EKS-CAF-00171
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00171
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb431.01.8E-129416675260
StatusUnreviewed
Ensembl ProteinENSCAFP00000021249
UniProt AccessionF1PH63;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000031793ENSCAFP00000021249ENSCAFT00000022875
OrganismCanis familiaris
Functional Description
Protein Length772
Protein Sequence
(FASTA)
MGDEDEDEGC AVELRITEAN LTGNEEKVSV ENFELLKVLG TGAYGKVFLV RKAVGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVNG 120
GEMFTHLYQR QHFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWAALA ARKVPAPFRP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMMTDVL EASGTGDRPG RAAVARSAMM QDSPFFQQYE LDLREPALGQ 420
GSFSVCRRCR QRQSGQEFAV KILSRRLEAN TQREVAALRL CQSHPNVVKL HDVHHDQLHT 480
YLVLELLRGG ELLEHIRKKR HFSESEASQI LRSLVSAVSF MHEEAGVVHR DLKPENILYA 540
DDTPGAPVKI IDFGFARLRP QSPAGPMQTP CFTLQYAAPE LLAQQGYDES CDLWSLGVIL 600
YMMLSGQVPF QGASGQGGQS QAAEIMCKIR EGRFSLDGEA WQGVSEEAKE LVRGLLTVDP 660
AKRLKLEGLR GSSWLQDGSA RSSPPLRTPD VLESSGPAVR SGLNATFMAF NRGKREGFFL 720
KSVENAPLAK RRKQKLRSAA TSRRVSPAPS AQGRAPAAKG APRRANGPLP PS 772
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA CGAGGGCTGC GCTGTGGAGC TGCGGATCAC CGAAGCCAAC 60
CTGACCGGGA ACGAGGAGAA GGTGAGCGTC GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGAAAAGCAG TCGGGCATGA TGCAGGGAAG 180
CTATATGCCA TGAAGGTGCT GCGCAAGGCA GCGCTGGTAC AGCGTGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC CGTGCTAGAA CTGGTGCGCC AGGCCCCCTT CCTGGTTACG 300
CTGCATTACG CCTTCCAGAC CGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAACGGA 360
GGCGAGATGT TCACCCACCT CTACCAGCGC CAGCACTTCA AAGAGGCCGA AGTGCGCGTG 420
TATGGGGGTG AGATTGTGCT GGCCCTAGAA CACCTGCACA AGCTGGGTAT CATCTATCGA 480
GATCTGAAGC TGGAGAATGT GCTGCTTGAC TCCGAGGGCC ACATCGTACT CACAGACTTT 540
GGGCTTAGCA AGGAGTTCCT GACGGAAGAG AAAGAACGAA CCTTCTCCTT CTGTGGCACT 600
ATCGAGTACA TGGCCCCCGA AATTATCCGC AGCAAGTCGG GTCATGGCAA GGCTGTGGAC 660
TGGTGGAGTC TGGGCATCCT CCTCTTCGAG CTGCTGACGG GGGCCTCGCC CTTCACCCTG 720
GAGGGCGAGA GGAACACGCA GGCAGAGGTC TCCCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCCC GGATCGGGCC CGTGGCACAG GACCTGCTGC AGCGGCTACT TTGCAAGGAC 840
CCCAAGAAGC GACTGGGTGC AGGGCCCCAG GGGGCACAGG AAGTCAAGAA CCACCCCTTC 900
TTCCAGGGTC TGGATTGGGC CGCTCTGGCT GCCAGGAAAG TTCCAGCCCC ATTCCGACCA 960
CAGATCCGCT CGGAGCTGGA TGTAGGCAAC TTTGCAGAGG AATTTACTCG GCTGGAGCCT 1020
GTATACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCCC GCATCTTCCA GGGGTACTCC 1080
TTCGTGGCGC CCTCTATCCT GTTTGATCAT AACAACGCGG TGATGATGAC GGATGTGCTG 1140
GAAGCGTCTG GCACTGGAGA CCGGCCAGGC CGGGCAGCGG TGGCCAGGAG TGCCATGATG 1200
CAGGACTCGC CCTTCTTCCA GCAGTACGAA CTGGACCTGC GGGAGCCCGC GCTGGGCCAG 1260
GGCAGCTTCT CCGTGTGTCG CCGCTGCCGC CAGCGCCAGA GCGGCCAGGA GTTCGCGGTC 1320
AAGATCCTCA GCCGCAGGCT GGAGGCGAAC ACGCAGCGAG AAGTGGCCGC CCTACGTCTT 1380
TGCCAGTCGC ACCCCAACGT GGTGAAGTTG CATGACGTGC ATCACGACCA GCTGCACACG 1440
TATCTGGTGC TGGAGCTGCT GCGGGGCGGG GAGCTGCTGG AGCACATCCG CAAGAAGCGG 1500
CACTTCAGCG AGTCCGAAGC GAGCCAGATT CTGCGCAGCC TCGTGTCGGC CGTGAGCTTC 1560
ATGCACGAGG AGGCGGGCGT GGTGCATCGC GACCTCAAGC CCGAGAACAT TCTGTACGCC 1620
GATGACACGC CCGGAGCCCC CGTGAAGATC ATCGACTTTG GGTTTGCGCG GCTGCGCCCG 1680
CAGAGCCCCG CGGGGCCCAT GCAGACGCCC TGCTTCACGC TGCAGTACGC AGCTCCCGAG 1740
CTGTTGGCGC AGCAGGGCTA CGACGAATCC TGCGACCTCT GGAGCCTCGG CGTCATTCTG 1800
TACATGATGC TGTCGGGGCA GGTCCCCTTC CAGGGGGCCT CAGGCCAGGG CGGGCAGAGC 1860
CAGGCGGCAG AGATAATGTG CAAGATCCGT GAGGGCCGCT TCTCCCTTGA TGGGGAAGCC 1920
TGGCAAGGCG TGTCTGAGGA GGCTAAGGAG CTGGTCCGAG GGCTCCTGAC GGTGGACCCG 1980
GCCAAGAGGC TGAAACTTGA GGGGCTGCGA GGCAGCTCGT GGCTGCAGGA CGGCAGCGCG 2040
CGTTCCTCGC CCCCGCTCCG GACCCCCGAC GTGCTGGAGT CCTCCGGGCC GGCGGTGCGC 2100
TCCGGGCTCA ACGCCACCTT CATGGCCTTC AACCGGGGCA AGCGCGAGGG CTTCTTCCTG 2160
AAGAGCGTGG AGAACGCGCC ACTGGCCAAG CGCCGGAAAC AGAAGCTGCG GAGCGCCGCC 2220
ACCTCCCGCC GCGTCTCCCC CGCGCCCTCC GCCCAGGGCA GGGCCCCCGC CGCCAAGGGA 2280
GCCCCTAGAC GAGCGAACGG CCCCCTGCCG CCCTCCTAG 2319
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l+dv++
Q: 416   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVKLHDVHH  475
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 476   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  535
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 536   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  594
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 595   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  654
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 655   LLTVDPAKRLKLEGLRGSSWL  675
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVKLHDVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013