EKS-CAF-00067

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00067

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	365.3	2.4E-109	39	323	285

Status

Unreviewed

Ensembl Protein

ENSCAFP00000029349

UniProt Accession

E2R4K3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000019820	ENSCAFP00000029349	ENSCAFT00000031527

Organism

Canis familiaris

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MGDTESESEQ IRLKCIRKDG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTL 60

TDEIVALKKV RMDKEKDGVP ISSLREITLL LRLRHPNIVE LKEVVVGTHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHQNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYSI PMKPMTPKVV TLWYRAPELL LGTSTQTTSI DMWAMGCILA ELLAHKPLLP 240

GTSEIHQVDL IVQLLGTPSE NIWPGFSRLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300

NFLFMYDPKK RATARDGLDS SYFKEKPLPC EPELMPTFPH HRNKRAILAT SEGQSKRCKP 360

Nucleotide Sequence
(FASTA)

ATGGGGGACA CGGAGTCAGA GTCGGAGCAG ATCCGTCTGA AATGTATCCG TAAGGACGGC 60

TTCTTCACGG TGCCTCCGGA ACACAGGCTG GGACGGTGCC GGAGTGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATCGGGGA AGGCACCTAT GGCATCGTGT ATCGGGCCCG GGACACCCTG 180

ACAGATGAGA TTGTTGCCCT GAAGAAGGTA CGGATGGACA AGGAGAAGGA TGGGGTCCCC 240

ATCAGCAGCC TTCGAGAGAT CACACTGCTC CTTCGCCTTC GCCATCCCAA TATCGTGGAG 300

CTGAAGGAAG TGGTTGTGGG AACCCACCTG GAGAGCATCT TTCTGGTGAT GGGTTATTGT 360

GAGCAAGATC TGGCCAGCCT TCTGGAGAAT ATGCCGACAC CCTTCTCTGA GGCCCAGGTC 420

AAATGTATTG TGCTACAAGT GCTCCGAGGC CTTCAGTACC TGCACCAGAA CTTCATTATC 480

CACAGGGACC TGAAGGTGTC CAACCTGCTC ATGACTGATA AGGGCTGTGT GAAGACAGCG 540

GATTTCGGCC TGGCCCGGGC CTACAGCATC CCCATGAAGC CAATGACCCC CAAGGTGGTC 600

ACACTCTGGT ACCGAGCCCC TGAACTGCTT TTGGGAACCA GCACGCAGAC CACCAGCATC 660

GACATGTGGG CCATGGGCTG CATCCTGGCA GAGCTGCTGG CCCACAAGCC CCTTCTCCCC 720

GGCACTTCCG AGATCCACCA GGTGGACCTG ATAGTACAGC TGCTGGGGAC GCCCAGTGAG 780

AACATCTGGC CAGGTTTCTC CAGGCTGCCG CTGGTGGGCC AGTACAGCCT GAGGAAGCAG 840

CCCTACAACA ACCTCAAACA CAAATTCCCG TGGCTCTCAG AGGCCGGCCT GCGCCTGCTC 900

AACTTCCTCT TCATGTATGA CCCTAAGAAA AGGGCCACAG CCAGAGATGG CTTGGACAGC 960

TCATACTTCA AGGAGAAGCC ACTGCCTTGT GAGCCAGAGC TCATGCCCAC CTTCCCCCAC 1020

CACCGCAACA AGCGGGCCAT CCTGGCCACA TCTGAGGGCC AGAGCAAGCG CTGTAAGCCG 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d+ t+e+vAlKk+r++kek+gvpi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTLTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevva.kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVgTHLESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHQN  157

         ********4555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+s p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYSIPMKPMTPKVVTLWYRAPELLLGTSTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W++gcilaell++kpl++g+sei+q++ i++llgtpse++wp++s+lp +  +s+

Q: 218   TSIDMWAMGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSRLPLVGqYSL  277

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a++ l+++yf

Q: 278   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATARDGLDSSYF  323

         ********************************************98

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TLTDEIVALK KVRMDKEKDG VPISSLREIT LLLRLRHPNI 60

VELKEVVVGT HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHQNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY SIPMKPMTPK VVTLWYRAPE LLLGTSTQTT 180

SIDMWAMGCI LAELLAHKPL LPGTSEIHQV DLIVQLLGTP SENIWPGFSR LPLVGQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATARDGL DSSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:489655

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013