EKS-CAF-00151

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00151

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	547.9	8.3E-165	59	571	513

Status

Unreviewed

Ensembl Protein

ENSCAFP00000029929

UniProt Accession

E2RA52;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000020182	ENSCAFP00000029929	ENSCAFT00000032140

Organism

Canis familiaris

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MEASLGIHMD QPMAFSPRRR DQVQVDGSLK KHEQNFKLPG VKKDIEKLYE AVPQLGNLFK 60

IKDKIGEGTF SSVYLATAQL RVGPEEKIAL KHLIPTSHPI RIAAELQCLT VAGGQDNVMG 120

VKYCFRKNDH VVIAMPYLEH ESFLDILNSL SFQEVREYMF NLFKALKRIH QFGIVHRDVK 180

PSNFLFNRRL KKYALVDFGL AQGTHDTKIE LLKFVQSEAQ QESCSQNKSH VITGNKISLS 240

GPAAPKELDQ QPTMKTSVKR PYTNAQTQIK QGKDGKEGSV GLSVQRSVFG ERNFNIHSSI 300

SHESPAVKLM KQSKTMDVLS RKLATKKKAI STKVMNSGVM RKTASSCPAS LTCDCYATDK 360

VCSICLSRRQ QVAPRAGTPG FRAPEVLTKC PNQTTAIDMW SAGVIFLSLL SGRYPFYKAS 420

DDLTALAQIM TIRGSRETIQ AAKTFGKSIL CSKEVPAQDL RKLCEKLRGI NSNTPQLTSD 480

TQGPASHDPS FSEKTDHKAS HLIQTPQALP SGNSLCKGDS NGCGRGLNMD TADLEGWNEV 540

PDEAYDLLDK LLDLNPASRI TAEEALLHPF FKDMSL 576

Nucleotide Sequence
(FASTA)

ATGGAGGCGT CTTTGGGGAT TCACATGGAT CAACCAATGG CTTTTTCTCC CCGGCGTCGT 60

GACCAGGTTC AGGTGGATGG CTCGTTAAAA AAACATGAGC AGAATTTTAA ACTACCAGGT 120

GTTAAAAAAG ATATCGAGAA GCTTTATGAA GCTGTACCAC AGCTTGGTAA TCTGTTTAAG 180

ATTAAGGACA AAATTGGAGA AGGCACTTTT AGCTCTGTTT ATTTGGCCAC AGCACAGTTA 240

CGAGTAGGAC CTGAAGAGAA AATTGCTCTA AAACACTTAA TTCCAACAAG TCATCCTATA 300

AGAATTGCAG CTGAACTTCA GTGTCTAACA GTGGCTGGGG GGCAAGACAA TGTCATGGGA 360

GTTAAATACT GCTTTAGGAA AAATGATCAT GTGGTTATTG CTATGCCATA TCTGGAGCAT 420

GAGTCTTTTT TGGACATTTT GAATTCTCTT TCCTTTCAAG AAGTACGGGA ATATATGTTT 480

AATCTGTTCA AAGCTTTGAA ACGCATTCAT CAGTTTGGTA TTGTTCACCG TGATGTTAAA 540

CCCAGCAATT TTTTATTTAA TAGGCGCCTG AAAAAGTACG CACTGGTAGA CTTTGGTTTG 600

GCCCAAGGAA CCCATGATAC GAAAATAGAG CTTCTCAAAT TTGTCCAGTC TGAAGCTCAG 660

CAGGAAAGCT GCTCACAAAA TAAATCCCAT GTAATCACAG GAAACAAGAT TTCATTGAGT 720

GGCCCAGCAG CACCTAAGGA GTTGGATCAG CAGCCCACCA TGAAAACTTC TGTTAAAAGG 780

CCCTACACAA ATGCACAAAC TCAGATTAAA CAAGGAAAAG ATGGAAAGGA GGGATCTGTA 840

GGCCTTTCTG TCCAGCGCTC TGTTTTTGGA GAAAGAAATT TCAATATACA CAGCTCCATT 900

TCACATGAGA GCCCTGCAGT GAAACTTATG AAGCAGTCAA AGACTATGGA TGTACTATCT 960

AGAAAGTTAG CGACAAAAAA GAAGGCTATT TCTACAAAAG TTATGAATAG TGGTGTGATG 1020

AGGAAAACTG CCAGTTCTTG CCCAGCTAGC CTGACCTGTG ACTGTTATGC AACAGATAAA 1080

GTTTGCAGTA TTTGCCTTTC AAGGCGGCAA CAGGTTGCCC CTAGGGCGGG TACACCAGGA 1140

TTCAGAGCAC CAGAAGTTTT GACAAAGTGC CCCAATCAAA CTACAGCAAT TGACATGTGG 1200

TCTGCAGGTG TCATATTCCT TTCTTTGCTT AGTGGGCGAT ATCCATTTTA TAAAGCAAGT 1260

GATGATTTAA CTGCCTTGGC TCAAATTATG ACAATTCGTG GATCCAGGGA AACTATCCAA 1320

GCTGCTAAAA CTTTTGGCAA ATCAATATTG TGTAGCAAAG AAGTCCCAGC ACAAGACTTG 1380

AGAAAACTCT GTGAGAAGCT CAGAGGTATC AATTCTAACA CTCCCCAATT AACAAGTGAT 1440

ACACAAGGGC CTGCTTCTCA TGACCCAAGT TTTTCAGAGA AGACTGACCA TAAAGCTTCT 1500

CACCTTATAC AGACACCTCA AGCACTGCCC TCAGGGAATT CACTGTGTAA AGGGGACAGT 1560

AACGGCTGTG GGCGTGGTTT GAATATGGAT ACTGCCGATT TAGAAGGCTG GAATGAGGTA 1620

CCTGATGAAG CTTATGACCT TCTTGATAAA CTTCTAGATC TAAATCCAGC TTCAAGAATA 1680

ACAGCAGAAG AGGCTTTGTT GCATCCTTTT TTTAAAGATA TGAGCTTGTG A 1731

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylataql++g+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 59    FKIKDKIGEGTFSSVYLATAQLRVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV  118

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 119   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFKALKRIHQFGIVHRD  178

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn...........  155

         vkpsnfL+nrrlkk+aLvDfGLaq              seaq+e+cs+n

Q: 179   VKPSNFLFNRRLKKYALVDFGLAQgthdtkiellkfvqSEAQQESCSQNkshvitgnkis  238

         *************************************************77777777663

S: 156   llsaavekevd.................................................  166

         l   a++ke+d

Q: 239   LSGPAAPKELDqqptmktsvkrpytnaqtqikqgkdgkegsvglsvqrsvfgernfnihs  298

         2233445555599999999*****************************************

S: 167   .....................................................tcdcygt  173

                                                              tcdcy+t

Q: 299   sishespavklmkqsktmdvlsrklatkkkaistkvmnsgvmrktasscpaslTCDCYAT  358

         ************************************************************

S: 174   dkvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffk  233

         dkvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+LsllsgryPf+k

Q: 359   DKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYK  418

         ************************************************************

S: 234   asddlealaeivtilGsreiikaakafgksvllskevp......................  271

         asddl+ala+i+ti+Gsre+i+aak+fgks+l+skevp

Q: 419   ASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPaqdlrklceklrginsntpqlt  478

         ************************************************************

S: 272   ........................................dsdsye..............  277

                                                 ds+++

Q: 479   sdtqgpashdpsfsektdhkashliqtpqalpsgnslckgDSNGCGrglnmdtadlegwn  538

         ****************99999999999999999999999955555466666666666778

S: 278   ..PdeaydlldkllelnPakritaeealkhpff  308

           Pdeaydlldkll+lnPa+ritaeeal+hpff

Q: 539   evPDEAYDLLDKLLDLNPASRITAEEALLHPFF  571

         88******************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA QLRVGPEEKI ALKHLIPTSH PIRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MFNLFKALKR IHQFGIVHRD 120

VKPSNFLFNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AQQESCSQNK SHVITGNKIS 180

LSGPAAPKEL DQQPTMKTSV KRPYTNAQTQ IKQGKDGKEG SVGLSVQRSV FGERNFNIHS 240

SISHESPAVK LMKQSKTMDV LSRKLATKKK AISTKVMNSG VMRKTASSCP ASLTCDCYAT 300

DKVCSICLSR RQQVAPRAGT PGFRAPEVLT KCPNQTTAID MWSAGVIFLS LLSGRYPFYK 360

ASDDLTALAQ IMTIRGSRET IQAAKTFGKS ILCSKEVPAQ DLRKLCEKLR GINSNTPQLT 420

SDTQGPASHD PSFSEKTDHK ASHLIQTPQA LPSGNSLCKG DSNGCGRGLN MDTADLEGWN 480

EVPDEAYDLL DKLLDLNPAS RITAEEALLH PFF 513

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

cfa:479955

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013