EKS-CAF-00181
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00181
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC438.89.2E-132251517267
StatusUnreviewed
Ensembl ProteinENSCAFP00000028644
UniProt AccessionE2R2T7;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000019381ENSCAFP00000028644ENSCAFT00000030810
OrganismCanis familiaris
Functional Description
Protein Length591
Protein Sequence
(FASTA)
MPSRTGPKMH GSGCRVRLKA HHSGDILITS LDAAMTFEEL CDEVREMCSL RQGHPLTLKW 60
VDNEGDPCTV SSQMELEEAF RLACQRRDEG LIIHVFPSTP EQPGMPCPGE DKSIYRRGAR 120
RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHVLVPLTC 180
NRHMDTVMPS QEPAVDDKDD VDLPSEDTHG IAYISSTRKH DNIKDDSEDL KPVIDGMDGI 240
KISQGLGLQD FDLIRVIGRG SYAKVLLVRL KKNDQMYAMK VVKKELVHDD EDIDWVQTEK 300
HVFEQASSNP FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC 360
IALNFLHERG IIYRDLKLDN VLLDADGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE 420
ILRGEEYGFS VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL 480
SVKASHVLKG FLNKDPKERL GCRPQTGFSD IKSHAFFRSI DWDLLEKKQA LPPFQPQITD 540
EYGLDNFDTQ FTSEPVQLTP DDEDVIKRID QSEFEGFEYI NPLLLSTEES V 591
Nucleotide Sequence
(FASTA)
ATGCCCAGCA GGACCGGCCC CAAGATGCAC GGGAGCGGCT GCCGCGTCCG CCTGAAGGCG 60
CACCACAGCG GGGACATCCT GATCACCAGC CTAGATGCAG CAATGACCTT CGAGGAGCTC 120
TGTGATGAAG TGCGAGAGAT GTGCAGTCTC CGTCAGGGGC ACCCGCTCAC CCTTAAGTGG 180
GTGGACAATG AAGGTGACCC CTGCACTGTG TCCTCCCAAA TGGAGCTGGA GGAGGCCTTC 240
CGCCTGGCCT GTCAGCGCAG GGATGAAGGG CTCATCATTC ACGTGTTCCC TAGCACCCCT 300
GAGCAGCCAG GCATGCCGTG TCCAGGAGAA GACAAATCCA TCTACCGCCG CGGAGCCAGA 360
AGATGGAGGA AGCTGTACCG CGCCAACGGC CATCTCTTCC AGGCCAAGCG CTTTAACAGG 420
AGAGCGTACT GTGGCCAGTG CAGCGAAAGG ATATGGGGTC TCGCAAGGCA GGGCTACAGG 480
TGCATCAACT GCAAGCTGCT AGTCCATAAA CGCTGCCACG TGCTCGTCCC GCTGACCTGC 540
AACAGGCATA TGGATACTGT CATGCCTTCC CAAGAACCTG CAGTAGATGA CAAGGACGAT 600
GTGGATCTTC CTTCTGAGGA CACCCATGGA ATTGCTTACA TTTCTTCAAC CCGGAAACAC 660
GACAACATTA AAGATGATTC TGAGGACCTC AAGCCAGTTA TCGATGGGAT GGATGGAATC 720
AAAATATCTC AGGGGCTCGG GCTGCAGGAT TTTGACCTGA TCAGGGTCAT TGGGCGTGGG 780
AGCTACGCCA AAGTCCTCCT GGTCCGACTG AAGAAGAACG ACCAGATGTA TGCCATGAAG 840
GTGGTAAAGA AGGAGCTGGT GCACGATGAT GAGGATATTG ACTGGGTACA GACAGAGAAG 900
CATGTGTTTG AGCAGGCATC TAGCAACCCT TTCCTGGTCG GCTTACACTC CTGCTTCCAG 960
ACAACAAGTC GGCTGTTCCT GGTCATAGAG TACGTCAATG GCGGGGACCT CATGTTCCAC 1020
ATGCAGAGAC AGAGGAAGCT TCCGGAGGAG CATGCCAGAT TCTATGCTGC TGAGATCTGT 1080
ATCGCTCTCA ACTTCTTACA TGAGAGAGGG ATCATCTACC GGGATCTGAA GCTGGACAAT 1140
GTTCTCCTTG ACGCCGACGG CCACATCAAG TTAACGGACT ACGGCATGTG CAAGGAAGGC 1200
CTGGGCCCTG GTGACACGAC CAGCACTTTC TGCGGAACCC CAAATTATAT CGCCCCTGAA 1260
ATCCTGCGGG GGGAGGAGTA CGGATTCAGC GTGGACTGGT GGGCACTGGG CGTTCTGATG 1320
TTTGAGATGA TGGCTGGGCG CTCCCCGTTT GACATCATCA CTGACAACCC CGACATGAAC 1380
ACAGAGGACT ACCTTTTCCA AGTAATCCTA GAGAAACCCA TCCGGATCCC CCGATTCCTC 1440
TCCGTGAAAG CCTCCCACGT CTTGAAAGGA TTTTTAAACA AGGACCCCAA AGAGAGGCTT 1500
GGCTGCCGGC CACAGACAGG ATTTTCTGAT ATCAAGTCTC ACGCATTCTT CCGCAGCATA 1560
GACTGGGACC TGTTGGAGAA GAAGCAGGCC CTCCCGCCAT TCCAGCCCCA AATAACCGAC 1620
GAGTACGGTC TGGACAACTT CGACACCCAG TTCACCAGCG AGCCCGTGCA GCTGACCCCA 1680
GATGACGAGG ACGTCATAAA AAGGATCGAC CAGTCCGAGT TTGAAGGTTT TGAGTACATC 1740
AACCCGTTAC TGCTGTCCAC CGAGGAGTCC GTGTGA 1776
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 251   FDLIRVIGRGSYAKVLLVRLKKNDQMYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  310
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g
Q: 311   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  370
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvllda+Ghikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s
Q: 371   IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  430
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233
         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg
Q: 431   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  490
         **************************999*******************************
S: 234   lltkdpekrlGvk.eegeedikehaff  259
         +l+kdp++rlG++ ++g +dik+haff
Q: 491   FLNKDPKERLGCRpQTGFSDIKSHAFF  517
         ************889***********9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQMYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60
FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120
IIYRDLKLDN VLLDADGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180
VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240
FLNKDPKERL GCRPQTGFSD IKSHAFF 267
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-BOT-00174
EKS-DAR-00466
EKS-DIO-00088
EKS-DRM-00085
EKS-EQC-00172
EKS-FEC-00166
EKS-GAG-00149
EKS-GAA-00210
EKS-GOG-00173
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MAM-00174
EKS-MEG-00138
EKS-MOD-00171
EKS-MUP-00178
EKS-OCP-00108
EKS-ORL-00205
EKS-OTG-00179
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TEN-00219
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0045179; C:apical cortex
GO:0016324; C:apical plasma membrane
GO:0035748; C:myelin sheath abaxonal region
GO:0005635; C:nuclear envelope
GO:0016363; C:nuclear matrix
GO:0043234; C:protein complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
GO:0000226; P:microtubule cytoskeleton organization
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:2001181; P:positive regulation of interleukin-10 secretion
GO:2000667; P:positive regulation of interleukin-13 secretion
GO:0032753; P:positive regulation of interleukin-4 production
GO:2000664; P:positive regulation of interleukin-5 secretion
GO:2000553; P:positive regulation of T-helper 2 cell cytokine production
GO:0045630; P:positive regulation of T-helper 2 cell differentiation
GO:0072659; P:protein localization to plasma membrane
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013