EKS-CAF-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	348.1	4.4E-104	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSCAFP00000027467

UniProt Accession

F1PIY7;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018615	ENSCAFP00000027467	ENSCAFT00000029551
ENSCAFG00000018615	ENSCAFP00000039978	ENSCAFT00000049356

Organism

Canis familiaris

Functional Description

Protein Length

1152

Protein Sequence
(FASTA)

LQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVLF YLSDREPLRL GSGEYTAEEL 60

CIRAAQECCI SPLCHNLFAL YDENTKLWYA PNRTITVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

WFHPNDSGNI LYYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEMLGG QKQFKNFQIE VQKGRYSLHG SDRSFPSLGD LMSHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DIVQGEHLGR GTRTHIYSGT 600

LVDYKDDEGT SEEKRIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSERKP ATEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

SSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPPHCP EEVYQLMRKC WEFQPSNRTT 1140

FQNLIEGFEA LL 1152

Nucleotide Sequence
(FASTA)

CTACAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCCAAGA AGACTGAGGT GAATCTGGAG GCCCCTGAAC CAGGGGTGGA AGTGCTCTTC 120

TATCTTTCTG ATAGAGAGCC CCTCCGGCTG GGCAGCGGAG AGTACACAGC AGAGGAGCTA 180

TGCATCAGGG CCGCGCAGGA ATGCTGTATC TCTCCACTTT GTCACAACCT CTTTGCCCTG 240

TATGATGAGA ACACCAAGCT CTGGTATGCT CCGAATCGCA CCATCACCGT TGATGACAAG 300

ACATCGCTCC GGCTCCACTA CCGGATGAGG TTCTATTTCA CCAACTGGCA TGGGACTAAT 360

GATAATGAGC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAA 420

AAAAAAGTTC CAGATGCTAC CCCTCTTCTT GATGCCAGTT CTTTGGAGTA TCTCTTTGCT 480

CAGGGACAGT ATGATTTGGT CAAATGCCTG GCTCCCATTC GAGACCCCAA GACTGAGCAG 540

GATGGGCACG ATATTGAGAA TGAGTGTCTG GGAATGGCTG TCCTGGCCAT CTCCCACTAT 600

GCCATGATGA AGAAGATGCA GTTGCCAGAA CTTCCCAAGG ACATCAGCTA TAAGCGATAT 660

ATTCCAGAGA CCTTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720

AATAATGTTT TCAAGGATTT CCTGAAGGAA TTTAATAACA AGACTATTTG TGACAGTAGT 780

GTATCTACTC ATGACCTAAA GGTGAAATAT CTGGCTACCT TGGAAACTTT GACAAAGCAT 840

TATGGCGCTG AAATATTTGA GACTTCCATG TTACTGATTT CATCAGAAAA TGAGATGAAT 900

TGGTTTCATC CGAACGACAG TGGAAACATT CTCTACTATG AAGTGATGGT AACTGGAAAT 960

CTTGGAATCC AGTGGAGACA GAAACCAAAT GTTGTTCCTG TTGAAAAGGA AAAAAACAAA 1020

CTGAAACGGA AAAAACTGGA AAATAAACAC AAGAAGGACG AGGAGAAAAA CAAAATCCGG 1080

GAAGAGTGGA ACAATTTTTC TTACTTCCCT GAAATCACAC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TCAATAAGCA GGACAACAAA AAAATGGAAC TGAAGCTCTC ATCCCATGAG 1200

GAGGCCTTGT CCTTTGTGTC CCTGGTAGAC GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260

CATTACCTCT GCACTGATGT GGCTCCCCCA TTGATCGTCC ACAACATACA GAATGGTTGT 1320

CACGGTCCAA TCTGCACAGA ATACGCCATC AATAAGTTGC GGCAAGAAGG AAGCGAGGAG 1380

GGGATGTATG TGCTGAGGTG GAGCTGTACC GACTTCGACA ATATTCTCAT GACTGTCACC 1440

TGCTTTGAAA AATCTGAGAT GCTGGGTGGC CAGAAACAGT TCAAGAATTT TCAGATTGAG 1500

GTGCAGAAGG GCCGCTATAG CCTGCACGGC TCAGACCGCA GCTTCCCCAG CCTAGGGGAC 1560

CTGATGAGCC ACCTCAAGAA GCAGATCCTG CGTACGGACA ACATCAGCTT CGTGCTGAAG 1620

CGCTGCTGCC AGCCCAAGCC CCGAGAGATC TCCAATCTGC TGGTGGCTAC TAAGAAAGCC 1680

CAAGAGTGGC AGCCAGTCTA CCCCATGAGC CAGCTGAGTT TTGACCGGAT CCTCAAGAAG 1740

GATATTGTGC AAGGAGAGCA CCTTGGGAGA GGCACACGGA CACACATCTA CTCCGGTACT 1800

CTGGTGGATT ATAAGGATGA TGAAGGAACC TCTGAAGAAA AGAGAATAAA AGTCATCCTC 1860

AAAGTCTTAG ACCCCAGCCA CAGGGACATT TCTCTGGCTT TCTTTGAGGC AGCCAGCATG 1920

ATGAGGCAGG TCTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGACGTG 1980

GAGAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCTC TAGATCTCTT CATGCACCGG 2040

AAAAGTGATG TCCTCACCAC ACCATGGAAG TTCAAAGTTG CCAAACAGCT GGCCAGCGCC 2100

CTGAGTTACT TGGAGGATAA AGACCTAGTT CATGGAAATG TGTGCACTAA AAACCTTCTC 2160

CTGGCCCGTG AGGGCATTGA CAGCGAGTGC GGCCCGTTCA TCAAGCTCAG TGACCCTGGC 2220

ATCCCCATCA CTGTGCTGTC CAGGCAAGAG TGCATAGAAC GAATCCCATG GATTGCTCCT 2280

GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAATGGAG CTTTGGAACC 2340

ACATTGTGGG AAATCTGCTA CAATGGCGAG ATCCCTCTGA AAGACAAGAC CCTGATTGAG 2400

AAAGAGAGAT TCTACGAAAG CCGGTGCCGG CCAGTGACAC CATCTTGTAA GGAGCTGGCT 2460

GACCTTATGA CCCGCTGCAT GAACTATGAC CCCAACCAGA GACCCTTCTT CCGAGCCATC 2520

ATGAGAGACA TCAATAAACT GGAAGAGCAG AATCCAGACA TTGTTTCCGA AAGAAAGCCA 2580

GCAACCGAAG TGGATCCCAC ACATTTTGAA AAGCGGTTCT TGAAGAGGAT CCGTGACCTG 2640

GGAGAGGGCC ACTTTGGGAA GGTTGAGCTC TGCAGGTATG ACCCTGAGGG GGATAATACT 2700

GGAGAGCAGG TGGCTGTCAA ATCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 2760

CTGAAGAAGG AAATCGAAAT TCTAAGGAAC CTTTATCATG AGAACATTGT GAAGTACAAA 2820

GGCATCTGTA CAGAAGACGG AGGAAATGGT ATTAAGCTCA TCATGGAATT TCTGCCTTCA 2880

GGAAGTCTTA AGGAATATCT TCCAAAGAAT AAGAACAAAA TTAACCTCAA ACAACAGTTA 2940

AAATATGCTG TTCAGATTTG TAAGGGGATG GACTATTTAG GTTCTCGGCA ATATGTTCAC 3000

CGGGACTTAG CAGCAAGGAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA AATTGGAGAC 3060

TTTGGTTTGA CCAAAGCAAT TGAAACTGAC AAGGAGTACT ACACAGTCAA GGATGATCGG 3120

GACAGCCCTG TGTTTTGGTA TGCTCCTGAA TGTTTAATTC AATGTAAATT TTATATCGCC 3180

TCTGATGTCT GGTCGTTTGG AGTGACCCTG CATGAGTTGC TTACTTATTG TGACTCAGAT 3240

TCCAGCCCCA TGGCGTTGTT TCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 3300

ACAAGACTTG TGAATACATT AAAAGAAGGA AAACGTTTGC CTTGTCCACC TCACTGTCCA 3360

GAAGAGGTTT ATCAACTTAT GAGAAAATGC TGGGAATTCC AGCCATCTAA TCGGACAACT 3420

TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTA 3456

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +ps+r++F++++e

Q: 1107  LKEGKRLPCPPhCPEEVYQLMRKCWEFQPSNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPHCPEEV YQLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013