EKS-CAF-00095

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00095

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	407.1	7.3E-122	2096	2420	325

Status

Unreviewed

Ensembl Protein

ENSCAFP00000036405

UniProt Accession

J9NTC0;

Protein Name

Protein Synonyms/Alias

Gene Name

SMG1

Gene Synonyms/Alias

SMG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018156	ENSCAFP00000036405	ENSCAFT00000049918
ENSCAFG00000018156	ENSCAFP00000026839	ENSCAFT00000028861

Organism

Canis familiaris

Functional Description

Protein Length

3634

Protein Sequence
(FASTA)

MRFLRTDSAS ADPDTLKYSS SRDRGGSSSY GLQPSNSAVV SRQRHDDTRV HTDIQNDEKG 60

GYSVNGGSGE NTYGRKSLGQ ELRVNNVTSP EFTSIQHGSR ALAIKDMRKS QERSMSYSEE 120

SRLSNLLRRI TREDDRDRRL ATVKQLKEFI QQPENKLVLV KQLDNILAAV HDVLNESSKL 180

LQELRQEGAC CLGLLCASLS YEAEKIFKWI FSKFSSSAKD EVKLLYLCAT YKALETVGEK 240

KAFSSVMQLV MTSLQSILEN VDTPELLCKC VKCILLVARC YPHIFSTNFR DTVDILVGWH 300

IDHTQKPSLT QQVSGWLQSL EPFWVADLAF STTLLGQFLE DMEAYAEDLS HVASGESVDE 360

DVPPPSVSLP KLAALLRVFS TVVRSIGERF SPIRGPPITE AYVTDVLYRV MRCVTAANQV 420

FFSEAVLTAA NECVGVLLGS LDPSMTIHCD MVITYGLDQL ENCQTCGTDY IISVLNLLTL 480

IVEQINTKLP SSFVEKLFIP SSKLLFLRYH KEKEVVAVAH AVYQAVLSLK NIPVLETAYK 540

LILGEMTCAL NNLLHSLQLP DACSEIKHEA FKNHVFNVDN AKFVVIFDLS ALTTIGNAKN 600

SLIGMWALSP TVFALLSKNL MIVHGDLAVH FPAIQYAVLY TLYSHCTRHD HFISSSLSSS 660

SPSLFDGAVI STVTTATKKH FSIILNLLGI LLKKDNLNQD TRKLLMTWAL EVAVLMKKSE 720

TYAPLFSLPS FHKFCKGLLA NTLVEDVNIC LQACSSLHAL SSSLPDDLLQ RCVDVCRVQL 780

VHSGTRIRQA FGKLLKSIPL DVVLSNNNHT EIQEISLALR SHMSKAPSNT FHPQDFSDVI 840

SFILYGNSHR TGKDNWLERL FYSCQRLDKR DQSTIPRNLL KTDAVLWQWA IWEAAQFTVL 900

SKLRTPLGRA QDTFQTIEGI IRSLAAHTLN PDQDVSQWTT ADNDEGHSSN QLRLVLLLQY 960

LENLEKLMYN AYEGCANALT SPPKVIRTFF YTNRQTCQDW LTRIRLSIMR VGLLAGQPAV 1020

TVRHGFDLLT EMKTNLSQGS ELEVTIMMVV EALCELHCPE AIQGIAVWSS SVVGKNLLWI 1080

NSVAQQAEGR FEKASVEYQE HLCAMTGVDC CISSFDKSVL TLANTGRNSA SPKHSLNGES 1140

RKTVLSKPTD SSPEVINYLG NKACECYISI ADWAAVQEWQ NAVHDLKKTT SSTSLNLKAD 1200

FNYIKSLSSF ESGESVECTE QLELLPGENI NLLAGGSKEK IDMKKLLPNM LSPDPRELQK 1260

SIEVQLLRSS VCLATALNHI EQDQKWQSIT ENMVKYLKQT SRIAIGPLRL STLTVSQSLP 1320

VLSTLQLYCS SALENTVSNR LSTEDCLIPL FSEALRSCKQ HDVRPWMQAL RYTMYQSQLL 1380

EKIKEQTVPI RSHLMELGLT AAKFARKRGN VSLATRLLAQ CSEVQLGKTT TAQDLVQHFK 1440

KLSTQGQVDE KWGPELDIEK TKLLYTAGQS THAMEMLSSC AISFCKSAKA EYAVAKSILT 1500

LAKWIQAEWK EISGQLKQVY RAQQQQNFTG LSTLSKNILA LIELPSVNTM EEEYPRIESE 1560

STVHIGVGEP DFILGQLYHL SSVQAPEVAK SWAALASWAY RWGRKVVDNA SQGEGVRLLP 1620

REKSEVQNLL PDTITEEEKE RIYGILGQAV CRPAGIQDED ITLQITENED NEEDDMVEVI 1680

WRQLISSCPW LSELDDSATE GVIKVWRKVV DRIFSLYKLS CSAYFTFLKL NAGQVPLDED 1740

DPRLHLSHRA EQSTDDVIVM ATLRLLRLLV KHAGELRQYL EHGLETTPTA PWRGIIPQLF 1800

SRLNHPEVYV RQSICNLLCR VAQDSPHLIL YPAIVGTISL STESQASGNK FSSAIPTLLG 1860

NIQGEELLVS ECEGGSPPAS QDSNKDEPKS GLNEDQAMMQ DCYSKIVDKL SSANPTMVLQ 1920

VQMLVAELRR VTVLWDELWL GVLLQQHMYV LRRIQQLEDE VKRVQNNNTL RKEEKIAIMR 1980

EKHTALMKPI VFALEHVRSI TAAPAETPHE KWFQDNYGDA IENALEKLKT PSNPAKPGSS 2040

WIPFKEIMLS LQQRAQKRAS YILRLEEISP WLAAMTNTEI ALPGEVSARD TVTIHSVGGT 2100

ITILPTKTKP KKLLFLGSDG KSYPYLFKGL EDLHLDERIM QFLSIVNTMF ATINRQETPR 2160

FHARHYSVTP LGTRSGLIQW VDGATPLFGL YKRWQQREAA LQAQKAQDSY QTPQNPGIVP 2220

RPSELYYSKI GPALKAVGLS LDVSRRDWPL HVMKAVLEEL MEATPPNLLA KELWSSCTTP 2280

DEWWRVTQSY ARSTAVMSMV GYIIGLGDRH LDNVLIDMTT GEVVHIDYNV CFEKGKSLRV 2340

PEKVPFRMTQ NIETALGVTG VEGVFRLSCE QVLHIMRRGR ETLLTLLEAF VYDPLVDWTA 2400

GGEAGFAGAV YGGGGQQAES KQSKREMERE ITRSLFSSRV AEIKVNWFKN RDEMLVVLPK 2460

LDSSLDEYLS LQEQLTDVEK LQGKLLEEIE FLEGAEGVDH PSHTLQHRYS EHTQLQTQQR 2520

AVQEAIQVKL NEFEQWITHY QAAFNNLEAT QLASLLQEIS SQMDLGPPSY VPATAFLQNA 2580

GQAHLISQCE QLEGEVGALL QQRRSVLRGC LEQLHHYATV ALQYPKAIFQ KHRIEQWKTW 2640

MEELICNTTV ERCQELYRKY EMQYAPQPPP TVCQFITATE MTLQRYAADI NSRLIRQVER 2700

LKQEAVTVPV CEDQLKEIER CIKVFLHENG EEGSLSLASV IISALCTLTR RNLMMEGAAS 2760

SAGEQLVDLT SRDGAWFLEE LCSMSGNVTC LVQLLKQCHL VPQDLDIPNP MEASEAVHLA 2820

NGVYTSLQEL NSNFRQIIFP EALRCLMKGE YTLESMLHEL DSLIEQTTDG VPLQTLVESL 2880

QAYLRNAAMG LEEETHAHYI DVARILHAQY GELIQPRNGS VDETPKMSAG QMLLVAFDGM 2940

FAQVETAFGL LVEKLNKMEI PIAWRKIDII REARSTQVNF FDDDNHRQVL EEIFFLKRLQ 3000

TIKEFFRLCG TFSKTLSGSS SLEDQNTVNG PVQIVNVKTL FRNSCFSEDQ MAKPIKAFTA 3060

DFVRQLLIGL PNQALGLTLC SFISALGVDI IAQVEAKDFG AESKVSVDDL CKKAVEHNIQ 3120

IGKFSQLVMN RATVLASSYD TAWKKHDLVR RLETSISSCK TSLQRVQLHI AMFQWQHEDL 3180

LINRPQAMSV TPPPRSAILT SMKKKLHTLS QIETSIATVQ EKLAALEASI EQRLKWAGGA 3240

NPALAPVLQD FEATIAERRN LVLKESQRAS QVTFLCSNII HFESLRTRTA EALNLDAALF 3300

ELIKRCQQMC SFASQFNSSV SELELRLLQR VDTSLEHPIG SSEWLLSAHK QLTQDMSTQR 3360

AIQTEKEQQI ETVCETIQNL VDNIKTVLTG HNRQLGDVKH LLKAMAKDEE AALADGEDVP 3420

YENSVRQFLG EYKSWQDNIQ TVLFTLVQAM GQVRSQEHVE MLQEITPTLK ELKTQSQSIY 3480

NNLVGFASPL VTDATNECSS PTSSATYQPS FAAAVRSNTG QKTQPDVMSQ NARKLIQKNL 3540

ATSADTPPST IPGTGKSVAC SPKKAVRDPK TGKAVQERNS YAVSVWKRVK AKLEGRDVDP 3600

NRRMSVAEQV DYVIKEATNL DNLAQLYEGW TAWV 3634

Nucleotide Sequence
(FASTA)

ATGCGATTTT TGAGAACTGA TAGTGCATCA GCCGACCCAG ATACTTTAAA ATATTCTTCA 60

TCCAGAGATA GGGGTGGGTC ATCTTCTTAT GGACTGCAAC CTTCAAATTC AGCTGTGGTG 120

TCTCGGCAAA GGCACGATGA TACCAGAGTC CACACTGACA TACAGAATGA CGAAAAGGGT 180

GGCTACAGTG TCAATGGAGG ATCTGGGGAA AATACTTATG GTCGGAAGTC GTTGGGGCAA 240

GAGCTGAGGG TTAACAATGT GACCAGCCCT GAGTTCACCA GTATTCAGCA TGGCAGTCGT 300

GCGTTAGCCA TCAAAGACAT GAGGAAATCA CAGGAGCGAT CGATGTCTTA TTCTGAGGAG 360

TCTCGACTGT CAAATCTTCT TCGGAGGATC ACCCGGGAAG ACGACAGAGA CCGAAGACTG 420

GCTACTGTAA AGCAGTTGAA AGAATTTATT CAACAACCAG AAAATAAGCT GGTACTAGTT 480

AAACAATTGG ATAATATCTT GGCTGCTGTA CATGATGTGC TTAATGAAAG TAGCAAATTG 540

CTTCAGGAGT TGAGACAGGA GGGAGCTTGC TGTCTTGGCC TTCTTTGTGC TTCTCTGAGC 600

TATGAGGCTG AGAAGATCTT CAAATGGATT TTTAGCAAAT TTAGCTCATC TGCAAAAGAT 660

GAAGTTAAAC TACTCTACTT ATGTGCCACC TACAAAGCAT TAGAGACTGT GGGAGAAAAG 720

AAAGCCTTTT CATCTGTAAT GCAGCTTGTA ATGACCAGCC TACAGTCCAT TCTTGAAAAT 780

GTGGATACAC CAGAATTACT TTGCAAATGT GTTAAGTGCA TTCTTTTGGT GGCTCGATGT 840

TACCCTCACA TTTTCAGCAC TAATTTTAGG GATACAGTTG ATATATTAGT TGGATGGCAT 900

ATAGATCATA CTCAGAAACC TTCGCTCACA CAGCAGGTGT CTGGGTGGTT GCAGAGTTTG 960

GAGCCGTTTT GGGTAGCTGA TCTTGCATTT TCTACCACTC TTCTTGGTCA GTTTCTGGAG 1020

GACATGGAAG CATATGCTGA GGACCTCAGC CATGTGGCCT CTGGGGAGTC AGTGGATGAA 1080

GATGTTCCTC CTCCATCAGT GTCGTTACCA AAGCTGGCTG CACTTCTTCG GGTGTTCAGT 1140

ACTGTAGTGA GGAGCATTGG GGAACGCTTC AGCCCAATTC GGGGTCCTCC AATTACTGAG 1200

GCATATGTAA CAGATGTTCT GTACAGAGTA ATGAGATGTG TGACGGCTGC AAACCAAGTG 1260

TTTTTTTCTG AGGCTGTGTT GACAGCTGCT AATGAGTGTG TTGGTGTTTT GCTCGGCAGC 1320

TTGGATCCTA GCATGACTAT ACATTGTGAC ATGGTCATTA CATATGGATT AGATCAACTG 1380

GAGAACTGCC AGACTTGCGG TACAGATTAT ATCATCTCAG TCTTGAATTT ACTCACATTG 1440

ATTGTTGAAC AGATAAATAC AAAACTGCCA TCATCATTTG TAGAAAAACT GTTCATACCA 1500

TCATCGAAAC TACTATTTTT GCGTTATCAT AAAGAAAAGG AGGTTGTTGC CGTAGCCCAT 1560

GCTGTTTATC AAGCAGTGCT CAGCCTGAAG AATATTCCTG TTTTGGAGAC TGCCTATAAA 1620

TTAATTTTGG GGGAAATGAC TTGTGCCCTA AACAACCTGC TACATAGTCT ACAACTTCCT 1680

GATGCCTGCT CCGAAATAAA ACATGAGGCT TTTAAAAATC ATGTATTCAA TGTAGACAAT 1740

GCAAAATTTG TAGTTATATT TGACCTCAGT GCCCTAACTA CAATTGGAAA TGCCAAAAAC 1800

TCCCTAATAG GGATGTGGGC ACTGTCTCCA ACCGTCTTTG CCCTGCTGAG TAAGAATCTA 1860

ATGATTGTGC ACGGTGACCT GGCTGTTCAC TTCCCTGCCA TTCAGTATGC TGTGCTCTAC 1920

ACATTGTATT CTCATTGTAC CAGGCACGAT CACTTTATAT CTAGTAGTCT TAGTTCTTCA 1980

TCCCCATCTC TGTTTGATGG AGCTGTAATC AGTACTGTAA CTACAGCTAC AAAAAAACAT 2040

TTCTCAATTA TACTGAATCT CCTGGGAATA TTGCTTAAGA AAGATAATCT TAACCAGGAC 2100

ACAAGGAAAC TGTTAATGAC TTGGGCTTTG GAAGTGGCTG TTTTAATGAA GAAGTCTGAA 2160

ACATATGCAC CTTTATTCTC TCTTCCATCT TTCCATAAAT TTTGCAAAGG ACTTTTAGCC 2220

AACACTCTTG TTGAAGATGT GAATATCTGT CTGCAAGCAT GCAGCAGTCT ACATGCTTTG 2280

TCCTCTTCTT TGCCGGACGA TCTTTTACAG AGGTGTGTTG ATGTTTGCCG TGTTCAACTT 2340

GTCCATAGTG GAACTCGTAT TCGACAAGCA TTTGGAAAGC TGTTGAAGTC GATTCCTTTA 2400

GATGTTGTCT TGAGCAATAA CAATCACACA GAAATTCAAG AAATTTCTTT AGCGTTAAGA 2460

AGTCACATGA GCAAAGCACC AAGTAACACA TTCCATCCAC AAGATTTCTC TGATGTTATT 2520

AGTTTTATTT TGTATGGGAA TTCTCACAGA ACAGGGAAGG ACAATTGGTT AGAAAGATTG 2580

TTCTATAGCT GCCAGAGACT GGATAAGCGT GACCAATCAA CAATTCCCCG AAATCTTCTA 2640

AAGACAGATG CCGTCCTTTG GCAGTGGGCT ATTTGGGAGG CAGCACAGTT CACTGTCCTC 2700

TCTAAGTTGA GAACCCCATT GGGCAGAGCT CAGGATACCT TCCAGACCAT TGAAGGTATC 2760

ATTAGAAGTC TCGCAGCTCA CACGTTAAAC CCTGATCAAG ATGTTAGTCA GTGGACAACT 2820

GCAGACAATG ATGAAGGCCA CAGTAGCAAC CAGCTTAGAC TTGTTCTTCT TCTGCAGTAC 2880

CTGGAAAATC TGGAGAAGTT AATGTATAAT GCATATGAGG GGTGCGCTAA TGCATTAACA 2940

TCACCTCCCA AGGTCATTAG GACTTTTTTT TATACTAATC GCCAAACTTG CCAAGACTGG 3000

CTGACACGGA TCCGACTCTC CATTATGAGA GTTGGATTGT TGGCAGGCCA GCCTGCTGTG 3060

ACAGTGAGAC ATGGCTTTGA CTTGCTTACT GAAATGAAGA CAAATCTATC TCAGGGGAGT 3120

GAATTGGAAG TAACCATCAT GATGGTGGTA GAAGCACTGT GCGAGCTTCA TTGTCCTGAA 3180

GCTATACAGG GAATTGCTGT GTGGTCCTCT TCCGTTGTTG GAAAGAATCT TCTCTGGATA 3240

AATTCAGTGG CCCAACAGGC AGAAGGGAGG TTTGAAAAGG CCTCTGTGGA GTACCAGGAG 3300

CACTTGTGTG CCATGACGGG TGTCGATTGC TGCATCTCCA GCTTCGACAA ATCTGTTCTC 3360

ACGTTAGCCA ACACCGGGCG TAATAGCGCC AGCCCCAAAC ATTCTCTGAA TGGTGAATCC 3420

AGAAAAACGG TGCTGTCCAA GCCAACTGAC TCTTCCCCTG AGGTCATAAA TTATTTGGGA 3480

AATAAAGCCT GTGAGTGCTA CATCTCGATT GCCGACTGGG CGGCCGTACA GGAGTGGCAG 3540

AATGCCGTCC ACGACCTGAA GAAGACAACC AGCAGCACTT CTCTCAATCT GAAAGCTGAT 3600

TTCAACTACA TCAAATCACT AAGCAGTTTT GAATCTGGAG AATCTGTTGA ATGTACTGAG 3660

CAATTAGAAT TGTTACCAGG AGAAAATATC AATCTACTTG CTGGAGGATC AAAAGAGAAA 3720

ATAGATATGA AGAAACTGCT TCCTAACATG TTAAGTCCAG ATCCAAGGGA ACTTCAGAAA 3780

TCCATTGAAG TTCAGTTGTT GAGAAGTTCT GTTTGTTTGG CAACTGCTTT AAACCACATA 3840

GAACAAGATC AGAAGTGGCA GTCCATAACT GAAAACATGG TGAAGTACTT GAAGCAAACC 3900

TCCCGCATAG CTATCGGACC ACTGAGACTT TCTACTTTAA CAGTTTCACA GTCTCTGCCA 3960

GTTCTCAGTA CCTTACAGCT GTATTGCTCT TCTGCTTTGG AGAACACAGT TTCTAACAGA 4020

CTTTCAACAG AGGATTGTCT TATTCCACTC TTCAGTGAAG CCCTGCGTTC ATGTAAACAG 4080

CATGATGTGA GGCCATGGAT GCAGGCATTA AGATATACCA TGTACCAGAG TCAGTTGTTG 4140

GAGAAGATAA AAGAACAAAC GGTTCCAATT AGAAGCCATC TCATGGAATT AGGTCTGACA 4200

GCAGCAAAAT TTGCTAGAAA ACGAGGGAAT GTGTCACTTG CAACAAGACT GTTGGCACAG 4260

TGTAGTGAGG TTCAGCTGGG AAAGACTACT ACTGCACAGG ATTTAGTCCA GCATTTTAAA 4320

AAACTATCAA CTCAAGGTCA AGTGGATGAG AAATGGGGGC CTGAACTTGA CATTGAAAAA 4380

ACCAAATTGC TATATACAGC AGGCCAGTCA ACACACGCAA TGGAAATGTT GAGTTCTTGT 4440

GCCATATCTT TCTGCAAGTC TGCCAAAGCT GAATATGCAG TTGCCAAGTC AATTCTGACA 4500

TTGGCTAAAT GGATCCAGGC AGAATGGAAA GAAATTTCAG GGCAGCTGAA ACAGGTTTAC 4560

AGAGCTCAGC AACAGCAGAA CTTCACAGGT CTTTCTACTC TGTCTAAAAA CATACTCGCT 4620

TTAATAGAAC TGCCATCTGT TAATACAATG GAAGAAGAGT ATCCTCGGAT TGAGAGTGAA 4680

TCAACAGTAC ATATTGGAGT TGGAGAACCT GACTTCATTT TGGGACAGTT GTATCACCTG 4740

TCTTCAGTAC AGGCACCTGA AGTAGCCAAA TCTTGGGCAG CATTGGCTAG TTGGGCTTAT 4800

AGGTGGGGCA GAAAGGTGGT TGACAATGCC AGTCAGGGAG AAGGTGTTCG TCTGCTGCCT 4860

AGAGAAAAAT CTGAAGTTCA GAATCTGCTT CCAGACACTA TAACTGAAGA AGAAAAAGAG 4920

AGAATATATG GTATTCTTGG ACAGGCTGTG TGTCGACCAG CGGGGATTCA GGATGAAGAT 4980

ATAACGCTTC AGATAACAGA AAATGAAGAT AACGAGGAAG ATGACATGGT TGAGGTTATC 5040

TGGCGTCAGC TAATCTCAAG CTGCCCATGG CTTTCAGAAC TTGATGACAG TGCAACAGAA 5100

GGAGTTATTA AAGTGTGGAG GAAGGTTGTA GATAGAATCT TCAGCCTGTA CAAGCTGTCT 5160

TGTAGTGCAT ATTTTACTTT CCTCAAACTC AATGCTGGTC AGGTTCCTTT AGATGAAGAT 5220

GACCCGAGGC TACATTTAAG TCACAGAGCC GAGCAGAGTA CTGATGATGT GATTGTGATG 5280

GCCACACTGC GCTTACTCAG ATTGCTCGTT AAACATGCTG GCGAACTTAG GCAGTATCTG 5340

GAACATGGCT TGGAAACAAC ACCTACTGCT CCATGGAGAG GAATTATTCC ACAGCTTTTC 5400

TCACGCTTAA ACCACCCTGA AGTATATGTG CGCCAAAGTA TCTGTAATCT CCTTTGCCGA 5460

GTGGCTCAAG ATTCCCCGCA TCTCATATTG TACCCTGCAA TCGTGGGGAC CATATCACTC 5520

AGTACTGAAT CACAGGCTTC AGGAAATAAG TTTTCCTCTG CAATTCCAAC TTTGCTTGGC 5580

AATATTCAAG GAGAAGAATT GCTGGTTTCT GAATGTGAGG GAGGAAGCCC TCCTGCTTCT 5640

CAGGATAGCA ATAAGGATGA ACCTAAAAGT GGATTAAATG AAGACCAAGC CATGATGCAG 5700

GATTGCTACA GCAAAATTGT AGATAAGCTG TCCTCTGCAA ACCCAACTAT GGTGTTACAG 5760

GTTCAGATGC TTGTGGCTGA GCTGCGCAGG GTCACTGTTC TCTGGGATGA GCTGTGGTTG 5820

GGAGTTCTGT TACAGCAACA CATGTATGTC CTGAGACGGA TTCAGCAGCT GGAAGATGAG 5880

GTGAAGAGAG TCCAGAACAA CAACACCTTA CGCAAAGAAG AGAAGATTGC AATCATGCGG 5940

GAAAAGCACA CGGCTTTGAT GAAGCCCATT GTGTTTGCTT TGGAGCATGT AAGGAGCATC 6000

ACCGCAGCCC CTGCAGAAAC ACCTCATGAA AAGTGGTTTC AGGATAACTA TGGTGATGCA 6060

ATTGAAAATG CTCTTGAAAA GCTAAAGACA CCATCAAATC CTGCAAAGCC TGGAAGCAGC 6120

TGGATTCCAT TTAAAGAGAT AATGCTGAGT TTGCAACAGA GAGCACAGAA ACGTGCAAGT 6180

TATATCTTGC GTCTTGAAGA AATCAGCCCG TGGCTGGCTG CCATGACTAA CACTGAAATT 6240

GCTCTTCCTG GAGAAGTGTC AGCTAGAGAC ACTGTCACAA TCCACAGTGT GGGCGGAACC 6300

ATCACCATCT TACCTACCAA AACCAAGCCA AAGAAACTGC TCTTTCTAGG GTCAGATGGC 6360

AAGAGCTATC CGTATCTCTT CAAAGGATTG GAAGATTTAC ATCTGGATGA GAGAATAATG 6420

CAGTTCCTGT CTATTGTGAA TACCATGTTT GCTACAATCA ATCGCCAGGA AACACCCCGT 6480

TTCCATGCCC GACACTATTC TGTAACACCA CTAGGAACCC GATCAGGACT AATCCAGTGG 6540

GTGGATGGAG CCACACCCTT ATTTGGTCTT TACAAACGAT GGCAACAACG GGAAGCTGCC 6600

TTACAAGCAC AGAAGGCCCA AGATTCCTAC CAAACTCCTC AGAATCCTGG AATTGTACCT 6660

CGTCCTAGTG AACTTTATTA TAGTAAAATT GGTCCTGCTT TAAAAGCAGT TGGACTTAGC 6720

CTGGATGTGT CCCGACGGGA TTGGCCTCTT CATGTAATGA AGGCAGTATT AGAAGAGTTA 6780

ATGGAGGCTA CCCCCCCAAA TCTCCTTGCT AAAGAGCTCT GGTCATCTTG TACCACACCT 6840

GATGAATGGT GGAGAGTCAC ACAGTCTTAT GCCAGGTCTA CTGCAGTTAT GTCTATGGTC 6900

GGATACATAA TTGGCCTTGG AGATAGACAC CTGGATAATG TTCTCATAGA TATGACGACT 6960

GGAGAAGTGG TTCACATAGA TTACAATGTT TGCTTTGAAA AAGGTAAAAG CCTTAGAGTT 7020

CCTGAGAAAG TACCTTTTCG AATGACACAG AATATTGAAA CAGCACTGGG TGTAACTGGA 7080

GTAGAAGGTG TTTTTAGGCT TTCATGTGAG CAGGTTCTAC ACATCATGCG GCGTGGCAGG 7140

GAGACTCTGC TGACATTGCT GGAGGCTTTT GTGTATGACC CCCTGGTGGA CTGGACGGCT 7200

GGGGGTGAGG CAGGCTTTGC TGGCGCTGTC TATGGTGGAG GTGGCCAGCA GGCTGAGAGC 7260

AAGCAGAGCA AGAGAGAGAT GGAGCGAGAG ATCACCCGCA GCCTCTTTTC TTCCAGAGTA 7320

GCTGAAATTA AGGTGAACTG GTTTAAGAAT AGGGATGAGA TGCTGGTTGT GCTTCCCAAG 7380

CTGGACAGCA GCTTAGATGA ATACCTAAGC TTGCAAGAGC AGCTGACAGA TGTGGAAAAA 7440

CTTCAAGGCA AACTACTGGA AGAAATAGAG TTTCTAGAAG GAGCTGAAGG AGTGGACCAT 7500

CCTTCTCACA CTCTGCAACA CAGGTATTCT GAACACACTC AACTACAGAC TCAGCAAAGG 7560

GCTGTACAGG AAGCAATCCA GGTGAAGCTG AATGAATTTG AACAGTGGAT AACGCATTAT 7620

CAGGCTGCGT TCAATAATTT AGAAGCAACA CAACTTGCAA GTTTGCTTCA GGAGATAAGC 7680

TCACAAATGG ACCTTGGTCC TCCAAGCTAT GTGCCCGCAA CAGCCTTTCT ACAGAATGCT 7740

GGCCAGGCGC ACTTGATTAG CCAGTGTGAG CAGCTAGAGG GAGAAGTGGG CGCTCTTCTC 7800

CAGCAGAGGC GTTCAGTGCT CCGAGGTTGT CTGGAACAGC TGCATCACTA TGCAACTGTA 7860

GCTCTGCAGT ATCCAAAAGC CATATTTCAA AAACATCGAA TTGAGCAGTG GAAGACCTGG 7920

ATGGAAGAGC TCATCTGTAA TACCACAGTT GAGCGCTGTC AAGAACTGTA CAGGAAATAC 7980

GAGATGCAGT ATGCTCCCCA GCCTCCACCA ACAGTGTGTC AATTCATCAC GGCCACAGAG 8040

ATGACTCTGC AGCGGTACGC AGCTGACATC AACAGTAGGC TTATTAGACA AGTGGAACGC 8100

TTGAAACAGG AAGCTGTTAC TGTGCCTGTT TGTGAAGATC AGTTGAAAGA AATTGAACGT 8160

TGCATTAAGG TTTTCCTTCA CGAGAATGGG GAAGAAGGAT CTTTGAGTCT AGCAAGTGTT 8220

ATTATTTCCG CCCTTTGTAC TCTTACAAGG CGTAACCTGA TGATGGAAGG TGCAGCTTCA 8280

AGTGCTGGGG AGCAGCTGGT GGATCTGACC TCTCGGGATG GAGCCTGGTT CTTGGAAGAG 8340

CTCTGCAGTA TGAGTGGGAA CGTCACTTGC CTGGTGCAGT TACTGAAGCA GTGCCACCTG 8400

GTGCCACAGG ACTTAGACAT TCCGAACCCA ATGGAAGCTT CTGAGGCAGT TCACTTAGCT 8460

AATGGAGTTT ATACCTCACT TCAGGAATTA AATTCAAATT TCCGGCAAAT CATATTTCCA 8520

GAAGCACTGA GATGTTTAAT GAAAGGAGAA TACACGTTAG AAAGTATGCT TCATGAGCTG 8580

GACAGTCTTA TTGAGCAGAC AACTGATGGC GTTCCCCTGC AGACTCTAGT TGAATCTCTT 8640

CAGGCCTATT TAAGAAATGC AGCTATGGGA CTCGAGGAAG AAACACATGC TCATTACATC 8700

GATGTTGCCA GAATACTACA TGCTCAATAT GGTGAATTAA TCCAACCAAG AAATGGTTCA 8760

GTTGATGAAA CACCAAAAAT GTCAGCTGGC CAGATGCTTT TGGTAGCATT TGATGGGATG 8820

TTTGCCCAAG TTGAAACTGC TTTTGGCTTA TTAGTTGAAA AGTTAAACAA GATGGAAATT 8880

CCCATTGCTT GGCGAAAGAT TGACATTATA AGGGAAGCCA GGAGTACCCA AGTCAATTTT 8940

TTTGATGATG ATAATCACCG GCAGGTGCTA GAAGAGATTT TCTTTCTAAA AAGATTACAG 9000

ACAATTAAGG AATTTTTCAG GCTCTGTGGT ACCTTTTCTA AAACTTTATC AGGTTCGAGT 9060

TCGCTTGAGG ATCAGAATAC TGTAAATGGA CCTGTACAGA TTGTCAATGT GAAAACTCTT 9120

TTTAGAAACT CCTGTTTCAG TGAAGACCAG ATGGCCAAAC CTATAAAGGC ATTCACAGCT 9180

GACTTTGTGA GGCAGCTCTT GATTGGACTA CCGAACCAAG CCCTAGGACT CACCCTCTGC 9240

AGTTTTATCA GTGCCCTGGG TGTAGACATT ATTGCTCAAG TAGAGGCAAA GGACTTTGGT 9300

GCTGAAAGCA AAGTCTCTGT TGATGATCTT TGTAAGAAAG CAGTGGAGCA CAACATCCAG 9360

ATTGGGAAGT TCTCTCAGTT GGTAATGAAC AGGGCAACTG TGTTAGCAAG CTCCTATGAT 9420

ACTGCCTGGA AGAAACATGA CTTGGTACGC AGGCTAGAAA CCAGTATTTC TTCTTGTAAG 9480

ACAAGCCTGC AGCGTGTTCA GCTGCATATT GCCATGTTTC AATGGCAGCA TGAAGACCTT 9540

CTTATCAATA GACCACAAGC CATGTCAGTT ACACCTCCTC CTCGGTCAGC CATCCTAACC 9600

AGCATGAAAA AGAAACTCCA TACTCTGAGC CAAATTGAAA CTTCAATTGC AACAGTTCAG 9660

GAGAAACTAG CAGCACTTGA AGCAAGTATT GAACAGCGAC TTAAGTGGGC AGGTGGTGCC 9720

AACCCTGCAC TGGCACCTGT ACTACAGGAT TTTGAAGCAA CAATAGCCGA AAGAAGAAAT 9780

CTTGTCCTTA AAGAGAGCCA AAGAGCAAGC CAGGTCACTT TCCTCTGCAG CAATATCATC 9840

CATTTTGAAA GTTTACGAAC TAGAACTGCA GAAGCCTTAA ACCTGGATGC CGCATTATTT 9900

GAACTAATCA AACGATGTCA GCAAATGTGT TCATTTGCAT CACAGTTTAA CAGTTCAGTC 9960

TCTGAGTTAG AGCTTCGTTT ATTACAAAGA GTGGACACCA GTCTTGAGCA TCCTATTGGC 10020

AGCTCTGAGT GGCTTTTGTC AGCACACAAA CAATTGACCC AGGATATGTC TACTCAGAGG 10080

GCAATTCAGA CAGAGAAAGA GCAACAGATA GAAACAGTCT GTGAAACAAT TCAGAATCTG 10140

GTTGATAATA TAAAGACTGT GCTCACTGGT CATAACCGGC AACTTGGAGA TGTCAAACAT 10200

CTCCTGAAAG CAATGGCTAA GGATGAAGAA GCTGCCCTGG CAGATGGTGA AGATGTTCCC 10260

TATGAGAACA GTGTTAGGCA GTTCTTAGGT GAATATAAAT CATGGCAAGA CAACATTCAG 10320

ACGGTGCTGT TTACATTAGT CCAAGCTATG GGTCAGGTTC GAAGTCAAGA ACACGTTGAA 10380

ATGCTCCAGG AAATAACTCC CACCTTGAAA GAACTGAAAA CACAAAGTCA GAGTATCTAT 10440

AATAATTTAG TGGGTTTTGC ATCACCCTTA GTCACCGATG CAACAAATGA ATGTTCAAGT 10500

CCAACGTCAT CTGCTACTTA CCAGCCATCC TTTGCTGCAG CAGTCCGGAG CAACACTGGC 10560

CAGAAGACTC AGCCTGATGT CATGTCGCAG AATGCTAGAA AGTTGATTCA GAAAAATCTT 10620

GCCACCTCAG CAGATACTCC ACCAAGCACC ATTCCAGGAA CTGGCAAGAG TGTTGCTTGT 10680

AGTCCTAAAA AGGCTGTCAG AGACCCTAAA ACAGGGAAAG CTGTGCAAGA GAGAAACTCC 10740

TATGCAGTGA GTGTGTGGAA GAGGGTGAAA GCCAAGCTCG AGGGCCGAGA TGTTGATCCG 10800

AATAGGAGGA TGTCAGTTGC TGAACAGGTT GACTATGTCA TTAAGGAAGC AACTAATCTA 10860

GATAACTTGG CTCAGCTGTA TGAAGGTTGG ACAGCCTGGG TATGA 10905

Domain Profile

S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62

         ++  +++il++k+kpkkll++Gsdgk+ypyL+kg+eDl+ der++q++s+vNt++a+ ++

Q: 2096  SVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR  2155

         566789******************************************************

S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdl  120

         ++++++++r+y+V+pl+trsgli+wv+++++L+ l+k++++++a+l++q++  sy+++++

Q: 2156  QETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAqdSYQTPQN  2215

         **************************************************999*******

S: 121   stvqar.........kpklkhlkls.........levfkevlenlv...pkdllkkllle  159

         + +++r         +p+lk++ ls         l+v+k+vle+l+   p++ll+k+l++

Q: 2216  PGIVPRpselyyskiGPALKAVGLSldvsrrdwpLHVMKAVLEELMeatPPNLLAKELWS  2275

         ***************999999999999*****************99999***********

S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219

         ++++p+ew++++++y+rs+Av+s+vgyi+gLgdrhl+n+lid++tgevvhid++v+fek+

Q: 2276  SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG  2335

         ************************************************************

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

         k+ l+vpekvPFR+T+ni++algvtgveGvfr sce+vl+++r+ +e+llt+Le+f+ydp

Q: 2336  KS-LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDP  2394

         **.*********************************************************

S: 280   lvdwkk...................k  286

         lvdw+                    +

Q: 2395  LVDWTAggeagfagavyggggqqaeS  2420

         *****988777777666555522222

Domain Sequence
(FASTA)

SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL DERIMQFLSI VNTMFATINR 60

QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN 120

PGIVPRPSEL YYSKIGPALK AVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 180

SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH IDYNVCFEKG 240

KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI MRRGRETLLT LLEAFVYDPL 300

VDWTAGGEAG FAGAVYGGGG QQAES 325

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013