EKS-CAF-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	448.8	4.8E-135	194	437	244

Status

Unreviewed

Ensembl Protein

ENSCAFP00000041241

UniProt Accession

F1Q093;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000019187	ENSCAFP00000028300	ENSCAFT00000030460
ENSCAFG00000019187	ENSCAFP00000041241	ENSCAFT00000049566

Organism

Canis familiaris

Functional Description

Protein Length

466

Protein Sequence
(FASTA)

MPTRRWAPGT QCITKCEHMR PKPGELAFRK GDVVTILEAC ESKSWYRAKH HASGQEGLLA 60

AGALREREAL SADPKLSLMP WFHGKISGQE AVQQLQPPED GLFLVRESAR HPGDYVLCVS 120

FGRDVIHYRV LHRDGHLTID EAVCFCNLMD MVEHYSKDKG AICTKLVKPK RKQGTRSAEE 180

ELAKAGWLLN LQHLTLGARI GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT 240

KMQHKNLVRL LGVILHQGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FSLHVAEGME 300

YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAERKGL DSSRLPVKWT APEALKHGKF 360

SSKSDVWSFG VLLWEVFSYG RAPYPKMSLK EVSEAVEKGY RMEPPEGCPG PIHALMGSCW 420

EAEPARRPPF RKLAEKLARE LRSAGAPALV GGQDTDSSPS PRGQEP 466

Nucleotide Sequence
(FASTA)

ATGCCAACGA GGCGCTGGGC CCCAGGCACC CAATGCATCA CCAAGTGTGA GCACATGCGC 60

CCCAAGCCGG GAGAGCTGGC CTTCCGCAAG GGCGACGTGG TCACCATCCT GGAGGCCTGT 120

GAGAGCAAGA GCTGGTACCG CGCGAAGCAC CACGCCAGCG GCCAGGAGGG TCTGCTGGCG 180

GCGGGGGCGC TGCGGGAGCG AGAGGCCCTG TCGGCCGACC CCAAGCTCAG CCTCATGCCG 240

TGGTTCCACG GCAAGATCTC CGGGCAGGAG GCCGTGCAGC AGCTGCAGCC GCCCGAGGAC 300

GGGCTGTTCC TGGTGCGCGA GTCAGCGCGG CACCCCGGCG ACTACGTGCT GTGCGTGAGC 360

TTCGGCCGTG ATGTCATCCA CTACCGCGTG CTGCACCGCG ACGGCCACCT GACCATCGAC 420

GAGGCCGTCT GCTTCTGCAA CCTCATGGAC ATGGTGGAGC ACTACAGCAA GGACAAGGGA 480

GCCATCTGCA CGAAGCTGGT GAAGCCCAAG AGGAAGCAGG GCACCAGGTC CGCAGAGGAG 540

GAGCTGGCCA AAGCCGGCTG GTTACTGAAC CTGCAGCATC TGACGCTGGG CGCGCGGATA 600

GGAGAGGGTG AGTTTGGAGC GGTCCTCCAG GGCGAGTACT TGGGGCAGAA GGTGGCCGTG 660

AAGAACATTA AGTGCGATGT GACGGCCCAG GCCTTCCTGG ACGAGACGGC GGTCATGACG 720

AAGATGCAGC ATAAGAACCT GGTGCGTCTG CTGGGCGTCA TCCTGCACCA GGGGCTCTAC 780

ATCGTCATGG AGCACGTGAG CAAGGGCAAC CTGGTGAACT TTCTGCGGAC CCGAGGCCGG 840

GCCCTTGTGA GCACCTCCCA GCTCCTGCAG TTTTCCCTGC ACGTCGCTGA GGGCATGGAG 900

TACCTGGAGA GCAAGAAGCT GGTGCATCGA GACCTTGCCG CGCGCAACAT CCTCGTTTCC 960

GAGGACCTGG TGGCCAAGGT CAGTGACTTC GGTCTGGCCA AAGCCGAGCG GAAGGGGCTG 1020

GACTCAAGCC GGCTTCCGGT CAAGTGGACG GCACCCGAGG CTCTCAAACA CGGGAAGTTC 1080

TCCAGCAAGT CGGATGTCTG GAGTTTCGGG GTGCTTCTGT GGGAGGTGTT CTCATACGGC 1140

CGGGCTCCAT ACCCCAAGAT GTCGCTGAAG GAGGTGTCCG AGGCCGTGGA GAAGGGGTAC 1200

CGCATGGAGC CCCCCGAGGG CTGCCCGGGC CCCATCCATG CCCTCATGGG CAGCTGCTGG 1260

GAGGCTGAGC CTGCCCGCCG GCCGCCCTTC CGAAAACTGG CAGAGAAGCT GGCCCGGGAG 1320

CTGCGCAGCG CGGGGGCCCC GGCCCTGGTG GGGGGCCAGG ACACGGACAG TTCCCCCTCG 1380

CCCCGCGGCC AGGAGCCCTG A 1401

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtk++h+nlv+llgv

Q: 194   LTLGARIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHKNLVRLLGV  253

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+v+kg+lv++lr+rgral++++qll+f+l+vaegmeyleskklvhrdl

Q: 254   ILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFSLHVAEGMEYLESKKLVHRDL  312

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+lds++lpvkwtapealk++kfs+ksdvwsfg+l

Q: 313   AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFSSKSDVWSFGVL  372

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++avekgy+me+pegcp+ ++ lm ++we+e+a+rp+f+k

Q: 373   LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPIHALMGSCWEAEPARRPPFRK  432

         ************************************************************

S: 241   lkekl  245

         l+ekl

Q: 433   LAEKL  437

         **997

Domain Sequence
(FASTA)

LTLGARIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKMQ HKNLVRLLGV 60

ILHQGLYIVM EHVSKGNLVN FLRTRGRALV STSQLLQFSL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDSS RLPVKWTAPE ALKHGKFSSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEKGYRME PPEGCPGPIH ALMGSCWEAE PARRPPFRKL 240

AEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013