EKS-CAF-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.3	7.0E-111	136	432	297

Status

Unreviewed

Ensembl Protein

ENSCAFP00000037741

UniProt Accession

J9NWT0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000030200	ENSCAFP00000037741	ENSCAFT00000045008

Organism

Canis familiaris

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

MQRDAPPRAP APAPRLPAPP IGAAANSGGG GGGGSGGGGG ASAAPAAPGL PGTTSPRGPG 60

GGRRTEEAGS APRGRKWPWR RKWRGRGGAW STAAGPGAGA AAAAAAGGGG GGALEAAMAK 120

QYDSVECPFC DEVSKYEKLA KIGQGTFGEV FKAKHRKTGK KVALKKVLME NEKEGFPITA 180

LREIKILQLL KHENVVNLIE ICRTKASPYN RCKGSIYLVF DFCEHDLAGL LSNVLVKFTL 240

SEIKKVMQML LNGLYYIHRN KILHRDMKAA NVLITRDGVL KLADFGLARA FSLAKNSQPN 300

RYTNRVVTLW YRPPELLLGE RDYGPPIDLW GAGCIMAEMW TRSPIMQGNT EQHQLALISQ 360

LCGSITPEVW PNVDKYELFE KLDLVKGQKR KVKDRLKAYV RDPYALDLID KLLVLDPAQR 420

IDSDDALNHD FFWSDPMPSD LKGMLSTHLT SMFEYLAPPR RKGSQITQQS TNQSRNPATT 480

NQTEFERVF 489

Nucleotide Sequence
(FASTA)

ATGCAGCGGG ACGCACCGCC CCGAGCCCCA GCCCCGGCGC CCCGGCTCCC CGCGCCCCCG 60

ATCGGGGCAG CCGCCAACAG TGGCGGCGGC GGAGGCGGGG GCAGCGGCGG CGGCGGAGGC 120

GCCTCTGCAG CTCCGGCTGC TCCTGGCCTC CCGGGAACTA CAAGTCCCAG GGGGCCTGGC 180

GGCGGGCGGC GGACGGAAGA GGCGGGGTCG GCGCCGCGAG GCCGGAAGTG GCCGTGGAGG 240

CGGAAGTGGC GCGGCCGCGG AGGGGCCTGG AGCACGGCGG CGGGACCCGG AGCGGGAGCA 300

GCGGCGGCGG CGGCGGCTGG GGGCGGCGGC GGCGGCGCGC TGGAGGCGGC CATGGCAAAG 360

CAGTACGACT CGGTGGAGTG TCCCTTTTGT GATGAGGTGT CCAAATATGA GAAGCTCGCT 420

AAGATCGGCC AAGGCACCTT CGGGGAGGTA TTTAAGGCAA AGCACCGTAA GACCGGCAAA 480

AAGGTGGCTC TGAAGAAAGT GCTGATGGAG AACGAGAAGG AGGGGTTCCC CATTACGGCT 540

TTGCGGGAAA TCAAGATCCT CCAGCTTCTG AAACACGAGA ATGTGGTCAA CTTAATTGAG 600

ATCTGTCGAA CCAAAGCTTC CCCCTATAAC CGCTGCAAAG GCAGTATATA CCTAGTGTTT 660

GACTTCTGCG AGCACGATCT TGCTGGGCTG CTGAGCAATG TCTTGGTCAA GTTCACACTG 720

TCTGAGATCA AGAAGGTCAT GCAGATGTTG CTCAACGGCC TCTACTATAT CCACAGAAAC 780

AAGATCCTGC ACAGGGACAT GAAGGCAGCT AATGTGCTCA TCACTCGCGA TGGGGTTCTG 840

AAGCTGGCCG ACTTTGGGCT GGCCCGGGCC TTCAGCCTGG CCAAGAACAG CCAGCCCAAT 900

CGCTATACCA ACCGTGTGGT GACGCTCTGG TACCGGCCTC CGGAGCTGTT GCTCGGGGAG 960

CGGGACTACG GCCCCCCCAT TGACCTGTGG GGTGCTGGGT GCATCATGGC CGAGATGTGG 1020

ACCCGCAGCC CTATCATGCA GGGCAACACC GAGCAACACC AGCTTGCCCT CATCAGCCAG 1080

CTCTGTGGCT CCATCACCCC TGAGGTATGG CCCAATGTGG ACAAGTATGA GCTCTTTGAG 1140

AAGCTGGACC TGGTGAAGGG CCAGAAACGG AAGGTGAAGG ACAGGCTGAA GGCCTATGTG 1200

CGTGACCCCT ACGCGCTGGA CCTCATCGAC AAGTTGCTGG TGCTGGATCC TGCACAGCGC 1260

ATCGACAGTG ATGACGCCCT CAACCATGAC TTCTTCTGGT CGGACCCCAT GCCCTCGGAT 1320

CTCAAGGGCA TGCTCTCTAC CCACCTGACG TCCATGTTCG AGTATCTGGC GCCGCCACGC 1380

CGGAAGGGCA GTCAAATCAC CCAGCAATCC ACCAACCAGA GCCGCAATCC TGCCACCACC 1440

AACCAGACGG AATTCGAGCG TGTCTTCTGA 1470

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yekl+kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 136   YEKLAKIGQGTFGEVFKAKHRKTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV  195

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++    k++l+e+k+++++ll+gl

Q: 196   VNLIEICRtkaspynRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSEIKKVMQMLLNGL  254

         ********99999988889*********************9.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 255   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPP  314

         *************************************7776555557*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W++gci+ae++tr+p++qg++e++ql  i++l+g+++ +vwp+v

Q: 315   ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD  374

         ************************************************************

S: 230   klpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k++ ++  ++ k +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 375   KYELFEkLDLVKGQKRKVKDRLKAYVRDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  432

         ******7799999999999999887755469*************************98

Domain Sequence
(FASTA)

YEKLAKIGQG TFGEVFKAKH RKTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ASPYNRCKGS IYLVFDFCEH DLAGLLSNVL VKFTLSEIKK VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQPNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGAGCI MAEMWTRSPI MQGNTEQHQL ALISQLCGSI TPEVWPNVDK 240

YELFEKLDLV KGQKRKVKDR LKAYVRDPYA LDLIDKLLVL DPAQRIDSDD ALNHDFF 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013