EKS-CAF-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph485.72.8E-146637894258
StatusUnreviewed
Ensembl ProteinENSCAFP00000021576
UniProt AccessionF1PAD6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000023528ENSCAFP00000021576ENSCAFT00000023234
ENSCAFG00000023528ENSCAFP00000036391ENSCAFT00000048984
OrganismCanis familiaris
Functional Description
Protein Length1007
Protein Sequence
(FASTA)
MAPARGRLPP ALWVVSAAAA ATCVSAARGI VNLLDTSTIH GDWGWLTYPA HGWDSINEVD 60
ESFQPIHTYQ VCNVMSPNQN NWLRTSWVPR DGARRVYAEI KFTLRDCNSM PGVLGTCKET 120
FNLYYLESDR DLGASTQESQ FLKIDTIAAD ESFTGADLGV RRLKLNTEVR GVGPLSKRGF 180
YLAFQDIGAC LAILSLRIYY KKCPTMVRNL AAFSEAVTGA DSSSLVEVRG QCVRHSEERD 240
TPKMYCSAEG EWLVPIGKCV CSAGYEERRD ACVACELGFY KSAPGDQLCA RCPLHSHSAA 300
PAAQACRCDL SYYRAALDPP SAACTRPPSA PVNLISSVNG TSVTLEWAPP LDPGGRSDIT 360
YNAVCRRCPW ALGHCETCGS GTRFVPQQTS LVRASLMVAN LLAHMNYSFW IEAVNGVSDL 420
SPEPRRAAVV NITTNQAASP SRVVRYGIRQ ERAGQTSVSL LWQEPEQPNG IILEYEIKYY 480
EKDKEMQSYS TLKAVTTRAT VSGLKPGTRY MFQVRARTSA GCGRFSQAME VETGKPRPRY 540
DTRTIVWICL TLITGLVVLL LLLICKKRHC GYSKAFQDSD EEKMQYQNGQ APPPVFLPLH 600
HPPGKIPEPQ FYAEPHNYEE PGRAGRGFTR EIEASRIHIE KIIGSGESGE VCYGRLRVPG 660
QRDVPVAIKA LKAGYTERQR RDFLSEASIM GQFDHPNIIR LEGVVTRGRL AMIVTEYMEN 720
GSLDAFLRTH DGQFTIMQLV GMLRGVGAGM RYLSDLGYVH RDLAARNVLV DSNLVCKVSD 780
FGLSRVLEDD PDAAYTTTGG KIPIRWTAPE AIAFRTFSSA SDVWSFGVVM WEVLAYGERP 840
YWNMTNRDVI SSVEEGYRLP APMGCPRALH QLMLDCWHKD RAQRPRFSHI VSVLDALIRS 900
PESLRATATV NRCPPPAFAQ SCFDLRGGGG GGGGLTVGDW LDSIRMGRYR DHFAAGGYSS 960
LGMVLRMNAQ DVRALGITLM GHQKKILGSI QTMRAQLTST QGPRRHL 1007
Nucleotide Sequence
(FASTA)
ATGGCCCCCG CCCGGGGCCG CCTGCCCCCC GCGCTCTGGG TCGTATCGGC CGCGGCGGCC 60
GCCACCTGCG TGTCCGCGGC GCGCGGAATA GTGAACTTGC TGGACACGTC AACCATCCAC 120
GGAGACTGGG GCTGGCTCAC GTACCCGGCT CACGGGTGGG ACTCCATCAA CGAGGTGGAT 180
GAGTCTTTCC AGCCCATCCA CACGTACCAG GTGTGCAACG TCATGAGCCC CAACCAGAAC 240
AACTGGCTGC GCACGAGCTG GGTGCCCCGC GATGGTGCCC GGCGTGTCTA CGCTGAGATC 300
AAGTTCACCC TGCGTGACTG CAACAGCATG CCTGGCGTGC TGGGCACCTG TAAGGAGACC 360
TTTAACCTCT ACTACCTGGA GTCGGACCGT GACCTGGGCG CCAGCACACA AGAAAGCCAG 420
TTCCTCAAAA TCGACACCAT TGCAGCCGAC GAGAGCTTCA CGGGTGCTGA CCTGGGGGTG 480
CGGCGCCTCA AGCTCAACAC GGAGGTGCGC GGCGTGGGCC CCCTCAGCAA GCGCGGCTTC 540
TATCTGGCCT TCCAGGACAT CGGCGCCTGC CTCGCCATCC TGTCTCTCCG CATCTATTAC 600
AAGAAGTGCC CCACTATGGT GCGCAACCTG GCCGCCTTCT CGGAGGCGGT GACGGGGGCC 660
GACTCGTCCT CGCTGGTGGA GGTGCGGGGC CAGTGCGTGC GGCACTCAGA GGAGCGGGAC 720
ACGCCCAAGA TGTACTGCAG CGCGGAGGGC GAGTGGCTGG TGCCCATTGG CAAGTGCGTG 780
TGCAGCGCTG GCTACGAGGA GCGGCGGGAT GCCTGTGTGG CCTGTGAGCT GGGCTTCTAC 840
AAGTCGGCCC CTGGGGACCA GCTCTGCGCC CGCTGCCCCC TGCACAGCCA CTCTGCAGCC 900
CCTGCTGCCC AGGCCTGCCG CTGTGACCTC AGCTACTACC GCGCAGCCCT GGACCCGCCA 960
TCCGCAGCCT GCACCCGGCC ACCCTCGGCA CCGGTGAATC TCATCTCCAG CGTCAACGGG 1020
ACATCTGTGA CCCTGGAATG GGCCCCTCCC CTGGATCCGG GCGGCCGCAG CGACATCACC 1080
TACAACGCCG TGTGCCGCCG CTGCCCTTGG GCGTTGGGCC ACTGCGAGAC GTGCGGGAGT 1140
GGCACCCGCT TCGTGCCCCA GCAGACAAGC CTGGTGCGGG CCAGTCTGAT GGTGGCCAAC 1200
CTGCTGGCCC ACATGAACTA CTCCTTCTGG ATCGAGGCCG TCAACGGTGT GTCTGACCTG 1260
AGCCCCGAGC CCCGCCGGGC CGCCGTGGTC AACATCACCA CGAACCAGGC AGCCTCCCCA 1320
TCACGTGTTG TCCGGTACGG GATCCGCCAG GAGCGGGCGG GGCAGACCAG CGTGTCCCTG 1380
CTGTGGCAGG AGCCAGAGCA GCCCAACGGC ATCATCCTGG AGTATGAGAT CAAGTACTAC 1440
GAGAAGGACA AGGAGATGCA GAGCTACTCC ACCCTCAAGG CTGTCACCAC CAGGGCCACC 1500
GTCTCGGGCC TCAAGCCGGG CACCCGCTAC ATGTTCCAGG TCCGCGCCCG CACTTCCGCA 1560
GGCTGCGGCC GCTTCAGCCA GGCCATGGAG GTGGAGACCG GGAAACCCCG GCCCCGCTAC 1620
GACACCCGGA CCATTGTCTG GATCTGCCTG ACGCTCATCA CGGGCCTGGT CGTGCTTCTG 1680
CTCCTGCTCA TCTGCAAAAA GAGGCACTGT GGCTACAGCA AGGCCTTCCA GGACTCGGAC 1740
GAGGAGAAGA TGCAGTATCA GAACGGGCAG GCACCCCCAC CCGTCTTCCT GCCCCTGCAC 1800
CACCCCCCGG GGAAGATCCC AGAGCCCCAG TTCTATGCAG AGCCCCACAA CTACGAGGAG 1860
CCAGGCCGGG CGGGCCGCGG TTTCACTCGG GAGATTGAAG CCTCCAGGAT CCACATTGAG 1920
AAAATTATCG GCTCTGGGGA GTCCGGGGAA GTCTGCTACG GGCGGCTGCG GGTGCCGGGG 1980
CAGCGGGACG TGCCCGTGGC CATCAAGGCC CTCAAAGCCG GCTACACGGA GCGACAGCGA 2040
CGGGACTTCC TGAGTGAGGC GTCCATCATG GGGCAGTTTG ACCACCCCAA TATCATCCGC 2100
CTCGAGGGCG TCGTCACCCG CGGCCGCCTG GCAATGATTG TGACCGAGTA CATGGAGAAC 2160
GGCTCTCTGG ACGCCTTCCT GAGGACTCAC GACGGGCAGT TCACCATCAT GCAGCTGGTG 2220
GGCATGCTCA GAGGCGTGGG GGCCGGCATG CGCTACCTCT CGGACCTGGG CTACGTCCAC 2280
CGGGACCTGG CCGCCCGCAA CGTCCTGGTT GACAGCAACC TGGTGTGCAA GGTGTCCGAC 2340
TTCGGGCTCT CCCGGGTGCT GGAGGACGAC CCTGATGCGG CCTACACCAC CACGGGAGGC 2400
AAGATCCCCA TCCGCTGGAC CGCCCCCGAG GCCATCGCCT TCCGGACCTT CTCCTCGGCC 2460
AGCGACGTGT GGAGTTTCGG TGTGGTCATG TGGGAGGTGC TGGCCTACGG GGAGAGGCCC 2520
TACTGGAACA TGACGAACCG CGACGTCATC AGCTCCGTGG AGGAGGGCTA CCGCCTGCCC 2580
GCGCCCATGG GCTGCCCCCG CGCCCTGCAC CAGCTCATGC TCGACTGCTG GCACAAGGAC 2640
AGGGCTCAGA GACCTCGCTT TTCCCACATT GTCAGTGTCC TCGATGCCCT CATCCGGAGC 2700
CCGGAGAGCC TCAGGGCCAC CGCCACAGTC AACAGGTGCC CGCCCCCTGC CTTTGCCCAG 2760
AGCTGCTTTG ACCTCCGAGG GGGCGGGGGT GGCGGCGGGG GCCTCACCGT GGGGGACTGG 2820
CTGGACTCCA TCCGCATGGG CCGCTACCGG GACCACTTTG CTGCCGGCGG CTACTCCTCC 2880
CTGGGCATGG TGCTGCGGAT GAATGCTCAG GACGTGCGTG CCCTGGGCAT CACCCTCATG 2940
GGCCACCAGA AGAAGATCCT GGGCAGCATC CAGACCATGA GGGCCCAGCT GACAAGCACC 3000
CAGGGGCCCC GCCGGCACCT CTGA 3024
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc Grl++pg+r+++vaik+lkag+te+qrrdflseasi+Gqfdhp
Q: 637   IHIEKIIGSGESGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP  696
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 697   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  756
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv+snlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+
Q: 757   GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  816
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 817   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPRALHQLMLDC  876
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+kdra+rp+f++ivs+l
Q: 877   WHKDRAQRPRFSHIVSVL  894
         ***************985
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGRL RVPGQRDVPV AIKALKAGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVDSNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP RALHQLMLDC 240
WHKDRAQRPR FSHIVSVL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013