EKS-CAF-00287
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00287
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR432.87.3E-130204490287
StatusUnreviewed
Ensembl ProteinENSCAFP00000034899
UniProt AccessionE2R174;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000025220ENSCAFP00000034899ENSCAFT00000039088
OrganismCanis familiaris
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MTLDLPRRGL LMLLMAWGLT QGNPVKPSRG PLLTCTCESP HCRGPTCQGT WCTVVLVREE 60
GRHPQEHRGC GNLNEELCRG RPTEFVNHYC CYSPLCNHNV SLVLEATQIP PEQPKVDGQL 120
PLILGPVLAV VALVALGALG LWHVRWRQEK QRGLRSELGE SSLILKSSEQ GDSMLGDLLD 180
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
LKLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360
DYLDIGNNPR VGTKRYMAPE VLEEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIVNGIVE 420
DYRPPFYDVV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 480
LTALRIKKTL QKLSNGLEKS KVIH 504
Nucleotide Sequence
(FASTA)
ATGACCTTGG ACCTGCCCAG GAGAGGCCTT CTGATGCTAC TGATGGCCTG GGGCCTGACC 60
CAGGGCAACC CGGTGAAGCC CTCTCGGGGC CCGCTGCTGA CCTGCACGTG TGAGAGCCCA 120
CACTGCAGGG GGCCTACCTG CCAGGGGACC TGGTGCACGG TGGTGCTGGT GCGGGAGGAG 180
GGCCGACACC CCCAGGAGCA TCGGGGCTGC GGGAACCTGA ACGAGGAGCT GTGCCGGGGG 240
CGCCCCACCG AGTTCGTGAA CCACTACTGC TGCTACAGCC CCCTCTGCAA CCACAACGTG 300
TCCCTGGTGC TGGAGGCCAC CCAAATTCCT CCGGAGCAGC CGAAAGTAGA TGGCCAGCTG 360
CCTCTGATCC TGGGCCCTGT GCTGGCCGTG GTGGCCCTGG TGGCCCTGGG TGCCCTGGGC 420
CTGTGGCATG TCCGGTGGAG GCAGGAGAAG CAGCGGGGCC TACGCAGCGA GCTGGGCGAG 480
TCCAGCCTCA TCCTGAAGTC GTCGGAGCAG GGGGACAGCA TGCTGGGGGA TCTCCTGGAC 540
AGCGACTGTA CCACAGGCAG TGGCTCAGGA CTCCCCTTCC TGGTGCAGAG GACAGTGGCA 600
CGGCAGGTGG CCCTGGTGGA GTGTGTAGGC AAGGGCCGCT ACGGCGAGGT GTGGCGCGGC 660
CTGTGGCACG GCGAGAGCGT GGCCGTCAAG ATCTTCTCTT CGAGGGACGA ACAGTCCTGG 720
TTCCGGGAGA CCGAGATCTA CAATACGGTG CTGCTCAGAC ACGACAACAT CCTAGGCTTC 780
ATCGCCTCGG ACATGACGTC CCGCAACTCG AGCACGCAGC TGTGGCTCAT CACGCACTAC 840
CACGAGCACG GCTCGCTCTA CGACTTCCTG CAGAGGCAGA CGCTGGAGCC CCAGCTGGCC 900
CTGAAGCTGG CTGTGTCCGC CGCCTGCGGC CTGGCCCACC TGCACGTGGA GATCTTCGGC 960
ACCCAGGGCA AGCCGGCCAT CGCCCACCGG GACCTCAAAA GCCGCAACGT GCTGGTCAAG 1020
AGCAACCTGC AGTGCTGCAT CGCCGACCTG GGCCTGGCTG TGATGCACTC CCAGGGTAGC 1080
GATTACCTGG ACATCGGCAA CAACCCGCGA GTGGGCACCA AGCGGTACAT GGCCCCCGAG 1140
GTGCTGGAAG AGCAGATCCG CACCGACTGC TTCGAGTCCT ACAAGTGGAC GGACATCTGG 1200
GCCTTTGGTC TGGTGCTGTG GGAGATTGCC CGTCGGACCA TTGTCAACGG CATCGTGGAG 1260
GACTACAGGC CACCCTTCTA TGACGTGGTG CCCAATGATC CCAGCTTCGA GGACATGAAG 1320
AAGGTGGTGT GTGTTGATCA GCAGACTCCC ACCATCCCCA ACCGGCTGGC CGCAGACCCG 1380
GTCCTCTCCG GCCTGGCTCA GATGATGCGG GAGTGCTGGT ACCCCAACCC CTCCGCCCGC 1440
CTCACTGCGC TGCGGATCAA GAAGACACTA CAGAAACTGA GCAACGGTCT CGAGAAGTCC 1500
AAAGTGATTC ACTAG 1515
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 204   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +l+la s+a+GlahLH ei+gt+g
Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQG  323
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  381
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         lee++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 382   LEEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  440
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  490
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALKL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLE 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
cfa:477603;
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013