EPS-CAF-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	269.0	6.3E-80	66	373	308

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026193

UniProt Accession

F1PFI9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017757	ENSCAFP00000026193	ENSCAFT00000028162

Organism

Canis familiaris

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPW PRRSLSQPSP PRPSPPAPAG 60

SEVPGKGPAA AAREARDPPP DAAASPAPGR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 120

WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 180

RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 240

VNRVVWKRPR LSHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 300

LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 360

RMLRADNTSA IVICISPGVD SQGNFTNEDE LFLNLTDSPS YNSQETCLMT PSPCSTPPVK 420

SLEEDPWPRL NSKDHVPALV RSNAFSENYL EVPAEIARGS VHATAIPSKD PEPLEENCTK 480

ALTLRIHDSL NNSLSVGLVP TNSTNTITDQ KNLKMSTPGQ MKAQEVERTP PANFKRTLEE 540

SNSGPLMKKH RRNGLTRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK 600

TVCVC 605

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCGCT GGGAGTGAGC GTCTTCTCCG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TTACTCAGAT CGTGGTGGAG CCCGAGCCGA CGGCTGAAGA AAAGCCCTGG 120

CCGCGGCGGT CGCTCTCGCA GCCGTCGCCT CCGCGGCCGT CCCCGCCGGC TCCCGCTGGC 180

AGCGAAGTCC CGGGGAAAGG CCCAGCGGCC GCAGCCCGAG AGGCTCGCGA CCCTCCCCCG 240

GACGCCGCGG CCTCGCCAGC TCCCGGGCGC TGCTGCCGCC GCCGCTCCTC AGTGGCATTC 300

TTCGCCGTGT GCGACGGGCA CGGCGGGCGG GAGGCGGCAC AGTTTGCCCG GGAGCATTTG 360

TGGGGTTTCA TCAAGAAGCA GAAGGGATTC ACGTCGTCCG AGCCGGCGAA GGTTTGCGCT 420

GCCATCCGCA AAGGCTTCCT CGCTTGTCAC CTCGCCATGT GGAAGAAACT GGCAGAATGG 480

CCAAAGACAA TGACAGGTCT TCCCAGCACG TCAGGGACAA CTGCCAGTGT GGTCATCATA 540

CGGGGCATGA AGATGTATGT AGCTCACGTG GGTGACTCAG GGGTGGTTCT TGGAATTCAG 600

GATGACCCGA AGGATGATTT TGTCAGAGCT GTGGAGGTGA CACAGGACCA TAAACCAGAA 660

CTTCCCAAGG AAAGAGAACG AATCGAAGGA CTTGGTGGGA GTGTGATGAA CAAGTCTGGG 720

GTGAATCGTG TAGTTTGGAA ACGACCTCGG CTCTCTCACA ATGGACCTGT TAGAAGGAGC 780

ACAGTTATTG ACCAGATTCC TTTTCTGGCA GTAGCAAGAG CACTTGGTGA TTTGTGGAGT 840

TATGATTTCT TCAGTGGTGA GTTTGTGGTG TCACCTGAAC CAGACACGAG TGTCCACACT 900

CTTGACCCCC AGAAGCACAA GTATATTATT TTGGGGAGTG ATGGACTTTG GAATATGATT 960

CCACCGCAAG ATGCCATCTC AATGTGCCAG GACCAAGAGG AGAAAAAGTA CTTGATGGGT 1020

GAGCATGGAC AGTCTTGTGC CAAAATGCTT GTGAATCGAG CACTAGGCCG CTGGAGGCAG 1080

CGTATGCTTC GAGCAGATAA TACTAGTGCT ATAGTGATCT GCATTTCTCC AGGTGTGGAC 1140

AGTCAGGGAA ATTTCACCAA TGAAGATGAG CTCTTTCTGA ACTTGACTGA TAGTCCTTCC 1200

TATAATAGTC AAGAAACCTG CTTGATGACT CCTTCCCCAT GTTCTACACC ACCAGTCAAG 1260

TCACTGGAGG AGGACCCATG GCCAAGGCTG AACTCTAAGG ACCATGTACC TGCCCTTGTT 1320

CGTAGTAATG CCTTCTCAGA GAATTATTTA GAAGTCCCAG CTGAGATAGC TCGAGGAAGT 1380

GTCCATGCGA CAGCCATACC CTCAAAAGAT CCAGAGCCAC TTGAAGAAAA TTGCACTAAA 1440

GCCCTGACTT TAAGGATACA TGATTCTTTG AATAATAGCC TGTCAGTTGG CCTTGTGCCT 1500

ACCAATTCAA CAAATACCAT CACGGACCAA AAAAATTTAA AAATGTCAAC TCCAGGTCAA 1560

ATGAAAGCCC AAGAAGTTGA AAGAACCCCT CCAGCAAACT TTAAAAGGAC ATTAGAAGAA 1620

TCCAACTCCG GCCCTCTTAT GAAGAAGCAT AGACGAAATG GTTTAACTCG AAGTAGTGGT 1680

GCTCAGCCTG CAAGCCTCCC CACAACCTCA CAGCGAAAGA ACTCTGTTAA ACTTACTATG 1740

CGACGCAGAC TTAGGGGCCA GAAGAAAATT GGAAATCCTT TACTTCATCA GCACAGAAAA 1800

ACTGTTTGTG TCTGCTGA 1818

Domain Profile

S: 9     ngrrnemedavtsspnflkspekkdr......laffgvyDGhggsevakfcseklheila  62

         +g+    ++a+++ p++++sp+  ++      +aff+v+DGhgg+e+a+f++e+l+ +++

Q: 66    KGPAAAAREARDPPPDAAASPAPGRCcrrrssVAFFAVCDGHGGREAAQFAREHLWGFIK  125

         56667777888888888888888888888889****************************

S: 63    eelesseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvalikdskl  117

         +++ +++se +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i+++k+

Q: 126   KQKGFTSSEPAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVIIRGMKM  185

         ************************************************************

S: 118   yvanvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdga.Rv.  168

         yva+vGdS++vL+ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g+ Rv

Q: 186   YVAHVGDSGVVLGIQDDpkddfvrAVEVTQDHKPELPKERERIEGLGGSVMNKSGVnRVv  245

         **************77656999999***********************************

S: 169   ....................lGvLavsRalGdlylk......pyvtpePevtshrltsed  202

                             +++Lav+RalGdl+++      ++v+peP++++h+l++++

Q: 246   wkrprlshngpvrrstvidqIPFLAVARALGDLWSYdffsgeFVVSPEPDTSVHTLDPQK  305

         ************************************************************

S: 203   e.fliLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk.....  252

         + ++iL+sDGlw+++++++a+s+++d++e    ++e+ q++ak+Lv++al r+++

Q: 306   HkYIILGSDGLWNMIPPQDAISMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQrmlra  365

         ************************************************************

S: 253   dnvsaivv  260

         dn+saiv+

Q: 366   DNTSAIVI  373

         ******97

Domain Sequence
(FASTA)

KGPAAAAREA RDPPPDAAAS PAPGRCCRRR SSVAFFAVCD GHGGREAAQF AREHLWGFIK 60

KQKGFTSSEP AKVCAAIRKG FLACHLAMWK KLAEWPKTMT GLPSTSGTTA SVVIIRGMKM 120

YVAHVGDSGV VLGIQDDPKD DFVRAVEVTQ DHKPELPKER ERIEGLGGSV MNKSGVNRVV 180

WKRPRLSHNG PVRRSTVIDQ IPFLAVARAL GDLWSYDFFS GEFVVSPEPD TSVHTLDPQK 240

HKYIILGSDG LWNMIPPQDA ISMCQDQEEK KYLMGEHGQS CAKMLVNRAL GRWRQRMLRA 300

DNTSAIVI 308

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013