EKS-CAF-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	583.3	6.6E-176	13	271	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000026845

UniProt Accession

F1PB67;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK2A

Gene Synonyms/Alias

CAMK2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018163	ENSCAFP00000026845	ENSCAFT00000028867

Organism

Canis familiaris

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 60

ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120

EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 180

SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240

TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 300

GAILTTMLAT RNFSGGKSGG NKKNDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 360

ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 420

LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH 478

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCACCTGCAC CCGCTTCACA GAAGAGTATC AGCTCTTCGA GGAACTGGGA 60

AAGGGAGCCT TCTCAGTGGT ACGCAGGTGT GTGAAGGTGC TGGCTGGCCA GGAGTATGCT 120

GCTAAGATCA TCAACACCAA AAAGCTCTCA GCCAGAGACC ATCAGAAGCT GGAGCGCGAA 180

GCTCGCATCT GCCGCCTGCT GAAACACCCC AACATAGTCC GGCTTCACGA CAGCATCTCT 240

GAGGAGGGAC ATCATTACCT GATCTTCGAC CTGGTTACTG GCGGGGAGCT GTTTGAGGAC 300

ATCGTGGCCC GGGAGTATTA CAGTGAGGCT GATGCCAGCC ACTGTATCCA GCAGATCCTG 360

GAGGCCGTGT TGCACTGCCA TCAGATGGGT GTGGTGCACC GGGACCTGAA GCCGGAGAAT 420

CTGTTGTTGG CCTCCAAACT CAAGGGCGCA GCGGTGAAGC TGGCGGACTT TGGCCTGGCC 480

ATAGAGGTAG AAGGGGAGCA GCAGGCATGG TTCGGGTTCG CAGGGACGCC GGGATACCTC 540

TCCCCAGAAG TGCTGCGGAA GGACCCATAT GGGAAACCCG TGGATCTGTG GGCCTGTGGG 600

GTCATCCTCT ACATTCTGCT GGTTGGGTAT CCCCCATTCT GGGATGAAGA CCAGCACCGC 660

CTGTACCAGC AGATCAAAGC TGGCGCCTAT GATTTCCCAT CACCAGAATG GGACACCGTC 720

ACCCCGGAAG CCAAGGATCT GATCAATAAG ATGCTGACCA TCAACCCATC CAAACGCATC 780

ACGGCCGCTG AGGCCCTCAA GCACCCCTGG ATCTCGCACC GGTCCACCGT GGCCTCCTGC 840

ATGCACAGAC AGGAGACCGT GGACTGCCTG AAGAAGTTCA ACGCCAGGAG AAAACTGAAG 900

GGAGCCATCC TCACCACTAT GCTGGCTACC AGGAACTTCT CTGGAGGGAA GAGTGGAGGA 960

AACAAAAAGA ATGATGGTGT GAAGGAATCT TCAGAGAGTA CCAACACCAC CATTGAGGAT 1020

GAAGACACCA AAGTGCGGAA ACAGGAGATT ATAAAAGTGA CAGAGCAGCT GATTGAAGCC 1080

ATAAGCAATG GAGATTTTGA GTCCTACACG AAGATGTGTG ACCCCGGGAT GACAGCCTTC 1140

GAACCTGAGG CCCTGGGGAA CCTGGTCGAG GGCCTGGACT TCCATCGATT CTATTTTGAA 1200

AACCTGTGGT CTCGGAACAG CAAGCCTGTG CACACCACCA TCCTGAACCC CCATATCCAT 1260

CTGATGGGCG ACGAGTCGGC CTGCATCGCC TACATCCGCA TCACGCAGTA CCTGGATGCG 1320

GGTGGCATCC CCCGCACGGC CCAGTCAGAG GAGACCCGCG TCTGGCACCG CCGGGACGGC 1380

AAATGGCAGA TTGTCCACTT CCACAGATCT GGGGCACCCT CCGTCCTGCC CCATTGA 1437

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvkv +gqeyaakiintkklsardhqklerearicrllkhpni

Q: 13    YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  72

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv

Q: 73    VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV  132

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaiev+g+qqawfgfagtpgylspevlrkdpygk

Q: 133   HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK  192

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 193   PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  252

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 253   TINPSKRITAAEALKHPWI  271

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK VLAGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GHHYLIFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120

HRDLKPENLL LASKLKGAAV KLADFGLAIE VEGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDLWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013