EKS-CAF-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	393.2	8.0E-118	537	801	265

Status

Unreviewed

Ensembl Protein

ENSCAFP00000027497

UniProt Accession

F1PWG8;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR1

Gene Synonyms/Alias

KSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000018638	ENSCAFP00000027497	ENSCAFT00000029582
ENSCAFG00000018638	ENSCAFP00000027499	ENSCAFT00000029584

Organism

Canis familiaris

Functional Description

Protein Length

847

Protein Sequence
(FASTA)

QAKLVRYICK QQQCKLSVAP GERTPELNSY PRFSDWLCTF SVRPAVVQEI LSELTLDALL 60

DMNEVKVKET LRRYGANTEE CGRLQYALAC LRKVTGLGGE HKEDSGWSSL DARRESGSGS 120

SVDTPSPASL PWPPGSAQLG RMGSGAQGPR SVSVSALPTS DSLPPGPCEG LSDTCILLHT 180

SGRLTPRALH SFITPPTTPQ LRRHTKLKPP RTPPPPSRKV FQLLPSFPTL TRSKSHESQL 240

GNRIDEVSPM RFDLPHGSPQ MVRRDIGLSV THRFSTKSWL SQVCHVCQKS MMFGVKCKHC 300

RLKCHNKCTK EAPACRISFL PQPRLRRTES VPSDINNPVD RAAEPHFGTL PKALTKKEHP 360

PAMNHLDSSS NPSSTTSSTP SSPAPFPTSS NPSSATTPPN PSPGQRDSRF NFPAAYFIHH 420

RQQFIFPAPH AGDKIKCRTI CMALARNVAY ISAFPQAVPS PDAADSTRLE HQPKTDVLED 480

HEVEAEEPEA GKSEAEDDED EVDDLPSSRR PWRGPISRKA SQTSVYLQEW DIPFEQVELG 540

EPIGQGRWGR VHRGRWHGEV AIRLLEMDGH NQDHLKLFKK EVMNYRQTRH ENVVLFMGAC 600

MNPPHLAIIT SFCKGRTLHS FVRDPKTSLD INKTRQIAQE IIKGMGYLHA KGIVHKDLKS 660

KNVFYDNGKV VITDFGLFGI SGVVREGRRE NQLKLSHDWL CYLAPEIVRE MTPGKDEDQL 720

PFSKAADVYA FGTVWYELQA RDWPFKNQAA EALIWQIGSG EGMKRVLASV SLGKEVTEIL 780

SACWAFDLQE RPSFTLLMDM LEKLPKLNRR LSHPGHFWKS ADINSSKVVP RFERFGLGVL 840

ESSNPKM 847

Nucleotide Sequence
(FASTA)

CAGGCAAAGC TGGTCCGGTA CATTTGCAAA CAGCAGCAGT GCAAGCTGAG TGTGGCTCCT 60

GGCGAGAGGA CCCCAGAGCT CAACAGCTAC CCCCGTTTCA GTGACTGGCT GTGTACCTTC 120

AGTGTGAGGC CAGCAGTGGT GCAGGAGATC CTCAGCGAGC TCACACTGGA TGCCCTGCTG 180

GACATGAACG AGGTCAAGGT GAAGGAGACG CTTCGGCGCT ACGGGGCCAA CACCGAGGAG 240

TGTGGCCGCC TGCAGTATGC ACTTGCCTGC CTGCGGAAAG TGACAGGTCT GGGAGGGGAG 300

CACAAAGAAG ACTCAGGCTG GAGTTCGTTG GATGCCCGGC GGGAAAGTGG CTCTGGGTCT 360

TCGGTGGATA CCCCATCGCC AGCCAGCCTG CCCTGGCCCC CAGGGAGTGC CCAGCTGGGC 420

AGAATGGGCA GCGGTGCCCA GGGCCCACGC TCCGTGTCCG TGTCAGCTCT GCCCACCTCA 480

GACTCCCTGC CCCCTGGCCC CTGCGAGGGC CTCTCGGACA CCTGTATCCT CCTGCACACC 540

AGTGGTCGGC TGACTCCCCG GGCCCTGCAC AGCTTCATCA CCCCCCCAAC CACACCCCAG 600

CTGCGAAGGC ACACCAAGCT GAAGCCTCCG CGGACACCAC CCCCGCCCAG CCGCAAGGTC 660

TTTCAGCTGC TGCCCAGCTT CCCCACACTC ACCCGGAGCA AGTCCCATGA GTCACAGTTG 720

GGGAACCGCA TTGATGAGGT CTCCCCGATG AGGTTTGATC TCCCACATGG ATCCCCACAG 780

ATGGTACGAA GGGATATCGG ACTGTCAGTG ACTCACAGAT TCTCCACGAA GTCTTGGCTG 840

TCACAGGTCT GCCATGTGTG CCAGAAGAGC ATGATGTTTG GAGTGAAATG CAAGCATTGC 900

AGATTGAAGT GTCACAACAA GTGTACAAAA GAAGCCCCTG CCTGTCGAAT ATCCTTCCTT 960

CCACAACCTC GGCTTCGGAG GACAGAGTCT GTCCCCTCGG ACATCAACAA CCCAGTGGAC 1020

AGAGCAGCTG AGCCCCATTT CGGAACCCTC CCCAAAGCAC TAACAAAGAA GGAGCATCCT 1080

CCGGCCATGA ACCACTTGGA CTCCAGTAGC AACCCATCCT CTACCACCTC CTCCACACCC 1140

TCCTCGCCGG CACCTTTCCC AACATCGTCC AATCCATCCA GTGCAACCAC ACCCCCCAAC 1200

CCCTCTCCTG GCCAGCGGGA TAGCAGGTTC AACTTCCCAG CTGCCTACTT CATTCATCAT 1260

AGACAGCAGT TTATCTTTCC AGCGCCTCAT GCTGGCGATA AGATAAAATG CAGGACTATT 1320

TGTATGGCTT TGGCCAGAAA TGTTGCATAC ATTTCGGCAT TTCCACAGGC AGTGCCATCC 1380

CCTGATGCGG CGGACAGCAC CCGGCTCGAG CACCAGCCAA AAACAGATGT GCTGGAGGAT 1440

CACGAAGTGG AGGCTGAGGA GCCAGAGGCT GGCAAGTCAG AGGCAGAGGA CGACGAGGAC 1500

GAGGTAGATG ACTTGCCGAG CTCCCGCCGG CCCTGGCGGG GCCCCATCTC TCGCAAGGCC 1560

AGCCAGACCA GCGTGTACCT GCAGGAGTGG GACATCCCCT TCGAGCAGGT GGAGCTGGGT 1620

GAGCCCATTG GGCAGGGCCG CTGGGGCCGG GTGCACCGTG GCCGCTGGCA TGGCGAGGTG 1680

GCCATCCGCC TGCTGGAGAT GGACGGTCAC AACCAGGACC ACCTGAAGCT GTTCAAGAAG 1740

GAGGTGATGA ACTATCGGCA AACGCGACAC GAGAACGTGG TGCTCTTCAT GGGGGCTTGC 1800

ATGAACCCGC CCCACCTGGC CATCATCACC AGCTTCTGCA AGGGGCGGAC TTTGCACTCA 1860

TTTGTGAGGG ACCCCAAGAC GTCTCTGGAC ATCAACAAGA CCAGACAGAT TGCTCAGGAG 1920

ATCATCAAGG GCATGGGCTA TCTACATGCC AAAGGTATTG TGCATAAAGA TCTCAAATCC 1980

AAGAACGTCT TCTATGACAA TGGCAAAGTT GTCATCACCG ACTTCGGACT ATTTGGGATC 2040

TCGGGCGTGG TCCGAGAGGG CCGGCGTGAG AACCAGCTGA AGCTGTCGCA CGACTGGCTC 2100

TGCTACCTGG CCCCGGAGAT CGTACGAGAG ATGACCCCTG GGAAGGACGA GGACCAGCTG 2160

CCGTTCTCCA AAGCTGCTGA TGTCTATGCA TTTGGGACTG TTTGGTATGA ACTGCAAGCA 2220

AGAGACTGGC CATTTAAGAA CCAAGCCGCA GAGGCCTTGA TCTGGCAGAT TGGGAGCGGA 2280

GAGGGTATGA AGCGCGTCCT GGCCTCCGTC AGCCTGGGGA AGGAAGTCAC TGAGATCCTC 2340

TCTGCCTGCT GGGCTTTCGA CCTGCAGGAG AGGCCCAGCT TCACCCTGCT GATGGACATG 2400

CTGGAAAAAC TGCCCAAGCT GAACCGGAGG CTCTCCCACC CTGGGCACTT CTGGAAGTCT 2460

GCTGACATTA ACAGCAGCAA AGTTGTACCC CGGTTTGAAA GGTTTGGCTT GGGTGTCCTG 2520

GAGTCCAGTA ATCCAAAGAT GTAG 2544

Domain Profile

S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60

         vel+e iG+Gr+G+v+rg+whG+va++ll+++ +++++l+ Fkkev++y++tRhen+vLF

Q: 537   VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLF  596

         67899*******************************************************

S: 61    mG.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhk  119

         mG ++++p+lai+ts+ckg++L++++++ +t+ld++k+++ia++i++gm+YLhak+i+hk

Q: 597   MGaCMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHK  656

         ************************************************************

S: 120   DlksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidl  178

         Dlkskn+++++g kvvitDFgl+ ++ ++++ rre+ql+++++w++ylape++r++++++

Q: 657   DLKSKNVFYDNG-KVVITDFGLFGISGVVREgRRENQLKLSHDWLCYLAPEIVREMTPGK  715

         ************.***************9977****************************

S: 179   eqdelpfskesDvyafGivlyellarelpykeesadqilfavgrG..lkpdlskvksklp  236

         ++d+lpfsk++DvyafG+v+yel+ar++p+k+++a++ ++++g+G  +k++l++v  +l+

Q: 716   DEDQLPFSKAADVYAFGTVWYELQARDWPFKNQAAEALIWQIGSGegMKRVLASV--SLG  773

         ******************************************99988********..***

S: 237   kelkellleClkfekeeRPlftqilkkl  264

         ke++e+l++C++f+ +eRP+ft ++++l

Q: 774   KEVTEILSACWAFDLQERPSFTLLMDML  801

         ************************9985

Domain Sequence
(FASTA)

VELGEPIGQG RWGRVHRGRW HGEVAIRLLE MDGHNQDHLK LFKKEVMNYR QTRHENVVLF 60

MGACMNPPHL AIITSFCKGR TLHSFVRDPK TSLDINKTRQ IAQEIIKGMG YLHAKGIVHK 120

DLKSKNVFYD NGKVVITDFG LFGISGVVRE GRRENQLKLS HDWLCYLAPE IVREMTPGKD 180

EDQLPFSKAA DVYAFGTVWY ELQARDWPFK NQAAEALIWQ IGSGEGMKRV LASVSLGKEV 240

TEILSACWAF DLQERPSFTL LMDML 265

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0043410	; P:positive regulation of MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013