EKS-CII-00038

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00038

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	391.5	2.9E-117	380	661	282

Status

Unreviewed

Ensembl Protein

ENSCINP00000002868

UniProt Accession

F6VK85;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100178479

Gene Synonyms/Alias

LOC100178479;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000001460	ENSCINP00000002868	ENSCINT00000002868

Organism

Ciona intestinalis

Functional Description

Protein Length

754

Protein Sequence
(FASTA)

MKGLSDQNIS QVINFHKLST EHDRSWYKAW HSWAVVNFEC VLFYKNKLDI ATESQLPREI 60

PDYLEKGLSK DDSSEDSDLS CSDPELNQPI QLKNIAQPDF SSTILTYAIP SVQGFFHSIA 120

LSHGNSLQDT LRVLTLWFEY GHHHKLHDVI VEGIKTIKIE NWLQVIPQLI ARIDSPKSLV 180

SNINHLLLTD IGKHHPQALI YPLAVASKSA IPMRNIAANK ILNKMCDHSN TLVKQAILVS 240

EELIRVAILW HELWHEGLEE ASRLYFGERD VRSMLATLQP LHALLERGPQ TLKEISFNQA 300

YGRDLQEAQD WCRKFTQSSN IKDLNQAWDL YYHVFRRISK QLPQLTTIEL QYVSPKLMVC 360

KDLELAVPGT YNALKPIVCI RSIQHTLQVI TSKQRPRKLS IKGSNGRDYT FLLKGHEDLR 420

QDERVMQLFG LVNTLLSMDQ ASSRKNLGIQ RFSVVPLSTN SGLIGWVPNC DTLHALIRDY 480

RDKKKILLNI EHRIMLRMAP DYDHLSLMQK VEVFEHAINN TAGDDLARLI WLKSPTSEAW 540

FDRRTNYTRS LAVMSMVGHV LGLGDRHPSN LMLDRISGKV LHIDFGDCFE VAMAREKFPE 600

KIPFRLTRML TNAMEVTGIE GNYKHTCRMV MNVLRQHKES VMAVLEAFVY DPLLNWRLVE 660

SSEHGRIMES GSISDALGVG HTGIAQTPGE TGTARPEVLN KKALVIVNRV RDKLTGCDFS 720

AVSIDVPTQV DLLIKQATSH ENLCQCYIGW CPFW 754

Nucleotide Sequence
(FASTA)

ATGAAAGGAT TGAGCGACCA AAATATTTCT CAAGTCATCA ACTTTCATAA ACTTTCTACA 60

GAGCATGACC GCAGTTGGTA TAAGGCATGG CACTCATGGG CAGTTGTAAA CTTTGAGTGC 120

GTTTTGTTTT ATAAAAACAA ACTTGACATT GCCACTGAAA GTCAACTACC CCGGGAAATA 180

CCAGATTATT TGGAAAAAGG TTTAAGTAAG GACGATAGCA GTGAGGATTC TGACTTGAGT 240

TGTTCTGATC CTGAACTTAA TCAACCTATC CAGTTGAAAA ATATCGCGCA ACCAGATTTC 300

AGCTCCACAA TTCTCACATA CGCGATTCCA TCAGTTCAAG GATTCTTTCA TTCAATCGCT 360

TTATCCCATG GCAACTCTCT GCAAGACACA CTCAGAGTAT TAACATTATG GTTTGAATAT 420

GGCCACCACC ATAAGTTACA CGATGTCATC GTGGAAGGAA TTAAAACAAT CAAGATAGAA 480

AACTGGCTGC AGGTGATCCC ACAATTAATT GCAAGAATAG ATTCCCCAAA ATCTTTAGTT 540

TCAAATATAA ACCATCTCCT GTTAACTGAT ATTGGAAAGC ATCATCCACA GGCCTTAATC 600

TACCCACTGG CTGTTGCATC TAAATCAGCC ATCCCTATGA GAAACATTGC TGCCAATAAA 660

ATATTAAATA AAATGTGTGA TCATTCAAAT ACACTTGTCA AGCAAGCAAT ATTGGTATCT 720

GAAGAATTGA TAAGAGTTGC AATATTATGG CACGAGTTAT GGCATGAAGG GTTAGAAGAA 780

GCATCAAGAC TTTACTTTGG GGAGCGTGAC GTAAGATCAA TGCTCGCCAC TCTTCAACCA 840

CTGCATGCTT TGTTGGAACG AGGGCCACAA ACTTTGAAGG AGATCAGTTT CAATCAGGCT 900

TATGGTCGTG ACCTGCAAGA AGCTCAAGAC TGGTGTCGGA AATTTACGCA GTCGAGTAAT 960

ATTAAAGATC TTAATCAAGC ATGGGATCTT TATTATCATG TGTTTAGAAG GATATCTAAA 1020

CAATTACCAC AACTCACCAC CATAGAGTTA CAATACGTCT CACCCAAGTT AATGGTGTGC 1080

AAAGATCTGG AGTTGGCCGT ACCTGGAACT TATAATGCAT TGAAACCAAT TGTGTGTATA 1140

AGGTCCATAC AACATACATT ACAAGTGATT ACCTCAAAAC AAAGACCAAG AAAACTGTCC 1200

ATTAAAGGTA GTAATGGCAG AGATTACACG TTCCTGTTGA AAGGTCATGA GGACTTAAGA 1260

CAAGATGAGA GAGTTATGCA GTTGTTTGGG TTGGTGAATA CTTTGCTGTC AATGGACCAA 1320

GCTTCTAGCA GGAAAAACCT TGGAATACAA AGATTTTCGG TTGTTCCATT ATCTACTAAC 1380

TCCGGTTTGA TTGGTTGGGT TCCAAACTGT GACACGTTAC ATGCACTCAT TCGTGATTAT 1440

CGAGATAAAA AGAAAATTCT TCTAAACATC GAACACAGGA TCATGCTACG GATGGCACCA 1500

GATTATGATC ATTTATCATT GATGCAAAAA GTAGAGGTGT TTGAACATGC GATAAACAAC 1560

ACTGCTGGTG ATGATTTGGC TCGGTTAATC TGGTTAAAAA GTCCAACGTC AGAAGCTTGG 1620

TTTGATAGAA GAACGAACTA TACGCGATCA TTAGCTGTAA TGTCGATGGT AGGACATGTG 1680

TTGGGGTTGG GGGACAGACA TCCAAGCAAC TTAATGCTGG ATAGAATAAG TGGAAAAGTT 1740

CTTCATATTG ATTTTGGTGA TTGCTTCGAG GTTGCAATGG CTCGTGAAAA GTTTCCCGAA 1800

AAAATTCCGT TCCGCTTAAC TCGCATGCTG ACTAATGCTA TGGAGGTGAC GGGAATTGAA 1860

GGAAATTACA AACATACTTG TCGAATGGTA ATGAATGTAT TAAGACAACA CAAAGAAAGT 1920

GTGATGGCCG TCTTGGAAGC TTTTGTTTAC GATCCATTAC TTAACTGGAG ACTTGTTGAG 1980

AGTTCTGAAC ATGGTCGAAT AATGGAGAGT GGTTCAATAT CCGATGCATT GGGTGTTGGT 2040

CATACTGGTA TTGCGCAAAC ACCAGGTGAA ACAGGAACTG CCAGACCTGA GGTTCTCAAC 2100

AAAAAAGCGC TTGTTATTGT TAATAGAGTT CGAGATAAAC TGACAGGTTG TGATTTCAGT 2160

GCTGTTTCAA TAGATGTACC CACACAAGTA GATTTGTTAA TTAAACAAGC AACTTCTCAT 2220

GAAAACTTAT GCCAGTGTTA TATCGGATGG TGTCCTTTCT GGTGA 2265

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i ++++++++++skq+p+kl+++Gs+g+ y +L+kg+eDlrqderv+qlf+lvNtlL  d

Q: 380   IRSIQHTLQVITSKQRPRKLSIKGSNGRDYTFLLKGHEDLRQDERVMQLFGLVNTLLSMD  439

         678999******************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++sr++L i++++Vvplst+sgli+wv+n+++L++l++++++kk++ll+        ++

Q: 440   QASSRKNLGIQRFSVVPLSTNSGLIGWVPNCDTLHALIRDYRDKKKILLN-------IEH  492

         *************************************************9.......9**

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +++ +++p+++hl+l+  +evf+++ +n ++ d l++l++ k+p++e+wf++r++ytrsl

Q: 493   RIMLRMAPDYDHLSLMqkVEVFEHAINN-TAGDDLARLIWLKSPTSEAWFDRRTNYTRSL  551

         ****************************.999****************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         Av+s+vg++LgLgdrh++nl++d+ +g+v+hidfg +fe a+ ++k+pek+PFRLTr+++

Q: 552   AVMSMVGHVLGLGDRHPSNLMLDRISGKVLHIDFGDCFEVAMAREKFPEKIPFRLTRMLT  611

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkk  288

         na++vtg+eG+++ +c  v++vlr++ke+++++Le+f+ydpl++w+  ++

Q: 612   NAMEVTGIEGNYKHTCRMVMNVLRQHKESVMAVLEAFVYDPLLNWRLVES  661

         **********************************************8332

Domain Sequence
(FASTA)

IRSIQHTLQV ITSKQRPRKL SIKGSNGRDY TFLLKGHEDL RQDERVMQLF GLVNTLLSMD 60

QASSRKNLGI QRFSVVPLST NSGLIGWVPN CDTLHALIRD YRDKKKILLN IEHRIMLRMA 120

PDYDHLSLMQ KVEVFEHAIN NTAGDDLARL IWLKSPTSEA WFDRRTNYTR SLAVMSMVGH 180

VLGLGDRHPS NLMLDRISGK VLHIDFGDCF EVAMAREKFP EKIPFRLTRM LTNAMEVTGI 240

EGNYKHTCRM VMNVLRQHKE SVMAVLEAFV YDPLLNWRLV ES 282

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013