EKS-CAF-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	283.8	1.1E-84	121	318	198

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026149

UniProt Accession

E2RIJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

EEF2K

Gene Synonyms/Alias

EEF2K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017716	ENSCAFP00000026149	ENSCAFT00000028109

Organism

Canis familiaris

Functional Description

Protein Length

725

Protein Sequence
(FASTA)

MADEDLIFRL EGVDGGQTSQ AGHDGESEAD SDDEEGYFIC PITDDPRSHQ DVNSKVNNYY 60

SNLTKSEQYG SSGSPASSFH FKEAWKHAIE KAKHMPDPWA EFHLEDIATE CATRHRYNAV 120

TGEWLEDEVL IKMASQPFGR GAMRECFRTK KLSNFLHTQQ WKGASNYVAK RYIESVDRDV 180

YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCVVELKDR PGKPLFHLEH YIEGKYIKYN 240

SNSGFVRDDN LRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE KGTDFGDGNL 300

GVRGMALFFY SHACNRICKS MGLAPFDLSP RERDTVNQNT KLLQSAKTIL RGTEEKCGSP 360

RVRTLSGSRP PLLLRLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL HWPVFSDLDS 420

MASREHDHLD NHRDSENSGD SGYPSEKRGE LDDPEPREHG HSNGNRKYES DEDSLGSSGR 480

VCVDKWNLLN PSRLHLSRPS AVALEVQRLN TLNLEKKIGK SILGKVHLAM VRYHEGGRFC 540

EKGEDWDRES AVFHLEHAAD LGELEAIVGL GLMCSQLPHH ILADVSLKET EENKTKGFEY 600

LLKAAEAGDR QSMILVARAF DTGQNLSPDR SQDWPEALHW YNTALEMTDC DEGGEYDGMQ 660

DEPRYMLLAR EAEMLFIGGC GLAKDPQRSG DLYTQAAEAA MEAMKGRLAN QYYQKAEEAW 720

AQMEE 725

Nucleotide Sequence
(FASTA)

ATGGCAGACG AAGACCTCAT TTTCCGCCTG GAAGGTGTTG ATGGTGGCCA GACCTCCCAG 60

GCTGGTCATG ACGGTGAGTC CGAGGCAGAC AGCGACGATG AGGAAGGTTA CTTCATCTGC 120

CCCATCACTG ATGATCCCAG GTCACACCAG GATGTCAATT CCAAGGTTAA TAACTACTAC 180

AGCAACCTAA CAAAGAGTGA GCAGTATGGC TCCAGTGGGT CCCCGGCAAG CTCCTTCCAT 240

TTTAAGGAAG CTTGGAAGCA TGCGATTGAG AAGGCCAAAC ACATGCCTGA CCCCTGGGCT 300

GAGTTCCACC TGGAAGATAT TGCCACGGAA TGTGCCACAC GTCACAGGTA CAATGCTGTC 360

ACTGGGGAAT GGCTGGAAGA TGAAGTTCTG ATCAAGATGG CATCTCAGCC CTTCGGCCGT 420

GGAGCAATGA GGGAGTGCTT CAGGACAAAG AAGCTCTCCA ACTTTCTGCA CACTCAGCAG 480

TGGAAAGGAG CCTCCAACTA CGTGGCAAAG CGGTACATTG AGTCTGTGGA CAGGGATGTG 540

TACTTTGAGG ATGTGCGTCT ACAGATGGAG GCCAAGCTCT GGGGAGAGGA GTATAATCGA 600

CACAAGCCCC CCAAGCAGGT GGACATCATG CAGATGTGTG TGGTAGAGCT GAAAGACAGA 660

CCAGGCAAGC CGCTCTTCCA CCTGGAGCAC TACATCGAGG GCAAATACAT CAAGTACAAC 720

TCCAACTCAG GCTTTGTTCG CGATGACAAC CTGCGTCTGA CACCACAGGC CTTCAGCCAC 780

TTCACATTTG AGCGTTCTGG GCATCAGCTG ATTGTGGTAG ACATCCAGGG TGTGGGCGAC 840

CTCTACACTG ACCCACAGAT CCACACCGAA AAGGGCACTG ACTTCGGAGA TGGCAACCTA 900

GGTGTCCGGG GGATGGCGCT TTTCTTCTAC TCTCATGCCT GCAACCGGAT TTGCAAGAGC 960

ATGGGCCTAG CTCCCTTTGA CCTCTCACCC AGAGAGAGGG ACACAGTGAA TCAGAACACC 1020

AAGCTGCTGC AGTCCGCCAA GACCATCTTG AGGGGGACAG AGGAAAAGTG TGGGAGCCCC 1080

CGAGTCAGGA CCCTCTCTGG GAGTCGCCCT CCCTTGCTCC TTCGCCTTTC AGAGAACTCT 1140

GGAGATGAGA ACATGAGTGA TGTGACCTTT GACTCTCTCC CTTCCTCCCC ATCTTCGGCC 1200

ACACCACACA GCCAGAAACT GGACCACCTC CATTGGCCTG TGTTCAGCGA CCTTGACAGC 1260

ATGGCATCCA GAGAGCACGA CCATCTGGAC AACCACCGGG ACTCTGAGAA CAGTGGAGAC 1320

AGTGGATACC CCAGTGAGAA GCGGGGTGAG CTGGATGACC CAGAGCCCCG AGAACATGGC 1380

CACTCAAACG GTAACCGGAA GTACGAGTCA GACGAAGACA GCCTGGGCAG CTCTGGACGG 1440

GTCTGCGTGG ACAAGTGGAA TCTCCTCAAC CCCTCCCGCC TCCACCTGTC AAGACCTTCT 1500

GCTGTGGCCC TGGAAGTGCA AAGGCTTAAT ACTCTGAACC TTGAAAAGAA AATCGGGAAG 1560

TCCATTCTGG GGAAGGTGCA TTTGGCCATG GTGCGCTACC ATGAGGGTGG ACGCTTCTGT 1620

GAGAAGGGCG AGGACTGGGA CCGTGAGTCA GCCGTCTTCC ACTTGGAGCA CGCAGCCGAC 1680

CTGGGCGAAC TGGAGGCCAT CGTGGGCCTG GGGCTCATGT GCTCACAGCT GCCCCACCAC 1740

ATCCTGGCTG ATGTCTCTTT GAAGGAGACA GAAGAGAATA AGACCAAAGG ATTCGAATAC 1800

TTACTGAAGG CAGCTGAAGC TGGCGACAGA CAGTCCATGA TCCTGGTGGC TCGGGCTTTT 1860

GACACCGGCC AGAATCTCAG CCCAGACAGG TCCCAGGACT GGCCAGAGGC TCTGCACTGG 1920

TACAACACTG CCCTGGAGAT GACAGACTGT GATGAGGGCG GCGAGTATGA TGGGATGCAA 1980

GATGAGCCTC GGTACATGCT GCTGGCCCGG GAGGCTGAGA TGCTGTTCAT CGGTGGCTGT 2040

GGGCTAGCGA AGGACCCACA GAGATCAGGC GACTTGTACA CGCAGGCAGC CGAAGCGGCG 2100

ATGGAAGCCA TGAAGGGCCG GCTGGCCAAC CAGTACTACC AGAAGGCGGA GGAGGCCTGG 2160

GCGCAGATGG AGGAGTAG 2178

Domain Profile

S: 2     sesWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvl  61

         +++W+++e  vlik++s+++++Ga+R+++r+kk+s+fl+ +++k++++yvak+y+e++++

Q: 121   TGEWLEDE--VLIKMASQPFGRGAMRECFRTKKLSNFLHTQQWKGASNYVAKRYIESVDR  178

         789*****..**************************************************

S: 62    hlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqlltvEeyllGefv  121

         ++y++dv+ q++a+ +++e+n++kP+k+v+i++++ v+Lkdr++k +l+++E+y++G+++

Q: 179   DVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCVVELKDRPGK-PLFHLEHYIEGKYI  237

         *********************************************.**************

S: 122   KynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatksrgtk  181

         Kyn+n+g  ++r+++l+ +++afsHft+e+++++l+VvD+qGvg+ +TDpqi+t ++gt+

Q: 238   KYNSNSG--FVRDDNLRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHT-EKGTD  294

         *******..*********************************************.*****

S: 182   fgkanlgeraiknFfakhhCNeiC  205

         fg++nlg+r+++ Ff++h+CN+iC

Q: 295   FGDGNLGVRGMALFFYSHACNRIC  318

         ************************

Domain Sequence
(FASTA)

TGEWLEDEVL IKMASQPFGR GAMRECFRTK KLSNFLHTQQ WKGASNYVAK RYIESVDRDV 60

YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCVVELKDR PGKPLFHLEH YIEGKYIKYN 120

SNSGFVRDDN LRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE KGTDFGDGNL 180

GVRGMALFFY SHACNRIC 198

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004686	; F:elongation factor-2 kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0031952	; P:regulation of protein autophosphorylation

KEGG

cfa:479812

;

InterPros

IPR017400	; Elongation_factor_2_kinase.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.
IPR006597	; Sel1-like.
IPR011990	; TPR-like_helical.

Pfam

PF02816	; Alpha_kinase; 1.
PF08238	; Sel1; 4.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013