EKS-CII-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	350.4	5.0E-105	20	284	265

Status

Unreviewed

Ensembl Protein

ENSCINP00000010911

UniProt Accession

F6RUN6;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100184515

Gene Synonyms/Alias

LOC100184515;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000005299	ENSCINP00000010911	ENSCINT00000010911

Organism

Ciona intestinalis

Functional Description

Protein Length

1030

Protein Sequence
(FASTA)

MSGGLDDIDL AGLREPAGIF ELVQVVGNGT YGQVYKGRHV KTGQLAAIKV MDVTEEEEEE 60

IKLEINMLKK YSEHRNIATY YGAFVNKTAP GNDDQLWLVM EFCGAGSVTD LVKATKGNSL 120

KEDWIAYICR EILKGLQHLH KHKVIHRDIK GQNVLLTENA DVKLVDFGVS AQLDKTIGRR 180

NTFIGTPYWM APEVIACEQN ASATYDYRSD IWSLGITAIE MAEGSPPLCD MHPMRALFLI 240

PRNSPPRLRE KRWNSRFQSF VEQTLIKNYH QRSNTDSLLR HPFIKDQPNE RQVKIQLKDH 300

IDRTKRKKIG DTEYEYSGSE DETEDPPEEG APSSIAIAPG ESTLRRNFLK LQQENKERSE 360

LQKRERQQKE LNDERRKNEK KKEDRRKSDD QRENLRREQA KKEERAREQR RKLDAERKRK 420

EEEARLMQER IQQQRREQEE AHQRATEEAL RRKKENEAPP ISHQRSHSQH VREKPQWARQ 480

IEERSKQNRP ESPVQQRIRS GSVQLTPSQS PNRSPALPRR QPIIPALAQD RSNPGTVERI 540

VRNSPHHNRK QYPQVPDDLD RVAANLKAMA APSLTRPSGN HQTRVTDYSS SSNSSDSDDS 600

FIDANQHGGI SNQGTLVINN QAGDSYSGGD TRGRDNGGLS NSQSSWDRRA GPSVMPDLLP 660

RNHPHDLHDD TSASASGASV RDDRKVSVVN VNPHSSEHAP VVTTDMPEIR KYKKRFNSEI 720

LCASLWGVNL LIGADNGMML LDRSGQGKVY PLIGRRRFQQ LDVLEGLNLV VTISGKKNKL 780

RVYYLSWLRN KILRNDPEVE KKIGYAPVGD LEGCTQYKVV KYERIKFLVI ALRNNIEVYA 840

WAPRPYHKFM AFKSFSDLPH KPMIVDLTVE EGSRLKLLYG SAYGFHAIDV DSGQNYDLYI 900

PNHMTPPITA HAIIMLPNSD GMELLVCYED EGVYVNTYAN ISKDIVLQWG EHPTSVAYIR 960

SGQIMGWGEK AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVH SSSSSQVYFM 1020

ALNRNLQMNW 1030

Nucleotide Sequence
(FASTA)

ATGTCTGGTG GGCTGGATGA TATAGATCTA GCTGGATTAC GGGAACCTGC TGGGATATTC 60

GAACTGGTAC AAGTCGTGGG CAATGGAACT TATGGACAAG TGTACAAAGG CAGACATGTC 120

AAGACAGGTC AACTCGCTGC CATTAAAGTG ATGGATGTAA CTGAGGAAGA AGAAGAGGAA 180

ATAAAGTTGG AAATCAACAT GTTGAAGAAA TATTCAGAGC ATCGTAACAT TGCAACGTAT 240

TACGGGGCTT TTGTGAATAA AACTGCACCT GGCAACGATG ATCAACTGTG GTTGGTCATG 300

GAGTTCTGTG GGGCTGGATC TGTTACTGAT CTCGTTAAAG CAACAAAGGG AAATTCATTA 360

AAAGAAGACT GGATTGCATA TATTTGCCGC GAAATACTGA AGGGCTTACA ACATCTGCAC 420

AAACACAAAG TAATTCACCG TGATATAAAA GGCCAGAACG TCCTTTTAAC GGAAAACGCC 480

GATGTGAAAC TAGTTGACTT TGGAGTTAGT GCACAGCTTG ACAAAACAAT TGGACGACGT 540

AATACATTTA TCGGCACGCC TTACTGGATG GCACCAGAAG TTATAGCTTG TGAGCAAAAT 600

GCATCTGCCA CTTATGATTA TAGGAGTGAC ATATGGTCAT TAGGAATCAC TGCTATTGAA 660

ATGGCTGAAG GATCACCTCC TCTGTGCGAC ATGCACCCCA TGAGAGCTCT CTTTCTTATT 720

CCAAGAAATT CACCCCCGAG ACTCCGAGAA AAAAGATGGA ACTCAAGGTT CCAAAGCTTT 780

GTGGAGCAAA CACTGATAAA GAATTACCAC CAGCGTTCCA ACACTGACTC CTTGCTACGC 840

CACCCTTTTA TTAAGGACCA ACCGAACGAA CGACAAGTTA AAATTCAACT AAAGGACCAC 900

ATTGATAGAA CCAAGAGAAA AAAGATTGGA GATACAGAGT ATGAGTACAG CGGATCGGAA 960

GATGAAACTG AAGATCCTCC TGAAGAAGGA GCACCAAGCT CTATCGCCAT TGCTCCAGGA 1020

GAGTCAACTC TTCGGAGAAA TTTCCTCAAA TTGCAACAAG AGAATAAAGA AAGATCGGAA 1080

CTCCAGAAGC GAGAGAGACA GCAGAAGGAG TTAAACGATG AACGGAGAAA GAATGAGAAG 1140

AAGAAAGAAG ATCGAAGAAA ATCGGATGAC CAGCGCGAGA ATTTACGTCG TGAACAAGCG 1200

AAGAAAGAAG AGCGCGCACG TGAACAGAGA CGTAAATTAG ATGCAGAGCG TAAACGAAAG 1260

GAGGAAGAAG CAAGGTTGAT GCAGGAAAGG ATTCAACAAC AAAGAAGAGA GCAAGAGGAG 1320

GCTCATCAAA GAGCAACAGA GGAGGCTCTT AGGAGAAAAA AAGAAAATGA AGCTCCGCCA 1380

ATATCCCACC AGCGTAGCCA CTCTCAACAC GTTCGTGAAA AGCCGCAGTG GGCACGCCAG 1440

ATCGAAGAAA GAAGCAAACA GAATAGACCA GAGTCTCCCG TACAGCAACG AATAAGATCT 1500

GGCTCTGTAC AACTAACCCC TAGTCAATCC CCAAATCGAA GTCCTGCATT GCCACGACGA 1560

CAGCCAATAA TCCCAGCGCT TGCACAAGAC AGATCTAACC CTGGTACTGT AGAACGAATT 1620

GTCAGGAACT CGCCGCATCA TAACAGGAAA CAATACCCAC AAGTTCCTGA TGATTTGGAC 1680

AGAGTTGCTG CGAACTTAAA AGCAATGGCT GCACCCTCAT TAACCAGACC AAGTGGAAAT 1740

CACCAGACCA GAGTTACGGA TTATTCTTCT TCATCTAATA GCAGTGATAG TGATGATTCG 1800

TTCATTGATG CAAATCAACA TGGGGGGATT TCAAACCAAG GAACATTGGT GATAAACAAC 1860

CAAGCAGGGG ATTCATATAG TGGGGGAGAT ACACGTGGAA GGGATAATGG GGGTCTAAGT 1920

AACTCGCAAT CAAGTTGGGA TAGAAGAGCT GGTCCTTCAG TTATGCCGGA TCTACTTCCA 1980

AGGAACCATC CTCATGACCT ACATGATGAT ACATCAGCTT CTGCTTCGGG AGCAAGCGTT 2040

CGCGATGATC GTAAAGTGTC GGTCGTTAAC GTGAACCCTC ATTCATCCGA ACACGCACCT 2100

GTTGTGACCA CTGACATGCC GGAAATACGA AAATATAAGA AGAGGTTTAA CTCCGAGATT 2160

CTCTGTGCTT CTCTATGGGG GGTTAATTTA CTTATTGGAG CCGACAATGG AATGATGCTG 2220

TTGGATAGAA GTGGACAGGG AAAGGTTTAT CCTCTCATTG GAAGGAGAAG ATTTCAACAA 2280

CTCGATGTAT TGGAAGGTCT TAACTTGGTG GTTACTATTT CAGGTAAGAA GAACAAACTG 2340

CGAGTTTATT ACCTCAGTTG GTTGAGGAAC AAAATCCTCC GAAACGATCC GGAAGTTGAA 2400

AAAAAGATCG GTTACGCTCC TGTGGGAGAT TTGGAAGGTT GTACTCAATA TAAAGTTGTC 2460

AAGTACGAAA GAATTAAGTT TTTAGTCATT GCTTTAAGAA ACAACATAGA AGTCTACGCT 2520

TGGGCGCCTC GGCCCTACCA TAAGTTCATG GCTTTTAAAT CCTTCAGTGA TTTACCTCAC 2580

AAACCAATGA TAGTGGATCT AACAGTAGAA GAGGGCTCCA GACTTAAGCT TCTGTATGGT 2640

TCCGCATATG GATTTCATGC AATAGACGTT GATTCCGGTC AAAATTATGA TCTCTACATT 2700

CCTAATCATA TGACGCCACC TATAACAGCC CATGCTATTA TTATGTTGCC CAACTCTGAT 2760

GGGATGGAGT TGTTGGTTTG TTATGAGGAT GAAGGGGTGT ATGTTAACAC ATACGCCAAT 2820

ATTAGTAAAG ATATTGTTCT ACAATGGGGA GAACACCCAA CTTCAGTTGC TTACATTAGA 2880

TCAGGTCAGA TCATGGGTTG GGGGGAAAAG GCAATTGAAA TACGTTCCGT TGAAACCGGC 2940

CATTTAGACG GGGTGTTCAT GCACAAACGT GCGCAGAGAC TTAAGTTTTT ATGCGAACGA 3000

AATGACAAAG TTTTCTTTGC ATCCGTGCAC AGTTCATCAT CAAGTCAAGT CTACTTCATG 3060

GCCCTTAACA GGAATTTGCA AATGAATTGG TAA 3093

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el++++g+G++g+vy++r++ktg+l+aik++++++ e++ee++ ei++lkk+++ +ni

Q: 20    FELVQVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-EEEEEIKLEINMLKKYSEhRNIA  78

         899********************************9.9999***********9866****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+       +++lwlvme++ +Gs++dlvk ++ ++lkE++iayi+re+lk+L++

Q: 79    TYYGAFVNktapgnDDQLWLVMEFCGAGSVTDLVKATKGNSLKEDWIAYICREILKGLQH  138

         *******999***99*********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte+++VkL+dfgv+aql+kt  +r+t++gtpywmAPEvia+e

Q: 139   LHKHKVIHRDIKGQNVLLTENADVKLVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACE  198

         ***********************************************************9

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

              +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+l++k ++ ++f

Q: 199   qnaSATYDYRSDIWSLGITAIEMAEGSPPLCDMHPMRALFLIPRNSPPRLREK-RWNSRF  257

         888889********************************************887.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++fve+ l kn+++R+++++ll+h+F+

Q: 258   QSFVEQTLIKNYHQRSNTDSLLRHPFI  284

         **************************7

Domain Sequence
(FASTA)

FELVQVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEEEEE EIKLEINMLK KYSEHRNIAT 60

YYGAFVNKTA PGNDDQLWLV MEFCGAGSVT DLVKATKGNS LKEDWIAYIC REILKGLQHL 120

HKHKVIHRDI KGQNVLLTEN ADVKLVDFGV SAQLDKTIGR RNTFIGTPYW MAPEVIACEQ 180

NASATYDYRS DIWSLGITAI EMAEGSPPLC DMHPMRALFL IPRNSPPRLR EKRWNSRFQS 240

FVEQTLIKNY HQRSNTDSLL RHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013