EKS-CAF-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.4	1.2E-117	80	345	266

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026341

UniProt Accession

F1PBB6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017851	ENSCAFP00000026341	ENSCAFT00000028324

Organism

Canis familiaris

Functional Description

Protein Length

377

Protein Sequence
(FASTA)

ISFTLGFQIN FCEKAQSKRK ALKLNFANPP FKSTARFTLN PNPTGVQNPH IERLRTHSIE 60

SSGKLKISPE QHWDFTAEDL KDLGEIGRGA YGSVNKMVHK PSGQIMAVKR IRSTVDEKEQ 120

KQLLMDLDVV MRSSDCPYIV QFYGALFREG DCWICMELMS TSFDKFYKYV YSVLDDVIPE 180

EILGKITLAT VKALNHLKEN LKIIHRDIKP SNILLDRSGN IKLCDFGISG QLVDSIAKTR 240

DAGCRPYMAP ERIDPSASRQ GYDVRSDVWS LGITLYELAT GRFPYPKWNS VFDQLTQVVK 300

GDPPQLSNSE EREFSPSFIN FVNLCLTKDE SKRPKYKELL KHPFILMYEE RTVEVACYVC 360

KILDQMPATP SSPMYVD 377

Nucleotide Sequence
(FASTA)

ATCTCTTTTA CTTTAGGCTT TCAGATAAAC TTCTGTGAAA AGGCACAAAG TAAACGCAAA 60

GCACTGAAGT TGAATTTTGC AAATCCACCT TTCAAATCTA CAGCAAGGTT TACTCTGAAT 120

CCCAACCCTA CAGGAGTTCA AAACCCACAC ATAGAGAGAC TGAGAACACA CAGCATTGAA 180

TCATCAGGAA AGCTGAAGAT CTCCCCTGAG CAGCACTGGG ATTTCACTGC GGAGGACTTG 240

AAAGACCTTG GAGAAATTGG ACGAGGAGCT TATGGTTCTG TCAACAAAAT GGTCCACAAA 300

CCAAGTGGGC AAATAATGGC GGTGAAAAGA ATTCGGTCAA CAGTGGATGA AAAAGAACAA 360

AAACAGCTTC TTATGGATTT GGATGTAGTA ATGCGGAGTA GTGATTGCCC GTACATTGTT 420

CAGTTTTATG GTGCACTCTT CAGAGAGGGT GACTGTTGGA TCTGTATGGA ACTCATGTCT 480

ACCTCGTTTG ATAAGTTTTA CAAATATGTA TATAGTGTAT TAGATGATGT TATTCCAGAA 540

GAAATTTTAG GCAAAATCAC TTTAGCAACT GTGAAAGCAC TAAACCACTT AAAAGAAAAC 600

TTGAAAATCA TTCACAGAGA TATCAAACCT TCCAATATTC TTCTGGACAG GAGTGGGAAT 660

ATTAAGCTCT GTGACTTTGG CATCAGTGGA CAGCTGGTGG ACTCCATTGC CAAGACAAGA 720

GATGCCGGGT GTAGGCCATA TATGGCACCT GAAAGAATAG ACCCGAGTGC ATCACGACAA 780

GGATATGACG TCCGCTCTGA TGTCTGGAGT TTGGGGATCA CATTGTATGA GTTAGCCACA 840

GGCCGGTTTC CTTATCCAAA GTGGAATAGT GTATTCGATC AACTCACACA AGTCGTGAAA 900

GGGGACCCTC CACAGCTGAG TAACTCTGAG GAAAGGGAAT TCTCCCCAAG CTTCATCAAC 960

TTTGTCAACT TGTGCCTTAC GAAGGATGAA TCCAAAAGGC CAAAGTATAA AGAACTTCTG 1020

AAACATCCCT TTATTTTGAT GTATGAAGAA CGTACCGTAG AGGTTGCCTG CTATGTTTGT 1080

AAAATCCTGG ATCAAATGCC AGCTACTCCC AGCTCTCCCA TGTACGTTGA T 1131

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 80    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  139

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 140   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  198

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 199   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  258

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 259   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  318

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 319   INFVNLCLTKDESKRPKYKELLKHPFI  345

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013