EKS-CII-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	326.0	1.7E-97	231	526	296

Status

Unreviewed

Ensembl Protein

ENSCINP00000000345

UniProt Accession

F6WF86;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr-iib

Gene Synonyms/Alias

tgfbr-iib;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000000198	ENSCINP00000000345	ENSCINT00000000345

Organism

Ciona intestinalis

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

MKCLILISLL SYLHTGSSIH CRQCSAEIDA NDCNSTSCTI PCSTVDCSCL GLCYTNVILN 60

FSGKHSVQAA CIQQLCPTRA SYLNLYTKRQ IEGYCDVSKG VVTCECASDD CNHMISFEPI 120

TIDDEDIIIE DKYDLSSIIV GVLVGFLLLC LLVAVVWYSV GRYRRLKDEE FESKLTSGSR 180

LSSDDASLID GWDDSGKHSY SAYRYSSSVA TQYSRGSRGN VLNHNDQHLP IELQKIIGKG 240

RFAEVWKANL QQDASPPQVV SVKVFRLHNY GAWRQEKDML TESWMRHENI IEFYASEQHT 300

VRGRLQYWLI TSYYQEKSLA DFLGSNILDW DQFCDMATSI AKGLSYLHAE RDDVGRPKIP 360

IAHRDVKSCN ILVKDGRREC VLADFGLSLK LDPKLSRDEL ANAGQVGTSR YMAPELLERL 420

VNLTDIEMFK RVDVYAMALV LWEMANRCET SEGMASPYKP PFGDKINDRP TKDQMLLLVC 480

KERQLPSIPE KWKKHQGLSE FVDTILNETW EYDAEARITA SCVLERFKVL RHHGDVIGSD 540

GSDVEDKIRV KAKNESNRIS EVISTVV 567

Nucleotide Sequence
(FASTA)

ATGAAGTGTT TAATATTAAT ATCCTTGCTG TCATATTTAC ACACCGGTTC ATCCATACAT 60

TGTCGGCAAT GCAGCGCTGA AATAGATGCC AACGATTGCA ATTCAACATC ATGTACAATA 120

CCTTGTTCCA CCGTTGATTG TAGCTGCCTT GGTCTGTGTT ACACCAACGT TATTCTAAAC 180

TTCTCTGGCA AACACTCCGT ACAGGCGGCT TGTATACAAC AGTTATGTCC AACAAGAGCC 240

AGCTATCTAA ACCTCTACAC TAAGCGTCAG ATAGAGGGGT ATTGTGACGT AAGCAAGGGT 300

GTTGTGACGT GTGAATGTGC CTCAGATGAC TGCAATCACA TGATATCATT TGAACCAATC 360

ACAATCGATG ACGAAGATAT AATAATTGAA GACAAATACG ATTTGTCGTC CATCATCGTT 420

GGTGTCTTGG TAGGATTTCT CCTCCTTTGC CTTCTTGTGG CTGTGGTGTG GTACAGTGTA 480

GGCCGGTATA GAAGGTTAAA AGATGAAGAA TTTGAAAGTA AATTGACATC CGGGAGCAGA 540

CTATCCTCCG ATGATGCGAG TCTTATTGAT GGTTGGGATG ATAGTGGGAA ACATAGTTAC 600

TCAGCTTACA GATATTCATC AAGCGTTGCT ACCCAGTATA GTCGTGGGTC ACGTGGAAAC 660

GTACTCAACC ATAACGACCA ACATTTACCG ATCGAACTTC AAAAAATAAT CGGCAAAGGA 720

AGATTCGCTG AGGTTTGGAA AGCAAATCTA CAACAAGATG CTTCTCCTCC TCAAGTTGTT 780

TCAGTGAAAG TATTTCGTCT CCACAATTAT GGGGCGTGGA GACAAGAGAA AGACATGCTA 840

ACTGAAAGTT GGATGAGACA CGAAAACATC ATTGAATTTT ATGCTTCTGA GCAACACACA 900

GTGCGAGGTC GGTTGCAGTA TTGGCTCATA ACTTCTTACT ATCAAGAGAA AAGTTTAGCT 960

GACTTTTTGG GCTCCAATAT TCTTGACTGG GATCAGTTTT GTGACATGGC AACCTCAATA 1020

GCTAAAGGGT TATCATACCT GCATGCGGAG AGAGATGACG TGGGTCGCCC CAAGATACCA 1080

ATCGCCCACA GAGACGTCAA AAGTTGTAAC ATCCTTGTGA AAGATGGCAG GAGAGAATGC 1140

GTGTTGGCTG ACTTCGGGCT TTCACTCAAG TTGGACCCGA AGTTGAGTCG TGATGAACTT 1200

GCAAACGCTG GCCAGGTTGG AACATCAAGG TACATGGCTC CCGAGTTATT GGAAAGACTG 1260

GTTAACCTCA CAGATATTGA GATGTTTAAG CGAGTGGACG TTTACGCGAT GGCTTTAGTT 1320

TTGTGGGAGA TGGCGAATCG TTGTGAAACT TCAGAAGGCA TGGCGTCTCC GTATAAACCA 1380

CCGTTTGGAG ACAAAATAAA CGACCGACCC ACCAAAGATC AAATGCTGCT TCTTGTGTGC 1440

AAAGAGCGCC AACTACCGAG TATTCCGGAG AAATGGAAAA AGCACCAGGG TCTCTCTGAA 1500

TTCGTTGACA CCATACTGAA CGAAACATGG GAATATGACG CTGAAGCTAG AATCACCGCT 1560

AGTTGTGTGT TGGAGAGATT TAAAGTATTA CGTCATCATG GTGACGTCAT CGGCTCTGAC 1620

GGCAGTGACG TCGAGGATAA GATTCGTGTG AAAGCCAAGA ATGAATCGAA CAGAATATCT 1680

GAAGTTATTT CAACAGTTGT GTGA 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg.....eevAvKifstedeaswkrEkeiyqtvllrheni  55

         ++l+++igkGr++eVwka+l++     + v vK+f  ++  +w++Ek++ ++  +rheni

Q: 231   IELQKIIGKGRFAEVWKANLQQdasppQVVSVKVFRLHNYGAWRQEKDMLTESWMRHENI  290

         6899*****************99999999*******************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         ++f a+++++ + + +++l+t+y+++ sL d+L +++ld+++ + +a+s+a+Gl++LH+e

Q: 291   IEFYASEQHTVRGRLQYWLITSYYQEKSLADFLGSNILDWDQFCDMATSIAKGLSYLHAE  350

         ************************************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkk.dltcciaDlGLalkleeekeeldlaansqvGtk  174

              g+ K  iaHRD+ks Nilvk+  + c++aD+GL+lkl+ + ++ +la+  qvGt

Q: 351   R-DDVGRPKIPIAHRDVKSCNILVKDgRRECVLADFGLSLKLDPKLSRDELANAGQVGTS  409

         5.66699******************83568******************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPE+le  +nl+d+e fkr+DvY+++LvlWE+a Rce++++++ +yk+pf ++++ +

Q: 410   RYMAPELLERLVNLTDIEMFKRVDVYAMALVLWEMANRCETSEGMASPYKPPFGDKINDR  469

         ************************************************************

S: 235   PsleemkevvvekklrPkipeawkkkealkels.klleecWdadpeaRltalrvkkr  290

         P+ ++m  +v+++++ P+ipe+wkk++ l+e+  ++l+e+W+ d+eaR ta++v +r

Q: 470   PTKDQMLLLVCKERQLPSIPEKWKKHQGLSEFVdTILNETWEYDAEARITASCVLER  526

         ***************************99886515789***************9876

Domain Sequence
(FASTA)

IELQKIIGKG RFAEVWKANL QQDASPPQVV SVKVFRLHNY GAWRQEKDML TESWMRHENI 60

IEFYASEQHT VRGRLQYWLI TSYYQEKSLA DFLGSNILDW DQFCDMATSI AKGLSYLHAE 120

RDDVGRPKIP IAHRDVKSCN ILVKDGRREC VLADFGLSLK LDPKLSRDEL ANAGQVGTSR 180

YMAPELLERL VNLTDIEMFK RVDVYAMALV LWEMANRCET SEGMASPYKP PFGDKINDRP 240

TKDQMLLLVC KERQLPSIPE KWKKHQGLSE FVDTILNETW EYDAEARITA SCVLER 296

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004872	; F:receptor activity
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013