EKS-CAF-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	525.9	2.0E-158	985	1252	268

Status

Unreviewed

Ensembl Protein

ENSCAFP00000038176

UniProt Accession

E2RPM8;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSR

Gene Synonyms/Alias

INSR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018170	ENSCAFP00000026853	ENSCAFT00000028875
ENSCAFG00000018170	ENSCAFP00000038176	ENSCAFT00000049285

Organism

Canis familiaris

Functional Description

Protein Length

1344

Protein Sequence
(FASTA)

MDIRNNLTRL HELANCSVIE GHLQILLMFK TRPEDFRDLS FPKLIMITDY LLLFRVYGLE 60

SLKDLFPNLT VIRGSRLFFN YALVIFEMVH LKELGLYSLM NITRGSVRIE KNNELCYLAT 120

IDWSRILDSV EDNYIVLNKD DNEECGDICP GTAKGKTNCP ATVINGQFVE RCWTHSHCQK 180

VCPTICKSHG CTAEGLCCHS ECLGNCSEPD DPTKCVACRN FYLDGRCVET CPPPYYHFQD 240

WRCVNFSFCQ DLHNKCKNSR RQGCHQYVIH NNKCIPECPS GYTMNSSNLM CTPCLGPCPK 300

VCHILEGEKT IDSVTSAQEL RGCTVVNGSL IINIRGGNNL AAELEANLGL IEEISGYLKI 360

RRSYALVSLS FFRKLRLIRG ETLEIGNYSF YALDNQNLRQ LWDWSKHNLT ITQGKLFFHY 420

NPKLCLSEIH KMEEVSGTKG RQERNDIALK TNGDQASCEN ELLKFSYIRT SYDKILLKWE 480

PYWPPDFRDL LGFMLFYKEA PYQNVTEFDG QDACGSNSWT VVDIDPPLRS NDPKSQNHPG 540

WLMRGLKPWT QYAIFVKTLV TFSDERRTYG AKSDIIYVQT DATNPSVPLD PISVSNSSSQ 600

IILKWKPPSD PNGNITHYLV FWERQAEDSE LYELDYCLKG LKLPSRTWSP PFEAEGSQKH 660

NQSEYEESAG ECCSCPKTDS QILKELEESS FRKTFEDYLH NVVFVPRKSS SSPGAEDTRP 720

SRKRRALSDA GNVTAAIPTV PGFPNTSTST PTSPEEHKPF EKVVNKESLV ISGLRHFTGY 780

RIELQACNQD SPEERCSVAA YVSARTMPEA KADDIVGPVT HEIFENNVVH LMWQEPKEPN 840

GLIVLYEVSY RRYGDEELHL CVSRRHFALE RGCRLRGLPP GNYSVRVRAT SLAGNGSWTE 900

ATYFYVTDYL DVPSNIAKII IGPLIFVFLF SVVIGSIYLF LRKRQPDGPL GPLYASSNPE 960

YLSASDVFPC SVYVPDEWEV PREKITLLRE LGQGSFGMVY EGNARDIVKG EPETRVAVKT 1020

VNESASLRER IEFLNEASVM KGFTCHHVVR LLGVVFKGQP TLVVMELMAH GDLKSYLRSL 1080

RPEAENNPGR PPPTKQEMIQ MAAEIADGMV YLNAKKFVHR DLAARNCMVA HDYTVKIGDF 1140

GMTRDIYETD YYRKGGKGLL PVRWMAPESL KDGVFTTSSD MWSFGVVLWE ITSLAEQPYQ 1200

GLSNEQVLKF VMDGGYLDQP DNCPERVTDL MRMCWQFNPK MRPTFLEIVD LLKDDLHPSF 1260

PEVSFFHSEE NKAPESEELE MEFEDMESVP LDRASHSQRE EAGGRDAGSS LGLKRSYEEH 1320

IPYTHMNGGK KNGRILTLPR SNPS 1344

Nucleotide Sequence
(FASTA)

ATGGATATCC GGAACAACCT AACGAGGCTG CATGAGCTGG CCAACTGCTC GGTCATTGAA 60

GGACATTTGC AGATACTGTT AATGTTCAAA ACGAGGCCCG AGGATTTCCG AGACCTCAGT 120

TTCCCCAAAC TCATCATGAT CACTGATTAC TTGCTGCTCT TCCGGGTCTA TGGGCTGGAG 180

AGCCTGAAGG ACCTGTTCCC CAACCTCACG GTCATCCGAG GCTCGCGCCT CTTCTTCAAC 240

TACGCGCTGG TCATCTTCGA GATGGTCCAC CTGAAGGAGC TTGGCCTCTA CAGCTTGATG 300

AACATCACCC GGGGCTCCGT CCGCATCGAG AAGAACAATG AGCTCTGCTA CCTGGCCACC 360

ATCGACTGGT CCCGCATCCT GGATTCTGTG GAGGATAATT ATATTGTGCT GAACAAAGAC 420

GACAACGAGG AGTGTGGGGA CATCTGTCCA GGCACTGCCA AGGGCAAGAC CAACTGCCCT 480

GCCACTGTCA TCAATGGGCA GTTTGTCGAG CGGTGTTGGA CACACAGCCA CTGCCAGAAA 540

GTTTGTCCGA CCATCTGCAA GTCGCATGGC TGCACCGCCG AGGGCCTCTG CTGCCACAGC 600

GAGTGTTTAG GCAACTGCTC CGAGCCCGAC GACCCCACCA AGTGCGTGGC CTGTCGCAAC 660

TTCTACCTGG ATGGCAGGTG CGTGGAGACC TGCCCACCCC CGTACTACCA CTTCCAAGAC 720

TGGCGCTGCG TGAACTTCAG CTTCTGCCAG GACCTGCACA ACAAATGCAA GAACTCCCGG 780

AGACAGGGCT GCCACCAGTA CGTCATCCAC AATAACAAGT GCATCCCCGA GTGCCCCTCT 840

GGCTACACGA TGAATTCCAG CAACCTGATG TGCACTCCGT GCCTGGGCCC CTGTCCCAAG 900

GTCTGCCACA TTCTGGAAGG CGAGAAGACC ATCGACTCAG TGACGTCTGC CCAGGAGCTT 960

CGAGGCTGCA CTGTTGTCAA CGGAAGTCTA ATCATCAACA TTCGAGGGGG CAACAACCTG 1020

GCGGCCGAGC TGGAGGCCAA CCTCGGACTC ATTGAAGAGA TTTCCGGGTA CCTGAAAATC 1080

CGGAGATCCT ATGCTCTTGT GTCTCTTTCC TTTTTCCGGA AGTTGCGGCT GATTCGAGGG 1140

GAGACCTTGG AGATCGGGAA CTACTCTTTC TATGCCTTGG ACAACCAGAA CCTAAGGCAG 1200

CTATGGGACT GGAGCAAACA CAACCTCACC ATCACTCAGG GGAAACTCTT CTTCCACTAT 1260

AATCCCAAAC TCTGCTTGTC TGAGATCCAC AAGATGGAGG AAGTCTCAGG AACCAAGGGG 1320

CGCCAGGAGA GGAACGACAT TGCCCTGAAG ACCAACGGGG ACCAGGCGTC TTGTGAAAAC 1380

GAACTACTTA AATTTTCTTA CATTCGGACG TCTTATGACA AGATCTTGCT GAAATGGGAG 1440

CCCTACTGGC CCCCCGACTT CCGAGACCTC CTGGGGTTCA TGCTCTTCTA CAAAGAGGCC 1500

CCTTATCAGA ATGTGACCGA GTTTGATGGG CAGGACGCGT GTGGCTCCAA CAGCTGGACG 1560

GTGGTGGACA TTGACCCACC TCTGCGGTCC AACGACCCCA AATCGCAGAA CCACCCGGGG 1620

TGGCTGATGC GGGGTCTCAA GCCCTGGACC CAATATGCCA TCTTTGTCAA GACCTTGGTC 1680

ACCTTTTCTG ATGAACGCCG CACGTATGGA GCCAAGAGTG ACATCATCTA TGTGCAGACA 1740

GATGCCACTA ATCCTTCCGT CCCCCTGGAT CCAATCTCGG TTTCGAATTC CTCGTCCCAG 1800

ATTATTCTGA AGTGGAAGCC TCCCTCTGAC CCCAATGGCA ATATCACGCA CTACCTGGTT 1860

TTCTGGGAGA GGCAGGCCGA AGACAGTGAG CTCTATGAGT TGGATTATTG CCTCAAAGGG 1920

TTGAAGCTGC CCTCCCGGAC CTGGTCTCCG CCGTTCGAGG CCGAGGGCTC CCAGAAGCAC 1980

AACCAGAGTG AATACGAGGA GTCTGCCGGC GAATGCTGCT CCTGCCCCAA AACGGACTCT 2040

CAGATCCTCA AGGAGCTAGA GGAGTCCTCT TTTAGGAAGA CGTTTGAGGA TTACCTGCAC 2100

AACGTGGTGT TTGTCCCCAG AAAATCCTCT TCGAGCCCTG GTGCTGAGGA CACTAGGCCA 2160

TCGAGGAAAC GCAGGGCGCT CAGTGATGCT GGCAACGTGA CAGCAGCTAT ACCCACAGTT 2220

CCCGGTTTCC CCAACACCTC GACCAGCACG CCCACGAGCC CGGAGGAGCA CAAGCCCTTC 2280

GAGAAAGTGG TGAACAAAGA ATCTCTGGTC ATCTCCGGTC TGCGCCACTT CACTGGCTAC 2340

CGCATCGAGC TGCAGGCTTG CAACCAAGAC TCCCCCGAGG AGAGGTGCAG CGTGGCGGCC 2400

TATGTCAGCG CCAGGACCAT GCCCGAAGCC AAGGCAGACG ACATCGTTGG CCCCGTGACC 2460

CACGAAATCT TCGAGAACAA TGTCGTTCAC TTGATGTGGC AGGAGCCAAA GGAACCCAAT 2520

GGTCTGATCG TGCTTTATGA AGTGAGTTAC CGACGGTATG GCGATGAGGA GCTGCACCTG 2580

TGTGTCTCCC GGAGGCATTT TGCTCTGGAG CGTGGCTGCA GGCTACGCGG GCTGCCTCCG 2640

GGGAATTACA GCGTGCGAGT CCGGGCCACC TCCCTGGCGG GTAATGGCTC CTGGACAGAA 2700

GCCACCTATT TCTACGTGAC AGACTATTTA GATGTCCCAT CGAATATTGC AAAAATTATC 2760

ATCGGCCCCC TCATCTTTGT CTTTCTCTTC AGTGTTGTGA TTGGAAGTAT TTACCTGTTC 2820

CTGAGAAAGA GGCAGCCGGA TGGGCCACTG GGACCGCTGT ATGCTTCTTC AAACCCTGAG 2880

TACCTCAGTG CCAGTGATGT GTTTCCATGT TCTGTGTATG TGCCGGACGA GTGGGAGGTG 2940

CCGCGGGAGA AGATCACCCT CCTGCGCGAG CTGGGGCAAG GCTCCTTCGG CATGGTGTAC 3000

GAGGGCAACG CCAGGGACAT CGTCAAGGGT GAGCCCGAGA CCCGCGTGGC CGTCAAGACC 3060

GTCAACGAGT CCGCCAGCCT GCGAGAGAGG ATCGAGTTTC TCAATGAGGC ATCAGTCATG 3120

AAGGGCTTCA CCTGTCACCA CGTGGTCCGC CTCCTGGGGG TGGTGTTCAA AGGCCAACCG 3180

ACGCTGGTGG TGATGGAGCT GATGGCTCAT GGAGACCTGA AGAGCTACCT CCGCTCCCTG 3240

CGGCCGGAGG CTGAGAATAA CCCCGGCCGC CCTCCGCCTA CCAAGCAAGA GATGATTCAG 3300

ATGGCGGCGG AGATCGCCGA CGGGATGGTC TACCTGAACG CCAAGAAGTT TGTGCACCGG 3360

GATCTAGCAG CCCGAAACTG CATGGTTGCC CACGATTACA CTGTCAAAAT TGGAGACTTT 3420

GGGATGACCA GAGACATCTA TGAGACGGAT TACTATCGGA AAGGAGGCAA GGGTCTGCTC 3480

CCCGTGCGGT GGATGGCACC GGAGTCCCTG AAGGACGGGG TCTTTACCAC TTCTTCTGAC 3540

ATGTGGTCCT TTGGCGTGGT CCTTTGGGAA ATCACCAGCT TGGCAGAGCA GCCTTACCAA 3600

GGCCTGTCTA ATGAACAGGT GTTGAAATTT GTCATGGACG GAGGGTATCT GGATCAACCC 3660

GACAATTGTC CAGAGAGAGT CACTGACCTG ATGCGCATGT GCTGGCAGTT CAATCCCAAG 3720

ATGCGGCCCA CCTTCCTGGA GATTGTCGAC CTGCTCAAGG ATGATCTGCA CCCCAGCTTT 3780

CCAGAAGTTT CCTTCTTCCA CAGCGAGGAG AACAAGGCAC CCGAGAGCGA GGAGTTGGAG 3840

ATGGAGTTTG AGGACATGGA GAGTGTCCCT CTGGATCGGG CCTCACACTC TCAGAGGGAG 3900

GAGGCCGGGG GCCGGGATGC AGGGTCCTCG CTGGGCCTAA AGCGGAGCTA CGAGGAGCAC 3960

ATCCCCTACA CTCACATGAA CGGGGGCAAG AAAAATGGAC GGATTCTGAC TCTGCCAAGG 4020

TCGAATCCTT CCTAA 4035

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+a+d+vkge etrva+ktvne+as reriefl+easvmk f+

Q: 985   ITLLRELGQGSFGMVYEGNARDIVKGEPETRVAVKTVNESASLRERIEFLNEASVMKGFT  1044

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvv kgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+ +++iqmaae

Q: 1045  CHHVVRLLGVVFKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTKQEMIQMAAE  1104

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGm yl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1105  IADGMVYLNAKKFVHRDLAARNCMVAHDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1164

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp

Q: 1165  MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1224

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         e++t+lmr+cwq+npk+rp+fleiv+ll

Q: 1225  ERVTDLMRMCWQFNPKMRPTFLEIVDLL  1252

         *************************976

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNA RDIVKGEPET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60

CHHVVRLLGV VFKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT KQEMIQMAAE 120

IADGMVYLNA KKFVHRDLAA RNCMVAHDYT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240

ERVTDLMRMC WQFNPKMRPT FLEIVDLL 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013