EKS-CAF-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	296.4	2.1E-88	463	719	257

Status

Unreviewed

Ensembl Protein

ENSCAFP00000030269

UniProt Accession

F1P6V7;

Protein Name

Protein Synonyms/Alias

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000020408	ENSCAFP00000030269	ENSCAFT00000032502

Organism

Canis familiaris

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYVIIIER LEDDLQIEEK ELTELRHIFS SDDAFSKVNL 60

NYRTENGLSL LHLCCICGGN KSHVRTLMLK GLRPSRLTRN GFTALHLAVY KDSAELITSL 120

LHSGADIQQV GYGGLTALHI ATIAGHLEAA DVLLQHGANV NVQDAVFFTP LHIAAYYGHE 180

QVTRLLLKFG ADVNVSGEVG DRPLHLASAK GFFNIAKLLM EDGSKADVNA QDNEDHVPLH 240

FCSRFGHHDI VKYLLQSDSE VQPHVVNIYG DTPLHLACYN GKFEVAKEII QISGIESMTK 300

ENIFSETAFH SACTYGKSID LVKFLLDQNV ISINHQGRDG HTGLHSACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE LPCNEYSQPG 420

GDGSYVSLPS PLGKIKSMTK EKADVLLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCRLNHPC IIQFVGACLN DPSQFAIVTQ 540

YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLCEDG 600

HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWELLT 660

GEIPFAHLKP AAAAADMAYH HLRPPIGYSI PKPISSLLMR GWNACPEGRP EFSEVVTKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLV SRGGPGRSHV AALRSRFELE YALNERSCAT 780

WSQSAGPCSS QGLSLEEMKR GLQSSPVDKY GYVSDPMSPM QLHSCRSRGR CEDSG 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCTAG ACCAACCCAA ACTTGTACTG ATGAATGGAA GAAGAAAGTC 60

AGTGAATCTT ATGTTATTAT AATAGAAAGA TTAGAAGATG ACCTGCAGAT CGAAGAAAAA 120

GAACTTACAG AACTAAGGCA CATATTTAGC TCTGATGATG CCTTCAGTAA AGTCAACTTA 180

AATTACCGCA CAGAAAATGG GCTGTCTCTA CTTCATCTAT GTTGCATATG TGGAGGCAAC 240

AAGTCACATG TTAGAACCCT TATGTTAAAA GGACTTCGCC CATCTCGACT GACAAGAAAT 300

GGATTTACAG CCTTGCACCT GGCAGTCTAC AAGGACAGTG CGGAATTGAT CACTTCTCTG 360

CTTCACAGTG GAGCTGACAT ACAGCAGGTT GGGTATGGTG GCCTCACTGC CCTGCATATT 420

GCTACAATCG CTGGTCACCT AGAGGCTGCT GATGTCCTGC TGCAACACGG AGCTAATGTC 480

AATGTTCAGG ATGCAGTTTT TTTCACTCCG CTGCACATTG CAGCATACTA TGGACATGAA 540

CAGGTAACCC GCCTTCTTTT GAAATTTGGT GCTGATGTAA ATGTAAGCGG TGAGGTTGGA 600

GATAGGCCTC TCCACCTAGC ATCTGCAAAA GGATTCTTTA ATATTGCAAA ACTCTTGATG 660

GAAGACGGCA GCAAAGCAGA TGTGAATGCT CAGGACAATG AAGACCACGT CCCCCTCCAT 720

TTCTGCTCCC GCTTTGGACA CCATGACATA GTGAAGTACC TGCTCCAGAG CGATAGTGAA 780

GTTCAGCCAC ATGTTGTTAA TATCTACGGA GATACCCCCT TGCACCTGGC GTGCTACAAT 840

GGCAAATTTG AAGTCGCCAA GGAAATCATC CAAATATCAG GAATAGAAAG TATGACTAAA 900

GAAAACATCT TCAGTGAAAC GGCTTTTCAC AGTGCTTGTA CCTATGGTAA GAGCATTGAC 960

CTGGTTAAAT TCCTTCTTGA TCAAAATGTC ATAAGCATCA ACCACCAAGG AAGGGATGGG 1020

CACACAGGAT TGCACTCTGC CTGCTACCAT GGTCACATTC GCCTGGTTCA ATTCTTACTG 1080

GATAATGGAG CTGATATGAA TCTGGTAGCT TGTGATCCTA GCAGGTCTAG TGGTGAAAAA 1140

GATGAGCAGA CATGTTTGAT GTGGGCTTAT GAAAAAGGAC ATGATGCAAT CGTGACCCTC 1200

CTGAAGCATT ATAAAAGACC GCAGGATGAA TTGCCCTGTA ATGAATATTC TCAACCTGGA 1260

GGAGATGGCT CCTATGTGTC TCTTCCATCC CCCTTGGGGA AGATTAAAAG CATGACAAAA 1320

GAAAAGGCAG ATGTTCTCCT CCTAAGGGCT GGACTGCCCT CGCATTTCCA TCTTCAGCTC 1380

TCAGAAATTG AGTTCCATGA AATCATCGGC TCAGGTTCTT TCGGGAAAGT GTATAAAGGA 1440

CGATGCAGAA ATAAAATAGT GGCTATAAAA CGTTACCGGG CCAACACCTA CTGCTCCAAA 1500

TCCGATGTGG ATATGTTCTG CCGAGAGGTG TCCATTCTCT GCCGCCTCAA TCATCCCTGT 1560

ATAATTCAGT TTGTGGGTGC CTGCTTGAAT GACCCCAGCC AGTTTGCCAT CGTCACTCAG 1620

TACATATCAG GGGGTTCCCT GTTCTCCCTC CTTCATGAGC AGAAGAGGAT TCTTGATTTG 1680

CAGTCTAAAT TAATTATTGC AGTAGACGTT GCCAAAGGTA TGGAGTACCT TCACAACCTG 1740

ACACAACCAA TTATACACCG TGACTTAAAC AGTCACAATA TTCTTCTCTG TGAGGATGGG 1800

CATGCTGTGG TGGCAGATTT TGGAGAATCA AGATTTCTAC AGTCTCTGGA TGAAGACAAC 1860

ATGACAAAAC AACCTGGGAA CCTCCGCTGG ATGGCTCCCG AGGTGTTCAC ACAGTGCACA 1920

CGCTACACCA TCAAAGCTGA CGTCTTCAGC TACGCCCTGT GTCTGTGGGA ACTTCTCACC 1980

GGTGAGATTC CATTCGCTCA TCTCAAGCCA GCGGCTGCTG CAGCAGACAT GGCTTACCAC 2040

CATCTCAGAC CTCCCATTGG CTATTCCATT CCCAAGCCCA TATCATCTCT GCTGATGCGA 2100

GGGTGGAATG CATGTCCTGA AGGAAGACCT GAATTTTCTG AAGTTGTTAC CAAGTTAGAA 2160

GAGTGTCTCT GCAACATTGA GCTGATGTCA CCTGCATCAA GTAACAGCAG TGGTTCTCTC 2220

TCACCTTCCT CTTCTTCTGA CTGCCTGGTG AGCCGGGGAG GGCCTGGCCG GAGCCACGTG 2280

GCCGCTTTAA GGAGTCGTTT TGAACTGGAA TATGCTCTCA ATGAGAGGTC CTGTGCCACC 2340

TGGTCCCAAA GCGCCGGGCC GTGTTCCTCT CAAGGCCTGT CTTTGGAGGA GATGAAGAGA 2400

GGTCTCCAGT CCTCGCCCGT TGACAAATAC GGCTACGTGT CCGACCCCAT GAGCCCGATG 2460

CAGCTTCATT CCTGCCGGAG TAGAGGCCGC TGCGAGGACA GCGGCTGA 2508

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp+ii

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCRLNHPCII  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-CEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  639

         6.9*************.89999*************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a+++lr+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHLRPPIGYSIPKPISSLLM  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVTKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCRLNHPCII 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLCEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHL RPPIGYSIPK PISSLLMRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013