EKS-CAF-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.9	1.7E-116	203	501	299

Status

Unreviewed

Ensembl Protein

ENSCAFP00000031969

UniProt Accession

F1PCC1;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000023687	ENSCAFP00000031969	ENSCAFT00000036570

Organism

Canis familiaris

Functional Description

Protein Length

1037

Protein Sequence
(FASTA)

MPPSLQRPLW VPSLLWTVLL VRTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60

SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180

QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240

INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300

SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360

NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420

TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480

EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 540

GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600

PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYSDETNL HATNVSQPIG PTPVCLQLTE 660

EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 720

QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLLN TKNSTKEPRL KFGSKHKSNL 780

KQVETGVAKM NTINAAEPHV VTVTMNGVAG RNHSVNSHAA TTQYVNGAVP SGQAANTVVH 840

RGQEMLQNQF VGEDTRLNIN SSPDEHEPLL RREQQAGHDE GVLDRLVDRR ERPLEGGRTN 900

SNNNNSNPCS EQDVLTQGVP STVADPGPSK PRKAQRPNSL DLSATNVLDG SGLQLGESTQ 960

DGKSGSGEKI KKRVKTPYSL KRWRPSTWVI STEPLDCEVN NNGSDRAVHS KSSTAVYLAE 1020

GGTATTMVSK DIGMNCL 1037

Nucleotide Sequence
(FASTA)

ATGCCTCCTT CGCTGCAGCG GCCCCTGTGG GTGCCGTCGC TCCTGTGGAC CGTCCTGCTG 60

GTCAGAACTG CGGCCGCTTC TCAGAACCAG GAACGTCTAT GTGCATTTAA AGATCCATAT 120

CAACAAGACC TTGGGATAGG TGAGAGTCGA ATCTCTCATG AAAATGGAAC GATATTATGC 180

TCAAAAGGTA GCACTTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGATAT AAATCTCGTA 240

AAGCAAGGAT GTTGGTCTCA CATTGGAGAT CCTCAGGAGT GTCACTATGA AGAATGTGTA 300

GTGACTACTA CTCCTCCCTC AATTCAGAAT GGAACATACC GTTTCTGCTG CTGTAGCACA 360

GACTTGTGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CAGACACAAC GCCACTCAGT 420

CCACCTCATT CATTTAACCG AGATGAGACA ATAATCATTG CTTTGGCATC AGTCTCTGTA 480

TTAGCTGTTT TGATAGTTGC CTTATGCTTT GGATACAGGA TGCTGACAGG AGACCGTAAA 540

CAAGGTCTTC ACAGTATGAA CATGATGGAG GCAGCAGCAT CAGAGCCCTC TCTTGACCTA 600

GATAACCTGA AACTGTTGGA GCTGATTGGC CGGGGTCGAT ATGGAGCAGT ATATAAAGGT 660

TCCTTAGATG AGCGTCCAGT TGCTGTGAAA GTGTTTTCCT TTGCAAACCG TCAGAATTTT 720

ATCAATGAGA AGAATATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCTCGCTTT 780

ATAGTTGGAG ATGAGAGAGT TACTGCAGAT GGACGCATGG AGTATTTGCT TGTGATGGAG 840

TATTATCCCA ATGGATCTCT ATGCAAGTAT TTGAGTCTCC ATACAAGTGA TTGGGTCAGC 900

TCTTGCCGTC TGGCTCATTC TGTGACTAGA GGATTGGCTT ATCTCCATAC AGAATTGCCA 960

CGAGGAGATC ATTATAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTG 1020

GTGAAAAATG ATGGAACTTG TGTTATTAGT GACTTTGGAT TGTCTATGAG GCTGACTGGA 1080

AATAGACTGG TACGCCCAGG GGAAGAAGAT AATGCAGCCA TAAGTGAGGT TGGCACAATC 1140

AGATATATGG CACCAGAAGT TCTAGAAGGA GCTGTGAACC TGAGGGACTG TGAATCAGCT 1200

TTGAAACAAG TAGACATGTA TGCACTTGGA CTCATTTATT GGGAGATATT TATGAGATGT 1260

ACAGACCTCT TCCCAGGTGA ATCTGTACCA GAATACCAGA TGGCTTTTCA GACAGAAGTT 1320

GGAAACCATC CCACTTTTGA AGATATGCAG GTTCTGGTAT CTAGGGAAAA ACAGAGACCC 1380

AAGTTCCCAG AAGCTTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA GGAGACAATC 1440

GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGGCTTACTG CACAATGTGC TGAGGAGAGG 1500

ATGGCTGAAC TTATGATGAT ATGGGAAAGA AACAAATCTG TGAGCCCCAC AGTCAATCCC 1560

ATGTCTACTG CTATGCAGAA TGAGCGCAAC CTGTCACACA ATAGGCGTGT GCCAAAGATT 1620

GGCCCTTATC CAGATTATTC TTCTTCCTCA TACATTGAAG ACTCCATCCA TCATACTGAC 1680

AGCATTGTGA AGAATATTTC CTCCGAGCAT TCGATGTCTA GCACACCTTT GACTATAGGG 1740

GAAAAGAACC GGAACTCAAT TAACTATGAA CGGCAGCAAG CACAAGCTCG AATCCCTAGC 1800

CCTGAAACAA GTGTCACCAG CCTGTCCACT AACACAACAA CCACAAACAC CACTGGCCTC 1860

ACTCCAAGCA CTGGCATGAC CACTATATCT GAGATGCCAT ATTCAGATGA AACCAATCTG 1920

CATGCCACAA ATGTTTCACA GCCAATTGGG CCAACCCCTG TCTGCTTACA ACTTACAGAA 1980

GAAGACTTGG AGACCAATAA GCTGGACCCA AAAGAAGTTG ATAAGAACCT CAAGGAAAGT 2040

TCTGATGAGA ATCTCATGGA GCATTCTCTT AAACAGTTCA GTGGACCAGA CCCACTGAGC 2100

AGTACCAGTT CTAGCTTGCT TTACCCACTT ATAAAACTTG CAGTAGAGGT GACTGGACAG 2160

CAGGACTTCA CACAAGCTGC AAATGGCCAA GCATGTTTAA TTCCTGATGT TCCACCCGCT 2220

CAGATCTATC CTCTCCCCAA GCAGCAAAAC CTTCCTAAGA GACCTACTAG TTTGTTAAAC 2280

ACCAAAAATT CAACAAAGGA GCCCCGGCTG AAATTTGGCA GCAAGCACAA ATCAAACTTG 2340

AAACAAGTAG AAACTGGAGT TGCCAAGATG AATACAATCA ATGCTGCAGA ACCTCATGTG 2400

GTGACAGTCA CCATGAATGG TGTAGCAGGT AGAAACCACA GTGTTAACTC CCATGCTGCC 2460

ACTACCCAGT ATGTTAACGG GGCAGTACCA TCTGGCCAGG CAGCTAACAC AGTGGTACAT 2520

AGGGGCCAAG AAATGCTGCA GAATCAATTC GTTGGTGAGG ATACCCGACT GAATATTAAT 2580

TCCAGTCCTG ATGAACATGA ACCTTTGCTG AGACGAGAGC AGCAGGCTGG CCATGATGAA 2640

GGTGTTCTGG ATCGTCTTGT GGACAGGAGG GAACGGCCAC TGGAAGGTGG CCGAACTAAT 2700

TCCAATAACA ACAACAGTAA TCCATGTTCA GAGCAAGATG TTCTTACACA GGGTGTTCCA 2760

AGCACAGTAG CAGATCCTGG ACCATCAAAG CCCAGGAAAG CACAGAGGCC CAATTCTCTG 2820

GATCTTTCAG CCACAAATGT CCTTGATGGC AGTGGTTTGC AGTTAGGTGA GTCAACACAA 2880

GATGGAAAAT CGGGATCTGG TGAAAAGATC AAGAAACGTG TGAAAACTCC CTATTCTCTT 2940

AAGCGGTGGC GCCCCTCCAC CTGGGTCATT TCCACTGAAC CACTGGACTG TGAGGTCAAC 3000

AACAATGGCA GTGACAGAGC AGTTCATTCC AAATCCAGCA CCGCAGTTTA CCTTGCAGAA 3060

GGAGGCACTG CCACAACTAT GGTGTCTAAA GATATAGGAA TGAACTGTCT G 3111

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013