EKS-CII-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	366.6	7.4E-110	210	500	291

Status

Unreviewed

Ensembl Protein

ENSCINP00000000633

UniProt Accession

F6WDR9;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr-iia

Gene Synonyms/Alias

tgfbr-iia;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000000348	ENSCINP00000000633	ENSCINT00000000633

Organism

Ciona intestinalis

Functional Description

Protein Length

622

Protein Sequence
(FASTA)

MRQFILFACL FTSVTTQTLK CEHFNKNHAI RSPTDYTCKD SEIDGNGSCN TTELCVKDEE 60

VPGRQPNCFV SWTNESGKVE IIRKGCWSQS KPCLAKCEAV TIKSVFFCCC DNDLCNSHFS 120

LGHINKTIKT NEENPVVVPT NEETWVVLVY TLVPITLLSL LVVLIYWIYR KRKHSYGDID 180

NASVQTPGSG LTTSTQNTQL LIPPEINLPQ LIDIKARGRF GCVWKAQLHD RFVAVKVFFL 240

QDKQSWLNEQ EVFNTELVHY HPHILNFIAA ASRGVGVETE LWLITEFHEY GSLADYLKTH 300

TMSLPVALKF METMATGLSF LHEDIPHKQP HKGHKPAIAH RDFKSKNVLI SNDMTAVIAD 360

FGLAVKFIPG ECTGESHGQV GTRRYMAPEI LEGAINFQRD AFLRIDMYAF ALVMWEIITR 420

CSDVPGGSTP TYMMPYELEL GQHPTLDEMQ ACVIDQKTRP VVNDLWRQDE VVGILCETME 480

ECWDHDAEAR LSAGCVEERI NHLHRRIQPP NELAVHPNMI NNDVIRNGAP VIGNGAPVIG 540

NGAPVIGNGT SMIGNGTHVI IPPSPTSDTD IQNQINNRKN QELPVNSNEK LTNEVNAAGL 600

VATVTCDAET ALLSAGDRES NV 622

Nucleotide Sequence
(FASTA)

ATGCGGCAGT TTATCTTGTT TGCGTGCTTG TTTACATCGG TTACTACACA GACATTAAAA 60

TGTGAACACT TTAACAAAAA TCATGCTATT CGTTCTCCTA CCGACTATAC ATGTAAAGAT 120

TCAGAGATTG ATGGAAATGG ATCCTGCAAT ACCACAGAGT TATGTGTTAA GGATGAAGAA 180

GTTCCAGGGA GGCAACCAAA CTGTTTCGTT TCATGGACAA ATGAATCTGG GAAAGTAGAA 240

ATAATACGAA AGGGTTGCTG GAGCCAAAGT AAACCATGTT TAGCAAAGTG TGAAGCCGTA 300

ACAATTAAAA GTGTTTTCTT CTGTTGCTGT GACAATGATT TATGCAACTC TCATTTCTCC 360

CTTGGTCATA TTAACAAAAC AATTAAAACA AATGAAGAAA ATCCTGTTGT CGTCCCAACG 420

AATGAAGAGA CCTGGGTAGT ATTGGTGTAT ACACTGGTAC CTATTACTCT GCTCAGTCTA 480

CTGGTGGTTC TTATATATTG GATTTACAGG AAAAGAAAAC ATAGTTATGG TGACATCGAC 540

AATGCAAGTG TGCAAACTCC AGGTTCAGGT TTAACCACTT CAACACAAAA CACCCAACTG 600

CTTATTCCAC CTGAGATCAA CTTGCCCCAG TTAATCGACA TCAAAGCACG AGGAAGGTTC 660

GGTTGTGTTT GGAAAGCTCA ACTACACGAC AGATTTGTTG CAGTCAAAGT CTTTTTTCTA 720

CAAGATAAGC AGTCATGGCT TAATGAACAA GAAGTTTTTA ACACAGAGCT GGTTCACTAT 780

CATCCGCATA TATTAAACTT TATCGCTGCT GCCAGCAGGG GTGTTGGGGT CGAAACTGAA 840

CTATGGTTGA TCACAGAGTT TCATGAATAT GGGTCATTGG CTGATTATTT GAAGACGCAC 900

ACGATGTCAC TTCCTGTGGC TCTCAAGTTC ATGGAAACCA TGGCAACAGG GCTGTCTTTT 960

CTACATGAAG ATATTCCACA CAAGCAACCA CACAAAGGAC ACAAGCCTGC AATTGCTCAT 1020

CGTGACTTTA AAAGCAAGAA TGTTCTCATC AGTAACGACA TGACGGCTGT TATCGCTGAT 1080

TTTGGACTCG CTGTCAAGTT CATACCAGGC GAATGCACGG GGGAAAGCCA TGGACAGGTT 1140

GGAACGCGAA GATACATGGC TCCTGAGATC CTGGAGGGAG CGATTAACTT CCAACGCGAT 1200

GCTTTCCTAC GTATTGATAT GTATGCATTC GCTCTTGTTA TGTGGGAAAT CATAACAAGA 1260

TGTTCAGATG TACCAGGAGG TTCTACACCT ACATATATGA TGCCGTATGA GTTGGAACTT 1320

GGACAACACC CAACACTTGA TGAAATGCAA GCTTGTGTGA TCGACCAGAA GACACGACCC 1380

GTAGTTAACG ACCTCTGGAG ACAAGATGAG GTCGTTGGGA TCTTGTGTGA GACCATGGAG 1440

GAATGTTGGG ATCACGATGC GGAGGCGAGA TTATCGGCAG GATGTGTGGA GGAGAGGATC 1500

AACCATCTTC ATCGAAGAAT TCAACCTCCT AATGAACTTG CCGTGCATCC CAACATGATC 1560

AATAATGATG TGATCAGGAA CGGAGCTCCC GTGATTGGAA ACGGAGCTCC TGTGATTGGA 1620

AATGGGGCTC CTGTGATTGG AAACGGGACT TCAATGATTG GAAACGGGAC TCACGTGATC 1680

ATTCCTCCAT CTCCAACATC TGACACCGAT ATTCAGAATC AAATTAACAA CAGAAAGAAC 1740

CAAGAGCTTC CTGTTAACAG TAATGAAAAA CTCACAAATG AAGTTAACGC TGCTGGGTTG 1800

GTTGCCACGG TAACATGTGA TGCTGAAACT GCCTTGTTGT CAGCAGGTGA CAGGGAATCA 1860

AATGTTTGA 1869

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllr.henilqfia  60

         +l+++ ++Gr+g+Vwka+l+++ vAvK+f+ +d++sw +E+e+++t l++ h++il+fia

Q: 210   QLIDIKARGRFGCVWKAQLHDRFVAVKVFFLQDKQSWLNEQEVFNTELVHyHPHILNFIA  269

         578999****************************************998769********

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a ++  +++tel+l+te+he gsL dyLk++t+++  +l++++++a+Gl++LHe+i+ ++

Q: 270   AASRGVGVETELWLITEFHEYGSLADYLKTHTMSLPVALKFMETMATGLSFLHEDIPHKQ  329

         ********************************************************8776

S: 121   g..kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYma  178

             +KpaiaHRD+kskN+l+ +d+t++iaD+GLa+k+   + + +  ++ qvGt+RYma

Q: 330   PhkGHKPAIAHRDFKSKNVLISNDMTAVIADFGLAVKFIPGECTGE--SHGQVGTRRYMA  387

         53579***********************************999666..8***********

S: 179   PEvleealnlkdfeafkraDvYslgLvlWEvasRcee.vdeeveeyklpfeevvgsdPsl  237

         PE+le+a+n+++ +af r+D+Y+++Lv+WE+++Rc++ ++++++ y++p+e ++g++P+l

Q: 388   PEILEGAINFQR-DAFLRIDMYAFALVMWEIITRCSDvPGGSTPTYMMPYELELGQHPTL  446

         ***********9.9***********************99*********************

S: 238   eemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +em+++v+++k+rP +++ w+++e++  l++++eecWd+d+eaRl+a +v++r+

Q: 447   DEMQACVIDQKTRPVVNDLWRQDEVVGILCETMEECWDHDAEARLSAGCVEERI  500

         ***************************************************985

Domain Sequence
(FASTA)

QLIDIKARGR FGCVWKAQLH DRFVAVKVFF LQDKQSWLNE QEVFNTELVH YHPHILNFIA 60

AASRGVGVET ELWLITEFHE YGSLADYLKT HTMSLPVALK FMETMATGLS FLHEDIPHKQ 120

PHKGHKPAIA HRDFKSKNVL ISNDMTAVIA DFGLAVKFIP GECTGESHGQ VGTRRYMAPE 180

ILEGAINFQR DAFLRIDMYA FALVMWEIIT RCSDVPGGST PTYMMPYELE LGQHPTLDEM 240

QACVIDQKTR PVVNDLWRQD EVVGILCETM EECWDHDAEA RLSAGCVEER I 291

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013