EKS-CII-00235

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00235

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	315.8	1.8E-94	479	753	275

Status

Unreviewed

Ensembl Protein

ENSCINP00000026874

UniProt Accession

F6U7K8;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000000360	ENSCINP00000026874	ENSCINT00000027120

Organism

Ciona intestinalis

Functional Description

Protein Length

757

Protein Sequence
(FASTA)

TGTQLRCVAE GAQPISIRWQ KNGRGLSSLN HITQWNTEKN SQTLLSTLQF QSLTRHDAAS 60

YTCVATDRLS RTVVSHAASV TILGPPVIIQ GPTDIHSTLH NSSINIPCVA EGPPDITSVT 120

WDYTMFANDG TPVHSGEFET NQQYLPKLPA VNIAINHSVT QYDISCTANN SRGSVTSSVA 180

TVYVVRVPAT PLIMSVILGS STAEIQWMVD YSDVQVCIVR VIEDRNTLFA STEVPAPYNV 240

FTVRNLDATQ QYTARVKCHN YIGYSEWSEP YTFSPATNLI PPQNVSVHFR PNITYVTWRV 300

SPNPVKGQLT GYKLELYDPS TPDVFLLQIG INSAVVNISL PSHGSHDITS YTATLTTNSL 360

LNIKTPYTSS RNIIMLSATS SPIANVKDDA TIIIIAVVVS LAIIVIILAA AFRHFYRKRL 420

TKQSVTANPN VTYGPVATGN TLRSENAYYT SMSSTGSISI VQQLEELVQD VLIENKRLKL 480

GKILGEGEFG FVYKATISAD ANSNNNSNQT ATVQGHVAVK SIKVTGHTYT EVEGFVKEGL 540

RMKDLDHPNV MALIGIAFTA EDLNKPASPL VVLPYMPNGD LRSYLFSMRT AGLSEKFTVQ 600

KLLLFALDVA KGMQYLSNRN FIHRDLAARN CMLDENYKVV VSDFGLSRTV YSESYYRQTH 660

ISKMPVKWMA LESLADNIFT PLSDVWSFGV TVWEILTMGQ SPYPGVGNHE VYQLLRNGTR 720

LNKPEHCPSK VWFSVVFPCW TVQVKDRITF DKLVEVL 757

Nucleotide Sequence
(FASTA)

ACTGGTACCC AACTTAGATG TGTAGCTGAA GGTGCACAGC CTATATCTAT AAGATGGCAG 60

AAGAATGGAC GTGGTTTATC TTCATTAAAC CATATTACTC AGTGGAACAC AGAAAAAAAC 120

AGCCAAACTT TATTAAGTAC TTTACAATTT CAAAGCTTAA CCAGACATGA CGCGGCAAGT 180

TATACTTGTG TGGCAACTGA TAGGTTAAGT AGAACTGTGG TATCGCACGC TGCAAGCGTT 240

ACCATACTAG GGCCCCCTGT TATTATTCAA GGGCCTACAG ATATCCATTC AACTTTGCAT 300

AATTCATCCA TTAATATCCC ATGTGTTGCT GAAGGACCTC CAGATATTAC ATCGGTTACT 360

TGGGACTACA CCATGTTTGC GAATGATGGG ACACCAGTAC ACAGTGGTGA GTTCGAAACA 420

AACCAACAAT ACCTACCAAA ACTTCCTGCG GTAAATATTG CAATAAACCA TAGTGTGACG 480

CAATATGATA TTTCATGTAC TGCCAATAAT TCCCGCGGCT CAGTTACATC AAGCGTGGCT 540

ACAGTGTATG TTGTAAGGGT GCCAGCCACT CCACTTATTA TGAGCGTAAT TTTAGGAAGT 600

TCTACAGCAG AAATCCAATG GATGGTCGAT TATTCTGACG TACAAGTTTG CATTGTTCGA 660

GTTATTGAAG ACAGAAATAC TTTATTTGCA TCAACTGAAG TACCTGCTCC ATATAATGTG 720

TTTACTGTTA GAAACCTGGA TGCAACACAG CAGTATACAG CACGAGTTAA ATGTCACAAC 780

TATATCGGGT ATTCAGAATG GAGTGAACCG TATACTTTCT CACCCGCAAC AAACTTAATA 840

CCTCCACAAA ATGTTTCAGT CCATTTTCGT CCAAATATAA CCTATGTAAC CTGGCGTGTA 900

TCGCCCAATC CAGTTAAAGG ACAATTAACA GGTTATAAAT TGGAACTTTA TGATCCAAGC 960

ACCCCGGACG TATTTCTACT TCAAATTGGA ATAAATTCTG CCGTAGTCAA CATATCCTTA 1020

CCTTCGCATG GAAGTCATGA CATTACAAGT TACACTGCAA CACTTACAAC CAACAGCCTG 1080

CTGAACATTA AGACTCCTTA CACATCAAGT CGAAACATCA TTATGCTTTC AGCTACAAGT 1140

AGTCCCATAG CAAATGTCAA AGATGATGCA ACCATTATCA TAATAGCTGT TGTTGTATCA 1200

CTTGCCATAA TTGTAATAAT TTTGGCGGCC GCGTTTCGGC ATTTTTATAG AAAAAGGTTA 1260

ACAAAACAAA GTGTGACAGC TAATCCTAAT GTCACTTATG GACCAGTGGC CACTGGTAAT 1320

ACCCTGCGTT CAGAGAATGC TTATTACACA TCCATGTCTT CAACTGGATC TATTTCTATT 1380

GTACAACAGT TGGAAGAATT GGTGCAGGAT GTTTTGATCG AAAACAAACG ACTAAAACTT 1440

GGTAAAATAT TAGGGGAGGG TGAATTTGGA TTTGTGTACA AAGCTACAAT AAGTGCTGAT 1500

GCTAATAGCA ACAATAACAG CAACCAGACT GCAACAGTAC AGGGTCATGT TGCTGTGAAA 1560

TCAATTAAAG TAACTGGGCA CACTTATACA GAAGTGGAGG GATTCGTAAA AGAAGGTCTT 1620

CGCATGAAAG ATTTGGACCA CCCTAATGTT ATGGCCTTGA TTGGAATCGC TTTCACAGCG 1680

GAAGATTTAA ATAAACCTGC GTCCCCATTA GTTGTCTTAC CATACATGCC AAATGGTGAT 1740

TTACGTTCCT ATCTGTTTTC AATGCGAACG GCGGGTTTGT CCGAGAAATT TACGGTTCAA 1800

AAGTTGCTTT TATTCGCATT GGATGTAGCA AAAGGAATGC AGTACCTTTC TAATAGAAAT 1860

TTCATTCATC GAGATTTAGC TGCAAGAAAT TGTATGCTGG ATGAGAATTA CAAAGTTGTT 1920

GTTTCAGATT TCGGTCTTTC ACGGACTGTA TATTCGGAAA GTTATTACAG ACAAACACAC 1980

ATCTCAAAAA TGCCAGTTAA ATGGATGGCT TTGGAAAGCT TGGCTGATAA TATATTTACC 2040

CCTTTGTCTG ATGTTTGGTC CTTTGGTGTC ACTGTTTGGG AAATACTTAC AATGGGTCAA 2100

AGCCCATATC CTGGCGTTGG TAACCACGAG GTATATCAAC TTTTACGAAA CGGAACTCGG 2160

CTTAATAAAC CCGAGCACTG CCCTTCCAAA GTTTGGTTCA GCGTCGTTTT CCCGTGCTGG 2220

ACTGTACAGG TGAAAGATCG GATTACTTTT GATAAACTTG TTGAAGTTTT G 2271

Domain Profile

S: 2     vlgkvlgegefgsvmegqlkqedgs....il......kvavktlkldiiarseieeflse  51

          lgk+lgegefg v ++ +  +  s     +      +vavk +k+   + +e+e f++e

Q: 479   KLGKILGEGEFGFVYKATISADANSnnnsNQtatvqgHVAVKSIKVTGHTYTEVEGFVKE  538

         79**********998876644332211111111122379*********************

S: 52    aacmkefdhpnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylp  111

            mk++dhpnv+ l+g+++ +++ ++   p+v+lp+m  gdl ++l+  r      ++

Q: 539   GLRMKDLDHPNVMALIGIAFTAEDLNKPASPLVVLPYMPNGDLRSYLFSMRTAGLSEKFT  598

         **************************999*******************************

S: 112   lqtlvkfmvdiasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrq  171

         +q l+ f +d+a+gm+yls+rnfihrdlaarncml+e+  v+v+dfgls+ +ys  yyrq

Q: 599   VQKLLLFALDVAKGMQYLSNRNFIHRDLAARNCMLDENYKVVVSDFGLSRTVYSESYYRQ  658

         ************************************************************

S: 172   griaklpvkwiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqg  231

           i+k+pvkw+a+eslad+++t  sdvw+fgvt+wei t gq+py+gv n+e+y+ l++g

Q: 659   THISKMPVKWMALESLADNIFTPLSDVWSFGVTVWEILTMGQSPYPGVGNHEVYQLLRNG  718

         ************************************************************

S: 232   nrlkqpedcldel.ydlmyrcweadpkdrpsfsvl  265

          rl++pe+c  ++ +++++ cw+++ kdr +f +l

Q: 719   TRLNKPEHCPSKVwFSVVFPCWTVQVKDRITFDKL  753

         *********99984699***************877

Domain Sequence
(FASTA)

KLGKILGEGE FGFVYKATIS ADANSNNNSN QTATVQGHVA VKSIKVTGHT YTEVEGFVKE 60

GLRMKDLDHP NVMALIGIAF TAEDLNKPAS PLVVLPYMPN GDLRSYLFSM RTAGLSEKFT 120

VQKLLLFALD VAKGMQYLSN RNFIHRDLAA RNCMLDENYK VVVSDFGLSR TVYSESYYRQ 180

THISKMPVKW MALESLADNI FTPLSDVWSF GVTVWEILTM GQSPYPGVGN HEVYQLLRNG 240

TRLNKPEHCP SKVWFSVVFP CWTVQVKDRI TFDKL 275

Keyword

Complete proteome; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013