EKS-CAF-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR571.11.2E-171579908330
StatusUnreviewed
Ensembl ProteinENSCAFP00000026920
UniProt AccessionE2RJV2;
Protein Name
Protein Synonyms/Alias
Gene NameCfa.5689
Gene Synonyms/Alias Cfa.5689;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000018219ENSCAFP00000026920ENSCAFT00000028942
OrganismCanis familiaris
Functional Description
Protein Length967
Protein Sequence
(FASTA)
MGLGAPLVLL VATAWHVRGV PVIEPRGPEL VVEPGTAVTL RCVGNGSVEW EGPISPHWNL 60
DPDSPSSILS TNNATFLNTG TYRCTEPGSP LGGSATIHIY VKDPVRPWKV LTQEVTVLEG 120
QDALLPCLLT DPALEAGVSL MRVRGRPVLR QTNYSFSPWY GFTIHKAQFT ETQGYQCSAR 180
VGGRTVTSMG IWLKVQKVIP GPPTLTLKPA ELVRIQGEAA NIECSASNVD VNFDVFLQHE 240
DTKLTIPQQS DFQGNQYQKV LTLELDHVGF QDAGNYTCVA TNVRGISSTS MIFRVVESAY 300
LNLTSEQSLL QEVTVGEKVD LQVKVEAYPS LEGYNWTYLG PFSDQQAKLK FVITKDTYRY 360
TSTLSLPRLK PSEAGRYSFL ARNTRGGDSL TFELTLLYPP EVRITWTTVN GSDALLCEAS 420
GYPQPNVTWL QCRGHTDRCD EAQALVLEDS YSEVLSQEPF HKVIVHSLLA MGTMEHNMTY 480
ECRALNSVGN SSQAFRPIPI GAHIQPPDEP LFTPVLVTCM SIMVLLLLLL LLLFYKYKQK 540
PKYQVRWKII ESYEGNSYTF IDPTQLPYNE KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG 600
LGKEDAVLKV AVKMLKSTAH ADEKEALMSE LKIMSHLGQH ENIVNLLGAC THGGPVLVIT 660
EYCCYGDLLN FLRRKAEAML GPSVSVGQDP GAGAGYKNIH LEKKYVRRDS GFSSQGVDTY 720
VEMRPVSTSS SNDSFSEQDL DKEDGRPLEL RDLLHFSSQV AQGMAFLASK NCIHRDVAAR 780
NVLLTSGRVA KIGDFGLARD IMNDSNYIVK GNARLPVKWM APESIFDCVY TVQSDVWSYG 840
ILLWEIFSLG LNPYPGILVN SKFYKLVKDG YQMAQPAFAP KNIYSVMQAC WALEPTRRPT 900
FQQICSLLQE QAQADRREPD YTNLPSSSSS SGSSSEPEEE SSSEHLACCE QGDIAQPLLQ 960
PNNYQFC 967
Nucleotide Sequence
(FASTA)
ATGGGCCTAG GGGCTCCACT GGTTCTGCTG GTGGCCACAG CTTGGCATGT TCGAGGAGTC 60
CCAGTGATAG AACCCAGAGG CCCAGAGCTG GTCGTGGAGC CAGGCACAGC AGTGACCCTG 120
CGATGTGTGG GCAACGGCAG CGTGGAATGG GAAGGCCCCA TCTCCCCACA CTGGAACCTG 180
GACCCTGATT CCCCCAGCAG CATCCTGAGC ACGAATAATG CCACCTTCCT GAACACCGGG 240
ACCTATCGCT GCACTGAGCC TGGAAGCCCC CTGGGGGGCA GTGCCACCAT CCACATCTAT 300
GTCAAAGACC CTGTTCGGCC TTGGAAGGTG CTGACCCAGG AAGTGACGGT GTTGGAGGGG 360
CAGGATGCGC TGCTGCCCTG CCTGCTTACC GACCCAGCGT TGGAGGCAGG CGTCTCGCTG 420
ATGCGGGTGC GTGGCCGGCC TGTCTTGCGC CAAACCAACT ATTCCTTCTC GCCCTGGTAT 480
GGCTTCACCA TCCACAAGGC CCAGTTCACC GAGACCCAGG GCTACCAATG CAGCGCTCGA 540
GTAGGCGGCA GGACGGTAAC GTCGATGGGC ATCTGGCTTA AAGTGCAGAA AGTCATCCCA 600
GGGCCCCCGA CCTTGACGCT GAAGCCTGCA GAGCTGGTAC GGATTCAGGG AGAGGCCGCC 660
AACATCGAGT GCTCGGCCAG CAATGTTGAT GTTAACTTTG ACGTCTTCCT GCAACACGAA 720
GACACCAAGC TCACAATCCC TCAACAATCT GACTTCCAAG GTAACCAGTA CCAAAAAGTC 780
CTGACCCTCG AGCTCGATCA CGTAGGCTTC CAAGATGCTG GCAACTACAC CTGCGTGGCC 840
ACCAATGTTC GAGGCATCAG CTCCACCTCC ATGATCTTCC GGGTGGTAGA GAGTGCCTAC 900
TTGAACTTGA CCTCTGAGCA GAGCCTCCTC CAGGAAGTGA CTGTGGGTGA GAAGGTCGAT 960
CTCCAAGTCA AGGTGGAGGC CTACCCAAGC CTGGAAGGTT ATAACTGGAC CTATCTGGGA 1020
CCTTTCTCCG ACCAGCAGGC CAAACTCAAG TTTGTCATCA CGAAGGACAC ATACAGGTAT 1080
ACCTCCACCC TCTCCCTGCC TCGCTTGAAG CCTTCAGAGG CCGGTCGCTA TTCCTTCCTG 1140
GCCAGAAACA CTAGAGGCGG GGATTCTCTG ACCTTTGAGC TCACCCTACT ATACCCCCCA 1200
GAGGTCAGGA TCACATGGAC CACTGTCAAC GGCTCTGACG CACTGCTCTG TGAAGCCTCT 1260
GGGTATCCCC AGCCCAATGT GACATGGCTG CAGTGCAGAG GCCACACAGA TAGATGTGAT 1320
GAGGCCCAAG CGCTGGTCCT AGAGGACTCC TACTCGGAGG TCCTGAGCCA GGAGCCCTTC 1380
CACAAGGTGA TCGTCCACAG CCTGCTGGCC ATGGGGACCA TGGAACACAA CATGACTTAT 1440
GAGTGCAGGG CCCTCAACAG CGTGGGGAAC AGCTCCCAGG CCTTCAGGCC CATCCCCATA 1500
GGAGCCCACA TCCAGCCTCC TGACGAGCCG CTCTTCACGC CTGTGTTGGT CACCTGCATG 1560
TCCATCATGG TCTTGCTGCT TTTGCTGCTC TTGCTGCTTT TCTACAAATA TAAGCAGAAG 1620
CCCAAGTACC AGGTGCGCTG GAAGATCATC GAGAGCTACG AGGGCAACAG CTACACGTTC 1680
ATTGACCCCA CCCAGCTGCC CTACAATGAG AAGTGGGAGT TTCCACGAAA CAACCTGCAG 1740
TTTGGGAAGA CTCTCGGAGC CGGTGCCTTT GGGAAGGTGG TAGAGGCCAC AGCCTTTGGT 1800
TTGGGCAAGG AGGATGCTGT CCTGAAGGTG GCTGTGAAGA TGCTGAAGTC CACAGCTCAC 1860
GCAGACGAGA AGGAGGCCCT CATGTCGGAA CTGAAGATCA TGAGTCACCT GGGCCAGCAC 1920
GAGAACATAG TCAACCTTCT GGGAGCCTGT ACCCATGGAG GCCCGGTTCT GGTCATCACC 1980
GAGTACTGTT GCTATGGTGA CCTGCTCAAC TTTCTGCGAA GGAAGGCTGA GGCCATGCTG 2040
GGACCCAGTG TGAGTGTGGG CCAGGACCCC GGGGCAGGTG CTGGCTACAA GAACATCCAC 2100
CTGGAGAAGA AATATGTCCG CAGGGACAGC GGCTTCTCCA GCCAGGGTGT AGACACCTAC 2160
GTGGAAATGA GGCCTGTCTC TACTTCTTCG TCAAACGACT CCTTTTCTGA ACAAGACCTG 2220
GACAAAGAGG ATGGGCGACC ACTAGAGCTG CGGGACCTGC TCCATTTCTC GAGCCAGGTG 2280
GCTCAGGGCA TGGCCTTCCT TGCATCCAAG AACTGCATCC ACCGGGACGT GGCAGCCCGA 2340
AACGTCTTGC TGACCAGTGG GCGTGTGGCC AAGATTGGGG ACTTTGGGCT GGCCAGGGAC 2400
ATCATGAATG ACTCCAACTA CATCGTCAAA GGCAATGCCC GCCTGCCCGT GAAGTGGATG 2460
GCTCCAGAGA GCATCTTTGA CTGTGTCTAC ACGGTTCAGA GTGACGTCTG GTCCTACGGC 2520
ATCCTGCTCT GGGAAATCTT CTCACTCGGG CTGAACCCCT ACCCTGGCAT CCTGGTGAAC 2580
AGCAAGTTCT ATAAACTAGT GAAGGATGGA TACCAAATGG CCCAGCCTGC ATTCGCCCCC 2640
AAGAACATAT ACAGCGTCAT GCAGGCCTGC TGGGCCCTGG AGCCCACCCG AAGACCCACC 2700
TTCCAGCAGA TCTGCTCCCT CCTCCAGGAG CAGGCCCAAG CAGACAGGAG AGAGCCAGAC 2760
TACACCAATC TGCCAAGCAG CAGCAGTAGC AGTGGCAGCA GTAGTGAGCC AGAGGAGGAG 2820
AGCTCTAGCG AGCACCTGGC CTGCTGTGAA CAGGGGGATA TTGCCCAGCC CCTGCTGCAG 2880
CCCAACAACT ACCAGTTCTG CTGA 2904
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 579   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  638
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  s++  +++ + + +k+
Q: 639   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSVSVGQDPGAGAGYKN  698
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s+++   se+            l++e
Q: 699   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSSNDSFSEQ-----------DLDKE  743
         *999***********************....6666555544444...........37899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 744   DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMN  803
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 804   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  863
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy++mq+cw+ ep++rp+f+q+++ll
Q: 864   YKLVKDGYQMAQPAFAPKNIYSVMQACWALEPTRRPTFQQICSLL  908
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSVSVGQ DPGAGAGYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTSGR VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APKNIYSVMQ ACWALEPTRR PTFQQICSLL 330
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013