EKS-CII-00107

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CII-00107

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	448.5	5.7E-135	412	669	258

Status

Unreviewed

Ensembl Protein

ENSCINP00000011573

UniProt Accession

F6U3T3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

LOC100175855

Gene Synonyms/Alias

LOC100175855;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCING00000005582	ENSCINP00000011573	ENSCINT00000011573

Organism

Ciona intestinalis

Functional Description

Protein Length

730

Protein Sequence
(FASTA)

MPLAPFGNAP FVNSANTQPL TEEVLCLVSE EKNDEQMHEI EIKENTIKGC QKADPSQFEL 60

LKVLGQGSFG KVFLVRKIVG NDRHQLYAMK VLKKAKLKVR DRVRTKMERN ILVDVNHPFI 120

VKVYYAFQTD GNLYMVLAYL RGGDLFTRLS KELMFTEDDV KIYLAELALA LDHLHSLGII 180

YRDLKPENIL LDVDGHIALT DFGLSKESTD GSEKAYSFCG TVEYMAPEVV NRRGHDHSAD 240

WWSFGVLMYE MLTGQLPFQG RDRKDTMTQI LKAKLGMPQF LSPEAQSLLR MLFKRNPANR 300

LGSGSDGVEE IKRHPFFSGI DWNRLLRKDI DPPFKPSASR AEDATYFDSE FTSRTPRDSP 360

GVPASAAAQQ LFRGFSFVAP IIEEDAVGTG VIGIMVLKFL LNNSPKKFYD EYDVREEIGI 420

GSYSVCKRCI HKGTKKEYAV KIIFKNKRDC EEEVQILLRY GQHPNIITLK DVFDDGQHVF 480

LVTELMKGGE LLDKILRQKF FTEKEASAVL KTVAKVVVYL HKNGVVHRDL KPSNILYADE 540

TGNPESLRVC DFGFAKQLRH DNGLLMTPCY TANFVAPEVL KKKGYDEACD IWSLGVLLYT 600

MLAGYTPFAN GPDDTPTDIL KRIETGKFNM SGGNWKSVSE TAKDLVRRML HVDPNRRLSA 660

PQVLMHSFIA RPDQLPEFHL NQSKDYKFVK GAMSAMFSAA RSHKPLNLNP VGTSLLAQRR 720

GAKKVTSTAL 730

Nucleotide Sequence
(FASTA)

ATGCCTTTGG CTCCTTTCGG AAATGCTCCG TTTGTTAATT CAGCGAATAC TCAGCCTCTC 60

ACAGAAGAGG TATTGTGCCT TGTGAGTGAA GAGAAAAATG ATGAACAGAT GCACGAGATA 120

GAAATCAAAG AAAATACGAT CAAGGGTTGT CAGAAAGCTG ATCCGAGTCA GTTTGAACTT 180

CTTAAGGTTC TGGGACAAGG CTCGTTTGGG AAAGTTTTTC TTGTGCGAAA AATTGTTGGT 240

AATGACCGTC ACCAGTTATA TGCCATGAAA GTTTTAAAGA AAGCAAAACT GAAGGTCAGA 300

GACAGAGTTC GAACTAAAAT GGAACGAAAT ATATTGGTTG ATGTAAACCA TCCTTTTATT 360

GTCAAGGTTT ACTATGCGTT TCAAACGGAT GGTAACCTTT ACATGGTGCT TGCCTATCTT 420

CGAGGAGGTG ACCTGTTCAC TCGTCTATCT AAGGAGTTGA TGTTCACTGA GGATGACGTG 480

AAGATTTATC TCGCTGAGCT TGCTCTTGCT CTCGATCATC TTCATTCACT TGGGATTATT 540

TACCGGGACT TGAAACCAGA AAACATCTTA CTTGACGTTG ACGGCCATAT CGCCCTCACT 600

GATTTCGGGT TGAGTAAGGA GTCCACAGAT GGCTCAGAGA AGGCGTATTC ATTCTGTGGC 660

ACGGTGGAAT ACATGGCACC TGAGGTTGTC AATCGTCGCG GTCATGACCA CTCCGCAGAT 720

TGGTGGTCGT TTGGTGTCCT GATGTATGAG ATGCTGACTG GCCAACTCCC TTTTCAAGGC 780

AGAGACAGGA AAGACACAAT GACTCAGATT TTGAAGGCAA AGTTAGGTAT GCCACAGTTC 840

TTGAGTCCTG AAGCACAAAG CTTGCTAAGA ATGCTGTTCA AACGAAACCC AGCCAACAGA 900

TTGGGAAGTG GGTCAGATGG AGTGGAAGAG ATCAAGAGAC ATCCCTTCTT CAGCGGAATC 960

GATTGGAACC GTCTCCTCCG TAAAGACATT GATCCTCCAT TTAAACCATC TGCATCAAGA 1020

GCGGAAGATG CAACTTATTT CGACTCCGAG TTCACCTCTA GAACACCAAG AGATTCACCT 1080

GGAGTGCCTG CCAGTGCGGC AGCTCAACAA TTATTCCGAG GATTTTCGTT CGTGGCTCCC 1140

ATTATTGAAG AGGACGCTGT TGGAACAGGT GTAATTGGTA TAATGGTATT AAAGTTTTTG 1200

TTAAACAATT CACCCAAGAA GTTTTACGAC GAATATGACG TGAGAGAAGA AATTGGAATT 1260

GGATCTTACT CCGTGTGCAA GAGGTGTATT CATAAGGGGA CTAAGAAAGA ATACGCTGTC 1320

AAGATTATTT TCAAGAATAA GAGAGATTGT GAAGAAGAAG TTCAGATTCT ACTTAGATAT 1380

GGCCAACATC CTAATATTAT TACTCTCAAG GATGTATTTG ATGATGGGCA GCACGTGTTC 1440

TTGGTAACTG AGCTCATGAA AGGGGGAGAA TTACTCGATA AAATATTACG ACAAAAGTTT 1500

TTCACTGAGA AGGAGGCCAG CGCTGTGCTT AAAACTGTGG CGAAAGTTGT GGTGTACCTG 1560

CACAAGAATG GGGTTGTGCA TCGTGATTTA AAACCAAGCA ACATTCTTTA TGCTGATGAG 1620

ACAGGCAACC CTGAATCTCT ACGTGTATGC GACTTTGGAT TTGCCAAACA ACTTAGACAC 1680

GACAATGGAC TTCTTATGAC GCCATGTTAT ACGGCAAATT TTGTGGCTCC AGAGGTGCTA 1740

AAGAAAAAGG GTTATGATGA GGCTTGTGAT ATCTGGAGTT TGGGTGTCTT GTTATACACC 1800

ATGTTAGCTG GTTATACACC ATTTGCTAAT GGCCCAGATG ACACACCAAC TGATATTTTG 1860

AAACGCATTG AAACTGGAAA GTTTAATATG TCGGGTGGAA ACTGGAAAAG TGTCTCGGAA 1920

ACTGCAAAGG ATCTGGTGCG TAGAATGCTT CATGTTGATC CTAACCGTCG ATTGTCAGCT 1980

CCGCAAGTCC TCATGCACTC ATTTATCGCT CGACCAGACC AATTGCCCGA GTTTCATCTC 2040

AACCAATCAA AGGATTATAA ATTTGTCAAG GGTGCCATGT CTGCTATGTT CAGTGCTGCA 2100

CGTTCACATA AACCACTGAA CCTGAATCCT GTTGGGACAT CACTGCTTGC ACAGCGCCGT 2160

GGGGCCAAAA AAGTCACTTC CACAGCCCTT TAA 2193

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y v+e++G Gsysvckrc+hk t++e+avkii k+krd +ee++illry+qhpni+tlkd

Q: 412   YDVREEIGIGSYSVCKRCIHKGTKKEYAVKIIFKNKRDCEEEVQILLRYGQHPNIITLKD  471

         57899*******************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v+ddg++v+lv+el+kGGelld+i+++kff+e+easa+l+t++k v ylh++Gvvhrdlk

Q: 472   VFDDGQHVFLVTELMKGGELLDKILRQKFFTEKEASAVLKTVAKVVVYLHKNGVVHRDLK  531

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+de++n+es++++dfGfak++r++ngll+tpcyt+nfvapevlk++Gydeacd+

Q: 532   PSNILYADETGNPESLRVCDFGFAKQLRHDNGLLMTPCYTANFVAPEVLKKKGYDEACDI  591

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaGy+pfangp+dt+++il++i+ Gkf +sG++w+svse+akdlv+++l+

Q: 592   WSLGVLLYTMLAGYTPFANGPDDTPTDILKRIETGKFNMSGGNWKSVSETAKDLVRRMLH  651

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl + q+l hs++

Q: 652   VDPNRRLSAPQVLMHSFI  669

         **************9986

Domain Sequence
(FASTA)

YDVREEIGIG SYSVCKRCIH KGTKKEYAVK IIFKNKRDCE EEVQILLRYG QHPNIITLKD 60

VFDDGQHVFL VTELMKGGEL LDKILRQKFF TEKEASAVLK TVAKVVVYLH KNGVVHRDLK 120

PSNILYADET GNPESLRVCD FGFAKQLRHD NGLLMTPCYT ANFVAPEVLK KKGYDEACDI 180

WSLGVLLYTM LAGYTPFANG PDDTPTDILK RIETGKFNMS GGNWKSVSET AKDLVRRMLH 240

VDPNRRLSAP QVLMHSFI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013