EKS-CAF-00441

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00441

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	470.4	2.0E-141	76	338	263

Status

Unreviewed

Ensembl Protein

ENSCAFP00000027021

UniProt Accession

F1PU60;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018282	ENSCAFP00000027021	ENSCAFT00000029058

Organism

Canis familiaris

Functional Description

Protein Length

1372

Protein Sequence
(FASTA)

MSTGDSFEAR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 60

DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300

DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360

SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY SNRRYLSSAN PNDNRSSPNV 420

DKSLQENLQK TIYKLEEQLH NEMQLKDEME QKCRTSNIKL DKIMKELDEE GNQRRNLEST 480

VSQIEKEKML LQHRINEYQR KAEQENEKRR NVEHEVSTLK DQLEDLKKVN QNSQLANEKL 540

AQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSVSQLES LNRELQERNR ILENSKTQMD 600

KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLERVEG ERKEAQDLLN 660

HSEKEKNNLE IDLNYKLKSL QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL 720

KEEREAREKA ENRVVQIEKQ CSMLDVDLKQ SQQKLEHLTE NKERMEDEVK NLSLQLEQES 780

NKRLLLQNEL KTQAFEADNL KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR 840

ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLKKIQE LQNEKETLAT QLDLAETKAE 900

SEQLARGLLE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEESNSMLTK DNELLRKENE 960

ELTDKMKRAE EEYKLKKEEE INNLKAAFEK NINTERTLKT QAVNKLAEIM NRKDFKIDRK 1020

KANTQDLRKK EKENRKLQLE LNQEREKFNQ MVVKHQKELN DMQAQLVEEC THKNELQMQL 1080

ASKESDIEQL RAKLLDLSDS TSIASFPSAD ETDGNLPESR IEGWLSIPNR GNIKRYGWKK 1140

QYVVVSSKKI LFYNDEQDKE QSNPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY 1200

ANEGECRKDV EMEPVQQAEK TNFQNHKGHE FIPTLYHFPA NCEACAKPLW HVFKPPPALE 1260

CRRCHVKCHR DHLDKKEDLI SPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP 1320

PSGFVRASPR TLSTRSTANQ SFRKVVKNTS GKTSSPSWEV NLKCACNPSS TK 1372

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAGGCTCGG TTTGAAAAAA TCGACAACCT GCTGCGGGAT 60

CCGAAATCAG AAGTGAATTC GGATTGTTTG CTGGATGGAT TGGATGCTTT GGTATATGAT 120

TTGGATTTTC CTGCCTTAAG AAAAAACAAA AATATTGACA ACTTTTTAAG CAGATATAAA 180

GACACAATAA ATAAAATTAG AGATTTACGA ATGAAAGCTG AAGATTATGA AGTAGTGAAG 240

GTGATTGGTC GAGGTGCATT TGGAGAAGTT CAATTGGTAA GGCATAAATC CACCAGGAAG 300

GTATATGCTA TGAAGCTTCT CAGTAAATTT GAAATGATTA AGAGATCTGA TTCTGCTTTT 360

TTCTGGGAAG AAAGGGACAT CATGGCTTTT GCTAATAGCC CTTGGGTCGT CCAGCTTTTT 420

TATGCATTCC AAGATGATCG TTATCTCTAC ATGGTGATGG AATACATGCC TGGTGGAGAT 480

CTTGTAAATT TAATGAGCAA CTATGATGTG CCTGAAAAAT GGGCACGATT CTATACTGCA 540

GAAGTAGTAC TTGCGTTGGA TGCAATCCAT TCCATGGGTT TCATTCATAG AGATGTGAAG 600

CCTGATAACA TGCTGCTGGA TAAATCTGGA CATTTGAAGT TAGCAGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGGAAGG TATGGTACGA TGTGATACAG CAGTTGGAAC ACCTGATTAC 720

ATTTCCCCTG AAGTATTAAA ATCTCAAGGT GGTGATGGCT ATTATGGACG AGAATGTGAC 780

TGGTGGTCAG TTGGGGTATT TTTATATGAA ATGCTTGTAG GTGATACACC TTTTTATGCA 840

GATTCTCTGG TAGGAACTTA CAGTAAGATT ATGAACCATA AAAATTCACT TACTTTCCCT 900

GATGATAATG ATATATCAAA AGAAGCAAAA AATCTTATTT GTGCCTTCCT TACTGACAGA 960

GAGGTGAGAT TAGGGCGAAA TGGTGTAGAA GAAATCAAAC GACATCTCTT CTTCAAAAAT 1020

GATCAATGGG CTTGGGAGAC ACTCCGAGAC ACTGTAGCAC CAGTTGTACC TGATTTAAGT 1080

AGTGACATTG ATACAAGTAA TTTTGATGAC TTGGAAGAAG ATAAAGGAGA TGAAGAAACG 1140

TTTCCCATAC CTAAAGCTTT TGTTGGCAAT CAGTTACCCT TTGTAGGATT TACATATTAT 1200

AGCAATCGTA GATACTTATC TTCAGCAAAT CCTAATGATA ACCGAAGTAG CCCCAATGTG 1260

GATAAAAGCT TGCAGGAAAA TTTGCAAAAA ACAATTTATA AGCTGGAAGA ACAGCTGCAT 1320

AATGAAATGC AATTAAAAGA TGAAATGGAG CAGAAATGCA GAACTTCAAA CATAAAACTA 1380

GACAAGATAA TGAAAGAATT GGATGAAGAG GGGAATCAAA GAAGAAACCT AGAATCTACA 1440

GTGTCTCAGA TTGAGAAGGA GAAAATGTTG CTACAGCATA GAATTAATGA GTACCAGAGA 1500

AAAGCAGAAC AGGAAAATGA GAAAAGAAGG AATGTAGAAC ATGAAGTTTC TACATTAAAG 1560

GATCAGTTGG AAGACTTAAA AAAAGTAAAT CAGAATTCAC AGCTTGCTAA TGAGAAACTT 1620

GCACAATTAC AAAAACAGCT AGAAGAAGCC AATGACTTAC TTAGGACAGA ATCAGACACA 1680

GCTGTAAGAT TAAGGAAGAG CCACACAGAA ATGAGTAAGT CAGTTAGTCA GCTAGAATCT 1740

CTGAACAGAG AATTGCAAGA GAGAAACAGA ATTTTAGAGA ATTCCAAGAC ACAGATGGAC 1800

AAGGACTATT ACCAGCTGCA GGCTGTATTA GAAGCTGAAC GAAGAGACAG AGGTCATGAT 1860

TCTGAGATGA TTGGAGACCT TCAAGCTCGA ATTACATCCT TACAAGAGGA GGTGAAGCAT 1920

CTCAAACATA ATCTTGAAAG AGTGGAGGGA GAAAGGAAAG AAGCTCAGGA CTTGCTTAAT 1980

CACTCGGAAA AGGAAAAGAA TAATTTAGAG ATAGATTTAA ACTATAAGCT TAAATCATTA 2040

CAACAACGGC TAGAACAAGA GGTGAATGAA CATAAAGTAA CCAAAGCTCG TTTAACTGAC 2100

AAACATCAAT CTATTGAAGA AGCAAAGTCT GTTGCAATGT GTGAAATGGA AAAAAAGCTG 2160

AAGGAAGAGA GAGAAGCTCG AGAGAAGGCT GAAAATAGAG TTGTTCAGAT TGAGAAACAG 2220

TGTTCAATGC TGGATGTTGA TCTGAAACAA TCTCAGCAGA AGCTCGAACA TTTGACTGAG 2280

AATAAAGAAA GGATGGAGGA TGAAGTTAAG AATCTATCCC TGCAGCTGGA GCAGGAATCA 2340

AATAAGCGAC TATTGTTACA GAATGAATTG AAGACTCAAG CATTTGAAGC AGACAATTTA 2400

AAAGGTCTAG AAAAGCAGAT GAAACAGGAA ATAAATACTT TATTGGAAGC AAAGAGATTA 2460

TTAGAATTTG AATTAGCTCA GCTTACAAAA CAGTATAGAG GAAATGAAGG ACAGATGCGG 2520

GAGCTACAAG ATCAGCTTGA AGCTGAGCAG TATTTCTCGA CACTTTATAA AACCCAGGTA 2580

AAGGAACTTA AGGAAGAAAT TGAAGAAAAA AACAGAGAAA ATTTAAAGAA AATACAAGAG 2640

CTACAAAATG AAAAAGAAAC TCTTGCTACT CAGTTGGATC TGGCAGAAAC AAAAGCTGAG 2700

TCTGAGCAGT TGGCTCGAGG GCTTCTGGAA GAACAGTATT TTGAATTAAC CCAAGAAAGC 2760

AAGAAAGCTG CTTCCAGAAA TAGGCAAGAG ATTACAGATA AAGATCACAC TGTTAGTCGG 2820

CTTGAAGAAT CGAACAGCAT GTTAACCAAA GATAATGAAT TATTAAGAAA AGAAAATGAA 2880

GAGCTAACTG ATAAAATGAA GAGGGCAGAG GAAGAATATA AATTGAAGAA GGAGGAGGAG 2940

ATCAATAATC TTAAGGCTGC CTTTGAAAAG AATATCAATA CAGAGAGAAC CCTTAAAACG 3000

CAGGCTGTTA ACAAGTTGGC AGAAATAATG AATCGGAAAG ATTTTAAAAT TGATAGAAAG 3060

AAAGCTAACA CACAGGATTT GAGAAAGAAA GAAAAGGAAA ATCGAAAGCT CCAACTGGAA 3120

CTCAACCAAG AAAGAGAGAA ATTCAACCAG ATGGTGGTGA AGCATCAGAA GGAACTGAAT 3180

GACATGCAAG CGCAATTGGT AGAAGAATGT ACGCATAAGA ATGAGCTTCA GATGCAATTA 3240

GCTAGCAAAG AGAGTGATAT TGAGCAACTG CGTGCCAAAC TTTTGGACCT TTCCGATTCT 3300

ACAAGTATTG CTAGTTTTCC TAGTGCTGAT GAAACTGATG GAAACCTTCC AGAGTCAAGA 3360

ATTGAAGGTT GGCTTTCAAT ACCAAATAGA GGAAATATCA AACGATATGG CTGGAAGAAA 3420

CAGTATGTTG TGGTAAGCAG CAAAAAAATT TTGTTCTATA ATGATGAACA AGATAAGGAA 3480

CAATCCAATC CATCCATGGT ATTGGACATA GATAAATTGT TTCATGTTCG ACCTGTAACC 3540

CAAGGAGATG TTTACAGAGC TGAAACTGAA GAAATTCCTA AAATATTCCA GATACTATAT 3600

GCAAATGAAG GTGAATGTAG AAAAGATGTA GAGATGGAAC CAGTACAACA AGCTGAAAAG 3660

ACTAATTTTC AAAACCACAA AGGCCATGAG TTCATTCCTA CACTCTACCA CTTCCCTGCC 3720

AACTGTGAGG CCTGTGCCAA ACCTCTCTGG CATGTTTTTA AGCCACCTCC TGCCCTAGAA 3780

TGTCGAAGAT GCCATGTTAA GTGCCACAGA GATCACTTAG ATAAGAAAGA GGATTTAATT 3840

TCTCCATGTA AAGTAAGTTA CGATGTAACA TCAGCAAGAG ATATGCTGCT GTTAGCATGT 3900

TCTCAGGATG AACAAAAAAA ATGGGTAACA CATTTGGTAA AGAAGATCCC TAAGAATCCA 3960

CCATCTGGTT TTGTTCGTGC ATCGCCTCGA ACGCTTTCTA CAAGATCTAC TGCAAATCAG 4020

TCTTTCCGAA AGGTGGTCAA AAATACATCT GGAAAAACTA GTTCTCCTTC TTGGGAGGTG 4080

AATCTCAAAT GTGCCTGCAA TCCATCTTCA ACCAAGTAA 4119

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 313   ICAFLTDREVRLGRNGVEEIKRHLFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013