EKS-CAF-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	426.2	5.5E-128	53	305	253

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026047

UniProt Accession

J9P0Q4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017658	ENSCAFP00000039127	ENSCAFT00000045457
ENSCAFG00000017658	ENSCAFP00000026047	ENSCAFT00000028005

Organism

Canis familiaris

Functional Description

Protein Length

551

Protein Sequence
(FASTA)

MSAAATAGKL ARAPADPGKA GAPGAAAPGA PVAAPPAKEI PEVLVDPRSR RRYLRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHIVGFHGFF 120

EDSDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNDYSI PKHINPVAAS LIQKMLQTDP AARPTIHELL 300

NDEFFTSGYI PARLPITCLT IAPRFSIAPS SLDPSNRKPL TVLNKGTENP MSERPREKEE 360

PAVRETNEAV DCHLRDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGCV QINFFQDHTK 540

LILCPLMAGG G 551

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CGGCAACTGC AGGGAAGCTG GCGCGGGCAC CAGCCGACCC AGGGAAAGCC 60

GGGGCCCCCG GAGCTGCAGC TCCCGGGGCT CCGGTGGCCG CTCCGCCGGC GAAAGAGATC 120

CCGGAGGTCC TAGTGGACCC GCGCAGCCGG CGGCGCTACC TGCGGGGACG CTTTCTGGGC 180

AAAGGCGGCT TTGCTAAGTG CTTCGAGATC TCGGACGCCG ACACTAAGGA GGTGTTCGCT 240

GGCAAGATCG TGCCTAAGTC GCTGCTGCTC AAGCCGCACC AGAAGGAGAA GATGTCCATG 300

GAGATCTCCA TTCACCGCAG CCTCGCTCAC CAGCACATCG TAGGCTTCCA CGGCTTTTTC 360

GAGGACAGCG ACTTCGTGTT CGTGGTGCTA GAGCTCTGCC GCCGGAGATC TCTCCTGGAA 420

CTCCACAAGC GGAGGAAAGC ACTGACTGAG CCCGAAGCGC GCTACTACCT TCGACAGATT 480

GTCCTTGGCT GCCAGTACCT GCACCGAAAC CGGGTTATTC ACCGGGACCT CAAGCTGGGT 540

AACCTTTTCC TGAATGAGGA TCTCGAGGTG AAAATAGGGG ATTTTGGACT GGCAACCAAA 600

GTGGAATATG ACGGGGAACG CAAGAAGACC CTGTGTGGGA CTCCTAATTA CATAGCTCCT 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGATG TGTGGTCCAT TGGGTGTATC 720

ATGTATACCT TGTTAGTGGG CAAACCACCT TTTGAGACCT CTTGCCTCAA AGAGACCTAC 780

CTCCGGATCA AAAAGAATGA CTACAGTATC CCCAAGCACA TCAATCCTGT GGCCGCCTCC 840

CTCATCCAGA AGATGCTCCA GACAGACCCT GCTGCCCGCC CCACCATTCA CGAGCTGCTC 900

AATGATGAGT TTTTCACTTC TGGCTACATC CCTGCCCGGC TCCCCATCAC CTGTCTCACC 960

ATTGCACCCC GGTTTTCCAT CGCTCCTAGC AGTCTGGACC CCAGCAACCG GAAGCCTCTT 1020

ACAGTCCTCA ATAAAGGCAC AGAGAACCCA ATGTCTGAGC GGCCTCGGGA GAAAGAGGAG 1080

CCAGCAGTCC GGGAGACCAA TGAGGCAGTT GACTGCCACT TGAGGGATAT GCTGCAGCAG 1140

CTACACAGCG TCAATGCATC CAAACCCTCA GAGCGGGGGC TGGTGAGGCA AGAGGAGGCT 1200

GAGGATCCCG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA TTCAGACAAG 1260

TACGGCCTTG GGTACCAGCT GTGCGACAAC AGTGTGGGGG TGCTCTTCAA CGACTCGACA 1320

CGCCTGATCC TCTACAATGA TGGTGACAGC CTGCAGTACA TAGAGCGTGA TGGCACAGAG 1380

TCCTACCTCA CCGTGAGTTC CCATCCCAAC TCCCTGATGA AGAAGATCAC CCTCCTGAAG 1440

TATTTCCGGA ACTACATGAG TGAACACTTG CTAAAGGCAG GTGCCAATAT CACGCCCCGG 1500

GAAGGTGATG AACTCGCCCG GCTCCCCTAC TTGCGCACCT GGTTTCGTAC CCGCAGCGCC 1560

ATCATCCTGC ACCTCAGCAA TGGCTGTGTG CAAATCAACT TCTTCCAGGA CCATACCAAA 1620

CTCATCCTGT GCCCACTAAT GGCAGGAGGG GGC 1653

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YLRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   IVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk++ys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNDYSIPKHINPVAASLIQKMLQTDPAA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 293   RPTIHELLNDEFF  305

         ************8

Domain Sequence
(FASTA)

YLRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

IVGFHGFFED SDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNDYSIPK HINPVAASLI QKMLQTDPAA 240

RPTIHELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013