EKS-CII-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	416.6	7.8E-125	106	469	364

Status

Unreviewed

Ensembl Protein

ENSCINP00000007167

UniProt Accession

F6TLX0;

Protein Name

Protein Synonyms/Alias

Gene Name

vegfr

Gene Synonyms/Alias

vegfr;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000003493	ENSCINP00000007167	ENSCINT00000007167
ENSCING00000003493	ENSCINP00000007171	ENSCINT00000007171

Organism

Ciona intestinalis

Functional Description

Protein Length

540

Protein Sequence
(FASTA)

DGGVYICVAE NQYGKDNKSV SLNIQGDHQM QIMFAASGVS CLVLILACGL IAMRLRKKVT 60

HDKSMATLLQ RLMMPSLLNI KDMPLEEQAQ CSEYDSKKWE FPRDRLRFGK TLGRGAFGKV 120

IQATAFDLEK SSSCKTVAVK MLKVGSRSNE YRALMTELRI LIHLGPHLNI VNLLGACTTK 180

EGPLMVIVEY CRHGNLSNYL RGLRHCYTGG RSDDTSKQEI KKQRLMSDDS ADDGAFSGTD 240

ETDRSSWITD KRGSRASYLS GTGSLTSHEG DIRSHTRLSS GCEDSRMNLE KHHEANDDGD 300

EKGKEQKDQL TLTDLLSYSL QVARGMEFLA SKKCIHRDLA ARNVLLSDYQ VVKICDFGLA 360

RDIYKDPDYV RSGGDARLPI KWMAPESIFD KVYSNKSDVW SFGVLLWEIF TLGGSPYPGL 420

QMDEDFCNKL RRGVRMGKPE HATDSVYSAM LGCWDNNPED RPTFTKLCEE ISDVLQEEAG 480

HEYLDVLKIF EKEAEGKETL RGLRLYETPQ ETFTEGKNKM EEETSATINY TFVKVRASYT 540

Nucleotide Sequence
(FASTA)

GATGGAGGTG TTTATATTTG TGTTGCGGAG AATCAATATG GGAAGGATAA CAAATCTGTT 60

TCTTTGAACA TACAAGGTGA TCATCAAATG CAAATCATGT TTGCAGCCAG CGGTGTCTCG 120

TGTCTTGTGT TAATTCTCGC ATGTGGTTTA ATTGCAATGA GACTTAGAAA AAAGGTGACA 180

CACGATAAAA GCATGGCAAC ATTGCTTCAG AGACTAATGA TGCCATCGTT GCTCAACATT 240

AAGGACATGC CACTTGAGGA GCAAGCCCAG TGTTCAGAGT ACGACAGCAA GAAATGGGAG 300

TTTCCTCGAG ATCGACTCAG GTTTGGGAAA ACTCTTGGAA GAGGAGCATT CGGAAAAGTT 360

ATCCAAGCTA CTGCGTTTGA TCTCGAAAAA TCATCTTCCT GCAAGACAGT GGCTGTGAAA 420

ATGCTCAAAG TTGGATCTCG AAGCAATGAA TATCGAGCCC TGATGACCGA GCTTCGAATT 480

CTGATTCATT TAGGACCTCA CTTGAACATT GTTAACCTGC TTGGGGCTTG TACTACCAAA 540

GAAGGTCCGC TCATGGTGAT TGTCGAGTAT TGTCGCCATG GTAACTTATC CAACTATCTT 600

CGTGGGTTGA GACATTGTTA CACGGGTGGT AGAAGTGATG ACACAAGTAA ACAGGAGATA 660

AAAAAACAAC GACTTATGAG CGATGACTCA GCAGATGACG GAGCGTTTTC TGGCACAGAC 720

GAAACTGACC GCTCAAGTTG GATTACAGAT AAGAGAGGAA GTCGCGCATC GTATTTGAGC 780

GGAACTGGAT CCTTAACGTC ACATGAAGGA GATATTAGGA GTCACACAAG ACTATCATCT 840

GGTTGCGAAG ACAGCAGGAT GAACTTGGAG AAACATCATG AAGCAAATGA TGATGGAGAT 900

GAGAAGGGCA AAGAACAGAA GGATCAACTC ACTCTTACCG ATCTTCTTTC ATACAGTCTT 960

CAAGTCGCCC GCGGCATGGA GTTTCTCGCT TCTAAAAAAT GCATACATCG AGACCTGGCA 1020

GCAAGGAATG TCTTGCTTTC CGATTACCAA GTTGTTAAGA TTTGTGACTT TGGGCTTGCA 1080

CGTGATATTT ATAAAGATCC AGACTATGTT AGGAGTGGGG GGGACGCAAG ACTGCCAATC 1140

AAATGGATGG CACCAGAGTC CATTTTCGAT AAAGTTTACT CCAACAAAAG TGATGTTTGG 1200

TCGTTTGGAG TTCTTCTGTG GGAGATATTT ACACTTGGTG GTTCCCCTTA CCCTGGATTG 1260

CAAATGGATG AAGATTTCTG CAACAAACTG CGAAGAGGTG TTCGCATGGG GAAACCTGAA 1320

CATGCCACAG ACTCTGTATA TTCTGCCATG CTTGGTTGTT GGGATAACAA TCCTGAAGAT 1380

CGGCCGACAT TCACCAAGTT ATGCGAGGAA ATAAGTGATG TCCTGCAAGA AGAAGCCGGC 1440

CATGAATATC TGGATGTGTT AAAAATATTT GAGAAAGAAG CAGAAGGTAA AGAAACTCTG 1500

CGTGGGCTCC GACTCTATGA AACACCTCAA GAAACTTTTA CTGAAGGTAA AAACAAAATG 1560

GAGGAAGAAA CATCTGCAAC AATTAACTAC ACCTTTGTTA AGGTAAGGGC TTCTTATACT 1620

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lG GafGkv++ata+ l ks ++ +vavkmlk  +rs+e +alm+el+il hlG

Q: 106   LRFGKTLGRGAFGKVIQATAFDLEKSSSCKTVAVKMLKVGSRSNEYRALMTELRILIHLG  165

         78**********************************************************

S: 61    ehenivnllGact.kgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldsk  119

         +h+nivnllGact k Gp++vi+eyc++G+l nylr  r+ +    ++    +++e++++

Q: 166   PHLNIVNLLGACTtKEGPLMVIVEYCRHGNLSNYLRGLRHCYTGGRSDD--TSKQEIKKQ  223

         ************7378**************************9888877..566778888

S: 120   alladkslrsksslssesseeyvdlkkd.......................vsdvssska  156

          l++d s      + +++++    + ++                        + +ss  +

Q: 224   RLMSDDSADDGAFSGTDETDRSSWITDKrgsrasylsgtgsltshegdirsHTRLSSGCE  283

         888888777766666655554444443356999************999877667777777

S: 157   dklasekkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaar  216

         d++++ +k++  + +  ++  +e+++ l+l+dlls+s qva+Gmeflask+c+hrdlaar

Q: 284   DSRMNLEKHHEANDDG-DEKGKEQKDQLTLTDLLSYSLQVARGMEFLASKKCIHRDLAAR  342

         7777766555554444.4566777999*********************************

S: 217   nvllteGkvvkicdfGlardimkdsnyvvk.Gnarlpvkwmapesifdslytvksdvwsy  275

         nvll++ +vvkicdfGlardi kd +yv   G+arlp+kwmapesifd +y+ ksdvws+

Q: 343   NVLLSDYQVVKICDFGLARDIYKDPDYVRSgGDARLPIKWMAPESIFDKVYSNKSDVWSF  402

         ****************************65279***************************

S: 276   GillweifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrp  335

         G+llweif+lG++pypgl +d++f +++++G rm +p++at+ +y+ m  cw+++pe rp

Q: 403   GVLLWEIFTLGGSPYPGLQMDEDFCNKLRRGVRMGKPEHATDSVYSAMLGCWDNNPEDRP  462

         ************************************************************

S: 336   sfkqlve  342

         +f++l+e

Q: 463   TFTKLCE  469

         ****996

Domain Sequence
(FASTA)

LRFGKTLGRG AFGKVIQATA FDLEKSSSCK TVAVKMLKVG SRSNEYRALM TELRILIHLG 60

PHLNIVNLLG ACTTKEGPLM VIVEYCRHGN LSNYLRGLRH CYTGGRSDDT SKQEIKKQRL 120

MSDDSADDGA FSGTDETDRS SWITDKRGSR ASYLSGTGSL TSHEGDIRSH TRLSSGCEDS 180

RMNLEKHHEA NDDGDEKGKE QKDQLTLTDL LSYSLQVARG MEFLASKKCI HRDLAARNVL 240

LSDYQVVKIC DFGLARDIYK DPDYVRSGGD ARLPIKWMAP ESIFDKVYSN KSDVWSFGVL 300

LWEIFTLGGS PYPGLQMDED FCNKLRRGVR MGKPEHATDS VYSAMLGCWD NNPEDRPTFT 360

KLCE 364

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013