EKS-CAF-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	509.0	2.7E-153	164	422	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000037800

UniProt Accession

J9JHE0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000031979	ENSCAFP00000037800	ENSCAFT00000046516
ENSCAFG00000031979	ENSCAFP00000035869	ENSCAFT00000044295

Organism

Canis familiaris

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

MCRTLLDPGL RRKTSKDIFE HVPTFQSLPE EILSKLADVL EETHYENGEY IIRQGARGDT 60

FFIISKGTVN VTREDSPSED PVFLRTLGKG DWFGEKALQG EDVRTANVIA AEAVTCLVID 120

RDSFKHLIGG LDDVSNKAYE DAEAKAKYEA EAAFFANLKL SDFNIIDTLG VGGFGRVELV 180

QLKSEESKTF AMKILKKRHI VDTRQQEHIR SEKQIMQGAH SDFIVRLYRT FKDSKYLYML 240

MEVCLGGELW TILRDRGSFE DSTTRFYTAC VVEAFAYLHS KGIIYRDLKP ENLILDHRGY 300

TKLVDFGFAK KIGFGKKTWT FCGTPEYVAP EIILNKGHDI SADYWSLGIL MYELLTGSPP 360

FSGPDPMKTY NIILRGIDMI EFPKKIAKNA ANLIKKLCRD NPSERLGNLK NGVKDIQKHK 420

WFEGFNWEGL RKGTLTPPII PSVASPTDTS NFDSFPEDND EPPPDDNSGW DIDF 474

Nucleotide Sequence
(FASTA)

ATGTGTAGAA CCTTACTGGA TCCTGGTTTG AGAAGAAAAA CCAGTAAAGA CATTTTTGAA 60

CATGTCCCCA CGTTCCAGAG CCTTCCTGAA GAGATCCTGA GTAAGCTTGC TGATGTCCTT 120

GAAGAGACCC ACTATGAGAA TGGGGAATAT ATCATCAGGC AAGGTGCAAG AGGCGACACC 180

TTCTTTATCA TCAGCAAAGG AACGGTGAAT GTCACTCGGG AAGACTCACC CAGTGAAGAC 240

CCGGTCTTTC TTAGAACTTT AGGGAAAGGA GACTGGTTTG GAGAGAAAGC CTTGCAGGGG 300

GAGGATGTGA GGACAGCAAA CGTAATTGCC GCAGAAGCTG TGACCTGCCT TGTCATCGAC 360

AGAGACTCTT TCAAGCATTT GATTGGAGGA CTGGATGATG TTTCCAATAA AGCATATGAA 420

GATGCAGAAG CTAAAGCAAA ATACGAAGCC GAAGCTGCTT TCTTCGCCAA CCTGAAGCTG 480

TCTGACTTCA ACATCATCGA CACCCTCGGC GTCGGAGGCT TCGGACGCGT GGAGCTGGTC 540

CAGTTGAAAA GTGAAGAATC CAAAACCTTT GCTATGAAGA TTCTCAAGAA ACGCCACATC 600

GTAGACACAA GACAGCAGGA GCACATCCGC TCCGAGAAGC AGATCATGCA GGGGGCGCAT 660

TCCGACTTCA TAGTGAGATT GTACAGGACG TTTAAGGACA GCAAATATTT GTACATGTTG 720

ATGGAAGTGT GCCTAGGTGG AGAGCTCTGG ACCATTCTCA GGGATCGAGG TTCATTTGAA 780

GATTCTACGA CCAGATTCTA CACAGCATGC GTGGTGGAGG CGTTCGCCTA TCTGCATTCC 840

AAAGGAATCA TTTACAGGGA CCTCAAGCCA GAGAATCTCA TCCTGGATCA CAGAGGCTAC 900

ACCAAGCTGG TTGATTTTGG CTTTGCAAAG AAAATAGGAT TTGGAAAGAA AACATGGACT 960

TTTTGTGGGA CTCCAGAATA CGTAGCTCCA GAGATCATCC TGAACAAAGG CCATGACATT 1020

TCAGCCGACT ACTGGTCACT GGGAATCCTA ATGTATGAAC TTCTGACTGG CAGCCCACCT 1080

TTCTCAGGCC CAGATCCTAT GAAAACCTAT AACATCATAC TGAGGGGGAT TGACATGATA 1140

GAATTTCCAA AGAAGATTGC CAAAAATGCT GCTAACTTAA TTAAAAAACT CTGCAGGGAT 1200

AACCCATCAG AAAGATTAGG GAATTTGAAA AACGGCGTGA AAGACATTCA GAAGCACAAA 1260

TGGTTTGAGG GCTTTAATTG GGAAGGCTTA AGAAAAGGCA CCTTGACACC TCCTATAATA 1320

CCAAGTGTTG CATCACCCAC AGACACAAGC AATTTCGACA GTTTCCCTGA GGACAATGAT 1380

GAACCGCCAC CTGATGACAA CTCAGGATGG GACATAGACT TCTAA 1425

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 164   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  223

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+e+clggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 224   IVRLYRTFKDSKYLYMLMEVCLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  283

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 284   IYRDLKPENLILDHRGYTKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  343

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 344   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  403

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 404   ERLGNLKNGVKDIQKHKWF  422

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEV CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYTKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013