EKS-CAF-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	472.4	3.0E-142	195	440	246

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026494

UniProt Accession

E2RFF7;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000017945	ENSCAFP00000026494	ENSCAFT00000028485

Organism

Canis familiaris

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60

PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLCPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180

DEFFRSGWAL NMKDLKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240

TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420

NCWHLDAATR PSFLQLREQL EHIKTHELHL 450

Nucleotide Sequence
(FASTA)

ATGTCAGCAA TCCAGGCCGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAATTTC 60

CATGGCACTG CCGAGCAGGA CCTTCCCTTC TGCAAAGGAG ACGTGCTCAC CATTGTGGCG 120

GTCACCAAGG ACCCAAACTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 180

CCAGCCAACT ACGTCCAGAA ACGGGAGGGC GTGAAGGCCG GCACCAAGCT CAGCCTCATG 240

CCCTGGTTCC ATGGCAAGAT CACGCGGGAG CAGGCCGAGC GGCTGCTGTG CCCGCCCGAG 300

ACCGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCGG GGGACTACAC GCTGTGCGTG 360

AGCTGTGACG GCAAGGTGGA GCACTACCGC ATCATGTACC ACGCCAGCAA GCTCAGCATC 420

GACGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCGGACGCG 480

GACGGACTCT GTACTCGCCT CATCAAGCCA AAGGTCATGG AGGGCACGGT GGCCGCCCAG 540

GATGAGTTCT TCCGCAGCGG CTGGGCACTG AACATGAAGG ACCTGAAGCT GCTGCAGACC 600

ATTGGGAAGG GGGAGTTTGG AGACGTGATG CTAGGCGATT ACCGAGGGAA CAAGGTTGCT 660

GTCAAGTGCA TTAAAAATGA CGCCACTGCC CAGGCCTTTC TGGCTGAAGC CTCTGTGATG 720

ACGCAACTTC GGCATAGCAA CCTGGTACAG CTTCTGGGTG TGATCGTGGA AGAGAAGGGC 780

GGGCTGTACA TTGTCACGGA GTACATGGCC AAGGGAAGCC TGGTGGACTA TCTGCGGTCA 840

AGGGGTCGAT CGGTGCTGGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA TGTCTGTGAG 900

GCCATGGAAT ACCTGGAGGG CAACAACTTC GTGCACCGGG ATCTGGCTGC CCGCAACGTG 960

CTGGTGTCTG AAGACAACGT GGCCAAGGTC AGCGACTTTG GCCTCACCAA GGAGGCCTCC 1020

AGCACCCAGG ACACGGGCAA GCTGCCAGTC AAGTGGACGG CCCCGGAGGC CCTGAGAGAG 1080

AAGAAATTCT CCACCAAGTC TGACGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAC 1140

TCCTTTGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200

AAGGGCTACA AGATGGACGC CCCCGACGGC TGCCCACCTG CGGTCTACGA GGTCATGAAG 1260

AACTGCTGGC ACCTGGATGC TGCCACAAGG CCCTCCTTCC TGCAGCTCCG GGAGCAGCTC 1320

GAGCACATCA AAACCCACGA GTTGCACCTG TGA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFL  434

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 435   QLREQL  440

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120

LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAATRPSFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013