EKS-CII-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	494.0	6.7E-149	352	610	259

Status

Unreviewed

Ensembl Protein

ENSCINP00000007398

UniProt Accession

F6XJD6;

Protein Name

Protein Synonyms/Alias

Gene Name

Cin.21955

Gene Synonyms/Alias

Cin.21955;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000003587	ENSCINP00000007398	ENSCINT00000007398

Organism

Ciona intestinalis

Functional Description

Protein Length

662

Protein Sequence
(FASTA)

ERIRELECIL AEKDEEIEEL KAKLDKFQSI FPTATQQRHL GTFGAGMPRT QRAQGISAEP 60

NLVIGDPSLA QVRTYAKSEK TKTLIRQAIL ENDFMKHLED CQIEEIVDCM YPVEYSNGSC 120

IIKEGDVGSL VYVLEDGKVA VTKAGAHLCN MGEGKVFGEL AILYNCTRTA TVKATTNVRL 180

WAIDRHCFQA IMMRTGLLKH TEYLEFLTSV PTFSKLDEDL LRRIVDVMEE CHFEYGDYII 240

RQGAIGDTFY IISKGNVQVT KRKSASSEPV VIRKLAKGDW FGERALQGED MRTANVVVDD 300

TEGVTCLVID RQSFTQLIGD LDSVKQKKYD EVPVQNSKSD GFYVGLTLED FTAIDTLGVG 360

GFGRVELVEL KNDITKTYAM KVLKKRHIVD TRQQEHIKNE KAIMMECQSD FIVKMYRTFR 420

DTKYIYMLLE CCLGGELWTV LRDKGHFDDS AARFYTGCVV EAFTYMHSRG IIYRDLKPEN 480

LLLDTRGYAK LVDFGFAKRI GFSRKTWTFC GTPEYVAPEI ILNKGHDLSA DYWSLGILMY 540

ELMTGSPPFS GSDPMKTYNQ ILKGIDMIEF PKKISKNAQS LIRKLCRDNP SERLGNQRNG 600

IKDIQKHKWF DGFHWVGLRK GSMSPPIKPQ VSSSSDSSNF DKFPEDEEEP PPDDLSGWDV 660

DF 662

Nucleotide Sequence
(FASTA)

GAAAGAATAC GAGAATTGGA ATGTATTCTC GCAGAGAAAG ACGAAGAAAT TGAAGAACTG 60

AAAGCAAAAC TTGATAAATT TCAGTCTATA TTTCCAACGG CCACTCAGCA GCGACACCTG 120

GGGACGTTTG GAGCAGGAAT GCCACGAACA CAGAGGGCGC AAGGGATCAG CGCTGAACCA 180

AATCTTGTTA TAGGCGATCC TTCGCTGGCA CAAGTTCGCA CTTATGCAAA ATCCGAAAAA 240

ACGAAAACCT TAATACGTCA AGCCATTTTG GAAAATGACT TCATGAAACA TCTAGAAGAT 300

TGCCAGATCG AAGAAATAGT GGATTGCATG TACCCTGTCG AATACAGCAA TGGGAGTTGT 360

ATTATCAAGG AGGGTGACGT CGGATCTCTG GTTTACGTTC TCGAAGATGG TAAAGTCGCT 420

GTTACGAAGG CTGGCGCACA TCTATGCAAC ATGGGAGAAG GGAAAGTGTT TGGCGAACTA 480

GCTATACTCT ACAACTGCAC ACGCACAGCT ACAGTTAAAG CAACAACGAA CGTCAGATTA 540

TGGGCCATAG ACCGACATTG TTTCCAAGCC ATAATGATGC GAACAGGGTT GCTAAAACAC 600

ACAGAGTATC TGGAGTTCCT TACCAGCGTC CCAACGTTTT CAAAGTTGGA TGAAGATTTA 660

CTGCGACGTA TTGTTGACGT CATGGAAGAG TGCCACTTCG AGTACGGTGA TTACATTATC 720

CGCCAGGGGG CGATAGGCGA CACCTTCTAC ATCATAAGCA AAGGCAATGT CCAAGTAACG 780

AAGCGTAAAA GTGCGTCCAG CGAACCAGTT GTCATACGTA AGCTGGCTAA AGGTGACTGG 840

TTTGGAGAAA GAGCTTTGCA AGGTGAGGAT ATGCGAACAG CGAATGTGGT TGTTGACGAT 900

ACGGAAGGAG TCACGTGTCT TGTGATTGAC AGGCAGTCGT TCACGCAACT CATCGGAGAC 960

CTGGACAGCG TTAAACAGAA AAAATACGAC GAAGTACCAG TACAAAACTC AAAATCTGAC 1020

GGTTTTTACG TTGGACTGAC ACTGGAAGAC TTCACTGCGA TTGACACCCT GGGAGTTGGC 1080

GGTTTTGGGA GAGTTGAGCT GGTGGAGCTA AAGAACGACA TTACAAAAAC TTACGCTATG 1140

AAAGTTTTGA AAAAGCGCCA CATTGTAGAC ACTCGACAGC AAGAACATAT AAAGAACGAA 1200

AAAGCGATAA TGATGGAATG CCAGTCTGAT TTTATCGTCA AAATGTACCG AACTTTCCGC 1260

GACACCAAAT ACATTTATAT GTTGTTGGAA TGTTGTTTGG GTGGCGAGCT GTGGACGGTG 1320

CTACGAGATA AAGGCCACTT CGATGACTCG GCTGCAAGAT TTTATACTGG CTGCGTAGTG 1380

GAGGCATTTA CGTATATGCA TTCACGTGGC ATCATATACA GGGACTTGAA ACCAGAAAAT 1440

CTTTTACTCG ACACGCGGGG ATATGCAAAA CTGGTCGACT TCGGGTTCGC AAAGCGGATA 1500

GGTTTTAGTC GGAAAACTTG GACATTTTGT GGAACTCCCG AATATGTAGC TCCGGAAATT 1560

ATTCTGAACA AGGGCCACGA CCTATCGGCG GATTACTGGT CACTTGGGAT CCTAATGTAT 1620

GAACTAATGA CCGGCAGTCC GCCTTTTTCG GGTTCTGATC CAATGAAAAC ATACAACCAG 1680

ATATTAAAAG GAATCGACAT GATTGAATTC CCGAAGAAAA TATCTAAGAA CGCACAAAGT 1740

CTTATACGTA AACTATGCAG GGATAACCCC TCTGAAAGAC TGGGCAACCA ACGGAATGGA 1800

ATCAAAGATA TTCAAAAACA CAAATGGTTT GATGGTTTCC ATTGGGTTGG CTTGCGCAAA 1860

GGAAGTATGT CACCGCCCAT CAAACCTCAG GTTTCCAGCT CGTCTGACTC TTCTAACTTC 1920

GATAAATTCC CGGAGGACGA AGAGGAGCCT CCTCCCGATG ATCTTTCCGG GTGGGACGTG 1980

GATTTCTGA 1989

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

           i+tlgvggfgrvelv++k+d +k++a+k+lkk+hivdt+qqeh+ +ek i++e++sdf

Q: 352   TAIDTLGVGGFGRVELVELKNDITKTYAMKVLKKRHIVDTRQQEHIKNEKAIMMECQSDF  411

         579*********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         ivk+yrtf+d ky+y+lle+clggelwt+lrd+g+fdd++a+f+++cvvea+ y+hs++i

Q: 412   IVKMYRTFRDTKYIYMLLECCLGGELWTVLRDKGHFDDSAARFYTGCVVEAFTYMHSRGI  471

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenllld++gy+klvdfgfak+++ ++ktwtfcgtpeyvapeiilnkghdls+d

Q: 472   IYRDLKPENLLLDTRGYAKLVDFGFAKRIGFSRKTWTFCGTPEYVAPEIILNKGHDLSAD  531

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yel+tg+ppfsg+dp+ktyn+ilkgid++e+p+ki+k+a++li+klcrdnp+

Q: 532   YWSLGILMYELMTGSPPFSGSDPMKTYNQILKGIDMIEFPKKISKNAQSLIRKLCRDNPS  591

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg++++gikdi+khkwf

Q: 592   ERLGNQRNGIKDIQKHKWF  610

         ******************9

Domain Sequence
(FASTA)

TAIDTLGVGG FGRVELVELK NDITKTYAMK VLKKRHIVDT RQQEHIKNEK AIMMECQSDF 60

IVKMYRTFRD TKYIYMLLEC CLGGELWTVL RDKGHFDDSA ARFYTGCVVE AFTYMHSRGI 120

IYRDLKPENL LLDTRGYAKL VDFGFAKRIG FSRKTWTFCG TPEYVAPEII LNKGHDLSAD 180

YWSLGILMYE LMTGSPPFSG SDPMKTYNQI LKGIDMIEFP KKISKNAQSL IRKLCRDNPS 240

ERLGNQRNGI KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013