EKS-CAF-00175
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00175
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC479.82.8E-144284542259
StatusUnreviewed
Ensembl ProteinENSCAFP00000025992
UniProt AccessionF1PKU7;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000017622ENSCAFP00000025992ENSCAFT00000027949
OrganismCanis familiaris
Functional Description
Protein Length615
Protein Sequence
(FASTA)
GFGKQGFQCQ VCCFVVHKRC HEFVTFSCPG ADKGPASDDP RSKHKFKIHT YSSPTFCDHC 60
GSLLYGLIHQ GMKCDTCMMN VHKRCVMNVP SLCGTDHTER RGRIYIQAHI EREVLIVVVR 120
DAKNLVPMDP NGLSDPYVKL KLIPDPKSES KQKTKTIKCS LNPEWNETFR FQLKESDKDR 180
RLSVEIWDWD LTSRNDFMGS LSFGISELQK AGVDGWFKLL SQEEGEYFNV PVPPEGSEGN 240
EELRQKFERA KISQGTKAPE EKTTNTISKL DNNGNRDRMK LTDFNFLMVL GKGSFGKVML 300
SERKGTDELY AVKILKKDVV IQDDDVECTM VEKRVLALPG KPPFLTQLHS CFQTMDRLYF 360
VMEYVNGGDL MYHIQQVGRF KEPHAVFYAA EIAIGLFFLQ SKGIIYRDLK LDNVMLDSEG 420
HIKIADFGMC KENIWDGVTT KTFCGTPDYI APEIIAYQPY GKSVDWWAFG VLLYEMLAGQ 480
APFEGEDEDE LFQSIMEHNV AYPKSMSKEA VAICKGLMTK HPGKRLGCGP EGERDIKEHA 540
FFRYIDWEKL ERKEIQPPYK PKACGRNAEN FDRFFTRHPP VLTPPDQEVI RNIDQSEFEG 600
FSFVNSEFLK PEVKS 615
Nucleotide Sequence
(FASTA)
GGCTTCGGGA AGCAAGGATT CCAGTGCCAA GTCTGCTGTT TCGTTGTGCA CAAGCGGTGC 60
CATGAATTTG TCACCTTCTC CTGCCCAGGC GCTGACAAGG GCCCAGCCTC TGATGACCCT 120
CGGAGCAAAC ACAAGTTTAA GATCCACACA TACTCCAGCC CCACGTTCTG TGACCACTGT 180
GGCTCACTGC TGTATGGACT CATCCACCAG GGGATGAAAT GTGACACCTG CATGATGAAC 240
GTGCACAAGC GCTGTGTGAT GAACGTCCCT AGCCTGTGCG GCACTGACCA CACGGAGCGC 300
CGCGGCCGCA TCTATATCCA GGCCCACATC GAGAGGGAAG TCCTCATCGT TGTCGTAAGA 360
GATGCTAAAA ACCTTGTACC TATGGACCCC AATGGCTTGT CAGACCCTTA TGTGAAGCTG 420
AAACTGATTC CTGACCCCAA GAGTGAGAGC AAGCAGAAGA CCAAAACTAT CAAGTGCTCC 480
CTCAACCCTG AGTGGAACGA AACATTCAGA TTCCAACTGA AAGAATCGGA CAAAGACAGA 540
AGACTGTCTG TAGAGATTTG GGATTGGGAT CTGACCAGCA GGAATGACTT CATGGGATCT 600
TTGTCGTTTG GGATTTCTGA ACTGCAGAAA GCTGGTGTTG ATGGCTGGTT TAAGTTGCTG 660
AGCCAGGAGG AAGGCGAGTA CTTCAATGTA CCTGTGCCGC CGGAAGGAAG TGAGGGCAAT 720
GAGGAACTAC GGCAGAAATT CGAGAGAGCC AAGATCAGCC AGGGGACCAA GGCTCCAGAA 780
GAAAAGACGA CCAACACCAT ATCCAAACTT GACAACAATG GAAACAGAGA CCGAATGAAA 840
CTGACGGATT TTAACTTCCT GATGGTGCTG GGGAAAGGAA GCTTTGGCAA GGTCATGCTC 900
TCAGAGCGAA AAGGCACAGA TGAGCTCTAT GCCGTGAAGA TCCTGAAGAA GGATGTTGTG 960
ATCCAGGATG ACGATGTGGA ATGTACGATG GTGGAGAAAC GGGTGCTCGC CCTGCCTGGG 1020
AAGCCACCCT TCCTGACCCA GCTCCATTCC TGCTTCCAGA CCATGGACCG CCTGTACTTT 1080
GTTATGGAGT ACGTGAACGG GGGTGACCTC ATGTACCACA TCCAACAAGT TGGCCGGTTT 1140
AAGGAGCCTC ATGCTGTATT TTACGCTGCA GAAATTGCCA TCGGTCTGTT CTTCTTACAG 1200
AGCAAGGGCA TCATTTACCG TGACCTCAAA CTTGACAATG TGATGCTGGA TTCAGAGGGC 1260
CACATCAAGA TTGCTGATTT TGGCATGTGT AAGGAAAACA TCTGGGATGG GGTGACCACC 1320
AAGACATTCT GTGGCACTCC AGACTACATC GCCCCTGAGA TAATCGCCTA TCAGCCCTAT 1380
GGGAAGTCTG TGGATTGGTG GGCATTCGGA GTCCTGCTGT ATGAAATGTT GGCTGGGCAG 1440
GCACCCTTTG AAGGGGAGGA TGAGGATGAG CTCTTCCAGT CCATCATGGA ACACAATGTG 1500
GCTTACCCAA AGTCCATGTC CAAGGAAGCT GTGGCCATCT GCAAAGGGCT GATGACCAAA 1560
CACCCGGGCA AGCGTCTGGG TTGTGGACCT GAAGGTGAAC GTGACATCAA AGAGCATGCA 1620
TTTTTCCGAT ACATTGATTG GGAGAAACTT GAACGCAAAG AGATTCAGCC CCCGTATAAG 1680
CCAAAAGCCT GTGGGCGAAA TGCTGAAAAC TTCGACCGGT TTTTCACTCG TCATCCACCA 1740
GTCCTAACAC CTCCCGACCA GGAAGTCATC AGGAATATTG ACCAGTCAGA ATTCGAAGGA 1800
TTTTCCTTTG TTAACTCTGA ATTTTTAAAA CCTGAAGTCA AGAGC 1845
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 284   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  343
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 344   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  403
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 404   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  463
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 464   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  523
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 524   KRLGCGPEGERDIKEHAFF  542
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAP-00168
EKS-DAR-00459
EKS-EQC-00173
EKS-FEC-00158
EKS-GAM-00088
EKS-GAG-00144
EKS-GAA-00202
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-LOA-00167
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORN-00212
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-PES-00148
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013