EKS-CAF-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.4	4.0E-112	323	615	293

Status

Unreviewed

Ensembl Protein

ENSCAFP00000038488

UniProt Accession

J9P287;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000029250	ENSCAFP00000038488	ENSCAFT00000043154
ENSCAFG00000029250	ENSCAFP00000039663	ENSCAFT00000046011

Organism

Canis familiaris

Functional Description

Protein Length

1129

Protein Sequence
(FASTA)

SPSPYSSSGE RRSRSPSSPV IRRSAKSRSR SPYSSRHSRS RSRHRLSRSR SRHSSISPST 60

LTLKSSLAAE LNKNKKARAA EAARAAEAAK AAEAAKAAEA AAKAAKASNT STPTKGSTET 120

GAGASQTNHV KDVKKLKTEH APSPSSGGTL KNDKAKTKPP LQVTKVDNNL IVDKATKKAV 180

VVGKESKSAA TKDEPVSLKE KTKPLTPSLG AKEKEQHVAL VTSTLPPLPL PPMLPEDKDT 240

DSLRGNISVK AVKKEVEKKL RCLLADLPLP PELPGGDDLS KSPEEKKTAT QLHSKRRPKI 300

CGPRYGEIKE KDIDWGKRCV DKFDIIGIIG EGTYGQVYKA RDKDTGEMVA LKKVRLDNEK 360

EGFPITAIRE IKILRQLTHQ SIINMKEIVT DKEDALDFKK DKGAFYLVFE YMDHDLMGLL 420

ESGLVHFNEN HIKSFMRQLM EGLDYCHKKN FLHRDIKCSN ILLNNRGQIK LADFGLARLY 480

SSEESRPYTN KVITLWYRPP ELLLGEERYT PAIDVWSCGC ILGELFTKKP IFQANQELAQ 540

LELISRICGS PCPAVWPDVI KLPYFNTMKP KKQYRRKLRE EFVFIPAAAL DLFDYMLALD 600

PSKRCTAEQA LQCEFLRDVE PSKMPPPDLP LWQDCHELWS KKRRRQKQMG MTDDVSTIKA 660

PRKDLSLGLD DSRTSTPQGV LPSSQLKPQG NSNVAPVKTG PGQQLNHSEL AILLNLLQSK 720

TSVNMADFVQ VLNIKVNSET QQQLNKINLP AGILATGEKQ TDPSTPQQES SKPLGGIQPS 780

SQSVQPKVET DAAQAAVQSA FAVLLTQLIK AQQSKQKDVL LEERENGSGH EASLQLRPPP 840

EPSTPASGQD DLIQHQDMRM LELTPEPDRP RILPPDQRPP EPPEPPPVTE EDLDYRTENQ 900

HVPTTSSSLT DPHAGVKAAL LQLLAQHQPQ DDPKRESGID YQAGDTYVPA SDYKDNFGSS 960

FSSAPYVSTD GLGGSSAPPL ERRSFIGNSD IQPLENYSTT SSHSGGPPQP SAFSESFPSS 1020

VAGYGDIYLN TGPMLFSGDK DHRFEYSHGP IAVLANSSDP AAGPESTHPL PAKMHNYNYG 1080

GSLQENPGGP GLMHGQTWTS PAQGPGYSQG YRGHISTSTG RGRGRGLPY 1129

Nucleotide Sequence
(FASTA)

TCCCCCAGCC CCTACAGCAG CAGCGGCGAG CGCCGCTCCC GGAGCCCGTC CAGCCCGGTG 60

ATCAGACGTT CAGCTAAATC CCGAAGCAGA AGCCCGTATT CATCTAGGCA TTCAAGATCT 120

CGTAGCAGGC ACAGATTGTC TAGATCCAGA AGTCGTCATT CTAGCATTTC TCCTAGCACA 180

CTAACTCTGA AGAGTAGCCT GGCAGCTGAG TTGAACAAGA ATAAAAAAGC CCGGGCTGCC 240

GAGGCGGCAA GGGCTGCAGA AGCGGCGAAA GCTGCAGAAG CGGCAAAGGC TGCTGAGGCC 300

GCTGCCAAAG CTGCCAAAGC TTCCAACACT TCTACACCTA CGAAAGGGAG CACAGAGACT 360

GGGGCCGGTG CATCACAAAC CAACCATGTG AAGGATGTGA AGAAACTGAA AACTGAACAT 420

GCACCTTCTC CCTCAAGTGG TGGAACTTTA AAAAATGACA AGGCAAAAAC AAAGCCACCT 480

CTTCAGGTAA CAAAGGTGGA TAATAATTTG ATTGTAGATA AAGCCACCAA GAAAGCAGTT 540

GTAGTTGGGA AGGAGAGTAA ATCTGCTGCT ACAAAGGATG AACCAGTATC TCTTAAAGAG 600

AAAACCAAAC CACTTACACC AAGCTTAGGA GCCAAGGAGA AGGAGCAACA TGTGGCTTTA 660

GTGACCTCTA CATTACCACC GTTACCTTTG CCTCCCATGC TGCCTGAAGA TAAAGACACT 720

GATAGCTTAC GAGGAAATAT TTCAGTAAAA GCAGTTAAAA AAGAAGTAGA GAAGAAACTA 780

CGATGTTTAC TTGCTGATTT ACCACTGCCC CCTGAGCTAC CAGGAGGAGA TGATCTCTCA 840

AAGAGTCCAG AGGAAAAGAA AACAGCAACA CAGTTACATA GTAAAAGGAG GCCTAAAATA 900

TGTGGGCCTC GCTATGGTGA AATCAAAGAA AAAGATATTG ACTGGGGAAA ACGCTGCGTG 960

GATAAATTTG ATATCATCGG AATTATTGGA GAAGGTACCT ATGGACAAGT TTATAAGGCC 1020

AGGGATAAAG ACACTGGAGA AATGGTAGCC TTAAAGAAAG TACGTCTAGA TAATGAAAAG 1080

GAAGGCTTTC CAATTACAGC AATTCGAGAA ATTAAAATTC TCCGGCAGCT TACCCACCAG 1140

AGTATTATTA ATATGAAGGA AATAGTGACT GATAAAGAAG ATGCTTTGGA TTTTAAGAAG 1200

GATAAAGGTG CATTTTATCT GGTGTTTGAA TATATGGACC ATGATCTGAT GGGACTACTG 1260

GAATCAGGCT TGGTTCATTT TAATGAAAAT CACATAAAGT CATTTATGAG ACAGCTCATG 1320

GAAGGTCTGG ATTATTGTCA TAAGAAGAAC TTTTTGCATA GAGATATCAA GTGTTCAAAT 1380

ATTCTTCTAA ACAATAGAGG GCAAATAAAA CTTGCAGATT TTGGACTTGC TCGATTGTAT 1440

AGCTCAGAAG AAAGTCGGCC ATATACTAAC AAGGTCATCA CTTTATGGTA CCGCCCACCT 1500

GAACTGCTGT TGGGAGAAGA ACGATATACC CCTGCTATTG ATGTATGGAG CTGTGGATGT 1560

ATCCTTGGTG AACTCTTCAC TAAAAAACCT ATATTTCAAG CAAATCAAGA ACTTGCACAA 1620

CTCGAACTAA TAAGCCGTAT ATGTGGGAGT CCATGTCCTG CAGTGTGGCC TGATGTAATC 1680

AAACTACCAT ATTTCAACAC CATGAAACCA AAGAAGCAAT ATCGTCGAAA GTTAAGAGAA 1740

GAATTTGTTT TTATTCCTGC AGCCGCACTA GACTTATTTG ATTACATGCT CGCCTTGGAT 1800

CCTAGTAAGC GCTGCACTGC AGAACAGGCT CTCCAGTGCG AGTTCCTCCG GGATGTGGAA 1860

CCCTCAAAAA TGCCTCCACC AGACCTTCCT TTATGGCAAG ATTGTCATGA GCTATGGAGT 1920

AAAAAGCGGA GAAGACAGAA GCAGATGGGC ATGACTGATG ACGTGTCCAC TATTAAAGCC 1980

CCCAGAAAGG ACTTGTCCCT TGGCTTAGAT GACAGCAGAA CCAGCACACC TCAGGGCGTG 2040

CTGCCATCTT CACAGCTGAA ACCTCAGGGC AACTCGAACG TAGCACCTGT AAAAACAGGC 2100

CCTGGACAAC AGTTAAACCA CAGTGAATTG GCAATTCTTC TAAACCTACT ACAGTCTAAA 2160

ACAAGTGTTA ATATGGCTGA TTTTGTCCAA GTGTTGAACA TTAAGGTAAA CTCTGAGACT 2220

CAACAGCAGC TAAATAAAAT AAACCTTCCT GCTGGAATTT TGGCAACAGG TGAAAAACAG 2280

ACAGATCCGT CAACACCACA GCAGGAGTCT TCGAAACCAC TGGGAGGAAT TCAGCCTTCT 2340

TCTCAGAGCG TGCAGCCCAA AGTGGAGACT GATGCTGCGC AGGCGGCTGT GCAGAGCGCA 2400

TTTGCAGTTC TGCTGACTCA GTTAATAAAG GCCCAGCAGT CAAAGCAGAA GGATGTGCTA 2460

TTAGAAGAGA GGGAAAACGG ATCAGGACAC GAGGCGTCAC TACAGCTCAG GCCCCCTCCA 2520

GAACCTAGCA CTCCGGCGTC GGGGCAAGAT GACCTCATTC AGCACCAGGA TATGAGGATG 2580

TTGGAGCTCA CGCCGGAACC CGACCGGCCT CGCATTCTGC CTCCGGATCA GCGACCTCCC 2640

GAACCACCTG AACCACCACC AGTCACCGAG GAAGATCTGG ATTATCGGAC AGAAAACCAG 2700

CACGTCCCCA CCACTAGTTC TTCGTTAACT GACCCTCACG CCGGAGTGAA AGCAGCCCTG 2760

TTACAGCTGC TTGCTCAGCA TCAGCCCCAG GATGACCCCA AGAGAGAGAG TGGCATTGAT 2820

TACCAGGCCG GAGACACCTA TGTCCCCGCG TCAGACTACA AGGACAATTT TGGATCTTCT 2880

TTCTCTTCTG CTCCCTACGT CAGCACCGAT GGTCTCGGGG GTAGCTCTGC TCCGCCACTG 2940

GAACGACGCA GCTTCATTGG GAACTCCGAT ATCCAGCCTT TGGAGAACTA CAGTACTACT 3000

TCATCTCATT CTGGCGGTCC ACCTCAGCCT TCTGCCTTTT CCGAGTCATT TCCCAGTTCA 3060

GTAGCTGGAT ACGGAGACAT TTACCTCAAT ACCGGTCCCA TGTTGTTCAG TGGAGACAAG 3120

GACCACAGAT TTGAATACAG CCACGGCCCC ATTGCCGTCC TGGCAAACAG CAGTGACCCT 3180

GCCGCGGGGC CAGAGAGTAC TCATCCTTTG CCAGCAAAGA TGCACAACTA TAACTATGGC 3240

GGGAGCTTGC AGGAGAACCC GGGCGGCCCC GGCCTCATGC ATGGACAGAC CTGGACTTCT 3300

CCGGCCCAAG GACCCGGGTA TTCACAAGGA TACAGGGGAC ACATTAGCAC ATCAACTGGC 3360

AGAGGTCGAG GCAGAGGGTT ACCATAC 3387

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 323   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  382

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 383   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  441

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 442   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  501

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 502   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  561

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 562   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF  615

         *****7777777777******999999************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013