EKS-CAF-00303
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00303
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.62.5E-151659916258
StatusUnreviewed
Ensembl ProteinENSCAFP00000020924
UniProt AccessionF1PQ05;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000023258ENSCAFP00000020924ENSCAFT00000022535
OrganismCanis familiaris
Functional Description
Protein Length1249
Protein Sequence
(FASTA)
MGNLEITSIE HNRDLSFLRS IREVTGYVLV ALNQFRYLPL ENLRIIRGTK LYEDRYALAV 60
FLNYRKDGNF GLQELGLKNL TEILNGGVYV DQNKFLCYTD TIHWQDIVRN PWPSNLTLVS 120
TNGSSGCGRC HKSCTGRCWG PTENHCQTLT RTVCAEQCDG RCYGPYVSDC CHRECAGGCS 180
GPKDTDCFAC MNFNDSGACV TQCPQTFVYN PTTFQLEHNF NAKYTYGAFC VKKCPHNFVV 240
DSSSCVRACP SSKMEVEENG IKMCKPCTDI CPKACDGIGT GSLMSAQTVD SSNIDKFINC 300
TKINGNLIFL VTGIHGDPYN AIEAIDPEKL NVFRTVREIT GFLNIQSWPP NMTDFSVFSN 360
LVTIGGRVLY SGLSLLILKQ QGITSLQFQS LKEISAGNIY ITDNSNLCYY HTINWTTLFS 420
TINQRIVIRD NRKAENCTAE GMVCNHLCSS DGCWGPGPDQ CLSCRRFSRG RSCIESCNLY 480
DGEFREFENG SICVECDPQC EKMEDGILTC HGPGPDNCTK CSHFKDGPNC VEKCPDGLQG 540
ANSFIFKYAD QDRECHPCHP NCTQGCSGPT SHDCIYYPWT GHSTLPQHAR TPLIAAGVIG 600
GLFILVIVGL TFAVYVRRKS IKKKRALRRF LETELVEPLT PSGTAPNQAQ LRILKETELK 660
RVKVLGSGAF GTVYKGIWVP EGETVKIPVA IKILNETTGP KANVEFMDEA LIMASMDHPH 720
LVRLLGVCLS PTIQLVTQLM PHGCLLDYVH EHKDNIGSQL LLNWCVQIAK GMMYLEERRL 780
VHRDLAARNV LVKSPNHVKI TDFGLARLLE GDEKEYNADG GKMPIKWMAL ECIHYRKFTH 840
QSDVWSYGVT IWELMTFGGK PYDGIPTREI PDLLEKGERL PQPPICTIDV YMVMVKCWMI 900
DADSRPKFKE LAAEFSRMAR DPQRYLVIQG DDRMKLPSPN DSKFFQNLLD EEDLEDMMDA 960
EEYLVPQAFN IPPPIYTSRA RIDSNRSEIG HSPPPAYTPM SGNQFVYRDG GFAAEQGVPV 1020
PYRATTSTIP EAPVAQGATA EIFDDSCCNG TLRKPVAPHV QEDSSTQRYS ADPTVFAPER 1080
SPRGELDEEG YMTPMRDKPK QEYLNPVEEN PFVSRRKNGD LQALDNPEYH NASNGPPKAE 1140
DEYVNEPLYL NTFANALGNA EYLKNNVLSV PEKAKKAFDN PDYWNHSLPP RSTLQHPDYL 1200
QEYSTKYFYK QNGRIRPIVA ENPEYLSEFS LKPGTVLPPP PYRHRNTVV 1249
Nucleotide Sequence
(FASTA)
ATGGGCAACC TGGAGATAAC CAGCATCGAG CACAACCGGG ACCTCTCCTT TCTGCGGTCT 60
ATTCGGGAAG TCACAGGCTA CGTGTTAGTG GCTCTTAATC AGTTTCGTTA CCTGCCTCTG 120
GAGAATTTAC GCATTATCCG TGGGACAAAA CTTTATGAGG ATCGATATGC CTTGGCAGTA 180
TTTTTAAACT ACAGAAAAGA TGGGAACTTT GGACTTCAAG AACTTGGATT GAAGAATTTG 240
ACAGAAATCC TTAATGGTGG AGTATATGTA GACCAGAACA AATTTCTCTG TTACACAGAC 300
ACAATTCATT GGCAAGATAT TGTTCGGAAT CCATGGCCTT CCAACTTGAC TCTGGTATCA 360
ACAAATGGTA GCTCAGGATG TGGACGTTGT CATAAGTCCT GTACTGGCCG ATGCTGGGGA 420
CCCACAGAAA ATCATTGCCA GACCTTGACA AGGACGGTGT GTGCAGAACA GTGTGATGGC 480
AGGTGCTATG GGCCCTATGT CAGTGACTGC TGTCATAGAG AATGTGCTGG GGGCTGCTCA 540
GGACCTAAGG ACACAGACTG CTTTGCCTGC ATGAATTTCA ATGACAGTGG AGCATGTGTT 600
ACTCAGTGTC CTCAAACTTT TGTCTATAAT CCAACCACCT TTCAACTGGA GCATAACTTC 660
AATGCAAAGT ATACATATGG AGCATTTTGT GTCAAGAAAT GTCCACATAA CTTTGTGGTG 720
GATTCCAGTT CTTGTGTGCG TGCCTGCCCT AGTTCCAAGA TGGAAGTAGA AGAAAATGGG 780
ATTAAAATGT GTAAACCTTG CACTGATATT TGCCCAAAAG CTTGTGATGG CATCGGCACA 840
GGATCATTGA TGTCGGCTCA GACTGTGGAT TCCAGTAACA TTGACAAATT CATAAACTGC 900
ACCAAAATCA ATGGGAATTT GATCTTCCTT GTCACTGGTA TTCATGGGGA CCCTTACAAT 960
GCAATTGAAG CCATAGACCC AGAGAAACTG AATGTCTTCC GCACAGTTCG AGAGATAACG 1020
GGTTTCTTGA ACATACAGTC ATGGCCTCCA AACATGACCG ACTTCAGTGT TTTTTCCAAC 1080
CTGGTGACCA TTGGTGGAAG AGTACTCTAT AGTGGCCTCT CCTTGCTTAT CCTTAAGCAA 1140
CAGGGCATCA CTTCTCTACA ATTCCAATCC CTGAAGGAAA TCAGTGCGGG AAACATCTAT 1200
ATTACTGACA ACAGCAACCT GTGTTATTAC CATACCATTA ATTGGACAAC ACTCTTCAGC 1260
ACTATCAACC AAAGAATAGT GATCCGGGAT AACAGGAAAG CTGAAAACTG TACTGCTGAA 1320
GGAATGGTGT GCAACCATCT GTGTTCAAGC GATGGCTGTT GGGGACCTGG CCCCGACCAG 1380
TGCCTGTCCT GCCGTCGCTT CAGCAGAGGA AGGAGCTGCA TAGAGTCTTG TAACCTCTAT 1440
GACGGTGAAT TTCGAGAGTT TGAGAATGGC TCCATCTGTG TGGAGTGTGA CCCCCAGTGT 1500
GAGAAGATGG AAGATGGCAT CCTCACCTGC CATGGACCGG GACCTGACAA CTGCACAAAG 1560
TGCTCCCATT TTAAGGATGG CCCGAACTGT GTGGAAAAAT GTCCAGATGG CTTACAGGGG 1620
GCAAACAGTT TTATTTTCAA GTATGCTGAT CAGGATCGGG AGTGCCACCC ATGTCATCCA 1680
AACTGCACCC AAGGGTGTAG CGGTCCCACT AGTCATGACT GCATTTATTA TCCTTGGACG 1740
GGCCATTCCA CTTTACCACA ACATGCTAGA ACTCCTCTAA TTGCAGCGGG AGTCATCGGT 1800
GGGCTCTTCA TCCTGGTCAT CGTGGGTCTA ACATTTGCAG TTTATGTTAG AAGGAAGAGC 1860
ATTAAAAAGA AAAGAGCCTT GAGAAGGTTT CTGGAAACAG AGTTGGTAGA ACCCTTAACT 1920
CCCAGTGGCA CGGCGCCCAA TCAAGCTCAA CTTCGTATTT TGAAAGAAAC TGAGCTTAAA 1980
AGAGTGAAAG TACTTGGCTC AGGTGCTTTT GGAACAGTTT ATAAAGGTAT CTGGGTACCT 2040
GAAGGAGAAA CAGTAAAGAT TCCTGTGGCT ATTAAAATTC TTAATGAAAC AACTGGTCCC 2100
AAAGCCAATG TGGAATTCAT GGATGAAGCT TTGATCATGG CAAGTATGGA CCATCCACAC 2160
TTAGTCCGGT TATTGGGTGT GTGTCTGAGC CCAACCATTC AGCTGGTTAC ACAGCTTATG 2220
CCCCATGGTT GCCTGTTGGA TTATGTCCAT GAACACAAGG ATAACATTGG ATCCCAGCTG 2280
CTGCTTAACT GGTGTGTCCA GATAGCTAAG GGGATGATGT ACCTGGAAGA AAGACGACTT 2340
GTTCATCGGG ACTTGGCAGC CCGAAATGTC TTAGTGAAAT CTCCAAACCA TGTGAAAATC 2400
ACAGATTTTG GACTAGCCAG ACTCTTAGAA GGAGATGAAA AAGAGTATAA TGCTGATGGA 2460
GGAAAGATGC CAATTAAATG GATGGCTCTC GAGTGTATAC ACTATAGAAA ATTCACCCAT 2520
CAGAGTGATG TTTGGAGCTA TGGAGTCACT ATATGGGAAC TGATGACATT TGGAGGAAAA 2580
CCCTACGATG GAATTCCAAC CCGAGAAATC CCTGATTTAT TAGAGAAAGG AGAACGTTTG 2640
CCGCAGCCTC CTATCTGCAC TATTGACGTT TACATGGTCA TGGTCAAATG TTGGATGATT 2700
GATGCTGACA GTAGGCCTAA ATTTAAGGAA CTGGCTGCTG AGTTTTCGAG GATGGCTCGA 2760
GACCCTCAAA GATATCTAGT CATTCAGGGT GACGATCGCA TGAAGCTTCC CAGTCCAAAT 2820
GACAGCAAGT TCTTTCAGAA TCTCTTGGAT GAAGAGGATT TGGAAGACAT GATGGATGCT 2880
GAGGAATACT TGGTCCCTCA GGCGTTCAAC ATTCCACCTC CCATCTACAC TTCCAGAGCA 2940
AGAATTGACT CAAATAGGAG TGAAATTGGA CACAGCCCTC CTCCTGCCTA CACCCCCATG 3000
TCAGGAAACC AGTTTGTATA CCGAGATGGG GGTTTTGCTG CAGAACAAGG AGTGCCTGTG 3060
CCCTACAGAG CCACGACCAG CACGATTCCA GAAGCTCCAG TTGCTCAGGG GGCTACAGCT 3120
GAGATTTTTG ATGACTCCTG TTGTAATGGC ACCCTACGCA AGCCAGTGGC ACCCCATGTC 3180
CAAGAGGATA GCAGCACCCA GAGGTACAGC GCTGATCCCA CTGTGTTTGC CCCAGAACGA 3240
AGCCCACGAG GAGAGCTGGA TGAAGAAGGT TACATGACCC CTATGCGAGA TAAACCTAAA 3300
CAAGAATACT TGAACCCTGT GGAGGAGAAC CCTTTTGTTT CTCGGAGGAA GAATGGAGAC 3360
CTTCAAGCTT TGGATAATCC CGAATATCAC AATGCTTCCA ATGGTCCACC CAAGGCAGAG 3420
GATGAGTATG TGAATGAGCC ACTGTACCTC AACACCTTTG CCAACGCATT GGGGAATGCC 3480
GAATACCTGA AGAACAATGT ACTGTCTGTG CCAGAGAAGG CCAAGAAAGC ATTCGACAAC 3540
CCTGACTACT GGAACCACAG CCTGCCACCT CGGAGCACCC TTCAGCACCC AGACTACCTG 3600
CAGGAGTACA GCACAAAATA TTTTTATAAA CAAAATGGAC GGATCCGGCC TATTGTGGCA 3660
GAGAATCCTG AATACCTCTC TGAGTTCTCG CTGAAGCCAG GCACTGTGCT GCCTCCTCCA 3720
CCCTACAGAC ACCGAAATAC TGTGGTGTAA 3750
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 659   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  718
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 719   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  778
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 779   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  838
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 839   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  898
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 899   MIDADSRPKFKELAAEFS  916
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAP-00332
EKS-DAR-00648
EKS-EQC-00288
EKS-GAM-00190
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013