EKS-CAF-00406
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00406
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK408.42.0E-122213519307
StatusUnreviewed
Ensembl ProteinENSCAFP00000028744
UniProt AccessionE2QX24;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK1
Gene Synonyms/Alias IRAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000019436ENSCAFP00000028744ENSCAFT00000030910
OrganismCanis familiaris
Functional Description
Protein Length722
Protein Sequence
(FASTA)
MAGGPGPGDP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60
RSGQRTASVL WPWINRNARV ADLVSILTHL QLLRARDIIT AWHPPAPLLP PSTSAPRPSS 120
PPAPCEADVP RPRKLPTASA STLPSPAFPG SQTHSGAELG PVHSPGILQP PPPRPAPSST 180
KPSAESPASL LQGAHPSPFC WPLSEISQGT HNFSDKLKIG EGGFGCVYRA VMRNTLYAVK 240
RLKEGADLEW TTVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGFYCLVYG FLPNGSLEDR 300
LHFQTEACAP LSWPQRLNIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD DRLMPKLGDF 360
GLARLSRFAG ANPGQSSTVA RTRTVRGTLA YLPEEYVKTG RLAVDTDTFS FGVVVLETLA 420
GQRAVRTQGA KTKYLKDLVE EEAEEAGVTL RSTQSTLQAG LATDAWAAPI ASQICKKHLD 480
PRPGPCPPEL GLVLGQLACC CLHRRAKRRP PMTQVYERLE KLQVAVAVAG AEAAHHGPPS 540
PQENSYVSVP SSGASPRQPL AAPSGAPAQA TEWLQKGPNQ PVESDESVSG LSAALCSWHM 600
SPSCPPGLAL PGSPAQGATL GAAAPLGQAG SARGGASQEP SWGGGPGPQL TAVEGSLLSS 660
SASSQPPQIV INPARQKMVQ KLALYEDGVL DSLQLLSSSS LPDLGGEHQH RPRPEESDEF 720
QS 722
Nucleotide Sequence
(FASTA)
ATGGCCGGTG GGCCGGGCCC GGGGGACCCC GCGGCCCCCG GCGCCCAGCA CTTCTTGTAC 60
GAGGTGCCGC CCTGGGTCAT GTGCCGCTTC TACAAAGTGA TGGACGCGCT GGAGCCCGCC 120
GACTGGTGCC AGTTCGCCGC CCTGATCGTG CGCGACCAGA CCGAGCTGCG GCTGTGCGAG 180
CGCTCCGGGC AGCGCACGGC CAGCGTCCTG TGGCCCTGGA TCAACCGCAA CGCCCGCGTG 240
GCCGACCTCG TGAGCATCCT CACGCACCTG CAGCTGCTCC GCGCCCGGGA CATCATCACG 300
GCCTGGCACC CGCCCGCCCC CCTCCTGCCC CCCAGCACCA GCGCCCCGAG GCCCAGCAGC 360
CCCCCTGCGC CCTGTGAGGC CGACGTCCCC CGCCCCCGGA AGCTGCCGAC GGCGTCGGCG 420
TCCACACTCC CGTCCCCAGC TTTTCCAGGC TCCCAGACCC ATTCTGGGGC TGAGCTCGGT 480
CCTGTCCACA GCCCTGGCAT CCTGCAGCCG CCACCGCCAC GTCCAGCCCC TTCCTCTACC 540
AAGCCCAGCG CAGAGAGCCC AGCGTCGCTC CTGCAGGGAG CCCACCCCTC TCCGTTCTGC 600
TGGCCCCTCA GTGAGATCTC CCAGGGCACC CACAACTTCT CGGACAAGCT GAAGATCGGG 660
GAGGGCGGCT TCGGCTGCGT GTACCGGGCG GTGATGAGGA ACACGCTGTA CGCGGTGAAG 720
AGGCTGAAGG AGGGGGCAGA CCTGGAGTGG ACCACAGTGA AGCAGAGCTT CCTGACCGAA 780
GTGGAACAAC TGTCACGGTT TCGTCACCCA AACATTGTGG ACTTTGCTGG CTACTGTGCC 840
GAGAGTGGCT TCTACTGCCT CGTCTACGGC TTCCTGCCCA ATGGCTCCCT GGAAGACCGC 900
CTGCACTTCC AGACCGAGGC CTGCGCCCCT CTCTCCTGGC CTCAGCGACT GAACATCCTT 960
CTGGGCACAG CACGGGCCAT TCAGTTTTTA CATCAGGACA GCCCCAGCCT CATCCACGGA 1020
GACATCAAAA GTTCCAACGT CCTCCTGGAT GACAGACTGA TGCCCAAACT GGGAGACTTT 1080
GGCCTGGCCC GTCTCAGCCG TTTTGCAGGG GCCAACCCCG GCCAGAGCAG CACAGTGGCC 1140
CGGACGCGGA CGGTGCGCGG CACCCTGGCC TACCTGCCCG AGGAGTACGT CAAGACGGGG 1200
AGACTGGCCG TGGACACGGA TACCTTCAGC TTCGGCGTGG TTGTGCTGGA GACCCTGGCT 1260
GGCCAGAGGG CTGTGAGGAC GCAGGGTGCC AAGACCAAGT ATCTGAAGGA CCTGGTGGAA 1320
GAGGAGGCCG AGGAGGCCGG GGTGACCCTC AGAAGCACCC AGAGCACACT CCAAGCAGGC 1380
CTGGCCACGG ATGCCTGGGC CGCCCCGATT GCCAGCCAGA TCTGTAAGAA GCACCTGGAC 1440
CCCAGGCCCG GGCCGTGCCC GCCGGAGCTG GGCTTGGTCC TGGGCCAGCT GGCTTGCTGC 1500
TGCCTGCACC GCCGGGCCAA GAGGAGGCCC CCCATGACCC AGGTGTACGA GCGTCTGGAG 1560
AAGCTGCAGG TGGCGGTGGC AGTGGCAGGA GCAGAGGCTG CCCACCACGG CCCCCCATCC 1620
CCGCAGGAGA ACTCGTACGT GTCCGTCCCC AGCAGCGGCG CCAGCCCACG GCAGCCCCTG 1680
GCGGCTCCGT CGGGAGCACC GGCCCAGGCC ACGGAGTGGC TCCAGAAAGG CCCCAACCAG 1740
CCCGTGGAGA GTGACGAGAG TGTGTCCGGC CTGTCCGCCG CCCTGTGTTC CTGGCACATG 1800
AGCCCCAGCT GCCCCCCGGG CCTGGCCTTG CCGGGCAGCC CTGCGCAGGG GGCCACCCTG 1860
GGGGCCGCGG CCCCCCTCGG GCAGGCCGGC AGTGCTCGGG GGGGCGCCAG CCAGGAGCCG 1920
AGCTGGGGCG GTGGCCCAGG GCCCCAGCTG ACAGCTGTGG AAGGATCACT GTTGAGCAGC 1980
TCCGCGTCAT CGCAGCCACC GCAGATCGTC ATCAACCCGG CCCGACAGAA GATGGTGCAG 2040
AAGCTGGCCT TGTACGAGGA CGGGGTCCTG GACAGCCTGC AGCTGCTGTC CTCTAGCTCC 2100
CTCCCAGACC TAGGAGGGGA GCACCAGCAC AGGCCGCGGC CCGAGGAGAG TGATGAATTC 2160
CAGAGCTGA 2169
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         fs++ +igeGgfg+vyr+ ++nt +avk+lke adl+++++kqsfltE+++l+rfrH+ni
Q: 213   FSDKLKIGEGGFGCVYRAVMRNTLYAVKRLKEGADLEWTTVKQSFLTEVEQLSRFRHPNI  272
         78899*******************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHe  119
         ++++gy+aes+++cLvY++++nGsLedrL+ q ++++pLsWpqRl+illGtarai+fLH+
Q: 273   VDFAGYCAESGFYCLVYGFLPNGSLEDRLHFQtEACAPLSWPQRLNILLGTARAIQFLHQ  332
         *******************************999**************************
S: 120   aspslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYl  176
         +spslihgdiks+N+LLD++l+pKlgDfglar   fa++++ qsstv+rt +vrgtlaYl
Q: 333   DSPSLIHGDIKSSNVLLDDRLMPKLGDFGLARlsrFAGANPGQSSTVARTRTVRGTLAYL  392
         *******************************99999************************
S: 177   peefirvgqltvkvDvySfGiVllEvltGlra.vdedrktkyLkdllkeeieeekv....  231
         pee++++g+l+v++D++SfG+V+lE+l+G+ra +++++ktkyLkdl++ee+ee++v    
Q: 393   PEEYVKTGRLAVDTDTFSFGVVVLETLAGQRAvRTQGAKTKYLKDLVEEEAEEAGVtlrs  452
         ********************************78999***********************
S: 232   ....................eilekfldkkagkleeellealielalaclaekakkrPtm  271
                             +i++k+ld ++g++++el   l +la++cl+++ak+rP+m
Q: 453   tqstlqaglatdawaapiasQICKKHLDPRPGPCPPELGLVLGQLACCCLHRRAKRRPPM  512
         ************************************************************
S: 272   sqvlell  278
         +qv+e+l
Q: 513   TQVYERL  519
         ****987
Domain Sequence
(FASTA)
FSDKLKIGEG GFGCVYRAVM RNTLYAVKRL KEGADLEWTT VKQSFLTEVE QLSRFRHPNI 60
VDFAGYCAES GFYCLVYGFL PNGSLEDRLH FQTEACAPLS WPQRLNILLG TARAIQFLHQ 120
DSPSLIHGDI KSSNVLLDDR LMPKLGDFGL ARLSRFAGAN PGQSSTVART RTVRGTLAYL 180
PEEYVKTGRL AVDTDTFSFG VVVLETLAGQ RAVRTQGAKT KYLKDLVEEE AEEAGVTLRS 240
TQSTLQAGLA TDAWAAPIAS QICKKHLDPR PGPCPPELGL VLGQLACCCL HRRAKRRPPM 300
TQVYERL 307
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00394
EKS-BOT-00406
EKS-CAE-00355
EKS-CAJ-00411
EKS-DAR-00793
EKS-DRM-00191
EKS-EQC-00398
EKS-ERE-00006
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-ORN-00520
EKS-ORA-00354
EKS-ORC-00381
EKS-OTG-00408
EKS-PAT-00384
EKS-PEM-00221
EKS-POA-00398
EKS-RAN-00420
EKS-SAH-00376
EKS-SUS-00360
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013