EKS-CII-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CII-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR416.43.4E-125124383260
StatusUnreviewed
Ensembl ProteinENSCINP00000002343
UniProt AccessionF6SZ23;
Protein Name
Protein Synonyms/Alias
Gene Nameegfr2
Gene Synonyms/Alias egfr2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCING00000001202ENSCINP00000002343ENSCINT00000002343
OrganismCiona intestinalis
Functional Description
Protein Length880
Protein Sequence
(FASTA)
SSSTLILERQ TCMPCYEGCN NCTGVAREDC LHALSSSQEF TAAIVVPVAV VVCALLFSIF 60
FGCRYRRKQI QKKRTQSMRK LGIDPHSPEE QNMDPRVRLM EPMTPSGVAP NQAQLRIVKE 120
AELRIGKILG SGAFGTVHKG YWIPDLAPRE RVKVPVAIKV LRDESSQVAS NEILDEAFVM 180
ASCEHPNLVR LLGISLSQRI MLITQLMPLG NLLEYVRDNK DNIGSQHLLN WSLQIAKGMK 240
YLSEEKHLVH RDLAARNVLV KSPNHVRITD FGLAKLLDVK EDVYRAEGGK MPIKWLALES 300
IQHRIFTQKS DVWSFGVTMW ELMTFGKKPY ESVPAREVHT LLERGERLPQ PYICTIDIYM 360
LLIKCWTVDA EARPTFKELT EELSKLARDP QRYLVIDNDG LLTDLPSPTT SEFLRSLVND 420
EGDDFPITDA EEYLHPQPLE GTENPLNSNQ FSLQPVPTMV PWKRQHHQQH LSSTSSQQGL 480
LGSRGSGSGR FVHPNRSADR RLDSVMTTMT NLSSVSGSLP NGASTPFSPV AMGLNPEDDD 540
DREVVLGATG DSLQGPIIHY NALAAPDNFR SFSESSDAVF APSPLIKHDR GYRTNRMDEG 600
CSTPEQQSRY LRAREDSTTM RYSAEPVSLM RQQTKPNEYL DPSEFPPSPF ALKPPVNIFD 660
SVRTPTSALA NPEYEPSFVP SVLDCESGTA GNTQDTFDED DREYQNIVPN GVTVIPDQHQ 720
LQIGLRRGSQ SEESVNSEKR DSGLQTDEED DKKALDVKAT SVANPEYDYL GDVTSGGSEN 780
PGSPGNNQNS PPSPNFVPNE TEYINDSVAP KSGPNHQNGF AEDEIFSALT LADPKMRERV 840
LYGKNSAGRT YSEPDSGVGI EVAMDNILYH KLGPNWDTTE 880
Nucleotide Sequence
(FASTA)
AGTAGTAGTA CACTCATTTT AGAAAGACAG ACATGTATGC CTTGTTACGA AGGATGCAAT 60
AACTGTACAG GAGTCGCAAG AGAAGATTGT TTACATGCGT TAAGTTCTAG CCAGGAGTTC 120
ACAGCAGCTA TTGTGGTTCC AGTAGCAGTT GTCGTTTGCG CTCTTCTCTT CAGCATCTTT 180
TTTGGCTGTA GATACAGAAG AAAACAGATT CAAAAGAAGA GAACGCAGTC GATGCGAAAA 240
CTAGGAATAG ACCCGCATTC ACCAGAAGAG CAAAACATGG ACCCGCGGGT AAGACTTATG 300
GAACCCATGA CACCAAGTGG GGTAGCACCC AACCAAGCCC AGCTTAGGAT TGTAAAGGAA 360
GCAGAATTGA GAATTGGAAA AATCTTGGGT TCTGGTGCAT TTGGGACTGT ACATAAAGGA 420
TATTGGATAC CAGATTTAGC ACCAAGGGAA CGGGTTAAAG TTCCCGTTGC AATAAAAGTT 480
TTACGGGATG AGTCGTCGCA AGTTGCCAGT AACGAAATTT TAGACGAGGC TTTCGTGATG 540
GCTTCATGTG AGCACCCGAA TCTTGTTCGG TTACTCGGGA TCAGTTTATC TCAGCGTATA 600
ATGCTTATAA CACAACTAAT GCCGCTTGGA AATCTACTGG AATACGTGCG TGATAATAAG 660
GACAATATCG GTTCCCAGCA TTTACTAAAC TGGAGTTTAC AAATTGCGAA GGGCATGAAA 720
TATCTATCTG AAGAAAAACA TCTCGTTCAT AGAGATTTGG CTGCCAGAAA TGTGCTTGTA 780
AAGTCGCCGA ATCATGTCAG AATAACAGAT TTTGGTCTCG CTAAGTTATT AGATGTAAAA 840
GAAGACGTTT ACAGAGCTGA AGGCGGCAAA ATGCCAATTA AATGGTTAGC TTTGGAATCT 900
ATACAGCATC GAATTTTCAC ACAAAAAAGC GACGTTTGGA GTTTTGGGGT TACAATGTGG 960
GAATTAATGA CGTTTGGGAA AAAACCTTAC GAGAGTGTAC CTGCTCGTGA AGTGCATACA 1020
TTACTTGAAC GAGGAGAAAG GTTACCACAA CCATATATAT GCACAATTGA CATATATATG 1080
CTGCTTATAA AATGTTGGAC GGTTGACGCC GAAGCGCGCC CTACATTTAA GGAGCTAACA 1140
GAAGAACTTT CTAAGCTGGC TAGAGACCCT CAGCGGTATT TGGTCATTGA TAACGACGGA 1200
CTTCTAACGG ATCTTCCGAG TCCGACAACT TCCGAGTTTC TTCGATCTCT CGTAAATGAT 1260
GAGGGAGACG ACTTCCCCAT TACAGATGCA GAGGAGTACC TGCATCCACA GCCGCTAGAG 1320
GGCACTGAAA ACCCGTTAAA TTCGAACCAA TTTTCTCTAC AACCCGTTCC TACTATGGTA 1380
CCATGGAAGA GACAGCACCA TCAGCAGCAT CTTTCCTCCA CTTCCTCCCA ACAGGGACTT 1440
CTTGGGAGCA GGGGAAGCGG AAGCGGACGC TTCGTTCACC CAAACAGATC CGCAGACAGA 1500
CGTTTAGATT CAGTTATGAC GACAATGACG AATCTGTCAA GCGTTAGTGG TTCGTTACCT 1560
AATGGGGCAA GTACCCCTTT CTCGCCAGTG GCTATGGGGC TTAACCCTGA AGATGACGAC 1620
GACAGAGAAG TTGTTTTGGG GGCCACGGGT GACTCCCTTC AGGGCCCTAT AATACACTAC 1680
AATGCACTAG CCGCTCCTGA CAATTTCCGG TCATTCAGTG AGTCTTCCGA CGCAGTTTTT 1740
GCGCCGTCAC CGCTGATAAA ACACGACCGT GGCTACAGAA CTAACAGGAT GGACGAAGGC 1800
TGCTCTACAC CAGAACAGCA ATCGCGCTAC TTACGAGCGA GAGAAGACAG CACAACGATG 1860
CGTTACAGCG CTGAACCAGT GTCTTTAATG CGACAACAGA CAAAACCCAA CGAATACCTT 1920
GATCCAAGTG AGTTCCCACC ATCCCCATTT GCTCTTAAAC CCCCAGTAAA CATATTTGAC 1980
AGCGTACGAA CACCTACTTC CGCACTGGCT AATCCAGAAT ACGAACCAAG TTTTGTCCCA 2040
TCAGTTTTAG ACTGCGAGTC TGGAACAGCT GGCAACACAC AAGATACGTT TGATGAGGAC 2100
GACAGAGAGT ACCAAAATAT CGTTCCGAAC GGAGTTACAG TAATACCCGA CCAGCACCAG 2160
CTGCAAATCG GCCTCCGTCG AGGTTCTCAA AGCGAAGAGA GTGTAAACTC AGAAAAACGA 2220
GACTCCGGAC TCCAAACGGA CGAAGAAGAT GATAAAAAGG CCCTCGATGT AAAAGCCACC 2280
TCCGTCGCGA ACCCGGAGTA TGATTATTTA GGGGACGTAA CGTCTGGGGG AAGCGAGAAC 2340
CCTGGCTCCC CTGGGAATAA CCAAAACTCG CCGCCTAGCC CAAATTTTGT GCCGAATGAA 2400
ACTGAGTATA TAAACGATTC TGTGGCCCCA AAATCTGGTC CCAATCACCA AAACGGCTTC 2460
GCTGAGGACG AAATTTTTTC GGCTTTGACT CTCGCGGACC CTAAAATGAG AGAGCGAGTG 2520
TTATACGGAA AAAACTCGGC CGGTAGGACC TACTCAGAGC CTGACAGTGG TGTAGGCATT 2580
GAAGTCGCAA TGGACAATAT ACTATACCAT AAACTAGGTC CAAATTGGGA TACAACTGAG 2640
TAA 2643
Domain Profile
S: 2     kklkvlGsGafGtvykGiwipe...genvkipvaikvleektgkkankelldealvlasl  58
         +  k+lGsGafGtv+kG wip+    e+vk+pvaikvl++++++ a++e+ldea+v+as 
Q: 124   RIGKILGSGAFGTVHKGYWIPDlapRERVKVPVAIKVLRDESSQVASNEILDEAFVMASC  183
         6789*****************987679*********************************
S: 59    dhanlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyl.  117
         +h+nlvrllg+ ls+ ++l+tql+plG+ll+yvr++kd++Gsq+llnw++qiakGm+yl 
Q: 184   EHPNLVRLLGISLSQRIMLITQLMPLGNLLEYVRDNKDNIGSQHLLNWSLQIAKGMKYLs  243
         **********************************************************96
S: 118   eekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilk  177
         eek+lvhrdlaarnvlvkspnhv+itdfGlakll+ +e+ ++aeggk+pikwlalesi++
Q: 244   EEKHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVKEDVYRAEGGKMPIKWLALESIQH  303
         7899********************************************************
S: 178   rkythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlv  237
         r++t++sdvws+Gvt+wel+tfG+kpy+++pa+e++ lle+Gerl+qp ictid+ym l+
Q: 304   RIFTQKSDVWSFGVTMWELMTFGKKPYESVPAREVHTLLERGERLPQPYICTIDIYMLLI  363
         ************************************************************
S: 238   kcwmidaesrpkfkelaeef  257
         kcw +dae+rp+fkel+ee+
Q: 364   KCWTVDAEARPTFKELTEEL  383
         ****************9986
Domain Sequence
(FASTA)
RIGKILGSGA FGTVHKGYWI PDLAPRERVK VPVAIKVLRD ESSQVASNEI LDEAFVMASC 60
EHPNLVRLLG ISLSQRIMLI TQLMPLGNLL EYVRDNKDNI GSQHLLNWSL QIAKGMKYLS 120
EEKHLVHRDL AARNVLVKSP NHVRITDFGL AKLLDVKEDV YRAEGGKMPI KWLALESIQH 180
RIFTQKSDVW SFGVTMWELM TFGKKPYESV PAREVHTLLE RGERLPQPYI CTIDIYMLLI 240
KCWTVDAEAR PTFKELTEEL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Loxodonta africana"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-CIS-00072
EKS-DRM-00152
EKS-EQC-00289
EKS-GAA-00368
EKS-LOA-00308
EKS-ORN-00386
EKS-OTG-00304
EKS-SAH-00279
EKS-SUS-00262
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013