EKS-CAF-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	253.3	2.6E-75	122	382	261

Status

Unreviewed

Ensembl Protein

ENSCAFP00000028888

UniProt Accession

F6XGD4;

Protein Name

Protein Synonyms/Alias

Gene Name

STK11

Gene Synonyms/Alias

STK11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000019538	ENSCAFP00000028888	ENSCAFT00000031055

Organism

Canis familiaris

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MKSLPSLRRT WPSSAFPMPF QSLEPGFWLP KARGCSPGRE PRPGPDGAGV PHRRARCPAL 60

ARLRTLLTIW PHVTHASLSE SCTRSLTDAK PALWLMGFHP FKARSTHPPP PRRKRAKLIG 120

KYLMGDLLGE GSYGKVKEVL DSETLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH 180

KNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF CQLVDGLEYL 240

HSQGIVHKDI KPGNLLLTTS GTLKISDLGV AEALHPFAED DTCRTSQGSP AFQPPEIANG 300

LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GKGDYTIPGD CGPPLSDLLR 360

GMLEYEPARR FSIQQIRQHS WFRKKHPPAE ELVPIPPSTD CKDRWRGMTV VPYLEDLHGC 420

ADDNGEEDLF DIEDDIIYTQ DFTVPGQVPE EEAGQNGQSR GPPKVVCMNG TESAQLSTKS 480

KVERRASAAS NPARKACSAS SKIRRLSACK QQ 512

Nucleotide Sequence
(FASTA)

ATGAAGAGCC TGCCCTCCCT CCGGCGCACG TGGCCCTCCT CCGCGTTCCC AATGCCGTTT 60

CAGAGCCTCG AACCAGGCTT CTGGCTCCCG AAAGCTCGGG GCTGCTCTCC GGGCAGAGAA 120

CCCCGGCCGG GCCCGGATGG GGCGGGGGTC CCTCACCGAC GCGCCCGCTG CCCGGCCCTG 180

GCACGCCTGA GGACCCTGCT CACCATCTGG CCTCACGTCA CCCACGCTTC CCTGTCAGAG 240

TCCTGCACCA GGAGCTTGAC AGATGCCAAG CCAGCTCTTT GGCTCATGGG CTTCCACCCA 300

TTCAAAGCCA GGAGCACCCA CCCCCCACCT CCCCGCCGCA AGCGGGCCAA GCTCATCGGC 360

AAGTACTTGA TGGGAGACCT GCTAGGGGAG GGCTCCTACG GCAAGGTGAA GGAGGTGCTG 420

GACTCGGAGA CGCTGTGCAG GAGGGCTGTC AAAATTCTCA AGAAGAAGAA GTTGCGGAGG 480

ATCCCCAACG GCGAGGCGAA CGTCAAGAAG GAAATCCAAC TTCTGAGGAG ATTACGGCAC 540

AAAAACGTCA TCCAGCTGGT GGACGTGTTA TACAATGAGG AGAAGCAGAA AATGTATATG 600

GTGATGGAGT ACTGCGTGTG TGGCATGCAG GAGATGCTGG ACAGTGTGCC GGAGAAGCGG 660

TTCCCTGTGT GCCAGGCCCA CGGGTACTTC TGCCAGCTGG TAGATGGCCT GGAGTACCTG 720

CACAGCCAGG GCATCGTGCA CAAGGACATT AAGCCGGGCA ACCTGCTGCT CACCACTAGC 780

GGCACGCTCA AGATCTCCGA CCTGGGTGTG GCTGAGGCCC TGCACCCCTT TGCCGAGGAC 840

GACACGTGCC GGACGAGCCA GGGCTCCCCA GCATTCCAGC CCCCTGAGAT TGCCAATGGC 900

CTGGACACCT TCTCTGGCTT TAAGGTGGAC ATCTGGTCGG CTGGGGTCAC TCTCTATAAC 960

ATCACGACAG GCCTGTACCC GTTCGAGGGG GACAACATCT ACAAGTTGTT TGAGAACATC 1020

GGGAAGGGAG ACTACACGAT CCCGGGTGAC TGCGGGCCCC CGCTCTCGGA CTTGCTGAGA 1080

GGGATGCTGG AGTACGAGCC AGCCAGGAGG TTCTCTATCC AGCAGATCAG ACAACACAGC 1140

TGGTTCCGGA AGAAGCACCC GCCGGCTGAG GAGCTGGTGC CCATCCCGCC TAGCACAGAC 1200

TGCAAGGACC GCTGGCGCGG CATGACGGTG GTGCCCTACC TGGAGGACCT GCACGGCTGT 1260

GCCGACGACA ACGGGGAGGA GGACCTGTTC GATATCGAGG ACGACATCAT CTACACTCAG 1320

GACTTCACGG TGCCCGGACA GGTCCCAGAG GAGGAGGCTG GTCAGAACGG GCAGAGCCGG 1380

GGCCCCCCCA AGGTGGTGTG CATGAACGGC ACAGAGTCGG CCCAGCTGAG CACCAAATCG 1440

AAGGTGGAGC GCCGGGCCAG CGCCGCCTCC AACCCCGCCC GCAAGGCCTG CTCAGCCAGC 1500

AGCAAGATCC GCCGGCTGTC GGCCTGCAAG CAGCAGTGA 1539

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 122   YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  181

         778999******************************965334567***************

S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114

         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f qlv++++Yl

Q: 182   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVCQAHGYFCQLVDGLEYL  240

         ********9888999********998888*****6.8899********************

S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171

         hs+givH+D+Kp Nlll++++++ki+D+G+a+    f e+++++t++Gsp++++Pe+ +g

Q: 241   HSQGIVHKDIKPGNLLLTTSGTLKISDLGVAEalhPFAEDDTCRTSQGSPAFQPPEIANG  300

         *******************************966567788******************99

S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230

          ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip  + + l++Llr

Q: 301   lDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYTIPGDCGPPLSDLLR  360

         899*********************************************************

S: 231   klLvvdpekRatieeilkhewl  252

          +L+ +p++R++i++i++h+w+

Q: 361   GMLEYEPARRFSIQQIRQHSWF  382

         *********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60

NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVCQAHGYFC QLVDGLEYLH 120

SQGIVHKDIK PGNLLLTTSG TLKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL 180

DTFSGFKVDI WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDYTIPGDC GPPLSDLLRG 240

MLEYEPARRF SIQQIRQHSW F 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013