EKS-CAF-00431

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00431

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	395.4	1.5E-118	9	271	263

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026786

UniProt Accession

E2RF62;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018126	ENSCAFP00000026786	ENSCAFT00000028803

Organism

Canis familiaris

Functional Description

Protein Length

1037

Protein Sequence
(FASTA)

MEVVGDFEYS KRDLVGHGAF AVVFRGRHRQ KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL 60

KELQHENIVA LYDVQELPNS VFLVMEYCNG GDLADYLQAK GTLSEDTIRV FLHQIAAAMR 120

ILHSKGIIHR DLKPQNILLS YANRRKSNVS GIRIKIADFG FARYLHSNMM AATLCGSPMY 180

MAPEVIMSQH YDAKADLWSI GTVVYQCLVG KPPFQANSPQ DLRMFYEKNR SLMPSIPRET 240

SPYLANLLLG LLQRNQKDRM DFEAFFSHPF LEQVPVKKSC PVPVPVYAGS VSGSSCGSSP 300

SCRFASPPSL PDMQHIQEEN LSSPPLGPPN YLQVSKDSAS TSSKNSSCDT DDFVLVPHNI 360

SSDHSYDMPM GTAGRRASNE FLVCGGQCQP TVSPHSETAP IPVPTQIRNY QRIEQNLTST 420

ASSGTNLHGS PRSTVVRRSN TSPMGFLRLG SCSPAPADTV QTVGRRLSTG SSRPYSPSPL 480

VGTIPEQFSQ CCCGHPQGHE SRSRNSSGSP VPQAQSPQPL LLGARLQSAP TLTDIYQNKQ 540

KLRKQHSDPV CPSHAGTGYS YSPQPSRPGS LGTSPTKHMG SSPRSSDWFF KTPLPTIIGS 600

PTKTTAPFKI PKTQASSNLL ALVTRHGPTE GQSKDGNDPR ECSHCLLVQG SERQKSEQQN 660

KAVFGRSVST GKLSDQQVKI PLGGHQGSTD SLNTERPMDI APAGACGGVL APPIGTAASS 720

RAVLFTVGSP PHSATAPTCT HMVLRTRTTS AGSSSSGGSV CSASGRVCVG SPPLGPCLGS 780

SPPGAEAAPG LRYMPHGASP PSLEGLITFE APELPEETLM EREHTDTLRH LNVMLTFTEC 840

VLDLTAVRGG HPELCTSAVS LYQIQESVVV DQISQLSKDW GRVEQLVLYM KAAQLLAASL 900

HLAKAQIKSG KLSPSTAVKQ VVKNLNERYK FCITMCKKLT EKLNRFFSDK QRFIDEINSV 960

TAEKLIYNCA VEMVQSAALD EMFQQTEDIV YRYHKAALLL EGLTKILQDP ADIENVHKYK 1020

TSIERRLSAL CCSTATL 1037

Nucleotide Sequence
(FASTA)

ATGGAGGTGG TGGGCGACTT CGAGTACAGC AAGAGGGACC TCGTGGGACA CGGGGCCTTC 60

GCCGTGGTCT TCCGGGGGCG GCACCGCCAG AAAACTGATT GGGAGGTAGC TATTAAAAGT 120

ATTAATAAAA AGAACTTGTC AAAATCACAA ATACTGCTTG GGAAGGAAAT TAAAATCTTA 180

AAGGAACTTC AACATGAAAA TATTGTAGCA CTCTATGATG TTCAGGAATT ACCCAACTCT 240

GTCTTTTTGG TGATGGAGTA CTGCAATGGT GGAGACCTGG CAGATTATTT GCAAGCTAAA 300

GGAACTCTTA GTGAAGACAC GATTAGAGTG TTTCTGCATC AGATCGCAGC TGCCATGCGA 360

ATTCTGCACA GCAAAGGAAT AATCCACAGG GATCTCAAAC CACAGAATAT CTTGCTGTCA 420

TATGCCAATC GCAGAAAGTC CAACGTCAGT GGTATTCGCA TCAAAATAGC GGATTTTGGG 480

TTTGCTCGTT ATCTACATAG TAACATGATG GCTGCAACGC TGTGTGGGTC CCCAATGTAC 540

ATGGCTCCTG AGGTTATTAT GTCTCAACAT TATGATGCTA AGGCAGACCT GTGGAGCATA 600

GGAACAGTGG TATATCAATG CCTAGTTGGA AAACCACCTT TTCAGGCCAA TAGTCCTCAA 660

GACCTAAGGA TGTTTTATGA AAAAAACAGA AGCTTAATGC CTAGTATTCC CAGAGAAACA 720

TCACCTTATT TGGCTAATCT CCTTTTGGGT TTGCTTCAGA GAAACCAGAA AGACAGAATG 780

GACTTTGAAG CATTTTTTAG CCATCCTTTT CTTGAGCAAG TTCCAGTGAA GAAATCTTGC 840

CCAGTCCCAG TGCCCGTGTA CGCTGGCTCT GTCTCTGGAA GCTCCTGTGG TAGCTCTCCA 900

TCTTGTCGCT TTGCATCTCC ACCATCCCTT CCAGATATGC AGCATATTCA GGAAGAAAAC 960

TTATCCTCCC CACCATTGGG TCCTCCCAAC TACCTACAAG TGTCCAAAGA TTCTGCCAGT 1020

ACTAGTAGCA AGAACTCTTC TTGTGACACG GATGACTTTG TTTTGGTTCC ACACAACATC 1080

TCGTCAGACC ACTCATATGA TATGCCAATG GGGACTGCTG GCAGACGTGC TTCAAATGAG 1140

TTTTTGGTGT GTGGAGGGCA GTGCCAGCCT ACTGTGTCAC CTCACAGTGA AACAGCACCA 1200

ATTCCAGTTC CTACTCAGAT ACGGAATTAT CAGCGCATAG AGCAGAACCT TACATCTACT 1260

GCCAGCTCTG GCACAAATCT ACATGGTTCT CCAAGATCTA CAGTGGTACG AAGGTCTAAC 1320

ACCAGTCCTA TGGGCTTCCT CCGGCTGGGA TCTTGCTCCC CAGCACCAGC AGACACAGTA 1380

CAGACAGTTG GACGAAGACT CTCCACTGGG TCTTCCAGGC CTTACTCACC CTCCCCCTTG 1440

GTTGGGACCA TTCCTGAGCA GTTTAGTCAG TGCTGCTGTG GGCATCCTCA GGGTCATGAA 1500

TCCAGGAGTA GAAACTCATC AGGTTCTCCA GTGCCACAGG CTCAGTCACC ACAGCCTCTC 1560

CTGTTGGGCG CTAGACTGCA GAGCGCCCCT ACCCTCACCG ACATCTACCA GAACAAGCAG 1620

AAACTCAGAA AGCAGCACTC GGACCCTGTG TGCCCATCCC ATGCTGGGAC TGGGTACAGC 1680

TACTCCCCCC AGCCCAGTCG GCCTGGCAGC CTTGGAACCT CTCCCACCAA GCACATGGGG 1740

TCCTCTCCTC GGAGTTCTGA CTGGTTCTTT AAAACTCCTT TACCGACCAT CATTGGCTCT 1800

CCTACTAAGA CCACAGCTCC TTTCAAAATA CCTAAAACTC AAGCGTCTTC CAACCTGCTA 1860

GCCTTGGTTA CTCGTCATGG ACCTACTGAA GGGCAATCTA AAGATGGGAA TGACCCACGG 1920

GAATGCTCTC ATTGTCTCTT AGTTCAAGGA AGTGAGAGGC AGAAGTCTGA GCAGCAGAAC 1980

AAAGCAGTGT TTGGCAGATC TGTCAGTACT GGAAAATTAT CAGATCAACA AGTGAAGATA 2040

CCTTTAGGTG GACATCAGGG CAGCACAGAC AGTTTAAATA CAGAACGACC AATGGATATA 2100

GCCCCTGCAG GAGCTTGTGG TGGTGTACTG GCACCTCCTA TAGGAACAGC AGCAAGTTCC 2160

AGGGCTGTCC TGTTCACTGT AGGATCTCCT CCACACAGTG CCACGGCCCC CACTTGTACC 2220

CATATGGTCC TTCGAACAAG AACAACCTCA GCCGGCTCCA GCAGCTCCGG AGGCTCCGTA 2280

TGCTCTGCAA GTGGCCGCGT GTGTGTGGGC TCCCCGCCGC TGGGTCCGTG CCTGGGGTCT 2340

TCCCCTCCAG GAGCAGAGGC AGCTCCCGGC CTGAGATACA TGCCTCATGG TGCTTCACCC 2400

CCCAGCCTAG AGGGGCTCAT CACCTTTGAG GCCCCCGAAC TGCCAGAGGA AACACTGATG 2460

GAGCGGGAAC ACACAGACAC CTTACGCCAC CTGAACGTGA TGTTAACGTT CACTGAATGT 2520

GTGCTGGATC TGACAGCCGT GCGGGGAGGA CACCCGGAGC TGTGCACATC TGCTGTCTCC 2580

TTATACCAGA TCCAGGAGAG TGTGGTTGTG GACCAGATCA GCCAACTAAG CAAAGACTGG 2640

GGGCGGGTGG AGCAGCTGGT GTTATACATG AAAGCGGCAC AGCTATTAGC AGCCTCTCTG 2700

CATCTCGCCA AAGCCCAGAT CAAGTCCGGG AAGCTGAGCC CATCCACAGC TGTGAAACAA 2760

GTTGTCAAAA ATCTGAACGA ACGATATAAA TTCTGCATCA CCATGTGCAA GAAGCTTACA 2820

GAAAAGCTGA ATCGCTTCTT CTCTGACAAA CAGAGATTTA TTGATGAAAT CAACAGTGTG 2880

ACTGCAGAGA AACTCATCTA TAATTGTGCT GTAGAAATGG TTCAGTCTGC AGCCCTGGAT 2940

GAGATGTTTC AGCAGACTGA AGATATTGTT TATCGTTATC ACAAGGCAGC CCTTCTTTTG 3000

GAAGGCCTCA CTAAGATTCT CCAGGACCCT GCAGATATTG AAAATGTACA TAAATATAAA 3060

ACTAGTATTG AAAGAAGATT GTCAGCACTC TGCTGTAGCA CCGCGACGCT GTGA 3114

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ +G+G+favv++gr+r+kt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 9     YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  68

         8899********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e  ++v+lvmeyc+ggdLa++l++k++Lsedt+r+fl+q+a+a+++Lhsk+i+

Q: 69    VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGII  128

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 129   HRDLKPQNILLSYANRRKsNVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  188

         ***************9999*****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll

Q: 189   QHYDAKADLWSIGTVVYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLL  248

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 249   LGLLQRNQKDRMDFEAFFSHPFL  271

         *********************96

Domain Sequence
(FASTA)

YSKRDLVGHG AFAVVFRGRH RQKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQELP NSVFLVMEYC NGGDLADYLQ AKGTLSEDTI RVFLHQIAAA MRILHSKGII 120

HRDLKPQNIL LSYANRRKSN VSGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVVYQCL VGKPPFQANS PQDLRMFYEK NRSLMPSIPR ETSPYLANLL 240

LGLLQRNQKD RMDFEAFFSH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013