EKS-CAF-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR515.72.7E-1559791246268
StatusUnreviewed
Ensembl ProteinENSCAFP00000024471
UniProt AccessionE2R795;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSRR
Gene Synonyms/Alias INSRR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000024151ENSCAFP00000024471ENSCAFT00000026349
OrganismCanis familiaris
Functional Description
Protein Length1300
Protein Sequence
(FASTA)
MAVPSLCPWV ACLLVILLSL GFGLDTLEVC PSLDIRSEVA ELRRLENCSV VEGHLQILLM 60
FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVVRGARLF LGYALVVYEM 120
PHLRDVGLPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP SPSANHIVGN KLREECADVC 180
PGVLGATGQP CARTTFSGHT DYRCWTSSHC QRVCPCPHGL ACTAGGECCH TECLGGCSRP 240
EDPRACVACR HLYFQGACHR ACPPGTYQHE SWRCVTAERC ASLRSVPGRT SIFGIHEGSC 300
LAQCPPGFTR NGSSMFCHKC EGLCPKECKV GTKTIDSTQA AQDLAGCTHV EGSLIINLRQ 360
GYNLELELQQ SLGLIETITG FLKIKHSFAL VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ 420
NLQQLGAWVA AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 480
ACQTRTLRFV SNVTQADSIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHTGPDACGT 540
QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLRT 600
LPAAPTVPQD VISTSNSSSH LLVRWKPPIQ RNGNITYYLV LWQRLAEDGD LYLNDYCHRG 660
LRLPTSNNDP RFDREDGELE AEMEPGCCPC QHPPPGQVLP PLEAQEASFQ KKFENFLHNA 720
ITIPKSPWKV TSVNKSPQRH AGRHRRAAGA LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF 780
TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVAWEAASKS SVLLRWLEPP 840
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKFGGVQLAL LPPGNYSARV RATSLAGNGS 900
WTESIAFYVP GPEEEDSGGL HVLLTVTPVG LMLFIILAAL GFFYGRKRNS TLYASVNPEY 960
FSASDMYIPD EWEVPREQIS IIRELGQGSF GMVYEGLAQG LEAGEESTPV ALKTVNELAS 1020
PRERIEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 1080
NPGLPRPALG DMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 1140
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 1200
VLKFVMDGGV LEELESCPLQ LQELMSRCWQ QNPRLRPTFT HILDSIRGEL RPSFRLFSFY 1260
YSPECQGSQG ALLPNAKPNS LPTPEGAPSD CMPQNGGPGH 1300
Nucleotide Sequence
(FASTA)
ATGGCAGTGC CCAGTCTGTG CCCATGGGTC GCATGCCTGC TGGTGATCCT CCTCTCCTTG 60
GGATTTGGCC TGGACACACT AGAGGTGTGC CCCAGCCTGG ACATCCGCTC AGAGGTGGCG 120
GAGCTGCGCC GGCTGGAGAA CTGCAGCGTG GTGGAGGGCC ATCTGCAGAT CCTGCTCATG 180
TTCACGGCCA CGGGCGAGGA CTTCCGCGGC CTCAGCTTCC CGCGCCTCAC TCAGGTCACT 240
GACTACCTGC TGCTCTTCCG CGTGTATGGC CTGGAGAGCC TGCGGGACCT CTTCCCCAAC 300
CTCGCGGTCG TGCGTGGCGC CCGCCTCTTC CTGGGTTATG CGCTGGTGGT CTACGAGATG 360
CCGCACCTGC GGGACGTGGG GCTGCCGGCG CTGGGGGCCG TGCTGCGTGG GGCCGTGCGG 420
GTGGAGAAGA ACCAGGAGCT CTGTCATCTC TCCACCATCG ACTGGGGGCT GCTGCAGCCC 480
TCGCCCAGCG CCAACCACAT CGTGGGCAAC AAGCTGCGTG AGGAGTGTGC CGACGTGTGC 540
CCTGGTGTGC TGGGTGCCAC CGGCCAGCCC TGCGCCAGGA CCACCTTCAG TGGGCACACC 600
GACTACAGAT GCTGGACCTC CAGCCACTGC CAGAGAGTGT GTCCCTGCCC CCATGGGCTG 660
GCCTGCACAG CTGGGGGTGA GTGCTGCCAC ACTGAATGCC TGGGGGGCTG CAGCCGGCCG 720
GAAGACCCCC GCGCCTGCGT CGCCTGTCGC CACCTCTACT TCCAGGGTGC CTGCCACCGG 780
GCCTGCCCTC CAGGCACCTA CCAGCACGAG TCCTGGCGCT GTGTCACGGC AGAGCGCTGT 840
GCCAGCCTGC GCTCTGTGCC CGGCCGCACC TCCATCTTTG GCATCCACGA GGGCAGCTGC 900
CTGGCCCAGT GCCCTCCGGG CTTCACCCGC AACGGCAGCA GCATGTTCTG CCACAAGTGT 960
GAGGGGCTGT GCCCCAAAGA GTGCAAGGTG GGTACCAAGA CCATCGACTC CACGCAGGCG 1020
GCACAGGACC TGGCGGGCTG CACCCACGTG GAGGGGAGCC TCATCATCAA CCTCCGCCAG 1080
GGCTACAACC TAGAGCTGGA GCTGCAACAG AGCCTGGGGC TGATAGAGAC CATCACTGGC 1140
TTCCTCAAGA TCAAGCACTC CTTTGCCCTC GTGTCCCTGG GCTTTTTCAA GAACCTCAAA 1200
CTCATCCGAG GGGACGCCAT GGTGGATGGG AACTACACCC TGTATGTGCT GGACAACCAG 1260
AACCTACAGC AGCTGGGGGC CTGGGTGGCT GCGGGGCTCA CCATTCCCGT GGGCAAGATA 1320
TACTTCGCTT TCAACCCTCG CCTCTGCTTG GAGCACATCT ACCGCCTGGA AGAGGTGACC 1380
GGCACGCGGG GACGGCAAAA CAAGGCTGAG ATCAACCCCC GCACCAACGG AGACCGCGCC 1440
GCCTGCCAAA CTCGCACCCT GCGCTTCGTG TCCAACGTGA CGCAAGCTGA CAGCATCTTG 1500
CTGCGCTGGG AGCGCTACGA GCCGCTGGAG GCTCGGGACC TGCTCAGCTT CATCGTGTAC 1560
TACAAGGAGT CCCCATTCCA GAATGCCACA GAGCACACAG GTCCAGATGC CTGTGGAACC 1620
CAGAGCTGGA ACCTGCTGGA TGTGGAGCTG CCCTTAAGCC GCACCCAAGA ACCCGGGGTA 1680
ACTCTAGCAC CCCTCAAGCC CTGGACACAA TATGCAGTGT TTGTACGGGC CATCACACTG 1740
ACCACTGCTG AGGACAGCCC CCACCAAGGA GCCCAGAGCC CCATCGTCTA CCTCCGAACC 1800
CTGCCTGCGG CGCCCACTGT GCCCCAGGAC GTCATCTCCA CGTCCAATTC CTCGTCCCAC 1860
CTGCTCGTGC GCTGGAAGCC ACCGATTCAG CGCAACGGGA ACATCACCTA CTACCTGGTG 1920
CTGTGGCAGC GTCTGGCGGA GGACGGCGAC CTCTATCTCA ACGACTACTG CCACCGCGGC 1980
CTGCGGCTGC CCACCAGCAA CAACGACCCG CGCTTCGACC GCGAGGACGG TGAACTCGAA 2040
GCCGAGATGG AGCCGGGCTG CTGCCCTTGC CAGCACCCAC CGCCTGGGCA GGTCCTGCCG 2100
CCGCTGGAGG CGCAAGAGGC CTCGTTCCAG AAGAAGTTCG AAAACTTCCT GCACAACGCC 2160
ATCACCATCC CCAAGTCCCC CTGGAAGGTG ACGTCCGTCA ATAAGAGCCC TCAAAGACAT 2220
GCGGGGAGGC ACCGCCGGGC GGCCGGGGCG CTCCGGCTTG GGGGCAACAG CTCGGATTTC 2280
GAGATCCAGG AGGACAAAGT GCCCCGGGAG CGAGCAGTGT TGAGTGGTCT GCGCCACTTT 2340
ACGGAATATC GTATCGACAT CCACGCCTGC AACCACGCGG CTCACACCGT GGGCTGCAGC 2400
GCGGCCACGT TCGTCTTCGC GCGCACCATG CCGCACAGAG AAGCTGATGG CATCCCAGGG 2460
AAGGTGGCCT GGGAGGCAGC CAGCAAAAGC AGTGTCCTCC TGCGCTGGCT GGAGCCACCT 2520
GACCCCAACG GACTCATCCT CAAGTATGAA ATCAAGTACC GCCGCTTGGG AGAGGAGGCC 2580
ACAGTGCTAT GTGTGTCCCG CCTACGATAT GCCAAATTTG GGGGTGTCCA GCTGGCCCTG 2640
CTGCCCCCTG GAAACTACTC CGCCAGAGTT CGGGCAACCT CGCTGGCTGG CAACGGCTCC 2700
TGGACAGAAA GTATCGCTTT CTACGTCCCA GGCCCAGAGG AGGAAGACTC CGGGGGGCTG 2760
CACGTCCTTC TCACTGTCAC CCCCGTGGGG CTCATGCTGT TCATCATTCT TGCCGCCCTC 2820
GGTTTCTTCT ACGGCAGGAA GAGAAACAGC ACCCTCTATG CCTCAGTGAA TCCGGAGTAC 2880
TTCAGCGCCT CTGATATGTA CATCCCTGAT GAGTGGGAGG TGCCTCGGGA GCAGATCTCC 2940
ATAATCCGAG AGCTGGGCCA GGGCTCCTTT GGGATGGTAT ATGAAGGCCT GGCACAAGGA 3000
CTAGAGGCTG GAGAGGAGTC CACACCCGTG GCCCTGAAGA CAGTGAATGA GTTGGCCAGC 3060
CCACGAGAAC GCATTGAGTT CCTCAAGGAA GCTTCTGTCA TGAAGGCATT CAAGTGTCAC 3120
CATGTGGTAC GTCTCCTGGG TGTTGTGTCT CAAGGCCAGC CAACTCTGGT CATCATGGAG 3180
TTAATGACTC GTGGGGACCT CAAGAGCCAT CTTCGATCTC TGCGGCCTGA GGCAGAGAAC 3240
AACCCTGGGC TCCCACGGCC AGCACTGGGA GATATGATCC AGATGGCTGG TGAGATTGCA 3300
GATGGCATGG CTTACCTCGC TGCCAACAAG TTTGTGCATC GAGACCTGGC AGCCAGAAAC 3360
TGCATGGTGT CCCAGGACTT CACCGTCAAG ATTGGGGACT TCGGGATGAC TCGAGACGTG 3420
TACGAGACAG ACTATTACCG CAAGGGCGGG AAAGGGCTGC TGCCCGTGCG CTGGATGGCC 3480
CCCGAGTCCC TCAAAGATGG AATCTTCACC ACACATTCGG ATGTTTGGTC CTTCGGGGTG 3540
GTGCTCTGGG AGATCGTGAC CCTAGCTGAA CAGCCCTACC AGGGTTTATC CAACGAGCAG 3600
GTGCTCAAGT TTGTCATGGA TGGTGGGGTC CTGGAGGAGC TGGAGAGCTG TCCCCTTCAG 3660
CTGCAAGAAC TGATGAGCCG CTGCTGGCAG CAGAACCCAC GCCTGCGGCC CACCTTCACC 3720
CACATCCTGG ACAGCATTCG GGGGGAACTG CGGCCCTCTT TCCGCCTCTT TTCCTTCTAT 3780
TACAGCCCAG AGTGCCAGGG GAGCCAGGGG GCCCTGCTGC CTAATGCCAA ACCCAACTCC 3840
CTACCAACCC CAGAAGGGGC TCCCTCAGAC TGCATGCCCC AAAATGGGGG TCCAGGGCAC 3900
TGA 3903
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as rerieflkeasvmk+fk
Q: 979   ISIIRELGQGSFGMVYEGLAQGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFK  1038
         6799********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e
Q: 1039  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPRPALGDMIQMAGE  1098
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw
Q: 1099  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1158
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e+cp
Q: 1159  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELESCP  1218
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
          +l+elm++cwq np+lrp+f++i++++
Q: 1219  LQLQELMSRCWQQNPRLRPTFTHILDSI  1246
         ************************9976
Domain Sequence
(FASTA)
ISIIRELGQG SFGMVYEGLA QGLEAGEEST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPRPA LGDMIQMAGE 120
IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180
MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELESCP 240
LQLQELMSRC WQQNPRLRPT FTHILDSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00014
EKS-BOT-00016
EKS-CAJ-00018
EKS-CAP-00017
EKS-EQC-00019
EKS-FEC-00017
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-LOA-00016
EKS-MAM-00017
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-MYL-00019
EKS-NOL-00017
EKS-ORC-00016
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-POA-00017
EKS-RAN-00018
EKS-SAH-00015
EKS-SUS-00014
EKS-XET-00017
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0071469; P:cellular response to alkalinity
GO:0030238; P:male sex determination
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
cfa:490405;
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013