EKS-CAF-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	323.2	1.8E-96	895	1165	271

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026321

UniProt Accession

F1PBD0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017834	ENSCAFP00000026321	ENSCAFT00000028302

Organism

Canis familiaris

Functional Description

Protein Length

1185

Protein Sequence
(FASTA)

AVKSMPLCHS GATTRDSRPD GDEAQPLATR GGLKVLLHWA GPGGGDPWVT FSEATLTAED 60

VCIHIAHKVG ITPSCFNLFA LFDAEAQVWL PPNHILEVSG DMNLTLYFRM RFYFRNWHGT 120

NSQEPAVYRC GPTGTKSSSE QAEQGVQLLD PASFEYLFEQ GKHEFVNDVA SLWDLSSEEE 180

IHHFKNESLG MAFLHLCHLA LSHGIPLEKV AKKIRPPSFK DCIPRSRLQI RRHNALTRLR 240

LRSIFRRFVR AFQPGHISQQ VIMVKYLATL EQLAPFGTER VPVCHLELLA QAVGESCYIR 300

DSGQAPPEPE LATGPPTHEV LVTGTGGIQW RPVQAESPRG DSSSRNRHAD PFRKKTKAGE 360

VGDQPVDRPQ EEPWVYFCDF QDITHVVLKE RHISIHCQDN KSLELTLPSR AMALSWVSLV 420

DGYFRLTADS SHYLCHEVAP PRLVMSIQDG IHGPLMEPFV LAKLRSEDGL YLIHWSTSHL 480

NRLILTVAQR DQSPGTQRLH LRKFPIELQA GVFRLEGWDR SFPSVRELRA ALQGCSLRAG 540

DDCFSLRRCC LPRPGEISNL IIMRGPRAVT SPPNVSQLSF HRICQADVTQ LSHLGQGTRT 600

NVYEGVLRVG ARAPKEGAAD GEDPPTPSED SGLELRVVLK VLDPSHHDIA LAFYETASLM 660

SQVSHVHLAF VHGICVYGSE NIMVTEYVEH GPLDVWLRRE KGHVPVAWKV AVAQQLASAL 720

SYLEDKSLVH GNVCGRNILL ARLGLEEGTS PFIKLSDPGV GLGALSREER IERIPWIAPE 780

CLTGGANSLT TAADKWGFGA TLLEICFDGE APLQGRGPSE KECFYQKQHL LPQPSCPELA 840

TLISQCLTYE PAQRPSFRTI LRDLTQLQPQ NLADVLAVNP DSPASDPTVF HKRYLKKIRD 900

LGEGHFGKVS LYCYDPTNDG TGEMVAVKAI KAGCGPQLRT CWRREIDILR TLHHKHIVKY 960

KGCCEDQGEK SVQLVMEYVP LGSLRDYLPR HSVGLAQLLL FAQQICEGMA YLHAQHYVHR 1020

DLAARNVLLD NDRLVKIGDF GLAKAVPEGH EYYRVREDGD SPVFWYAPEC LKECKFYYAS 1080

DVWSFGVTLY ELLTYCDSSQ SPPSKFIELI GLTQGQMTVL RLTELLERGE RLPRPEKCPY 1140

EIYLLMKNCW EAEASFRPTF QNLIPILKTV QEKYQGQAAS VFNVC 1185

Nucleotide Sequence
(FASTA)

GCTGTCAAAA GCATGCCTCT GTGCCATTCG GGTGCCACCA CCAGGGACAG CAGGCCTGAT 60

GGCGATGAAG CTCAGCCCCT GGCCACCAGG GGAGGCCTGA AGGTCCTTCT GCACTGGGCT 120

GGCCCTGGTG GCGGGGACCC ATGGGTCACC TTCAGCGAGG CCACACTGAC CGCAGAGGAT 180

GTCTGCATCC ACATTGCACA CAAAGTCGGC ATTACTCCAT CCTGCTTCAA TCTCTTTGCT 240

CTCTTCGATG CCGAGGCCCA GGTCTGGCTG CCTCCAAACC ACATCTTGGA GGTCTCCGGA 300

GACATGAACC TGACCCTGTA CTTCCGCATG AGGTTTTATT TCCGGAACTG GCATGGCACA 360

AATTCTCAGG AGCCGGCTGT GTACCGCTGT GGGCCCACAG GGACCAAGTC CTCCTCAGAA 420

CAAGCAGAGC AGGGGGTGCA GCTACTGGAC CCAGCCTCCT TTGAATACCT CTTTGAGCAG 480

GGCAAGCATG AGTTTGTGAA TGACGTGGCG TCACTGTGGG ATCTGTCGAG CGAGGAGGAG 540

ATCCACCATT TTAAGAACGA GAGTCTGGGC ATGGCCTTTC TGCACCTCTG CCACCTTGCT 600

CTCTCCCATG GCATCCCCCT GGAGAAGGTG GCCAAGAAGA TCAGGCCCCC CAGCTTCAAG 660

GACTGCATTC CACGCTCCCG GCTGCAGATC CGGCGGCACA ATGCGTTGAC CCGGCTGCGT 720

CTGCGGAGCA TCTTCCGCAG GTTCGTGCGG GCCTTCCAGC CGGGCCACAT CTCGCAGCAG 780

GTCATCATGG TCAAATACCT GGCCACGCTC GAGCAGCTGG CGCCCTTCGG CACGGAGCGC 840

GTGCCTGTGT GCCACCTGGA GCTCCTGGCC CAGGCCGTGG GGGAGTCCTG CTACATCCGG 900

GACAGCGGGC AGGCCCCTCC AGAGCCTGAG CTGGCCACCG GACCCCCCAC TCATGAGGTG 960

CTGGTGACAG GCACTGGTGG CATCCAGTGG CGGCCGGTAC AGGCAGAGAG TCCCAGAGGC 1020

GACAGCAGCA GCAGGAATCG CCATGCTGAC CCATTTAGGA AGAAAACCAA GGCCGGAGAG 1080

GTGGGCGACC AGCCAGTGGA CAGGCCTCAG GAAGAGCCAT GGGTCTACTT CTGTGACTTC 1140

CAGGATATCA CCCACGTGGT GCTCAAGGAA CGCCACATCA GCATCCACTG TCAGGACAAC 1200

AAGAGCCTGG AGCTGACCCT GCCTTCCCGG GCTATGGCCC TGTCCTGGGT GTCGCTGGTG 1260

GACGGCTACT TCCGCCTGAC AGCCGACTCA AGCCACTACC TGTGCCATGA GGTGGCCCCT 1320

CCACGGCTAG TGATGAGCAT CCAGGACGGT ATCCATGGAC CCTTGATGGA GCCCTTTGTG 1380

CTGGCCAAGC TGCGGTCTGA GGATGGCCTC TACCTCATCC ACTGGAGCAC CAGCCACCTC 1440

AACCGCCTCA TCCTGACGGT GGCCCAGCGG GACCAGAGCC CGGGCACACA GCGCTTGCAC 1500

CTGCGTAAAT TCCCCATTGA GCTGCAGGCC GGGGTCTTCA GGCTGGAGGG CTGGGACCGG 1560

TCCTTCCCCA GCGTGCGGGA GCTGCGAGCC GCCCTGCAGG GCTGCTCCCT GCGCGCCGGG 1620

GATGACTGCT TCTCCCTGCG CCGCTGCTGC CTGCCTCGGC CCGGAGAGAT CTCCAACCTC 1680

ATCATTATGC GGGGGCCCCG GGCTGTCACA AGTCCACCCA ACGTCAGCCA GCTCAGCTTC 1740

CACCGGATCT GCCAGGCTGA TGTCACCCAG CTGTCCCACC TGGGCCAAGG CACGAGGACC 1800

AATGTGTATG AGGGCGTGTT ACGAGTGGGG GCAAGAGCCC CCAAGGAGGG CGCGGCGGAC 1860

GGTGAGGACC CCCCCACACC CAGTGAGGAC TCTGGGCTGG AGCTCCGAGT GGTACTCAAG 1920

GTGCTAGACC CTAGTCACCA CGACATCGCC CTGGCCTTCT ACGAGACAGC CAGCCTCATG 1980

AGCCAGGTCT CCCATGTGCA CCTGGCCTTC GTACACGGCA TCTGCGTGTA TGGCTCTGAG 2040

AACATCATGG TGACAGAGTA CGTGGAGCAC GGGCCCCTGG ACGTGTGGCT GCGGCGAGAG 2100

AAGGGCCATG TGCCCGTGGC CTGGAAGGTG GCAGTGGCCC AACAGCTGGC CAGCGCCCTC 2160

AGCTACCTGG AAGACAAGAG CCTGGTTCAC GGTAATGTGT GTGGTCGGAA CATCCTGCTG 2220

GCGCGGCTGG GGCTGGAGGA GGGCACCAGC CCCTTCATCA AGCTGAGTGA CCCCGGTGTG 2280

GGCTTGGGTG CCCTTTCCAG AGAGGAGCGG ATCGAGCGGA TCCCCTGGAT AGCCCCCGAG 2340

TGCCTGACTG GCGGGGCCAA CAGCCTAACC ACTGCTGCCG ATAAATGGGG CTTCGGTGCT 2400

ACCCTCCTGG AGATCTGCTT CGACGGGGAG GCCCCCCTGC AGGGCCGTGG CCCCTCCGAG 2460

AAAGAGTGCT TCTACCAGAA GCAGCACCTG CTTCCTCAGC CCTCCTGCCC GGAGCTGGCC 2520

ACACTCATCA GCCAGTGCCT GACCTACGAA CCAGCTCAGC GGCCCTCCTT CCGCACCATC 2580

CTGCGTGACC TCACTCAGCT GCAGCCCCAG AATCTTGCTG ACGTCTTGGC TGTGAACCCC 2640

GACTCACCTG CATCAGACCC CACCGTCTTC CACAAGCGCT ATTTGAAAAA GATCCGGGAT 2700

CTGGGCGAGG GCCATTTCGG CAAGGTCAGT CTGTATTGCT ACGACCCAAC CAACGACGGC 2760

ACTGGTGAGA TGGTGGCGGT GAAGGCCATC AAGGCCGGCT GCGGCCCCCA GCTCCGCACC 2820

TGCTGGAGGA GGGAGATAGA CATCCTGCGG ACGCTCCATC ACAAGCACAT CGTCAAATAC 2880

AAGGGCTGCT GTGAGGACCA AGGAGAGAAG TCGGTGCAGC TCGTCATGGA GTACGTGCCC 2940

CTGGGAAGCC TACGAGACTA CCTGCCCCGG CACAGCGTCG GACTGGCCCA GCTGCTTCTC 3000

TTCGCTCAGC AGATCTGTGA GGGCATGGCC TACCTTCACG CACAGCACTA CGTGCATCGA 3060

GACCTGGCTG CCCGCAACGT GCTGCTGGAC AACGACAGAC TGGTCAAAAT CGGGGACTTT 3120

GGCCTAGCCA AGGCTGTGCC CGAAGGCCAC GAGTACTACC GCGTGCGCGA AGATGGGGAC 3180

AGCCCCGTGT TCTGGTATGC TCCAGAGTGC CTGAAAGAGT GTAAATTCTA CTATGCATCC 3240

GACGTCTGGT CCTTCGGGGT CACCCTGTAC GAGCTACTGA CCTACTGTGA CTCCAGCCAG 3300

AGCCCCCCCT CGAAATTCAT CGAGCTCATA GGCCTCACCC AGGGGCAGAT GACGGTGCTG 3360

AGGCTCACAG AGCTGCTGGA ACGAGGGGAG AGGCTGCCCC GGCCAGAGAA ATGTCCTTAT 3420

GAGATCTATC TCCTCATGAA GAACTGCTGG GAGGCAGAAG CTTCATTCCG CCCCACCTTC 3480

CAGAACCTCA TACCCATTCT CAAGACGGTC CAGGAGAAAT ACCAAGGCCA GGCCGCCTCA 3540

GTGTTCAATG TCTGCTGA 3558

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k++k  +g++ ++ + re++il++l+h

Q: 895   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAIKaGCGPQLRTCWRREIDILRTLHH  954

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         +hivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 955   KHIVKYKGCCEDQGEKsvQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  1012

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 1013  HAQHYVHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1066

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219

         apecl+e+k +++asdvWsFgvtlyellt c++++sp         l     +

Q: 1067  APECLKECK-FYYASDVWSFGVTLYELLTyCDSSQSPpskfieligL-----Tqgqmtvl  1120

         *********.****************************999555443.....45555588

S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         r++elle++erlp+p+ cp e++ lm+nc+++e+s+rp+F++++

Q: 1121  RLTELLERGERLPRPEkCPYEIYLLMKNCWEAEASFRPTFQNLIP  1165

         *****************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKAIKAGC GPQLRTCWRR EIDILRTLHH 60

KHIVKYKGCC EDQGEKSVQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120

QHYVHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVTLYELLT YCDSSQSPPS KFIELIGLTQ GQMTVLRLTE LLERGERLPR 240

PEKCPYEIYL LMKNCWEAEA SFRPTFQNLI P 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013