EKS-CII-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	377.9	1.9E-113	379	655	277

Status

Unreviewed

Ensembl Protein

ENSCINP00000001598

UniProt Accession

F6QQF5;

Protein Name

Protein Synonyms/Alias

Gene Name

fgfr

Gene Synonyms/Alias

fgfr;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000000875	ENSCINP00000001598	ENSCINT00000001598

Organism

Ciona intestinalis

Functional Description

Protein Length

665

Protein Sequence
(FASTA)

MIQLQNTFIF VALTIFTSAS TTSLKNETKP LNTISTLAAQ TNISNPEEDL FDTNGAPKSD 60

TVNASTTTDR HKIPRWVNEQ KMQKRLHAEP AGNTVQFRCA VQGARPITVD WYKDGEPIKK 120

NGRLGGYKFR QRNQQISLES VIMSDRAKYM CVAHNKYGSI NHTYELDVVA RIPIPPVLSA 180

DGMKNQTVKV GSTVTFRCRI VYSDAHPHVE WLKYNVNVTV LKRAGINTTD AEMEKLTLKN 240

VSFADAGEYT CLAGNSIGVS HVSAWLTVLP VVDENDVWTE EIPQDTHYLI YIFGVVCFII 300

LLAFIVYMCN SRYQNKDPPR LIPIENPDNI PPMSKMEEPV MLFGNEQAWR RMCLPHADHI 360

EINIQPDLQW ELKREDILLH ERIDEGFFGQ VFRADLIRCA GGRKEKVDAA VKMLKSETEK 420

DMLDLLTEMD QMKRVGKHKN IVNLLGVCTQ NGILWLVTEY AQKGNLRDYL RRNRPSELQY 480

ELSTPDSPAP PRDEPLTLRA LMSASHQVAR GMEYLSQKKC IHRDLAARNV LVANDFVMKI 540

ADFGLARDIR SNDYYRKETR GHLPYKWMAL EAMTDNMFTH ATDVWSFGIL LWEIFSLGGS 600

PYPGVKTHDL VRFLRNGDRL EQPQFASSEL YRLMRDCWEE SPRRRPQFRQ LVEDLDRMLA 660

SSSSL 665

Nucleotide Sequence
(FASTA)

ATGATACAAC TACAAAATAC GTTTATTTTT GTCGCTTTGA CAATTTTTAC TTCTGCTTCA 60

ACAACAAGCT TAAAGAATGA AACCAAACCC CTCAACACAA TTTCAACGCT AGCTGCTCAA 120

ACAAACATTT CAAACCCAGA AGAAGATTTG TTCGATACAA ACGGAGCACC AAAAAGTGAT 180

ACTGTGAATG CATCTACAAC TACGGATCGT CACAAGATTC CACGCTGGGT CAATGAACAG 240

AAGATGCAAA AGCGACTTCA CGCTGAACCA GCAGGTAACA CTGTCCAGTT TAGATGTGCA 300

GTTCAAGGTG CAAGACCAAT CACCGTGGAT TGGTATAAAG ATGGGGAACC AATCAAGAAG 360

AATGGAAGAC TGGGGGGATA CAAGTTCCGT CAACGCAACC AGCAAATATC ATTGGAGTCG 420

GTGATAATGT CCGACCGTGC TAAGTACATG TGTGTGGCCC ATAATAAGTA CGGCTCCATC 480

AACCATACTT ACGAACTGGA TGTAGTAGCG CGGATCCCCA TTCCCCCTGT GTTGTCAGCC 540

GATGGAATGA AGAATCAAAC TGTTAAAGTT GGTTCCACTG TCACTTTTCG GTGCCGAATA 600

GTCTACAGCG ACGCACACCC CCACGTAGAG TGGCTTAAAT ATAACGTCAA CGTCACTGTG 660

TTGAAGAGAG CTGGTATTAA CACTACTGAC GCGGAGATGG AAAAGTTAAC ATTGAAAAAC 720

GTTTCATTTG CCGACGCTGG GGAATATACT TGTCTTGCTG GAAATTCTAT CGGGGTGTCT 780

CATGTTTCTG CATGGCTCAC AGTGCTGCCA GTTGTAGATG AGAATGATGT ATGGACCGAA 840

GAAATCCCAC AAGACACTCA TTATCTCATA TATATCTTTG GGGTTGTGTG CTTCATAATA 900

CTACTTGCGT TCATTGTGTA TATGTGCAAC TCTCGCTATC AAAATAAAGA TCCTCCCCGT 960

TTGATCCCGA TCGAGAACCC CGACAACATC CCCCCCATGT CGAAGATGGA GGAGCCGGTG 1020

ATGTTGTTCG GGAACGAACA AGCTTGGAGG AGGATGTGTC TTCCTCATGC TGATCATATC 1080

GAGATCAACA TCCAACCTGA TCTACAGTGG GAACTGAAGA GGGAAGACAT CCTCCTCCAT 1140

GAGCGAATCG ACGAAGGCTT CTTTGGCCAA GTATTCCGTG CAGATCTTAT AAGATGCGCT 1200

GGTGGAAGGA AGGAAAAAGT TGACGCTGCT GTCAAGATGT TGAAGAGTGA GACAGAAAAA 1260

GACATGTTAG ATTTGCTAAC AGAGATGGAC CAAATGAAAA GGGTTGGGAA ACATAAGAAT 1320

ATCGTCAACC TGCTTGGTGT TTGTACACAG AACGGTATTT TATGGCTGGT GACAGAATAT 1380

GCTCAGAAAG GAAACTTGAG AGACTACTTG CGACGCAACC GACCGAGCGA GCTACAATAC 1440

GAACTCAGCA CCCCTGACTC TCCGGCCCCA CCTCGTGACG AACCACTAAC ATTGAGAGCG 1500

CTGATGTCAG CCTCCCACCA AGTGGCTCGG GGAATGGAAT ATTTATCACA AAAGAAGTGC 1560

ATTCATCGGG ACTTGGCGGC AAGAAACGTT CTTGTTGCGA ATGATTTTGT CATGAAGATT 1620

GCTGACTTTG GTTTGGCAAG AGATATTCGA TCCAATGATT ATTACAGGAA GGAAACCAGG 1680

GGTCACCTTC CATACAAATG GATGGCTTTG GAAGCAATGA CCGACAACAT GTTCACGCAC 1740

GCCACAGATG TATGGTCATT CGGGATTCTA CTTTGGGAGA TTTTCTCCTT AGGTGGTTCC 1800

CCCTACCCCG GGGTGAAGAC CCACGACCTT GTAAGGTTCC TCCGAAACGG GGACCGACTC 1860

GAACAGCCCC AGTTTGCTTC CTCGGAGCTT TATCGATTGA TGCGCGACTG TTGGGAGGAA 1920

TCGCCACGGA GACGACCCCA GTTCCGACAA CTTGTCGAGG ATTTGGATCG AATGCTGGCG 1980

AGTTCTTCAT CTCTG 1995

Domain Profile

S: 3     lgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkliG  62

         l + + eG fGqv++a+ i     + k++v  avkmlk++ t+kd+ dl++em+ +k +G

Q: 379   LHERIDEGFFGQVFRADLIRCAGGR-KEKVDAAVKMLKSE-TEKDMLDLLTEMDQMKRVG  436

         667889************9887766.567899*****976.89*****************

S: 63    khkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask....dkskaseeql  118

         khkni+nllG+ctq+G l+++ eya+kGnlr++lr++rp++ +++      ++   +e l

Q: 437   KHKNIVNLLGVCTQNGILWLVTEYAQKGNLRDYLRRNRPSELQYELstpdSPAPPRDEPL  496

         *******************************************9985552223334679*

S: 119   tekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyyk  178

         t + l+s ++qvarGmeyl+ kkcihrdlaarnvlv++d v+kiadfGlard++++dyy+

Q: 497   TLRALMSASHQVARGMEYLSQKKCIHRDLAARNVLVANDFVMKIADFGLARDIRSNDYYR  556

         ************************************************************

S: 179   kttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllke  238

         k+t G lp kwma+ea++d+++t+ +dvwsfG+llwei++lGgspypg+  ++l ++l++

Q: 557   KETRGHLPYKWMALEAMTDNMFTHATDVWSFGILLWEIFSLGGSPYPGVKTHDLVRFLRN  616

         ************************************************************

S: 239   Ghrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         G r+e+p+  ++ely lmr+cw++++  rp f+qlvedl

Q: 617   GDRLEQPQFASSELYRLMRDCWEESPRRRPQFRQLVEDL  655

         *************************************97

Domain Sequence
(FASTA)

LHERIDEGFF GQVFRADLIR CAGGRKEKVD AAVKMLKSET EKDMLDLLTE MDQMKRVGKH 60

KNIVNLLGVC TQNGILWLVT EYAQKGNLRD YLRRNRPSEL QYELSTPDSP APPRDEPLTL 120

RALMSASHQV ARGMEYLSQK KCIHRDLAAR NVLVANDFVM KIADFGLARD IRSNDYYRKE 180

TRGHLPYKWM ALEAMTDNMF THATDVWSFG ILLWEIFSLG GSPYPGVKTH DLVRFLRNGD 240

RLEQPQFASS ELYRLMRDCW EESPRRRPQF RQLVEDL 277

Keyword

Complete proteome; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013