EKS-CII-00175

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00175

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	378.8	1.0E-113	838	1099	262

Status

Unreviewed

Ensembl Protein

ENSCINP00000006067

UniProt Accession

F6R2Y1;

Protein Name

Protein Synonyms/Alias

Gene Name

egfr1

Gene Synonyms/Alias

egfr1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000002964	ENSCINP00000006067	ENSCINT00000006067

Organism

Ciona intestinalis

Functional Description

Protein Length

1462

Protein Sequence
(FASTA)

MRHCYPIVVL LVVLCLNIQT TESTSECDNV VCPEQVICQP PKTKLVLPYP GKEKCCVKVV 60

CTCKGTNSEL TSSGSREIQY SNLEKLYTNC TLVNGNLELT GLFPFGNITT IEFTKHIEQV 120

TGYLLIYRTI MDSINLSSLR LIRGLTQYYI GVDCRTNLTL ARDQPGYSVY ANRITGDQNY 180

LRELWMPKLT EISAGNVFFT KSRICNLESI KWRDEIFNDG SQTVEITNDP VRDRYCDPCP 240

SVCRDDSGST PVNRCWGNSS DLCQLITKSK CRRQCGNDRC NAGGACCNGK CAGGCYDNMP 300

ATGNKDKWCH ACKDMNNNGT CVEACPQGTQ MNPTSTITKT PKTYQFARYC VPKCPFNVPQ 360

TTSFCRTYCP EGTFDYNSNI CEPCENGKCE HVCYGLGVGH GPLKDDKEIN SENIKYFNKN 420

CTIIEGSLSF QASTFNGDSY CSIGKLNNLE MLSVFENVKE ITGYLAFDEW RMHDLCLFKN 480

LKKIRGKELK SELYSLYVYT NDKSLRELCL NSLENIYDGG VLVVRNPRLG HTDTITWENI 540

FSDSGNQNTM ILRNQKEVPC HTMCDQSQGC WGRDATNCVR CQYYTDYTDV NGQLTPAWVT 600

DQTTGLAVPG YNTTTCVEQC NQEKGVYASS DMRCLPCDSE CLSTCNGPTS YNCTSGCQNF 660

KLNSQCVPSC PLNYYIGLNK TCSACSPNCV GGCTGPLDIY GEGGCSSCHV SMDEKTSVYT 720

HRGAKCPFCL NDQLRETCAH GCTSFNNTGR LQCYYLPKPD ITVYIIIGVM VFIFIFIVIS 780

WVFYKHRKTI KRMRQTIGET MVGERIPLEP EAVPLTPSGA APNVAQLRIV KESELEFRKM 840

LGSGAFGTVQ KAIWTPLNIQ GEKVKIAVAV KTLKTSEDLL QSANNEIMDE AYMMASVECP 900

YLVRLLGISM TEQVALITQL MPLGSLLEYV RNPTTRDSIR SRQILSWCVQ IAKGMKYLEE 960

KHLVHRDLAA RNVLVKTPNH VKITDFGLAK MLDTKEEIYH AEGGKLPIKW LAIECITERE 1020

FSHLSDVWAF GVTCWELLTF GARPYEGVRA VDVLSLLERG DRLPQPATST IDIYMVLVKC 1080

WMVDRLCRPS FSNLVDEFSK MAADPSRFVV IKHDDTDNIM SPTSVDDASF FRQLMEDEKT 1140

AEEDLIADEP DEYLLNLNHP DNLPKYANIA HDPPQHPDQG ARDARLFSRN TPSSFPESST 1200

SSSTAGMRAE PPVTPQADPD DVFSEVVNSV KTVSPHPASV EQQATNRKDS EETQRYTEDP 1260

TTKRPLLDGM QSPTTLYKPN PGEVDENNYL LPTPLKKQPD YFDPSHVPSE PQPSPLLCNE 1320

TYVEGDSLPE SRPYPGQLDN GYAPICGSPQ EHHDYVNTDS EARNPMWFSN EEYMATDSGI 1380

GEDVQSLLSR GNTANRGQRR SNQSQSSVDD SEQIFLQKDA EVPYRPQQNR DSSPDSQKLN 1440

ETSLNNPEYM FLNPGSSGHP QT 1462

Nucleotide Sequence
(FASTA)

ATGAGGCATT GCTATCCAAT AGTTGTTTTG CTTGTTGTCC TTTGTCTCAA CATACAAACA 60

ACAGAATCCA CCAGTGAATG TGATAACGTG GTTTGTCCAG AACAAGTGAT ATGCCAACCT 120

CCTAAAACTA AACTTGTGTT GCCTTATCCT GGGAAGGAAA AATGCTGTGT TAAAGTTGTA 180

TGCACTTGCA AAGGAACAAA TTCCGAACTG ACTTCGTCAG GAAGTCGTGA AATCCAATAC 240

AGTAACTTGG AAAAACTGTA TACTAACTGT ACCTTGGTTA ATGGAAATTT AGAGCTGACT 300

GGTTTATTTC CATTTGGAAA TATCACTACT ATAGAATTTA CAAAGCATAT TGAGCAAGTG 360

ACAGGCTACC TGTTGATATA CCGCACAATA ATGGATTCTA TCAACCTCTC ATCTCTGCGT 420

CTAATAAGAG GACTCACACA ATATTATATT GGTGTTGACT GTAGAACAAA CTTAACATTG 480

GCAAGAGATC AACCAGGTTA TTCAGTATAT GCAAACCGAA TAACTGGTGA TCAAAATTAC 540

TTGAGAGAAT TATGGATGCC AAAACTGACA GAAATATCTG CTGGGAATGT CTTTTTCACA 600

AAATCAAGAA TTTGCAACCT GGAGTCAATA AAATGGAGAG ATGAAATTTT TAATGACGGA 660

AGTCAAACCG TCGAAATTAC AAATGATCCA GTTAGAGATA GATACTGTGA CCCATGTCCA 720

AGTGTCTGCA GAGATGATTC TGGCAGCACG CCTGTGAATC GGTGTTGGGG AAACTCTTCA 780

GATCTGTGTC AGCTAATTAC GAAATCAAAA TGTCGTCGGC AGTGTGGGAA TGACAGGTGT 840

AATGCTGGAG GAGCTTGTTG TAATGGGAAG TGTGCTGGGG GATGTTATGA TAACATGCCA 900

GCAACTGGTA ACAAGGATAA GTGGTGCCAT GCTTGCAAAG ATATGAATAA CAACGGTACA 960

TGTGTTGAAG CTTGTCCACA AGGCACACAA ATGAACCCCA CATCCACAAT AACTAAAACA 1020

CCAAAAACTT ATCAGTTTGC TCGATACTGT GTACCAAAGT GCCCATTCAA TGTCCCTCAA 1080

ACTACATCCT TCTGCCGCAC CTATTGTCCT GAAGGGACTT TTGATTATAA CAGCAACATT 1140

TGCGAACCTT GTGAAAATGG AAAATGTGAA CATGTATGTT ATGGCCTTGG TGTTGGCCAT 1200

GGACCCCTGA AGGACGATAA AGAAATCAAT TCTGAAAATA TCAAATATTT CAATAAGAAT 1260

TGCACAATTA TTGAAGGTTC CCTAAGTTTT CAAGCCTCAA CATTTAATGG GGACTCGTAT 1320

TGCAGCATCG GCAAACTGAA CAACCTGGAA ATGTTGTCCG TGTTTGAAAA CGTCAAAGAA 1380

ATAACCGGTT ACTTGGCATT TGATGAATGG CGAATGCACG ACTTGTGTTT ATTTAAAAAT 1440

CTAAAAAAGA TTCGGGGCAA AGAATTAAAA TCTGAGTTGT ACAGTTTGTA TGTTTATACA 1500

AATGATAAAA GCTTAAGGGA GCTGTGCTTG AACTCATTGG AAAACATTTA TGATGGGGGT 1560

GTATTGGTGG TTAGGAATCC AAGATTGGGT CACACTGATA CAATAACATG GGAAAATATA 1620

TTCAGTGACT CTGGAAATCA AAATACAATG ATTCTGCGTA ATCAAAAGGA AGTACCTTGT 1680

CACACCATGT GCGATCAAAG CCAAGGATGT TGGGGCAGAG ATGCAACAAA TTGTGTTCGG 1740

TGTCAATATT ACACAGATTA TACGGATGTT AACGGACAAC TCACCCCTGC ATGGGTGACG 1800

GACCAAACAA CAGGGTTGGC TGTTCCTGGT TATAACACAA CAACATGTGT GGAGCAATGT 1860

AACCAAGAAA AAGGGGTGTA TGCCTCAAGT GATATGCGAT GTCTTCCTTG TGATAGTGAA 1920

TGCTTAAGCA CTTGTAATGG ACCAACTTCA TATAACTGCA CAAGTGGTTG CCAAAACTTC 1980

AAGCTCAATT CTCAATGTGT GCCATCTTGT CCACTAAACT ATTATATTGG ATTGAACAAA 2040

ACTTGTTCAG CATGTAGTCC CAACTGTGTT GGCGGATGTA CTGGACCATT AGATATATAT 2100

GGAGAAGGTG GTTGTTCATC ATGTCATGTA TCTATGGATG AAAAAACATC CGTATACACT 2160

CACCGTGGAG CTAAATGTCC TTTTTGCTTG AATGACCAAT TGAGAGAAAC TTGTGCACAT 2220

GGATGTACTT CGTTTAACAA TACAGGCAGA TTGCAATGTT ACTACCTACC AAAACCCGAC 2280

ATCACAGTTT ACATCATCAT TGGAGTTATG GTCTTCATAT TTATATTTAT TGTAATTAGT 2340

TGGGTTTTCT ATAAACATCG AAAAACCATC AAACGAATGA GACAAACTAT TGGTGAAACT 2400

ATGGTTGGCG AGCGCATCCC ACTTGAGCCT GAAGCCGTTC CTCTCACCCC AAGTGGTGCC 2460

GCACCTAACG TAGCTCAACT TAGAATTGTT AAAGAAAGCG AACTTGAGTT TCGAAAGATG 2520

TTGGGTTCTG GTGCATTTGG AACAGTGCAG AAAGCTATTT GGACTCCATT AAATATACAA 2580

GGTGAAAAGG TAAAGATAGC AGTTGCTGTT AAAACTTTGA AAACATCAGA AGATTTGCTT 2640

CAATCTGCAA ACAATGAGAT AATGGATGAG GCTTACATGA TGGCTTCGGT TGAATGTCCG 2700

TACCTGGTTC GTCTGCTTGG TATTTCAATG ACTGAGCAAG TAGCTTTGAT CACCCAACTT 2760

ATGCCTCTTG GAAGTTTATT GGAATATGTA AGAAACCCAA CCACACGAGA CAGTATTCGC 2820

TCAAGACAAA TATTATCGTG GTGTGTCCAA ATAGCTAAGG GGATGAAATA TCTTGAAGAA 2880

AAACATCTCG TACATCGTGA CCTCGCAGCT CGTAACGTGC TCGTAAAAAC ACCAAACCAT 2940

GTCAAAATAA CAGACTTCGG ATTAGCGAAA ATGCTTGACA CAAAAGAGGA GATCTACCAC 3000

GCAGAGGGTG GTAAGCTTCC AATTAAATGG TTGGCCATTG AATGCATTAC TGAACGTGAG 3060

TTTTCACATC TCTCCGATGT TTGGGCGTTT GGTGTTACGT GTTGGGAGTT ATTGACGTTT 3120

GGAGCCAGAC CTTACGAGGG TGTACGAGCT GTTGATGTTT TATCGTTGTT AGAACGTGGT 3180

GACAGATTAC CCCAACCTGC AACTTCTACA ATTGATATCT ACATGGTTCT CGTTAAATGT 3240

TGGATGGTGG ACAGATTATG TCGACCATCG TTTTCAAATC TTGTTGATGA ATTTAGCAAA 3300

ATGGCCGCCG ACCCCAGCAG ATTCGTTGTA ATAAAGCATG ATGACACAGA CAACATCATG 3360

AGTCCAACAT CAGTGGATGA TGCTTCATTC TTCCGACAAT TGATGGAGGA TGAGAAGACA 3420

GCTGAGGAAG ACCTCATCGC TGATGAACCG GATGAATATC TTCTTAATCT TAATCATCCC 3480

GATAATTTAC CAAAATATGC GAACATCGCT CACGATCCTC CCCAACATCC GGATCAGGGA 3540

GCCCGGGATG CTCGGCTCTT CTCGAGGAAC ACTCCATCCT CGTTCCCTGA AAGTTCAACA 3600

TCCTCCTCAA CTGCTGGGAT GCGAGCTGAG CCTCCCGTCA CCCCACAAGC AGATCCGGAT 3660

GATGTTTTCT CTGAAGTCGT TAACTCAGTG AAAACAGTTT CACCGCATCC AGCATCTGTT 3720

GAACAGCAAG CAACGAACAG AAAAGATTCC GAAGAAACAC AAAGATACAC TGAAGATCCA 3780

ACAACAAAAC GACCACTGTT AGATGGAATG CAATCTCCCA CCACTTTATA CAAACCTAAC 3840

CCAGGAGAAG TTGATGAAAA TAACTATTTG CTTCCAACAC CACTGAAAAA ACAACCAGAT 3900

TACTTTGATC CCTCACATGT CCCTTCAGAA CCCCAGCCAT CACCTTTGTT ATGTAATGAA 3960

ACGTATGTCG AGGGTGATTC ATTACCCGAA TCCCGTCCTT ACCCAGGTCA ACTGGACAAT 4020

GGGTACGCCC CTATCTGTGG AAGTCCGCAA GAACATCATG ATTATGTGAA CACTGATAGT 4080

GAGGCGAGGA ACCCAATGTG GTTTTCGAAC GAAGAATATA TGGCAACTGA CAGTGGGATA 4140

GGGGAGGACG TTCAGTCGTT ACTTTCGCGC GGCAACACTG CAAATCGTGG GCAACGACGA 4200

TCTAACCAAT CACAATCCTC TGTTGATGAC AGCGAACAAA TATTCTTACA AAAAGACGCT 4260

GAGGTTCCGT ACCGGCCGCA ACAGAATCGA GATTCGTCTC CAGATTCGCA GAAACTTAAT 4320

GAAACTTCGC TTAATAATCC CGAGTATATG TTCCTTAACC CTGGTAGTAG TGGCCACCCA 4380

CAAACGTAG 4389

Domain Profile

S: 4     lkvlGsGafGtvykGiwip...egenvkipvaikvleektg..kkankelldealvlasl  58

          k+lGsGafGtv k iw p   +ge+vki va+k l+ + +  ++an+e++dea+++as+

Q: 838   RKMLGSGAFGTVQKAIWTPlniQGEKVKIAVAVKTLKTSEDllQSANNEIMDEAYMMASV  897

         689****************6555*************9776644899**************

S: 59    dhanlvrllglclsstlqlvtqllplGclldyvre..hkdklGsqellnwcvqiakGmsy  116

         + ++lvrllg+ +++++ l+tql+plG+ll+yvr+   +d++ s+++l wcvqiakGm+y

Q: 898   ECPYLVRLLGISMTEQVALITQLMPLGSLLEYVRNptTRDSIRSRQILSWCVQIAKGMKY  957

         **********************************74479*********************

S: 117   leekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesil  176

         leek+lvhrdlaarnvlvk+pnhvkitdfGlak+l+++e+ ++aeggk+pikwla+e+i+

Q: 958   LEEKHLVHRDLAARNVLVKTPNHVKITDFGLAKMLDTKEEIYHAEGGKLPIKWLAIECIT  1017

         ************************************************************

S: 177   krkythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvl  236

         +r ++h sdvw++Gvt+welltfGa+py+g++a ++ +lle+G+rl+qp   tid+ymvl

Q: 1018  EREFSHLSDVWAFGVTCWELLTFGARPYEGVRAVDVLSLLERGDRLPQPATSTIDIYMVL  1077

         ************************************************************

S: 237   vkcwmidaesrpkfkelaeefs  258

         vkcwm+d  +rp+f +l+ efs

Q: 1078  VKCWMVDRLCRPSFSNLVDEFS  1099

         ********************96

Domain Sequence
(FASTA)

RKMLGSGAFG TVQKAIWTPL NIQGEKVKIA VAVKTLKTSE DLLQSANNEI MDEAYMMASV 60

ECPYLVRLLG ISMTEQVALI TQLMPLGSLL EYVRNPTTRD SIRSRQILSW CVQIAKGMKY 120

LEEKHLVHRD LAARNVLVKT PNHVKITDFG LAKMLDTKEE IYHAEGGKLP IKWLAIECIT 180

EREFSHLSDV WAFGVTCWEL LTFGARPYEG VRAVDVLSLL ERGDRLPQPA TSTIDIYMVL 240

VKCWMVDRLC RPSFSNLVDE FS 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013