EKS-CAF-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	489.2	2.5E-147	402	652	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026084

UniProt Accession

E2RMF7;

Protein Name

Protein Synonyms/Alias

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017669	ENSCAFP00000026084	ENSCAFT00000028042

Organism

Canis familiaris

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTMHKLSYY EYDFERGRRG SKKGSIDVEK 60

ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180

HRKTKKPLPP TPEEDQILKK PLPPEPTAAP ASTSELKKVV ALYDYMPMNA NDLQLRKGEE 240

YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300

EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360

YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420

WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480

CLLNYLREMR NRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540

GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600

FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKAEE RPTFKILLSN ILDVMDEES 659

Nucleotide Sequence
(FASTA)

ATGGCTGCAG TGATACTGGA GAGCATCTTT CTGAAGCGAT CTCAACAGAA AAAGAAAACA 60

TCACCTTTAA ACTTCAAGAA GCGCCTCTTT CTCTTAACTA TGCACAAACT TTCCTACTAT 120

GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180

ATCACCTGCG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CCCCTGAAAG ACAGATTCCA 240

AGAAGGGGTG AAGAGTCCAG TGAAATGGAG CAGATTTCAA TCATTGAAAG GTTCCCTTAC 300

CCCTTCCAGG TTGTATATGA TGAAGGGCCT CTTTATGTCT TCTCCCCAAC TGAAGAACTG 360

AGGAAGCGTT GGATTCACCA GCTTAAAAAC GTAATCCGGT ATAACAGTGA TCTGGTACAG 420

AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480

AATGCGATGG GCTGCCAAAT TTTGGAAAAC AGGAATGGAA GTTTGAAACC TGGGAGTTCT 540

CACAGAAAGA CAAAAAAGCC TCTTCCTCCC ACGCCTGAGG AAGACCAGAT CTTGAAAAAG 600

CCACTGCCCC CTGAGCCAAC AGCAGCGCCT GCCTCTACAA GTGAGCTGAA AAAGGTTGTA 660

GCCCTTTATG ATTACATGCC AATGAATGCA AATGATCTAC AGCTGCGAAA GGGAGAGGAG 720

TATTTTATCC TGGAGGAGAG CAACTTACCC TGGTGGAGAG CACGGGATAA AAATGGGCAG 780

GAAGGCTACA TCCCTAGTAA CTATGTCACC GAAGCAGAAG ACTCCATAGA AATGTATGAG 840

TGGTATTCCA AACACATGAC TCGAAGTCAA GCTGAGCAAC TGCTGAAGCA AGAGGGGAAA 900

GAAGGAGGTT TCATTGTCAG AGACTCCAGC AAAGCTGGAA AATATACTGT GTCTGTGTTT 960

GCTAAATCTA CAGGGGACCC TCAAGGGGTG ATACGCCATT ATGTTGTGTG TTCCACACCT 1020

CAGAGCCAGT ATTACCTGGC AGAGAAGCAC CTTTTCAGCA CCATTCCTGA GCTCATTAAC 1080

TACCATCAGC ATAACTCTGC AGGGCTCATA TCTAGGCTCA AATATCCAGT GTCTCAACAA 1140

AACAAGAATG CACCTTCCAC TGCAGGCCTG GGCTACGGAT CATGGGAAAT TGATCCAAAG 1200

GACCTGACCT TCTTGAAGGA GCTGGGGACT GGACAGTTTG GGGTAGTGAA ATATGGGAAA 1260

TGGAGAGGCC AATATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCTGAGGAT 1320

GAATTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ATGAGAAGCT GGTACAATTG 1380

TATGGCGTCT GCACCAAACA GCGCCCTATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440

TGCCTCCTGA ACTACCTGAG GGAAATGCGC AACCGTTTCC AGACTCAGCA GCTGCTGGAG 1500

ATGTGCAAGG ATGTCTGTGA AGCCATGGAA TACCTGGAGT CAAAGCAATT CCTTCACCGA 1560

GACCTGGCAG CTCGAAACTG TTTGGTAAAC GATCAAGGAG TTGTTAAAGT ATCTGACTTC 1620

GGCCTGTCCA GGTATGTCCT GGATGATGAA TATACAAGCT CAGTAGGCTC CAAATTTCCA 1680

GTCCGATGGT CACCACCAGA AGTCCTTATG TATAGCAAGT TCAGCAGCAA ATCTGACATC 1740

TGGGCTTTTG GGGTTTTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC ATATGAAAGA 1800

TTTACTAACA GTGAAACTGC TGAACACATT GCCCAAGGCC TCCGTCTCTA TAGGCCTCAT 1860

CTAGCTTCAG AGAGAGTATA TACCATCATG TACAGCTGCT GGCATGAGAA AGCAGAGGAA 1920

CGTCCTACCT TCAAAATTCT TCTGAGCAAC ATCCTAGATG TCATGGATGA AGAATCCTGA 1980

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly

Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd

Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRNRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w

Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek+eer

Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKAEER  641

         ************************************************************

S: 241   ptfkellsale  251

         ptfk lls++

Q: 642   PTFKILLSNIL  652

         ********996

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNYLREMRN RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180

AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKAEER 240

PTFKILLSNI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031410	; C:cytoplasmic vesicle
GO:0005829	; C:cytosol
GO:0045121	; C:membrane raft
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005547	; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0048469	; P:cell maturation
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

cfa:492019

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013