACTT 1860

TAG 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd

Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRNQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++++g+rly+p+las+++y++m++cwkekpe+r

Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDITTGFRLYKPRLASSNIYQIMNHCWKEKPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f +lls+l+

Q: 603   PPFCRLLSQLA  613

         ********986

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRNQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIT TGFRLYKPRL ASSNIYQIMN HCWKEKPEDR 240

PPFCRLLSQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013