EKS-CAF-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.4	1.6E-134	275	524	250

Status

Unreviewed

Ensembl Protein

ENSCAFP00000027127

UniProt Accession

F1PSB7;

Protein Name

Protein Synonyms/Alias

Gene Name

CFA.42409

Gene Synonyms/Alias

CFA.42409;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018362	ENSCAFP00000027127	ENSCAFT00000029169

Organism

Canis familiaris

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKENK SPTIKYRTEN TAEPVSTSVS HYGTEHTAVA PSSSTKGASV NFSSLSMTPF 60

GGSSGVTPFG GASSSFSVVP SSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKNGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 360

GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAACCA TTAAATATAG AACTGAAAAT 60

ACTGCAGAAC CTGTAAGTAC AAGTGTCAGC CATTATGGAA CAGAACACAC TGCAGTGGCA 120

CCATCATCTT CGACAAAGGG AGCATCTGTT AATTTTAGCA GTCTTTCCAT GACGCCATTT 180

GGAGGATCCT CAGGAGTGAC ACCTTTTGGA GGAGCATCTT CTTCATTCTC AGTGGTGCCA 240

AGTTCATATC CTGCTGGTTT AACAGGTGGT GTTACTATAT TTGTGGCCTT ATATGATTAT 300

GAAGCTAGAA CTACAGAAGA CCTTTCATTC AAGAAGGGTG AACGGTTTCA AATTATTAAC 360

AACACGGAAG GAGACTGGTG GGAAGCAAGA TCAATTGCTA CAGGAAAGAA TGGCTATATC 420

CCTAGCAATT ATGTAGCCCC TGCAGATTCC ATTCAGGCAG AAGAATGGTA TTTTGGCAAA 480

ATGGGGAGAA AAGATGCTGA AAGATTACTT CTGAATCCTG GGAATCAACG AGGTATTTTC 540

TTAGTAAGAG AGAGTGAAAC TACTAAAGGT GCTTATTCTC TCTCTATTCG TGATTGGGAT 600

GAGGTAAGAG GTGACAATGT GAAACACTAC AAAATTAGGA AACTGGACAA TGGTGGATAC 660

TATATCACAA CCAGAGCACA ATTTGATACA CTGCAAAAGT TGGTAAAACA CTACACAGAA 720

CATGCTGATG GTTTATGCCA TAAGTTAACA ACCGTGTGTC CAACTGTGAA ACCCCAGACT 780

CAAGGTCTAG CAAAAGATGC TTGGGAAATC CCTCGAGAAT CTTTGCGACT AGAGGTTAAA 840

TTAGGACAAG GATGTTTTGG TGAAGTATGG ATGGGAACAT GGAATGGAAC CACAAAAGTA 900

GCAATCAAAA CACTAAAGCC AGGTACAATG ATGCCAGAAG CTTTTCTTCA AGAGGCTCAG 960

ATAATGAAAA AATTAAGACA CGATAAACTT GTTCCACTAT ATGCTGTTGT TTCTGAAGAG 1020

CCAATCTACA TTGTCACTGA ATTTATGTCA AAAGGGAGTT TATTGGATTT CCTGAAGGAA 1080

GGAGATGGAA AGTATTTGAA GCTCCCACAA CTGGTTGATA TGGCTGCTCA GATTGCTGAT 1140

GGTATGGCAT ATATTGAAAG AATGAATTAT ATTCACCGAG ATCTTCGGGC TGCTAACATT 1200

CTTGTAGGAG AAAATCTTGT CTGCAAAATA GCAGATTTTG GTTTAGCAAG GTTAATTGAA 1260

GACAATGAAT ATACAGCAAG ACAAGGTGCA AAGTTTCCAA TCAAATGGAC AGCTCCTGAG 1320

GCTGCACTAT ATGGTCGATT TACGATCAAG TCTGATGTAT GGTCATTTGG AATTCTACAG 1380

ACAGAACTGG TAACAAAGGG CAGAGTACCA TACCCAGGTA TGGTAAACCG TGAAGTACTA 1440

GAACAGGTGG AACGAGGATA CAGGATGCCT TGCCCTCAGG GCTGTCCAGA ATCCCTACAT 1500

GAATTGATGA ATCTTTGTTG GAAGAAGGAC CCTGATGAAA GACCAACATT TGAATATATT 1560

CAGTCCTTCT TGGAAGACTA CTTCACTGCT ACAGAGCCAC AGTACCAGCC AGGAGAAAAT 1620

TTATAA 1626

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 454   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0015758	; P:glucose transport

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013